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Chemical Structure| 769922-03-4 Chemical Structure| 769922-03-4

Structure of 769922-03-4

Chemical Structure| 769922-03-4

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Product Details of [ 769922-03-4 ]

CAS No. :769922-03-4
Formula : C11H12N2O2
M.W : 204.23
SMILES Code : NC1=CC=C(OCC)C=C1C2=NC=CO2

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Application In Synthesis of [ 769922-03-4 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 769922-03-4 ]

[ 769922-03-4 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 57279-72-8 ]
  • [ 145214-05-7 ]
  • [ 769922-03-4 ]
YieldReaction ConditionsOperation in experiment
45% tetrakis(triphenylphosphine) palladium(0); In 1,4-dioxane; at 35℃; for 3h;Heating / reflux; To a solution of 2-bromo-4-ethoxyaniline (4.0 g, 18.5 mol) in 1,4-dioxane (80 ml) is added PD (PH3P) 4 (2.1 g, 1.85 mmol) and 2- (TRIBUTYLSTANNYL)-1, 3-oxazole (21.2 g, 59.3 mmol). The reaction mixture is purged with argon and refluxed at 95oC for 3hr. The mixture is concentrated, diluted with n-hexanes, extracted with CH3CN, and concentrated under vacuum. The residue is purified by silica gel chromatography (CH2CL2) to afford 4-ETHOXY-2- (1, 3-oxazol-2-yl) aniline as a brown solid 1.65 g (45%). HRMS (ESI) calcd for CILHL2N202+H 205.0977, found 205.0973.
 

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