Name: 781-35-1|1,1-Diphenylacetone|99%
Brand: Ambeed
SKU: A446023
Price: 41.0 USD
Availability: InStock
Rating: 95 (40 reviews)

1
[ 50-00-0 ]
[ 781-35-1 ]
[ 6091-44-7 ]
[ 103281-49-8 ]

Reference： [1]Journal of the Chemical Society,1952,p. 1321,1325

2
[ 781-35-1 ]
[ 131-11-3 ]
[ 82-66-6 ]

Yield	Reaction Conditions	Operation in experiment
	With sodium methylate

Reference： [1]Osol et al. [Zhurnal Obshchei Khimii, 1958, vol. 28, p. 3083; engl. Ausg. S. 3114] Current Patent Assignee: PFIZER INC - US2672483, 1951, A

3
[ 781-35-1 ]
[ 33609-25-5 ]

Yield	Reaction Conditions	Operation in experiment
	With bromine; acetic acid
	With bromine In acetic acid; toluene	21 3-Diphenylmethyl-2,3,6,7-tetrahydro-5H-thiazolo[3,2]-a]pyrimidin-3-ol hydrobromide EXAMPLE 21 3-Diphenylmethyl-2,3,6,7-tetrahydro-5H-thiazolo[3,2]-a]pyrimidin-3-ol hydrobromide A solution of 2.1 g. of 1,1-diphenyl-2-propanone in 25 ml. of acetic acid is heated to 60°-70° C. and 0.5 ml. of bromine in 4 ml. of acetic acid is added dropwise. The reaction mixture is held at 60°-70° C. for one hour and then poured into ice. Toluene is added. The toluene layer is separated, washed with water, dried over magnesium sulfate and concentrated, giving 1-bromo-3,3-diphenyl-2-propanone.
	With bromine In acetic acid; toluene	22 3-Diphenylmethyl-2,3,5,6,7,8-hexahydrothiazolo[3,2-a][1,3]diazepin-3-ol hydrobromide EXAMPLE 22 3-Diphenylmethyl-2,3,5,6,7,8-hexahydrothiazolo[3,2-a][1,3]diazepin-3-ol hydrobromide A solution of 4.20 g. of 1,1-diphenyl-2-propanone in 25 ml. of acetic acid is heated at 60°-70° C. and 1.0 ml. of bromine in 8 ml. of acetic acid is added dropwise. The reaction mixture is held at 60°-70° C. for one hour and then poured into ice. Toluene is added. The toluene layer is separated, washed with water, dried over magnesium sulfate and concentrated to obtain 1-bromo-3,3-diphenyl-2-propanone.

	With bromine In acetic acid; toluene	84 3-Diphenylmethyl-2,3,5,6,7,8-hexahydrothiazolo[3,2-a][1,3]diazepin-3-ol hydrobromide EXAMPLE 84 3-Diphenylmethyl-2,3,5,6,7,8-hexahydrothiazolo[3,2-a][1,3]diazepin-3-ol hydrobromide A solution of 4.20 g. (0.02 mol) of 1,1-diphenyl-2-propanone in 25 ml. of acetic acid is heated at 60°--70° C. and 1.0 ml. (0.02 mol) of bromine in 8 ml. of acetic acid is added dropwise. The reaction mixture is held at 60°-70° C. for one hour and then poured into ice. Toluene is added. The toluene layer is separated, washed with water, dried over magnesium sulfate and concentrated to obtain 1-bromo-3,3-diphenyl-2-propanone.
	With bromine In acetic acid	1 3-Bromo-1,1-diphenyl-2-propanone EXAMPLE 1 3-Bromo-1,1-diphenyl-2-propanone The subject compound is prepared essentially by the procedure of C. L. Stevens and C. T. Lenh, J. Org. Chem. 19, 538 (1954). To a stirred solution of 42.0 g. of 1,1-diphenyl-2-propanone in 150 ml. of glacial acetic acid at 60°-70° C., is added dropwise, over 45 minutes, a solution of 32.0 of bromine in 25 ml. of glacial acetic acid. The mixture is then stirred for one hour at 60°-70° C. The mixture is poured into 500 ml. of ice, allowed to stand in a refrigerator overnight, and the solid is collected by filtration, washed with water and ice-cold isopropanol, and recrystallized from isopropanol, giving 29.0 of the desired product as light pink crystals, m.p. 62°-64° C.
52 g	With bromine; acetic acid at 60℃; for 1.5h; Inert atmosphere;	3 10167] To a solution ofA-i (50 g, 237 mmol) mAcOH (250 mE) at 60° C. under N2 was added 13r2 (38.0 g, 237 mmol) dropwise. After addition (30 mm), the mixture was stirred at the same temperature for 1 h. The solution was then cooled to RT and then poured into ice-water (250 mE). The reaction was quenched with saturated aq. Na2503. The mixture was extracted with DCM (3x250 mE). The combined organic layers were washed with aq. NaHCO3 and brine, and dried over Na2504. The mixture was filtered and concentrated. To the residue was added with PE (200 mE). The mixture was violently stirred for 20 mins and then filtered. The filtrate cake was washed with PE and dried in vacuum to provide crude A-2 as a white solid (52 g), which was used directly in the next step without further purification.

