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CAS No. : | 7789-45-9 | MDL No. : | MFCD00010970 |
Formula : | Br2Cu | Boiling Point : | - |
Linear Structure Formula : | - | InChI Key : | QTMDXZNDVAMKGV-UHFFFAOYSA-L |
M.W : | 223.35 | Pubchem ID : | 24611 |
Synonyms : |
|
Signal Word: | Danger | Class: | 8 |
Precautionary Statements: | P260-P264-P270-P273-P280-P301+P312+P330-P301+P330+P331-P303+P361+P353-P304+P340+P310-P305+P351+P338+P310-P363-P391-P405-P501 | UN#: | 3260 |
Hazard Statements: | H302-H314-H410 | Packing Group: | Ⅱ |
GHS Pictogram: |
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
In acetonitrile; | 1) Cupric bromide (11.8 g) and tertiary butyl nitrite (7.4 g) were added to 500 ml of acetonitrile, and stirring was performed at 50 C. 2,6-Diaminoanthraquinone (5.7 g) was added in three portions into the reaction system, and stirring was performed at 50 C. for 8 hours. After the reaction was completed, the mixture was allowed to stand to cool to room temperature, and the solvent was removed by distillation under reduced pressure. The residue was washed with water and air-dried for two days to yield 8.5 g of 2,6-dibromoanthraquinone. | |
With hydrogenchloride; tert.-butylnitrite; In acetonitrile; | 1) Synthesis of 2,6-dibromoanthraquinone In a 2-neck round flask, copper (II) bromide (24 g, 0.1 mol) and tert-butyl nitrite (10.8 g, 0.1 mol) were added to 200 mL of acetonitrile and stirred, the mixture was warned to -65 C., and then 2,6-diaminoanthraquinone (10 g, 0.04 mol) was gradually added dropwise thereto for 10 minutes. The reaction was monitored with TLC, the reaction mixture was cooled down to room temperature, and then 200 mL of aq. 2N HCl was added thereto. The resulting solid was filtered and washed with diluted water and methanol, thereby obtaining 2,6-dibromoanthraquinone (9.2 g, yield: 60%). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
80% | In methanol; for 0.25h;Heating / reflux; | 50 ml of degassed, anhydrous methanol were heated to reflux temperature, and 2.36 g (7.9 mmol) of 2-(di-tert-butylphosphino)biphenyl were added slowly to the methanol until the phosphine compound was completely dissolved. Subsequently, 0.59 g (2.6 mmol) of copper(II) bromide was added to the solution in portions. After the copper bromide had been added, the solution was heated to reflux temperature for a further 15 min, and then the solution was cooled. After the solution had been cooled, a solid precipitated out and was filtered off, and was washed with a little ethanol and diethyl ether and subsequently dried. 0.93 g (1.1 mmol) of the abovementioned compound was obtained. The yield was 80percent of theory. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
In acetonitrile; | Step (a) 3-Bromo-dibenzofuran 3-Amino-dibenzofuran (15 g, 81.9 mmoles) was added in portions to a suspension of cupric bromide (21.9 g, 98.2 mmoles) and tert.-butyl nitrite (12.66 g, 122.8 mmoles) in 350 mL of acetonitrile. This mixture was heated to reflux for 2 hours and then stirred for 16 hours at room temperature. The reaction was partitioned between 1 M HCl and diethyl ether. The diethyl ether layer was washed with brine, dried over magnesium sulfate, filtered, and concentrated to give an oily solid. Chromatography gave the title compound as a yellowish solid. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
