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Chemical Structure| 771581-60-3 Chemical Structure| 771581-60-3

Structure of 771581-60-3

Chemical Structure| 771581-60-3

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Product Details of [ 771581-60-3 ]

CAS No. :771581-60-3
Formula : C8H7ClF3NO
M.W : 225.60
SMILES Code : NCC1=CC(Cl)=C(OC(F)(F)F)C=C1
MDL No. :MFCD09745402

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Application In Synthesis of [ 771581-60-3 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 771581-60-3 ]

[ 771581-60-3 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 261763-18-2 ]
  • [ 771581-60-3 ]
YieldReaction ConditionsOperation in experiment
Preparation 16; 1-[3-chloro-4-(thfluoromethoxy)phenvl1methanamine; To a solution of 3-chloro-4-(thfluoromethoxy)benzyl bromide (10.0g, 34.5mmol) in DMF (10OmL) was added phthalimide (5.6g, 38.0mmol) and potassium carbonate (7.15g, 51.8mmol) and the mixture stirred at 8O0C for 5 hours. The mixture was cooled and treated with water (10OmL) and the resulting white precipitate filtered, washed with water and dried in vacuo. This crude solid (16g) was suspended in methylamine (10OmL of a 40% aqueous solution) and water (10OmL) and heated in a bomb at 100 0C for 3 hours. Additional methylamine (10OmL of a 40% aqueous solution) was added and heating at 100 0C continued for 8 hours. The reaction was then cooled to room temperature and diluted with brine (30OmL) and TBME (30OmL). The organic layer was separated, dried (Na2SO4) then concentrated in vacuo to provide the title compound as a yellow oil (9.Og, crude quant.). This material was used crude for subsequent reactions. 1H NMR (de-DMSO): 3.71 (s, 2 H), 7.37-7.41 (m, 1 H), 7.44-7.48 (m, 1 H), 7.63 (d, 1 H)
 

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[ 771581-60-3 ]

Chemical Structure| 2680540-37-6

A157344 [2680540-37-6]

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