Reference： [1]Stevens; Lenk [Journal of Organic Chemistry, 1954, vol. 19, p. 538,541]
[2]Current Patent Assignee: PFIZER INC - US4325955, 1982, A
[3]Current Patent Assignee: PFIZER INC - US4340734, 1982, A
[4]Current Patent Assignee: PFIZER INC - US4325955, 1982, A
[5]Current Patent Assignee: PFIZER INC - US4377589, 1983, A
[6]Current Patent Assignee: JOHNSON & JOHNSON INC - US2015/72982, 2015, A1 Location in patent: Paragraph 0165; 0167

4
[ 781-35-1 ]
[ 30955-98-7 ]

Yield	Reaction Conditions	Operation in experiment
91%	With sulfuryl dichloride In dichloromethane at 20℃; Inert atmosphere;

Reference： [1]Cordier, Pierre; Aubert, Corinne; Malacria, Max; Lacote, Emmanuel; Gandon, Vincent [Angewandte Chemie - International Edition, 2009, vol. 48, # 46, p. 8757 - 8760]
[2]Richard [Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences, 1935, vol. 200, p. 1944]

5
[ 781-35-1 ]
[ 33718-91-1 ]

Yield	Reaction Conditions	Operation in experiment
82%	With bromine In tetrachloromethane for 2h; Heating;
	With carbon disulfide; carbon dioxide; bromine
	With tetrachloromethane; carbon dioxide; bromine

Reference： [1]Dueggeli, Matias; Goujon-Ginglinger, Catherine; Ducotterd, Sarah Richard; Mauron, David; Bonte, Christophe; Von Zelewsky, Alexander; Stoeckli-Evans, Helen; Neels, Antonia [Organic and Biomolecular Chemistry, 2003, vol. 1, # 11, p. 1894 - 1899]
[2]Temnikowa [Zhurnal Obshchei Khimii, 1945, vol. 15, p. 514,521][Chem.Abstr., 1946, p. 4695]
[3]Temnikowa [Zhurnal Obshchei Khimii, 1945, vol. 15, p. 514,521][Chem.Abstr., 1946, p. 4695]

6
[ 781-35-1 ]
[ 6337-69-5 ]

Yield	Reaction Conditions	Operation in experiment
	With hydroxylamine hydrochloride; sodium acetate In methanol; water at 20℃; for 4h;
	With hydroxylamine hydrochloride; sodium acetate In methanol for 1h; Inert atmosphere; Reflux;
	With hydroxylamine hydrochloride; sodium acetate In methanol at 120℃;