In chloroform; ethyl acetate; | A. 4-Bromoacetyl-benzoic acid ethyl ester Copper(II) bromide (2.47 g, 10.9 mmol) was suspended in ethyl acetate (7.5 ml) and the solution was subsequently heated to reflux. To the reaction was added a solution of <strong>[38430-55-6]4-acetyl-benzoic acid ethyl ester</strong> (960.8 mg, 5.00 mmol) in chloroform (20 ml). After the mixture had stirred at reflux for 24 hours, the precipitate was removed via suction filtration and the resulting filtrate was partitioned between ethyl acetate and saturated NaHCO3 solution. The ethyl acetate layer was dried over MgSO4, filtered and concentrated under vacuum to give the titled compound as a white solid: 1 H NMR (CDCl3)delta 8.13 (m, 2H), 8.01 (m, 2H), 4.45 (s, 2H), 4.39 (q, J=7.2 Hz, 2H), 1.40 (t, J=7.2 Hz, 3H). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With tert.-butylnitrite; In acetonitrile; | Step 2 2-Bromo-6-ethoxycarbonylbenzothiazole A mixture of copper(II) bromide (2.70 g, 12.09 mmol) and anhydrous acetonitrile (50 mL) was purged with nitrogen, cooled in an ice bath, treated with tert-butyl nitrite (1.8 mL, 15.13 mmol), stirred 10 minutes at 0-5 C., and then treated with solid 2-amino-6ethoxycarbonylbenzothiazole (2.24 g, 10.08 mmol). The cooling bath was removed and the mixture was stirred at room temperature for 2 hours. The mixture was diluted with water (300 mL) and extracted with ether (2*100 mL). The extracts were filtered to remove copper salts, then washed with water (100 mL) and brine (100 mL), dried over sodium sulfate, filtered and evaporated under vacuum to provide crude 2-bromo-6-ethoxycarbonylbenzothiazole (1.90 g) as an orange-tan solid. 1 H NMR (CDCl3, 500 MHz) delta1.42 (t, CH3), 4.42 (q, CH2), 8.02 (d, H-4), 8.15 (dd, H-5), and 8.53 (d, H-7). 13 C NMR (CDCl3, 125.7 MHz) delta14.3, 61.5, 122.5, 122.9, 127.8, 137.2, 142.3, 155.0, and 156.7. | |
With tert.-butylnitrite; In acetonitrile; | Step 2 2-Bromo-6-ethoxycarbonylbenzothiazole A mixture of copper(II) bromide (2.70 g, 12.09 mmol) and anhydrous acetonitrile (50 mL) was purged with nitrogen, cooled in an ice bath, treated with tert-butyl nitrite (1.8 mL, 15.13 mmol), stirred 10 minutes at 0-5 C., and then treated with solid 2-amino-6 -ethoxycarbonylbenzothiazole (2.24 g, 10.08 mmol). The cooling bath was removed and the mixture was stirred at room temperature for 2 hours. The mixture was diluted with water (300 mL) and extracted with diethyl ether (2*100 mL). The extracts were filtered to remove copper salts, then washed with water (100 mL) and brine (100 mL), dried over sodium sulfate, filtered and evaporated under vacuum to provide crude 2-bromo-6-ethoxycarbonylbenzothiazole (1.90 g) as an orange-tan solid. 1 H NMR (CDCl3, 500 MHz) delta1.42 (t, CH3), 4.42 (q, CH2), 8.02(d, H-4), 8.15 (dd, H-5), and 8.53 (d, H-7). 13 C NMR (CDCl3, 125.7 MHz) delta14.3, 61.5, 122.5, 122.9, 127.8, 137.2, 142.3, 155.0, and 165.7. | |
With tert.-butylnitrite; In acetonitrile; | Step 2 2-Bromo-6-ethoxycarbonylbenzothiazole A mixture of copper(II) bromide (2.70 g, 12.09 mmol) and anhydrous acetonitrile (50 mL) was purged with nitrogen, cooled in an ice bath, treated with tert-butyl nitrite (1.8 mL, 15.13 mmol), stirred 10 minutes at 0-5 C., and then treated with solid 2-amino-6 ethoxycarbonylbenzothiazole (2.24 g, 10.08 mmol). The cooling bath was removed and the mixture was stirred at room temperature for 2 hours. The mixture was diluted with water (300 mL) and extracted with diethyl ether (2*100 mL). The extracts were filtered to remove copper salts, then washed with water (100 mL) and brine (100 mL), dried over sodium sulfate, filtered and evaporated under vacuum to provide crude 2-bromo-6-ethoxycarbonylbenzothiazole (1.90 g) as an orange-tan solid. 1 H NMR (CDCl3, 500 MHz) delta1.42 (t, CH3), 4.42 (q, CH2), 8.02(d, H-4), 8.15 (dd, H-5), and 8.53 (d, H-7). 13 C NMR (CDCl3, 125.7 MHz) delta14.3, 61.5, 122.5, 122.9, 127.8, 137.2, 142.3, 155.0, and 165.7. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
In chloroform; ethyl acetate; | (a) A solution of 16 g (0.09 mol) 2,3-dihydro-6-methoxy-4H1-benzopyran-4-one in 125 ml of chloroform was added dropwise to a stirred refluxing ethyl acetate solution (125 ml) of cupric bromide (25 g). After stirring under reflux for two hours, the mixture was filtered, and the filtrate was evaporated in vacuo. The residue was taken up into dichloromethane and washed free of excess bromine salts with aqueous sodium sulfite. The organic solution was evaporated in vacuo to yield 20.5 g of 3-bromo-2,3-dihydro-6-methoxy-4H1-benzopyran-4-one. | |
