CAS No. :	78-70-6
Formula :	C₁₀H₁₈O
M.W :	154.25
SMILES Code :	CC(C)=CCCC(C)(O)C=C
Synonyms :	dl-Linalool; Phantol; AI3-00942
MDL No. :	MFCD00008906
InChI Key :	CDOSHBSSFJOMGT-UHFFFAOYSA-N
Pubchem ID :	6549

GHS Pictogram:
Signal Word:	Warning
Hazard Statements:	H227-H303-H315-H317-H319-H402
Precautionary Statements:	P210-P261-P264-P272-P273-P280-P302+P352-P305+P351+P338-P312-P333+P313-P337+P313-P370+P378-P403+P235-P501

SH-SY5Y cells	0.54 µg/mL	24 hours	Linalool reduced IL-6 secretion and decreased α-synuclein mRNA expression.	Antioxidants (Basel). 2024 Jul 29;13(8):917
human dermal microvascular endothelial cells (HDMECs)	0.25-2 mM	24 hours	Inhibited HDMEC proliferation, migration, tube formation and spheroid sprouting	Angiogenesis. 2021 Aug;24(3):613-630
Saprolegnia parasitica CQT2 spores	0.025% (vol/vol, 0.216 mg/ml)	24 hours	Linalool exhibited strong anti-oomycete activity, inhibiting spore growth.	Elife. 2025 Apr 4;13:RP100393
Saprolegnia parasitica CQT2 mycelium	0.05% (vol/vol, 0.432 mg/ml)	60 hours	Linalool disrupted the mycelium cell membrane, causing intracellular component leakage, and inhibited ribosome function to suppress protein synthesis, ultimately affecting mycelium growth.	Elife. 2025 Apr 4;13:RP100393
human embryonic kidney 293 cells (HEK293)	117 μM (EC50)		To evaluate the activation of TRPA1 and TRPV1 channels by linalool. Results showed that linalool activated TRPA1 channels but not TRPV1 channels.	Br J Pharmacol. 2009 Aug;157(8):1398-409
dorsal root ganglia neurons	500 μM	5 seconds	To evaluate the activation of TRPA1 and TRPV1 channels by linalool. Results showed that linalool activated TRPA1 channels but not TRPV1 channels.	Br J Pharmacol. 2009 Aug;157(8):1398-409
HeyA8 cells	0.3 mM	24 h, 48 h, 72 h	To evaluate the cytotoxicity and pro-apoptotic effects of LN-NE-DOX-liposomes. Results showed that LN-NE-DOX-liposomes significantly increased apoptosis in HeyA8 cells (significant increase at 72 h, *p < 0.001) and exhibited higher cytotoxicity than DOX alone or DOX-liposomes (IC50: 0.25 μM vs 1.18 μM and 2.81 μM).	Int J Nanomedicine. 2020 Oct 29;15:8427-8436
HEK293 cells	6.7 ± 2.0 μM		To test the agonistic effect of Linalool on mTRPM8, results showed that Linalool is a weak TRPM8 agonist.	Br J Pharmacol. 2004 Feb;141(4):737-45
Caco-2 cells	0.5 mM	3 hours	To investigate the bioavailability of linalool, results showed that linalool exhibited moderate permeability in Caco-2 cells.	J Lipid Res. 2014 Jun;55(6):1098-110
HepG2 cells	1 mM	24 hours	To study the effect of linalool on intracellular triglyceride concentrations, results showed that linalool significantly reduced intracellular triglyceride accumulation.	J Lipid Res. 2014 Jun;55(6):1098-110
Primary cortical neurons	0.1, 1, 10 nM	24 hours	Linalool upregulated protein expression of SirT1, GABA A-α1, and GABA B in MPP+-treated primary cortical neurons.	Int J Mol Sci. 2024 Feb 21;25(5):2514
Primary mesencephalic neurons	0.1, 1, 10 nM	24 hours	Linalool enhanced the expressions of TH, SirT1, and parkin in MPP+-treated primary mesencephalic neurons.	Int J Mol Sci. 2024 Feb 21;25(5):2514
SH-SY5Y cells	1 pM–1 µM	24 hours	Linalool increased cell viability in MPP+-treated SH-SY5Y cells, reduced neurite retraction, enhanced antioxidant defense by downregulating apoptosis signaling (Bcl-2, cleaved caspase-3, and PARP) and phagocyte NADPH oxidase (gp91phox), and upregulated neurotrophic signaling (BDNF and NGF) and the Nrf2/HO-1 pathway.	Int J Mol Sci. 2024 Feb 21;25(5):2514