Reference： [1]Hoch [Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences, 1934, vol. 198, p. 1865,1866] Saleskaja [Zhurnal Obshchei Khimii, 1948, vol. 18, p. 1172,1176][Chem.Abstr., 1949, p. 1753] Richard [Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences, 1935, vol. 200, p. 753][Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences, 1942, vol. 214, p. 673]
[2]Taber, Douglass F.; Tian, Weiwei [Journal of the American Chemical Society, 2006, vol. 128, # 4, p. 1058 - 1059]
[3]Tan, Yichen; Hartwig, John F. [Journal of the American Chemical Society, 2010, vol. 132, # 11, p. 3676 - 3677]
[4]Zhao, Mi-Na; Zhang, Wei; Wang, Xu-Cai; Zhang, Ying; Yang, De-Suo; Guan, Zheng-Hui [Organic and Biomolecular Chemistry, 2018, vol. 16, # 23, p. 4333 - 4337]

7
[ 781-35-1 ]
[ 1530-03-6 ]

Yield	Reaction Conditions	Operation in experiment
	With potassium hydroxide; hydrazine hydrate; diethylene glycol at 210℃;

Reference： [1]Djerassi et al. [Journal of the American Chemical Society, 1958, vol. 80, p. 4723,4730]

8
[ 781-35-1 ]
1,1-diphenyl-2-propanol [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
74%	With sodium tetrahydroborate; lithium chloride In tetrahydrofuran; methanol Flow reactor;
	With lithium aluminium tetrahydride; diethyl ether
	With lithium aluminium tetrahydride

	With lithium aluminium tetrahydride In diethyl ether
	With hydrogen In diethylene glycol dimethyl ether; water at 30℃; for 5h;
	With sodium tetrahydroborate In ethanol Inert atmosphere;
	With C₃₈H₃₈IrN₄S₂⁽¹⁺⁾*F₆P^(1-); ammonium formate; 3-methyl-5-p-methoxyphenyl-1-hydropyrazole In tetrahydrofuran; water at 40℃;
	Multi-step reaction with 2 steps 1: iron(III)-acetylacetonate; sodium triethylborohydride / tetrahydrofuran / 24 h / 20 °C / Inert atmosphere; Schlenk technique; Glovebox 2: sodium hydroxide; dihydrogen peroxide / 1 h / 20 °C / Inert atmosphere; Schlenk technique; Glovebox

Reference： [1]Gilmore, Kerry; Vukeli, Stella; McQuade, D. Tyler; Koksch, Beate; Seeberger, Peter H. [Organic Process Research and Development, 2014, vol. 18, # 12, p. 1771 - 1776]
[2]Abd Elhafez; Cram [Journal of the American Chemical Society, 1953, vol. 75, p. 339,345] Winstein; Marshall [Journal of the American Chemical Society, 1952, vol. 74, p. 1120,1126]
[3]Christol,H. et al. [Bulletin de la Societe Chimique de France, 1963, p. 877 - 881] Arnold, Donald R.; Lamont, Laurie J. [Canadian Journal of Chemistry, 1989, vol. 67, p. 2119 - 2127]
[4]Haller; Schneider [Archiv der Pharmazie, 1973, vol. 306, # 11, p. 846 - 856]
[5]Fujitsu, Hiroshi; Matsumura, Eiichi; Takeshita, Kenjiro; Mochida, Isao [Journal of the Chemical Society. Perkin transactions I, 1981, p. 2650 - 2655]
[6]Zhang, Juanni; Yang, Xiangren; Zhou, Han; Li, Yanyun; Dong, Zhenrong; Gao, Jingxing [Green Chemistry, 2012, vol. 14, # 5, p. 1289 - 1292]
[7]Tian, Cheng; Gong, Lei; Meggers, Eric [Chemical Communications, 2016, vol. 52, # 22, p. 4207 - 4210]
[8]Tamang, Sem Raj; Findlater, Michael [Journal of Organic Chemistry, 2017, vol. 82, # 23, p. 12857 - 12862]

9
[ 52183-00-3 ]
[ 781-35-1 ]

Yield	Reaction Conditions	Operation in experiment
80%	With sulfuric acid In dichloromethane at 25℃; for 0.25h;
	With sulfuric acid
	With hydrogenchloride at 180℃;

	With hydrogenchloride at 180℃;
	With sulfuric acid at 150℃;