In chloroform; ethyl acetate; | (a) A solution of 16 g (0.09 mol) 2,3-dihydro-6-methoxy-4 H -1-benzopyran-4-one in 125 ml of chloroform was added dropwise to a stirred refluxing ethyl acetate solution (125 ml) of cupric bromide (25 g). After stirring under reflux for two hours, the mixture was filtered, and the filtrate was evaporated in vacuo. The residue was taken up into dichloromethane and washed free of excess bromine salts with aqueous sodium sulfite. The organic solution was evaporated in vacuo to yield 20.5 g of 3-bromo-2,3-dihydro-6-methoxy-4 H -1-benzopyran-4-one. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
In chloroform; ethyl acetate; | EXAMPLE 1 5-(5-Methylthien-2-yl)-2-(4-trifluoromethylphenyl)thiazole A warm soluton of 5-methyl-2-acetylthiophene (20.1 g, 0.14 mole) in chloroform (100 ml) was added to a stirred, refluxing mixture of copper (II) bromide (48.0 g, 0.22 mole) in ethyl acetate (100 ml). After complete addition the resultant mixture was heated at reflux for 2.5 hours. The mixture was cooled slightly and filtered. An additional 31.9 g (0.14 mole) of copper(II) bromide was added to the filtrate, and the mixture was heated at reflux for 1.5 hours. The mixture was cooled and filtered. The filtrate was evaporated under reduced pressure yielding 32.1 g of 2-bromo-1-(5-methylthien-2-yl)ethanone as a dark liquid. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Methyl 4-(2-bromobutyroyl)phenoxyacetate Methyl bromoacetate was reacted with <strong>[1009-11-6]4-hydroxybutyrophenone</strong> to give methyl 4-butyroylphenoxyacetate, m.p. 78-82 C. by the procedure described above to make isopropyl 4-acetylphenoxyacetate, and the methyl 4-butyroylphenoxyacetate was reacted with cupric bromide as described above to give methyl 4-(2-bromobutyroyl)phenoxyacetate, I.R. peaks at 1750 and 1680 cm-1. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
In ice-water; dimethyl sulfoxide; | A solution was prepared from 23.4 g. of cupric bromide and 225 ml. of DMSO in a 1000 ml. round bottom flask. The mixture was stirred vigorously. Next, 14.4 g. of 2-methyl-5-trifluoromethylphenyldiazoniumfluoborate in 100 ml. of DMSO were added to the cupric bromide solution over a period of about 30 minutes while maintaining the temperature in the range 25-30 C. After the addition had been completed, the reaction mixture was poured over 1 liter of an ice-water mixture. The aqueous solution was extracted three times with ether. The ether extracts were combined and the combined extracts washed with water and with saturated aqueous sodium chloride. The ether solution was dried and the ether removed by evaporation to yield 9.0 g. of a yellow oil containing 2-bromo-4-trifluoromethyltoluene formed in the above reaction. Distillation of the residue through a Vigreaux column yielded 4.2 g. of purified 2-bromo-4-trifluoromethyltoluene boiling in the range 58-49 C. at 10 torr. Analysis Calc.: C, 40.20; H, 2.53; Br, 33.43; Found: C, 40.44; H, 2.57; Br, 33.18. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With tert.-butylnitrite; In N,N-dimethyl-formamide; | [Referential Example 10] 2-Bromo-5-tert-butoxycarbonyl-4,5,6,7-tetrahydro-thiazolo[5,4-c]pyridine: Copper(II) bromide (1.05 g) was suspended in N,N-dimethylformamide, and tert-butyl nitrite (0.696 ml) was added. After 2-amino-5-tert-butoxycarbonyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine (1.00 g) was added with ice cooling, the reaction mixture was heated and stirred at 40C for 30 minutes. The reaction mixture was concentrated under reduced pressure, and the residue was purified by column chromatography on silica gel (ethyl acetate:hexane = 1:5) to obtain the title compound (568 mg) as a yellow solid. 1H-NMR (CDCl3) delta: 1.48(9H,s), 2.85(2H,br.s), 3.72(2H,t,J=5.6Hz), 4.56(2H,br.s). MS (FAB) m/z: 319(M+H)+. | |