BALB/c mice	Matrigel plug model	Subcutaneous injection	2 mM	Single dose, lasted for 7 days	Evaluated the effect of Linalool on in vivo angiogenesis, showing a significant reduction in microvessel density	Angiogenesis. 2021 Aug;24(3):613-630
Grass carp (Ctenopharyngodon idella)	Saprolegnia parasitica infection model	Immersion	0.00039%	Daily immersion for 7 days	Linalool enhanced the complement and coagulation system to activate host immune defense and lyse S. parasitica cells, promoted wound healing and tissue repair, modulated gut microbiota to increase beneficial Actinobacteriota abundance, and stimulated inflammatory cytokine and chemokine production.	Elife. 2025 Apr 4;13:RP100393
BALB/c nude mice	HeyA8 EOC tumor model	Intravenous injection	100 mg/kg	LN: twice a week, DOX: once a week, for 3-4 weeks	To evaluate the antitumor efficacy and biochemical toxicity of LN-NE-DOX-liposomes. Results showed that LN-NE-DOX-liposomes significantly inhibited HeyA8 EOC tumor growth (75% reduction, *p < 0.001), reduced the number of tumor nodules (*p < 0.01), and did not cause significant biochemical toxicity (AST, ALT, BUN levels were not significantly different from the control group).	Int J Nanomedicine. 2020 Oct 29;15:8427-8436
C57BL/6J mice	Western-diet-induced hypertriglyceridemia model	Oral	100 mg/kg body weight/day	Once daily for 3 weeks	To investigate the effect of linalool on plasma triglyceride concentrations, results showed that linalool significantly reduced plasma triglyceride levels.	J Lipid Res. 2014 Jun;55(6):1098-110
C57BL/6 mice	MPTP-induced Parkinson's disease model	Oral	12.5 and 25 mg/kg	Once daily for 7 days	Linalool attenuated the loss of dopamine neurons in SNpc and improved motor and nonmotor behavioral deficits and muscle strength in MPTP-induced PD-like mice.	Int J Mol Sci. 2024 Feb 21;25(5):2514
Mice	Anxiety-like behavior model	Inhalation	0.08%	2 hours per day for 7 consecutive days	Linalool reduces anxiety-like behaviors and increases dentate granule cell activity in mice by activating hippocampal endocannabinoid signaling.	Int J Mol Sci. 2024 Oct 4;25(19):10699

NCT03369132	Sore Throat	Not Applicable	Recruiting	September 30, 2018	Czechia ... More >> MUDr. Lenka Dybova Recruiting Brno, Czechia, 602 00 Contact: Lenka Dybova, M. D. MUDr. Libor Hemzsky Recruiting Choltice, Czechia, 533 61 Contact: Libor Hemzsky, M. D. NEFROMED s.r.o. Recruiting Dejvice, Czechia, 160 00 Contact: Krisitina Sadilkova, M. D. MEDIGATE care s.r.o Recruiting Hradec Králové, Czechia, 500 09 Contact: Ivana Skardova, M. D. Sub-Investigator: Jan Skarda, M. D. MUDr. Petra Hoskova Recruiting Hradec Králové, Czechia, 500 09 Contact: Petra Hoskova, M. D. MUDr. Jana Dvorakova s.r.o. Recruiting Hradec Králové, Czechia, 500 11 Contact: Jana Dvorakova, M. D. MUDr. Danuse Mikeschova Recruiting Karlovy Vary, Czechia, 360 17 Contact: David Macharacek, M. D. Azita s.r.o. Recruiting Malšice, Czechia, 108 00 Contact: Azita Gebauerova, M. D. Fortmedica s.r.o. Recruiting Praha 4, Czechia, 143 00 Contact: Tomas Fort, M. D. Sub-Investigator: Daniel Groh, M. D. GM ordinace s.r.o Recruiting Praha 4, Czechia, 148 00 Contact: David Macharacek, M. D. MUDr Sylva Kohoutova Recruiting Praha 6, Czechia, 160 00 Contact: Sylva Kohoutova, M. D. Ordinace Optima s.r.o Recruiting Praha 6, Czechia, 161 00 Contact: Radka Majerova, M. D. MUDr. Lenka Fejfarova Recruiting Praha 6, Czechia, 164 00 Contact: Lenka Fejfarova, M. D. Saniga s.r.o. Recruiting Sokolov, Czechia, 356 01 Contact: Zdenek Vlasak, M. D. MUDr. Jan Bartusek Recruiting Teplice, Czechia, 415 01 Contact: Jan Bartusek, M. D. A-MEDICOS s.r.o. Recruiting Zlín, Czechia, 760 01 Contact: Alena Malikova, M. D. Less <<
NCT03445130	Anxiety	Not Applicable	Not yet recruiting	March 2020	-

