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Chemical Structure| 7693-77-8 Chemical Structure| 7693-77-8

Structure of 7693-77-8

Chemical Structure| 7693-77-8

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Product Details of [ 7693-77-8 ]

CAS No. :7693-77-8
Formula : C9H9NO2
M.W : 163.17
SMILES Code : O=C1OC(C2=CC=CC=C2)CN1
MDL No. :MFCD01747962
InChI Key :ARILQDNHZGKJBK-UHFFFAOYSA-N
Pubchem ID :202193

Safety of [ 7693-77-8 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P280-P301+P312-P302+P352-P305+P351+P338

Application In Synthesis of [ 7693-77-8 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 7693-77-8 ]

[ 7693-77-8 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 552331-00-7 ]
  • [ 7693-77-8 ]
  • [ 1019650-97-5 ]
YieldReaction ConditionsOperation in experiment
77% With copper(l) iodide; potassium carbonate; N,N`-dimethylethylenediamine; In 1,4-dioxane; at 10 - 35℃; for 16h;Reflux; Inert atmosphere; Reference Example 42; 3-(2-aminopyridin-4-yl)-5-phenyl-1,3-oxazolidin-2-oneTo a solution of <strong>[552331-00-7]4-iodopyridin-2-amine</strong> (2.0 g, 9.09 mmol), 5-phenyl-1,3-oxazolidin-2-one (1.7 g, 10.5 mmol) obtained in Reference Example 41 and potassium carbonate (2.5 g, 18.2 mmol) in 1,4-dioxane (30 mL) were added copper iodide (173 mg, 909 mumol) and N,N'-dimethylethylenediamine (80 mg, 909 mumol) at room temperature, and the mixture was heated under reflux for 16 hr under an argon stream. The solid was filtered off, and the filtrate was concentrated under reduced pressure. The obtained residue was purified by silica gel column chromatography (ethyl acetate) to give the title compound (1.78 g, yield 77%) as crystals.melting point 155-156 C. (ethyl acetate-hexane)1H-NMR (CDCl3) delta: 3.90 (1H, dd, J=9.0, 7.5 Hz), 4.35 (1H, t, J=9.0 Hz), 4.49 (2H, br s), 5.64 (1H, t, J=7.5 Hz), 6.67 (1H, dd, J=6.0, 2.1 Hz), 6.93 (1H, d, J=2.1 Hz), 7.34-7.50 (5H, m), 8.00 (1H, d, J=6.0 Hz).
 

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