In N,N-dimethyl-formamide; | REFERENTIAL EXAMPLE 7 tert-Butyl 2-bromo-6,7-dihydrothiazolo[5,4-c]pyridine-5[4H]-carboxylate: Copper(II) bromide (1.05 g) was suspended in N,N-dimethylformamide(20 ml), and tert-butyl nitrite (0.696 ml) and the compound (1.00 g) obtained in Referential Example 6 were added with ice cooling, the reaction mixture was heated and stirred at 40 C. for 30 minutes. The reaction mixture was concentrated under reduced pressure, and the residue was purified by column chromatography on silica gel (ethyl acetate:hexane=1:5) to obtain the title compound (568 mg). 1H-NMR (CDCl3) delta: 1.48(9H,s), 2.85(2H,br.s), 3.72(2H,br.s), 4.56(2H,br.s). MS (FAB) m/z: 319(M+H)+. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With triethylamine; sodium nitrite; In methanol; dichloromethane; water; hydrogen bromide; | A solution of <strong>[180605-36-1]2-(4-methylpiperazin-1-yl)-aniline</strong> (23.77 grams, 0.124 mol) in 80 mL of 48% hydrobromic acid was cooled to 20 C. and treated with a solution of sodium nitrite (8.6 grams, 0.124 mol) in 35 mL of water while maintaining a temperature of 20-25 C. To this was added a solution of copper (II) bromide (3.5 grams, 0.024 mol) in 12 mL of 48% HBr. The mixture was heated to 85 C. for approximately 30 minutes, poured over crushed ice in a large beaker and neutralized with dilute aqueous sodium hydroxide. The crude product was extracted into diethyl ether and concentrated in vacuo to a black oil which was chromatographed on silica gel using triethylamine:methanol:methylene chloride (0.5:10:90) as the eluent. The product, 1-bromo-2-(4-methylpiperazin-1-yl)benzene, was obtained as a brown oil, 20 grams. Mass spectrum: 254 (M+), 256. 1H-NMR (CDCl3, 300 MHz) delta7.55 (1H, d), 7.30 (1H, t), 7.05 (1H, d), 6.9 (1H, t), 3.05 (4H, br s), 2.55 (4H, t), 2.35 (3H, s). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With tert.-butylnitrite; In acetonitrile; | Preparation 30 2-Bromo-5-methyl-1,3-thiazole To a solution of 2-amino-5-methyl-1,3-thiazole (11.7 g) in acetonitrile (200 ml) was added dropwise tert-butyl nitrite (8.33 ml) at 0 C. followed by addition of copper(II) bromide (5 g) over 0.5 minutes. After stirring at 0 C. for 3 hours, the mixture was concentrated and partitioned between 1N hydrochloric acid and ethyl acetate. The organic layer was washed with water, saturated aqueous sodium hydrogencarbonate solution and brine, dried over anhydrous magnesium sulfate, filtered through a pad of Celite, and concentrated in vacuo to give the title compound (3.24 g) as an oil. ESI-MS: 177.8(M+H) 1H-NMR (300 MHz, CDCl3) delta 7.25(s, 1H), 2.44(s, 3H). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
In ethyl acetate; | (Example 8) Synthesis of 2-(4-fluorophenyl)-6-iodoimidazo[1,2-a]pyridine (non-iodinated form) 40 mL of ethyl acetate was added to 3.70 g (corresponding to 16.6 mmol) of cupric bromide to obtain suspension, and 1.0 mL (corresponding to 8.27mmol) of 4-fluoroacetophenone was added thereto. Then, the resulting mixture was refluxed. After 3 hours, the reaction mixture was cooled down to room temperature and filtered. The resulting filtrate was concentrated under reduced pressure. The residue was dissolved in ethyl acetate and concentrated. The resulting crude product was purified by silica gel column chromatography (elution solvent: hexane/ethyl acetate = 10/1), to obtain 1.82 g (corresponding to 8.39 mmol) of 2-bromo-4 - fluoroacetophenone ( |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
First, 4 -hydroxyacetophenone is allowed to react with cupric bromide in accordance with ordinary methods, for example, the method described in a literature,, to prepare 2-bromo-4 -hydroxyacetophenone ( |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
96% | In ethanol; for 4h;Reflux; | General procedure: One mol equiv. of the corresponding transition metal salt was added to a solution of three mol equiv of <strong>[3366-95-8]secnidazole</strong> in 20 mL of ethanol (reagent grade) with constant stirring under reflux for 4 h, upon which the precipitate formed was collected by filtration. The remaining solution was concentrated and portions of hexane were added to further precipitate the product which was again collected by filtration. Both solids were combined and washed with portions of hexane and MeOH and dried overnight under vacuum resulting in microcrystalline product. Elemental Anal. Calc. for C14H22Br2N6O6Cu·0.5H2O: C, 27.90; H, 3.85; N, 13.94. Found: C, 27.22; H, 3.21; N, 14.71%. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
35% | In acetonitrile; at 20℃; for 168h; | CuBr2 (0.1198 g, 0.536 mM) in 11 mL of acetonitrile was added to 2-amino-5-chloro-3- fluoropyridine (0.1498 g, 1.02 mM) in 5 mL of acetonitrile, generating a dark green solution, which was left to evaporate at room temperature. After one week, dark prisms (purple when crushed) were recovered by vacuum filtration, washed with cold acetonitrile, and allowed to air dry to give 0.1891 g (35%). Single crystals (dark plates) were grown through recrystallization of the prisms from acetonitrile. CHN Calcd (found) for C10H8N4F2Cl2CuBr2: C, 23.26(23.08); H, 1.56(1.74); N, 10.84(10.36) %. IR (KBr) nu-3330 br, 1634 s (delta HNH), 1601 m, 1574 w, 1485 s, 1419 m, 1338 w, 1207 s, 1094 w, 936 m, 890 w, 880 m, 802 w, 697 w, 566 w cm-1. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
In water; at 20℃; for 1008h; | CuBr2 (0.1295 g, 0.0579mM) in 2mL of water was added to 2-amino-5-chloro-3 -fluoropyridine (0.1402 g, 0.0957mM) in 2.6mL of 6M HBr, yielding a dark red solution which was left to evaporate at room temperature until the volume reduced to 2 mL (~three months) and was subsequently placed in a desiccator. After six weeks, purple plates were recovered by vacuum filtration, washed with cold water, and allowed to air dry to give 0.2298 g (33%). CHN Calcd (found) for C10H10N4F2Cl2CuBr4: C, 17.71(17.51); H, 1.48(1.82); N, 8.25(7.92) %. IR (KBr) nu-3289m, 3238m, 3147m, 3037m (nu N-H, C-H) 1669 s (delta HNH), 1615 s, 1567 s, 1411m, 1339 m, 1281 m, 1190 m, 937m, 802 w, 757 w, 663 w, 563 w cm-1. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
21.8% | With hydrogen bromide; In propan-1-ol; at 20℃; for 504.0h; | CuBr2 (0.1121 g, 0.501 mmol) was dissolved in 20 mL of 1-propanol and warmedfor 0.5 h to yield a dark brown mixture. 2-F-4AP (0.1141 g, 1.02 mmol) in 10 mL of 1-propanoland 1.2 mL of 48% HBr (aq) (8.84 M) was added to the CuBr2 solution. The dark brown, opaquesolution was left to evaporate at room temperature for three weeks. When the solutionreached 3 mL, the beaker was set in a desiccator. After six days, purple needles were recoveredby vacuum filtration, washed with cold 1-propanol and allowed to air dry to give 0.133 g(21.8%). IR (KBr) nu - 3387 m, 3302 m, 3203 m, 3089 m, 2964 m, 1663 s, 1604 m, 1523 m,1207 m, 1004 m, 831 w, and 738 m cm-1. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
16.2% | In water; at 20℃; for 336.0h; | CuBr2 (0.121 g, 0.540 mmol) was dissolved in 2 mL of water to give a light blue solution. 2-F-4AP (0.114 g, 1.02 mmol) dissolved in 6 mL of water was added to the CuBr2 solution. Theresulting dark green solution was left to evaporate at room temperature for two weeks. Darkred plates were recovered by vacuum filtration, washed with drops of cold water and allowedto air dry to give 0.0724 g (16.2%). CHN Calcd (found) for C10H10N4F2Br2Cu: C, 26.83 (26.51);H, 2.25 (2.18); N, 12.52 (12.66) %. IR (KBr) nu - 3412 m, 3328 m, 3221 m, 1645 s, 1514 m, 1475 m,1271 m, 1199 m, 1032 m, 833 m, 658 w, and 572 w cm-1. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