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CAS No.: 78-70-6

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CAS No.: 78-70-6

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Product Details of Linalool

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Categories

Precautionary Statements-General

Prevention

Response

Storage

Disposal

Physical hazards

Health hazards

Environmental hazards

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Preparing Stock Solutions		1mg	5mg	10mg
Preparing Stock Solutions	1 mM 5 mM 10 mM	6.48mL 1.30mL 0.65mL	32.41mL 6.48mL 3.24mL	64.83mL 12.97mL 6.48mL
Dissolving Methods	Animal experiment Please choose the appropriate dissolution scheme according to your animal administration guide.For the following dissolution schemes, clear stock solution should be prepared according to in vitro experiments, and then cosolvent should be added in turn: in order to ensure the reliability of the experimental results, the clarified stock solution can be properly preserved according to the storage conditions; The working fluid for in vivo experiment is recommended to be prepared now and used on the same day; The percentage shown in front of the following solvent refers to the volume ratio of the solvent in the final solution; If precipitation or precipitation occurs in the preparation process, it can be assisted by heating and/or ultrasound. Protocol 1 Protocol 2

Precautionary Statements-General
Code	Phrase
P101	If medical advice is needed,have product container or label at hand.
P102	Keep out of reach of children.
P103	Read label before use
Prevention
Code	Phrase
P201	Obtain special instructions before use.
P202	Do not handle until all safety precautions have been read and understood.
P210	Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P211	Do not spray on an open flame or other ignition source.
P220	Keep/Store away from clothing/combustible materials.
P221	Take any precaution to avoid mixing with combustibles
P222	Do not allow contact with air.
P223	Keep away from any possible contact with water, because of violent reaction and possible flash fire.
P230	Keep wetted
P231	Handle under inert gas.
P232	Protect from moisture.
P233	Keep container tightly closed.
P234	Keep only in original container.
P235	Keep cool
P240	Ground/bond container and receiving equipment.
P241	Use explosion-proof electrical/ventilating/lighting/equipment.
P242	Use only non-sparking tools.
P243	Take precautionary measures against static discharge.
P244	Keep reduction valves free from grease and oil.
P250	Do not subject to grinding/shock/friction.
P251	Pressurized container: Do not pierce or burn, even after use.
P260	Do not breathe dust/fume/gas/mist/vapours/spray.
P261	Avoid breathing dust/fume/gas/mist/vapours/spray.
P262	Do not get in eyes, on skin, or on clothing.
P263	Avoid contact during pregnancy/while nursing.
P264	Wash hands thoroughly after handling.
P265	Wash skin thouroughly after handling.
P270	Do not eat, drink or smoke when using this product.
P271	Use only outdoors or in a well-ventilated area.
P272	Contaminated work clothing should not be allowed out of the workplace.
P273	Avoid release to the environment.
P280	Wear protective gloves/protective clothing/eye protection/face protection.
P281	Use personal protective equipment as required.
P282	Wear cold insulating gloves/face shield/eye protection.
P283	Wear fire/flame resistant/retardant clothing.
P284	Wear respiratory protection.
P285	In case of inadequate ventilation wear respiratory protection.
P231 + P232	Handle under inert gas. Protect from moisture.
P235 + P410	Keep cool. Protect from sunlight.
Response
Code	Phrase
P301	IF SWALLOWED:
P304	IF INHALED:
P305	IF IN EYES:
P306	IF ON CLOTHING:
P307	IF exposed:
P308	IF exposed or concerned:
P309	IF exposed or if you feel unwell:
P310	Immediately call a POISON CENTER or doctor/physician.
P311	Call a POISON CENTER or doctor/physician.