Reference： [1]Kanemoto, Shigekazu; Morizawa, Yoshitomi; Oshima, Koichiro; Nozaki, Hitosi [Bulletin of the Chemical Society of Japan, 1982, vol. 55, # 12, p. 3941 - 3942]
[2]McKenzie; Roger [Journal of the Chemical Society, 1924, vol. 125, p. 851] v. Auwers; Mauss [Biochemische Zeitschrift, 1928, vol. 192, p. 222] Tiffeneau; Dorlencourt [Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences, 1906, vol. 143, p. 127; 651 Anm.][Annales de Chimie (Cachan, France), 1909, vol. <8> 16, p. 256] Rack [Chemische Berichte, 1923, vol. 56, p. 1130]
[3]Stoermer [Chemische Berichte, 1906, vol. 39, p. 2302]
[4]Smith; Hoehn [Journal of the American Chemical Society, 1941, vol. 63, p. 1184,1186]
[5]Wittig; Gauss [Chemische Berichte, 1947, vol. 80, p. 363,373]

10
[ 781-35-1 ]
[ 118573-92-5 ]

Yield	Reaction Conditions	Operation in experiment
90%	With ammonia; hydrogen In tetrahydrofuran at 120℃; for 20h;
	(i) NH₂OH, (ii) H₂, Raney-Ni, aq. NaOH, EtOH; Multistep reaction;
	(i) HCONH₂, (heating), (ii) aq. HCl; Multistep reaction;

With ammonium acetate; sodium cyanoborohydride In methanol at 20℃; for 40h;

Reference： [1]Jagadeesh, Rajenahally V.; Murugesan, Kathiravan; Alshammari, Ahmad S.; Neumann, Helfried; Pohl, Marga-Martina; Radnik, Jörg; Beller, Matthias [Science, 2017, vol. 358, # 6361, p. 326 - 332]
[2]Zuccarello,W.A. et al. [Journal of Medicinal Chemistry, 1969, vol. 12, # 1, p. 9 - 15]
[3]Christol,H. et al. [Bulletin de la Societe Chimique de France, 1963, p. 877 - 881]
[4]Eey, Stanley T.-C.; Lear, Martin J. [Chemistry - A European Journal, 2014, vol. 20, # 36, p. 11556 - 11573]

11
[ 781-35-1 ]
[ 57272-43-2 ]

Yield	Reaction Conditions	Operation in experiment
	With potassium <i>tert</i>-butylate; oxygen In N,N-dimethyl-formamide

Reference： [1]Sawaki,Y.; Ogata,Y. [Journal of the American Chemical Society, 1975, vol. 97, # 24, p. 6983 - 6989]

12
[ 69034-90-8 ]
[ 781-35-1 ]

Yield	Reaction Conditions	Operation in experiment
	With hydrogenchloride In methanol Ambient temperature;

Reference： [1]Kitamura, Tsugio; Kobayashi, Shinjiro; Taniguchi, Hiroshi [Journal of the American Chemical Society, 1986, vol. 108, # 10, p. 2641 - 2645]

13
[ 5815-08-7 ]
[ 781-35-1 ]
[ 143547-74-4 ]

Yield	Reaction Conditions	Operation in experiment
	With hydrazine hydrate 1.) 110 deg C, 30 min, 2.) 120 deg C, 30 min; Yield given. Multistep reaction;

Reference： [1]Meanwell; Rosenfeld; Trehan; Romine; Wright; Brassard; Buchanan; Federici; Fleming; Gamberdella; Zavoico; Seiler [Journal of Medicinal Chemistry, 1992, vol. 35, # 19, p. 3498 - 3512]

14
[ 781-35-1 ]
[ 28178-42-9 ]
N-[2,6-bis(1-methylethyl)phenyl]-β-oxo-γ-phenyl-benzenebutanamide [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	With lithium diisopropyl amide 1.) ether, -78 deg C, 20 min, 2.) ether, from -78 deg C to RT, 16 h; Multistep reaction;
	With lithium diisopropyl amide	2 Preparation of N-[2,6-bis(1-methylethyl)phenyl]-β-oxo-γ-phenyl-benzenebutanamide EXAMPLE 2 Preparation of N-[2,6-bis(1-methylethyl)phenyl]-β-oxo-γ-phenyl-benzenebutanamide The title compound, mp 153°-155° C., was prepared from 1,1-diphenylacetone (5.0 g, 0.023 mol), 2,6-diisopropylphenyl isocyanate (4.6 g, 0.023 mol) and lithium diisopropylamide (0.023 mol) using the procedure described in Example 1. Analysis for C28 H31 NO2: Calcd: C, 81.31; H, 7.55; N, 3.38; Found: C, 80.75; H, 7.84; N, 3.01.

Reference： [1]Augelli-Szafran; Blankley; Roth; Trivedi; Bousley; Essenburg; Hamelehle; Krause; Stanfield [Journal of Medicinal Chemistry, 1993, vol. 36, # 20, p. 2943 - 2949]
[2]Current Patent Assignee: PFIZER INC - US5278326, 1994, A

15
[ 781-35-1 ]
[ 135664-25-4 ]

Yield	Reaction Conditions	Operation in experiment
87%	With sodium dodecyl-sulfate; Selectfluor In water at 80℃; Micellar solution; regioselective reaction;
81%	With N-fluorobis<(trifluoromethyl)sulfonyl>imide In chloroform at 22℃; for 6h;

Reference： [1]Location in patent: scheme or table Stavber, Gaj; Zupan, Marko; Stavber, Stojan [Synlett, 2009, # 4, p. 589 - 594]
[2]Resnati, Giuseppe; DesMarteau, Darryl D. [Journal of Organic Chemistry, 1991, vol. 56, # 16, p. 4925 - 4929]

16
[ 6337-69-5 ]
[ 781-35-1 ]

Yield	Reaction Conditions	Operation in experiment
81%	With dinitrogen tetraoxide In acetonitrile at -40℃; for 0.166667h;
81%	With dinitrogen tetraoxide In acetonitrile at -40℃; for 0.166667h;

Reference： [1]Shim, Sung Bo; Kim, Kweon; Kim, Yong Hae [Tetrahedron Letters, 1987, vol. 28, # 6, p. 645 - 648]
[2]Kim, Yong Hae [Phosphorus, Sulfur and Silicon and the Related Elements, 1993, vol. 74, # 1-4, p. 249 - 260]

17
[ 15795-69-4 ]
[ 781-35-1 ]
[ 6337-69-5 ]

Yield	Reaction Conditions	Operation in experiment
1: 27% 2: 56%	With titanium(III) chloride In tetrahydrofuran; water at 0℃; for 20h; pH 6.5;
1: 27% 2: 56%	With titanium(III) chloride; ammonium acetate In tetrahydrofuran; water at 0℃; for 20h;

Reference： [1]Sera, Akira; Fukumoto, Shoji; Tamura, Masako; Takabatake, Kiyoshi; Yamada, Hiroaki; Itoh, Kuniaki [Bulletin of the Chemical Society of Japan, 1991, vol. 64, # 6, p. 1787 - 1791]
[2]Sera, Akira; Fukumoto, Shoji; Yoneda, Takako; Yamada, Hiroaki [Heterocycles, 1986, vol. 24, # 3, p. 697 - 702]

18
[ 15795-69-4 ]
[ 781-35-1 ]
[ 105381-45-1 ]

Yield	Reaction Conditions	Operation in experiment
1: 14% 2: 84%	With titanium(III) chloride In tetrahydrofuran; water at 35℃; for 24h; pH 6.5;
1: 14% 2: 84%	With titanium(III) chloride; ammonium acetate In tetrahydrofuran; water at 35℃; for 24h;

Reference： [1]Sera, Akira; Fukumoto, Shoji; Tamura, Masako; Takabatake, Kiyoshi; Yamada, Hiroaki; Itoh, Kuniaki [Bulletin of the Chemical Society of Japan, 1991, vol. 64, # 6, p. 1787 - 1791]
[2]Sera, Akira; Fukumoto, Shoji; Yoneda, Takako; Yamada, Hiroaki [Heterocycles, 1986, vol. 24, # 3, p. 697 - 702]

19
[ 74050-54-7 ]
[ 781-35-1 ]
[ 2042-85-5 ]

Yield	Reaction Conditions	Operation in experiment
1: 72% 2: 24%	With diethylaluminum benzenethiolate In hexane at 25℃; for 0.2h; Title compound not separated from byproducts;

Reference： [1]Kanemoto, Shigekazu; Morizawa, Yoshitomi; Oshima, Koichiro; Nozaki, Hitosi [Bulletin of the Chemical Society of Japan, 1982, vol. 55, # 12, p. 3941 - 3942]

20
[ 781-35-1 ]
[ 459-57-4 ]
4-(4-Fluorophenyl)-1,1-diphenyl-3-buten-2-one [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
77%	With sodium ethanolate; acetic acid In ethanol	60.A A. A. 4-(4-Fluorophenyl)-1,1-diphenyl-3-buten-2-one A mixture of 4-fluorobenzaldehyde (3.54 gm, 28.5 mmol) and 1,1-diphenylacetone (5.000 gm, 23.8 mmol) in absolute EtOH (50 ml) was treated with a solution of EtONa in EtOH (21% solution, 900 μl, 2.4 mmol). After stirring at room temperature for 22 hours, the mixture was concentrated to 35 ml and the solution was treated with HOAc (200 mg). The solution was cooled to 0° C. and the precipitate that had formed was collected by filtration and washed with cold EtOH. The title compound was obtained as a pale yellow solid (5.787 gm, 77%). m.p. 122°-124° C. TLC: Rf 0.32 (20% EtOAc in hexane)
	With sodium ethanolate In ethanol for 15h; Ambient temperature;

Reference： [1]Current Patent Assignee: BRISTOL-MYERS SQUIBB CO - US5506219, 1996, A
[2]Robl, Jeffrey A.; Duncan, Laurelee A.; Pluscec, Jelka; Karanevsky, Donald S.; Gordon, Eric M.; et al. [Journal of Medicinal Chemistry, 1991, vol. 34, # 9, p. 2804 - 2815]

21
[ 24834-34-2 ]
[ 781-35-1 ]

Yield	Reaction Conditions	Operation in experiment
100%	With Dowex 50W ion-exchange resin In dichloromethane Heating;

Reference： [1]Johnson, Carl R.; Bade, Thomas R. [Journal of Organic Chemistry, 1982, vol. 47, # 7, p. 1205 - 1212]

22
[ 113388-56-0 ]
[ 781-35-1 ]

Yield	Reaction Conditions	Operation in experiment
94%	With hydrogenchloride In tetrahydrofuran; water for 48h; Ambient temperature;

Reference： [1]Syper, Ludwik [Tetrahedron, 1987, vol. 43, # 12, p. 2853 - 2872]

23
[ 781-35-1 ]
[ 1068-57-1 ]
[ 141981-35-3 ]

Yield	Reaction Conditions	Operation in experiment
73%	With acetic acid In ethanol for 24h; Heating;

Reference： [1]Jefferson, Elizabeth A.; Warkentin, John [Journal of the American Chemical Society, 1992, vol. 114, # 16, p. 6318 - 6325]

24
[ 781-35-1 ]
[ 57-14-7 ]
[ 90968-56-2 ]

Yield	Reaction Conditions	Operation in experiment
86%	With sodium acetate; acetic acid In ethanol for 24h; Heating;
	With sodium acetate; acetic acid In ethanol at 150℃; for 1h; Microwave irradiation;
	With trifluoroacetic acid In benzene for 4h; Reflux;

With sodium acetate; acetic acid In ethanol for 36h; Reflux;