In ethanol; for 12h;Reflux; | Compound 2 was synthesized by slow addition of ethanolic solution of <strong>[2305-79-5]4,5,6,7-tetrahydro-1H-indazole</strong> (0.488 g, 4.0 mmol) to CuBr2 (0.223 g, 1.0 mmol, solution in the same solvent).The reaction mixture was heated to reflux as discussed above; the color of the solutionchanged from light blue to red. The stirring was continued for 12 h to ensure maximumproduct formation. The reaction mixture was kept for crystallization at ambient temperature.After a few days, red blocks of the desired complex were grown, separated from the motherliquor and a crystal of suitable dimensions was characterized by X-ray diffraction.M.p. = 155-157 C. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
95% | In water; for 2191.5h; | 3,5-DiCAP (0.101 g, 0.619 mmol) and CuBr2 (0.271 g, 1.22 mmol, 2 equivalents) were separatelydissolved each in 1.0 mL of conc. aqueous HBr. The CuBr2 solution was added to thediCAP solution resulting in a dark purple solution. The reaction was partially covered withparafilm and left undisturbed for three months at which time dark purple (almost black)crystals of 1 were isolated by vacuum filtration, washed with tert-butyl alcohol and left toair-dry to give 0.271 g (95percent). CHN for C10H10N4Cl4Cu2Br6 calcd (found): C, 12.85(12.91); H, 1.07(1.05); N, 5.99 (5.81)percent. IR (ATR): nu 3365m, 3306w, 3277m, 3224m, 3170m, 3068w, 1652s,1611s, 1533m, 1430m, 1330m, 889m, 733s, 691s, 658m cm?1. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
72% | In water; for 2191.5h; | 3,5-DiBAP (0.051 g, 0.202 mmol) and CuBr2 (0.438 g, 1.96 mmol, 10 equivalents) were separatelydissolved each in 2.0 mL of conc. aqueous HBr. The CuBr2 solution was added to thediBAP solution resulting in a dark purple solution. The reaction was partially covered withparafilm and left undisturbed for three months at which time dark purple (almost black)crystals of 3 were isolated by vacuum filtration, washed with tert-butyl alcohol and left toair-dry to give 0.080 g (72%). CHN for C10H10N4Cu2Br10 calcd (found): C, 10.79(10.51); H,0.91(0.86); N, 5.03 (4.82)%. IR (ATR): nu 3364m, 3295w, 3272w, 3233m, 3166m, 3066w, 1646s,1610s, 1529m, 1423m, 1328m, 872m, 734s, 688s, 639 cm-1. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
General procedure: The copper complex Cu5-1 was dissolved in water, and an excessive amount of an aqueous solution of saturated sodium tetrafluoroborate (manufactured by Wako Pure Chemical Industries, Ltd.) was added while stirring. A precipitated solid was collected by filtering and a copper complex Cu5-72 was obtained. |
Tags: 7789-45-9 synthesis path| 7789-45-9 SDS| 7789-45-9 COA| 7789-45-9 purity| 7789-45-9 application| 7789-45-9 NMR| 7789-45-9 COA| 7789-45-9 structure
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P281 | Use personal protective equipment as required. |
P282 | Wear cold insulating gloves/face shield/eye protection. |
P283 | Wear fire/flame resistant/retardant clothing. |
P284 | Wear respiratory protection. |
P285 | In case of inadequate ventilation wear respiratory protection. |
P231 + P232 | Handle under inert gas. Protect from moisture. |
P235 + P410 | Keep cool. Protect from sunlight. |
Response | |
Code | Phrase |
P301 | IF SWALLOWED: |
P304 | IF INHALED: |
P305 | IF IN EYES: |
P306 | IF ON CLOTHING: |
P307 | IF exposed: |
P308 | IF exposed or concerned: |
P309 | IF exposed or if you feel unwell: |
P310 | Immediately call a POISON CENTER or doctor/physician. |
P311 | Call a POISON CENTER or doctor/physician. |
P312 | Call a POISON CENTER or doctor/physician if you feel unwell. |
P313 | Get medical advice/attention. |
P314 | Get medical advice/attention if you feel unwell. |
P315 | Get immediate medical advice/attention. |
P320 | |
P302 + P352 | IF ON SKIN: wash with plenty of soap and water. |
P321 | |
P322 | |
P330 | Rinse mouth. |
P331 | Do NOT induce vomiting. |
P332 | IF SKIN irritation occurs: |
P333 | If skin irritation or rash occurs: |
P334 | Immerse in cool water/wrap n wet bandages. |
P335 | Brush off loose particles from skin. |