P312	Call a POISON CENTER or doctor/physician if you feel unwell.
P313	Get medical advice/attention.
P314	Get medical advice/attention if you feel unwell.
P315	Get immediate medical advice/attention.
P320
P302 + P352	IF ON SKIN: wash with plenty of soap and water.
P321
P322
P330	Rinse mouth.
P331	Do NOT induce vomiting.
P332	IF SKIN irritation occurs:
P333	If skin irritation or rash occurs:
P334	Immerse in cool water/wrap n wet bandages.
P335	Brush off loose particles from skin.
P336	Thaw frosted parts with lukewarm water. Do not rub affected area.
P337	If eye irritation persists:
P338	Remove contact lenses, if present and easy to do. Continue rinsing.
P340	Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P341	If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P342	If experiencing respiratory symptoms:
P350	Gently wash with plenty of soap and water.
P351	Rinse cautiously with water for several minutes.
P352	Wash with plenty of soap and water.
P353	Rinse skin with water/shower.
P360	Rinse immediately contaminated clothing and skin with plenty of water before removing clothes.
P361	Remove/Take off immediately all contaminated clothing.
P362	Take off contaminated clothing and wash before reuse.
P363	Wash contaminated clothing before reuse.
P370	In case of fire:
P371	In case of major fire and large quantities:
P372	Explosion risk in case of fire.
P373	DO NOT fight fire when fire reaches explosives.
P374	Fight fire with normal precautions from a reasonable distance.
P376	Stop leak if safe to do so. Oxidising gases (section 2.4) 1
P377	Leaking gas fire: Do not extinguish, unless leak can be stopped safely.
P378
P380	Evacuate area.
P381	Eliminate all ignition sources if safe to do so.
P390	Absorb spillage to prevent material damage.
P391	Collect spillage. Hazardous to the aquatic environment
P301 + P310	IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P301 + P312	IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P301 + P330 + P331	IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P302 + P334	IF ON SKIN: Immerse in cool water/wrap in wet bandages.
P302 + P350	IF ON SKIN: Gently wash with plenty of soap and water.
P303 + P361 + P353	IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304 + P312	IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell.
P304 + P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P304 + P341	IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P306 + P360	IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes.
P307 + P311	IF exposed: call a POISON CENTER or doctor/physician.
P308 + P313	IF exposed or concerned: Get medical advice/attention.
P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P370 + P376	In case of fire: Stop leak if safe to Do so.
P370 + P378	In case of fire:
P370 + P380	In case of fire: Evacuate area.
P370 + P380 + P375	In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion.
P371 + P380 + P375	In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
Storage
Code	Phrase
P401
P402	Store in a dry place.
P403	Store in a well-ventilated place.
P404	Store in a closed container.
P405	Store locked up.
P406	Store in corrosive resistant/ container with a resistant inner liner.
P407	Maintain air gap between stacks/pallets.
P410	Protect from sunlight.
P411
P412	Do not expose to temperatures exceeding 50 oC/ 122 oF.
P413
P420	Store away from other materials.
P422
P402 + P404	Store in a dry place. Store in a closed container.
P403 + P233	Store in a well-ventilated place. Keep container tightly closed.
P403 + P235	Store in a well-ventilated place. Keep cool.
P410 + P403	Protect from sunlight. Store in a well-ventilated place.
P410 + P412	Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
P411 + P235	Keep cool.
Disposal
Code	Phrase
P501	Dispose of contents/container to ...
P502	Refer to manufacturer/supplier for information on recovery/recycling

Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed