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Chemical Structure| 768385-35-9 Chemical Structure| 768385-35-9

Structure of 768385-35-9

Chemical Structure| 768385-35-9

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Product Details of [ 768385-35-9 ]

CAS No. :768385-35-9
Formula : C13H19NO2
M.W : 221.30
SMILES Code : O=C(OCC1=CC=CC=C1)CCCN(C)C
MDL No. :MFCD29067631

Safety of [ 768385-35-9 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319
Precautionary Statements:P501-P270-P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313-P301+P312+P330

Application In Synthesis of [ 768385-35-9 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 768385-35-9 ]

[ 768385-35-9 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 768385-35-9 ]
  • [ 4263-52-9 ]
  • [ 1349808-74-7 ]
YieldReaction ConditionsOperation in experiment
20% With 2,6-di-tert-butyl-pyridine; 1-butyl-3-methylimidazolium Tetrafluoroborate; at 150℃; for 16h; b) Compound lb; [0169] A mixture of compound la, (0.1 g, 0.45 mmole), sodium 2- bromoethanesulfonate (0.19 g, 2 equivalents) and 2,6-di-tert-butylpyridine (99 muL, 0.45 mmole) in [BMIM]BF4] (1 mL, Aldrich) was heated in an oil bath at 150C with vigorous stirring for 16 hours. The reaction was then cooled to room temperature and a small portion of the reaction mixture was withdrawn, diluted with methanol/water and analyzed by analytical HPLC using a Phenomenex, Ci8,4.6 x 250 mm column and a 30 minute gradient of 10? 70% MeCN/water (with 0.05% TFA) at a flow rate of 1.0 mL/minute and UV detection at 260nm and 220 nm. Product was observed eluting at Rt = 13.3 minutes (-40% conversion). The reaction mixture was prepared by diluting it with water (15 mL) and washing this solution with ethyl acetate (2 x 25 mL). The aqueous solution was then treated with 3 to 4 drops of ammonia and further extracted with ethyl acetate (2 x 25 mL). The aqueous solution was then concentrated to about 7 mL by rotary evaporation. The product was then purified by preparative HPLC using an YMC, Ci8, 30 x 250 mm column and the same gradient as described above at a flow rate of 20 mL/minute. HPLC fractions containing product were combined and concentrated under reduced pressure. Yield = 30 mg (20%, white solid); MALDI-TOF MS 330.6 observed.
 

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