P336 | Thaw frosted parts with lukewarm water. Do not rub affected area. |
P337 | If eye irritation persists: |
P338 | Remove contact lenses, if present and easy to do. Continue rinsing. |
P340 | Remove victim to fresh air and keep at rest in a position comfortable for breathing. |
P341 | If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing. |
P342 | If experiencing respiratory symptoms: |
P350 | Gently wash with plenty of soap and water. |
P351 | Rinse cautiously with water for several minutes. |
P352 | Wash with plenty of soap and water. |
P353 | Rinse skin with water/shower. |
P360 | Rinse immediately contaminated clothing and skin with plenty of water before removing clothes. |
P361 | Remove/Take off immediately all contaminated clothing. |
P362 | Take off contaminated clothing and wash before reuse. |
P363 | Wash contaminated clothing before reuse. |
P370 | In case of fire: |
P371 | In case of major fire and large quantities: |
P372 | Explosion risk in case of fire. |
P373 | DO NOT fight fire when fire reaches explosives. |
P374 | Fight fire with normal precautions from a reasonable distance. |
P376 | Stop leak if safe to do so. Oxidising gases (section 2.4) 1 |
P377 | Leaking gas fire: Do not extinguish, unless leak can be stopped safely. |
P378 | |
P380 | Evacuate area. |
P381 | Eliminate all ignition sources if safe to do so. |
P390 | Absorb spillage to prevent material damage. |
P391 | Collect spillage. Hazardous to the aquatic environment |
P301 + P310 | IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. |
P301 + P312 | IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. |
P301 + P330 + P331 | IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. |
P302 + P334 | IF ON SKIN: Immerse in cool water/wrap in wet bandages. |
P302 + P350 | IF ON SKIN: Gently wash with plenty of soap and water. |
P303 + P361 + P353 | IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. |
P304 + P312 | IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell. |
P304 + P340 | IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. |
P304 + P341 | IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing. |
P305 + P351 + P338 | IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. |
P306 + P360 | IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes. |
P307 + P311 | IF exposed: call a POISON CENTER or doctor/physician. |
P308 + P313 | IF exposed or concerned: Get medical advice/attention. |
P309 + P311 | IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician. |
P332 + P313 | IF SKIN irritation occurs: Get medical advice/attention. |
P333 + P313 | IF SKIN irritation or rash occurs: Get medical advice/attention. |
P335 + P334 | Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages. |
P337 + P313 | IF eye irritation persists: Get medical advice/attention. |
P342 + P311 | IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician. |
P370 + P376 | In case of fire: Stop leak if safe to Do so. |
P370 + P378 | In case of fire: |
P370 + P380 | In case of fire: Evacuate area. |
P370 + P380 + P375 | In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion. |
P371 + P380 + P375 | In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion. |
Storage | |
Code | Phrase |
P401 | |
P402 | Store in a dry place. |
P403 | Store in a well-ventilated place. |
P404 | Store in a closed container. |
P405 | Store locked up. |
P406 | Store in corrosive resistant/ container with a resistant inner liner. |
P407 | Maintain air gap between stacks/pallets. |
P410 | Protect from sunlight. |
P411 | |
P412 | Do not expose to temperatures exceeding 50 oC/ 122 oF. |
P413 | |
P420 | Store away from other materials. |
P422 | |
P402 + P404 | Store in a dry place. Store in a closed container. |
P403 + P233 | Store in a well-ventilated place. Keep container tightly closed. |
P403 + P235 | Store in a well-ventilated place. Keep cool. |
