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[ CAS No. 777049-50-0 ] {[proInfo.proName]}

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Chemical Structure| 777049-50-0
Chemical Structure| 777049-50-0
Structure of 777049-50-0 * Storage: {[proInfo.prStorage]}
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Product Details of [ 777049-50-0 ]

CAS No. :777049-50-0 MDL No. :MFCD18815388
Formula : C8H15NO2 Boiling Point : -
Linear Structure Formula :- InChI Key :TUXFSVNDVGOMQY-UHFFFAOYSA-N
M.W : 157.21 Pubchem ID :21955364
Synonyms :

Safety of [ 777049-50-0 ]

Signal Word:Warning Class:N/A
Precautionary Statements:P261-P305+P351+P338 UN#:N/A
Hazard Statements:H315-H319-H335 Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 777049-50-0 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 777049-50-0 ]

[ 777049-50-0 ] Synthesis Path-Downstream   1~13

  • 1
  • [ 777049-50-0 ]
  • [ 24424-99-5 ]
  • [ 757239-42-2 ]
YieldReaction ConditionsOperation in experiment
90% With triethylamine; In dichloromethane; at 20.0℃; for 2.0h; tert-Butyl 4-hydroxy-2-oxa-8-azaspiro[4.5]decane-8-carboxylate (0326) To a solution of <strong>[777049-50-0]2-oxa-8-azaspiro[4.5]decan-4-ol</strong> (1.0 g, 6.4 mmol) in CH2Cl2 (15 mL), was added di-tert-butyl dicarbonate (1.7 g, 7.6 mmol) at RT, then Et3N (1.2 mL, 12.8 mmol) was added at RT. The reaction mixture was stirred at RT for 2 h, quenched with H2O (5 mL) and extracted with EtOAc (15 mL×3). The organic layer was separated and washed with brine, dried over Na2SO4, filtered, and concentrated under reduced pressure to give the title compound as a colorless oil (1.5 g, 90%), which was used directly without further purification. (0327) MS (ES+) C13H23NO4 requires: 257, found: 280 [M+Na]+.
90% With triethylamine; In dichloromethane; at 20.0℃; for 2.0h; To a solution of <strong>[777049-50-0]2-oxa-8-azaspiro[4.5]decan-4-ol</strong> (1.0 g, 6.4 mmol) in CH2CI2 (15 mL), was added di-tert-butyl dicarbonate (1.7 g, 7.6 mmol) at RT, then Et3N (1.2 mL,l2.8 mmol) was added at RT. The reaction mixture was stirred at RT for 2h, quenched with H2O (5 mL) and extracted with EtOAc (15 mL x 3). The organic layer was separated and washed with brine, dried over a2S04, filtered, and concentrated under reduced pressure to give the title compound as a colorless oil (l.5g, 90%), which was used directly without further purification. MS (ES+) C13H23NO4 requires: 257, found: 280 [M+Na]+.
  • 2
  • [ 777049-50-0 ]
  • (3-chloro-5-((S)-4-((R)-1-(4-methoxyphenyl)ethylamino)-2-oxa-8-azaspiro[4.5]-decan-8-yl)pyrazin-2-yl)(2,3-dichlorophenyl)methanone [ No CAS ]
  • 3
  • [ 777049-50-0 ]
  • (S)-8-(3-(2,3-dichlorophenyl)-1H-pyrazolo[3,4-b]pyrazin-6-yl)-N-((R)-1-(4-methoxyphenyl)ethyl)-2-oxa-8-azaspiro[4.5]decan-4-amine [ No CAS ]
  • 4
  • [ 777049-50-0 ]
  • (S)-8-(3-(2,3-dichlorophenyl)-1H-pyrazolo[3,4-b]pyrazin-6-yl)-2-oxa-8-azaspiro[4.5]decan-4-amine 2,2,2-trifluoroacetate [ No CAS ]
  • 5
  • [ 777049-50-0 ]
  • (3-chloro-2-methoxypyridin-4-yl)(3-chloro-5-((S)-4-((R)-1-(4-methoxy-phenyl)ethylamino)-2-oxa-8-azaspiro[4.5]decan-8-yl)pyrazin-2-yl)methanone [ No CAS ]
  • 6
  • [ 777049-50-0 ]
  • (S)-8-(3-(3-chloro-2-methoxypyridin-4-yl)-1H-pyrazolo[3,4-b]pyrazin-6-yl)-N-((R)-1-(4-methoxyphenyl)ethyl)-2-oxa-8-azaspiro[4.5]decan-4-amine [ No CAS ]
  • 7
  • [ 777049-50-0 ]
  • (S)-4-(6-(4-amino-2-oxa-8-azaspiro[4.5]decan-8-yl)-1H-pyrazolo[3,4-b]pyrazin-3-yl)-3-chloropyridin-2-ol [ No CAS ]
  • 8
  • [ 777049-50-0 ]
  • (3-chloro-2-(4-methoxybenzylamino)pyridin-4-yl)(3-chloro-5-((S)-4-((R)-1-(4-methoxyphenyl)ethylamino)-2-oxa-8-azaspiro[4.5]decan-8-yl)pyrazin-2-yl)methanone [ No CAS ]
  • 9
  • [ 777049-50-0 ]
  • (S)-8-(3-(3-chloro-2-(4-methoxybenzylamino)pyridin-4-yl)-1H-pyrazolo[3,4-b]-pyrazin-6-yl)-N-((R)-1-(4-methoxyphenyl)ethyl)-2-oxa-8-azaspiro[4.5]decan-4-amine [ No CAS ]
  • 10
  • [ 777049-50-0 ]
  • (S)-8-(3-(2-amino-3-chloropyridin-4-yl)-1H-pyrazolo[3,4-b]pyrazin-6-yl)-2-oxa-8-azaspiro[4.5]decan-4-amine [ No CAS ]
  • 11
  • [ 777049-50-0 ]
  • (S)-N-((R)-1-(4-methoxyphenyl)ethyl)-2-oxa-8-azaspiro[4.5]decan-4-amine [ No CAS ]
  • 12
  • [ 777049-50-0 ]
  • tert-butyl 4-oxo-2-oxa-8-azaspiro[4.5]decane-8-carboxylate [ No CAS ]
  • 13
  • [ 777049-50-0 ]
  • (S)-tert-butyl 4-((R)-1-(4-methoxyphenyl)ethylamino)-2-oxa-8-azaspiro[4.5]decane-8-carboxylate [ No CAS ]
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