P410 + P403 | Protect from sunlight. Store in a well-ventilated place. |
P410 + P412 | Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF. |
P411 + P235 | Keep cool. |
Disposal | |
Code | Phrase |
P501 | Dispose of contents/container to ... |
P502 | Refer to manufacturer/supplier for information on recovery/recycling |
Physical hazards | |
Code | Phrase |
H200 | Unstable explosive |
H201 | Explosive; mass explosion hazard |
H202 | Explosive; severe projection hazard |
H203 | Explosive; fire, blast or projection hazard |
H204 | Fire or projection hazard |
H205 | May mass explode in fire |
H220 | Extremely flammable gas |
H221 | Flammable gas |
H222 | Extremely flammable aerosol |
H223 | Flammable aerosol |
H224 | Extremely flammable liquid and vapour |
H225 | Highly flammable liquid and vapour |
H226 | Flammable liquid and vapour |
H227 | Combustible liquid |
H228 | Flammable solid |
H229 | Pressurized container: may burst if heated |
H230 | May react explosively even in the absence of air |
H231 | May react explosively even in the absence of air at elevated pressure and/or temperature |
H240 | Heating may cause an explosion |
H241 | Heating may cause a fire or explosion |
H242 | Heating may cause a fire |
H250 | Catches fire spontaneously if exposed to air |
H251 | Self-heating; may catch fire |
H252 | Self-heating in large quantities; may catch fire |
H260 | In contact with water releases flammable gases which may ignite spontaneously |
H261 | In contact with water releases flammable gas |
H270 | May cause or intensify fire; oxidizer |
H271 | May cause fire or explosion; strong oxidizer |
H272 | May intensify fire; oxidizer |
H280 | Contains gas under pressure; may explode if heated |
H281 | Contains refrigerated gas; may cause cryogenic burns or injury |
H290 | May be corrosive to metals |
Health hazards | |
Code | Phrase |
H300 | Fatal if swallowed |
H301 | Toxic if swallowed |
H302 | Harmful if swallowed |
H303 | May be harmful if swallowed |
H304 | May be fatal if swallowed and enters airways |
H305 | May be harmful if swallowed and enters airways |
H310 | Fatal in contact with skin |
H311 | Toxic in contact with skin |
H312 | Harmful in contact with skin |
H313 | May be harmful in contact with skin |
H314 | Causes severe skin burns and eye damage |
H315 | Causes skin irritation |
H316 | Causes mild skin irritation |
H317 | May cause an allergic skin reaction |
H318 | Causes serious eye damage |
H319 | Causes serious eye irritation |
H320 | Causes eye irritation |
H330 | Fatal if inhaled |
H331 | Toxic if inhaled |
H332 | Harmful if inhaled |
H333 | May be harmful if inhaled |
H334 | May cause allergy or asthma symptoms or breathing difficulties if inhaled |
H335 | May cause respiratory irritation |
H336 | May cause drowsiness or dizziness |
H340 | May cause genetic defects |
H341 | Suspected of causing genetic defects |
H350 | May cause cancer |
H351 | Suspected of causing cancer |
H360 | May damage fertility or the unborn child |
H361 | Suspected of damaging fertility or the unborn child |
H361d | Suspected of damaging the unborn child |
H362 | May cause harm to breast-fed children |
H370 | Causes damage to organs |
H371 | May cause damage to organs |
H372 | Causes damage to organs through prolonged or repeated exposure |
H373 | May cause damage to organs through prolonged or repeated exposure |
Environmental hazards | |
Code | Phrase |
H400 | Very toxic to aquatic life |
H401 | Toxic to aquatic life |
H402 | Harmful to aquatic life |
H410 | Very toxic to aquatic life with long-lasting effects |
H411 | Toxic to aquatic life with long-lasting effects |
H412 | Harmful to aquatic life with long-lasting effects |
H413 | May cause long-lasting harmful effects to aquatic life |
H420 | Harms public health and the environment by destroying ozone in the upper atmosphere |
Sorry,this product has been discontinued.
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