Reference： [1]Padwa, Albert; Rosenthal, Robert J.; Dent, William; Filho, Pedro; Turro, Nicholas J.; et al. [Journal of Organic Chemistry, 1984, vol. 49, # 17, p. 3174 - 3180]
[2]Jana, Samaresh; Clements, MacK D.; Sharp, Barry K.; Zheng, Nan [Organic Letters, 2010, vol. 12, # 17, p. 3736 - 3739]
[3]Okamoto, Kazuhiro; Mashida, Ayano; Watanabe, Masahito; Ohe, Kouichi [Chemical Communications, 2012, vol. 48, # 29, p. 3554 - 3556]
[4]Khaidarov, Adel R.; Rostovskii, Nikolai V.; Zolotarev, Andrey A.; Khlebnikov, Alexander F.; Novikov, Mikhail S. [Journal of Organic Chemistry, 2019, vol. 84, # 7, p. 3743 - 3753]

25
[ 781-35-1 ]
[ 140-88-5 ]
[ 13128-74-0 ]

Yield	Reaction Conditions	Operation in experiment
98%	With potassium <i>tert</i>-butylate In various solvent(s) at 20℃;
92%	With potassium <i>tert</i>-butylate In diethyl ether for 18h; Ambient temperature;
44%	With potassium <i>tert</i>-butylate In diethyl ether at 20℃; for 9h; Inert atmosphere;

Stage #1: 1,1-diphenylacetone With potassium <i>tert</i>-butylate In diethyl ether for 0.166667h; Stage #2: ethyl acrylate In diethyl ether at 20℃;

Intermediate 12-4,4-Diphenyl-cyclohexane-1,3-dione To a stirring suspension of 2.8 g (0.025 mole) of potassium t-butoxide in 50 ml ethyl ether was added 0.53 g (0.025 mole) of 1,1 diphenylacetone in 25 ml ethyl ether. The reaction was stirred for ten minutes; the white slurry became a clear yellow solution. 2.7 ml (0.025 mole) of ethyl acrylate in 50 ml ethyl ether was added. A white precipitate formed immediately. The reaction was stirred overnight at room temperature. The white precipitate was collected on a filter and washed with ethyl ether. The crude product was dissolved in water, acidified with dilute HCl and extracted (three times) into chloroform. The combined chloroform extracts were dried over sodium sulfate, filtered and stripped to a solid (4.1 g). MS: (-) ES (M-H)- 263, Elemental Anal. Calcd. for C18H16O2+0.5 mole H2O: C, 79.10%; H, 6.27%; N, 0.00%, Found: C, 79.09%; H, 5.90%; N, 0.02%, 1H-NMR (DMSO-d6) δ 11.13 (b, 1H); 7.27 (m, 6H); 7.10 (m, 4H); 5.38 (s,1H); 2.64 (m, 2H); (s, 2H).

Reference： [1]Daubie, Christophe; Mutti, Stephane [Tetrahedron Letters, 1996, vol. 37, # 43, p. 7743 - 7744]
[2]Zimmerman, Howard E.; Pasteris, Robert J. [Journal of Organic Chemistry, 1980, vol. 45, # 24, p. 4876 - 4891]
[3]Nagasawa, Shota; Sasano, Yusuke; Iwabuchi, Yoshiharu [Angewandte Chemie - International Edition, 2016, vol. 55, # 42, p. 13189 - 13194][Angew. Chem., 2016, vol. 128, p. 13383 - 13388,6]
[4]Current Patent Assignee: PFIZER INC - US2006/14826, 2006, A1 Location in patent: Page/Page column 15

26
1,2-diphenyl-1-phenylthio-2-propanol [ No CAS ]
[ 781-35-1 ]

Yield	Reaction Conditions	Operation in experiment
69%	With tetraethylammonium chloride In methanol; dichloromethane electrolysis;

Reference： [1]Kimura, Makoto; Kobayashi, Kazutaka; Yamamoto, Yasushi; Sawaki, Yasuhiko [Tetrahedron, 1996, vol. 52, # 12, p. 4303 - 4310]

27
[ 17789-14-9 ]
[ 781-35-1 ]
3-(3-[1,3]Dioxolan-2-yl-phenyl)-1,1-diphenyl-propan-2-one [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
72%	With tol-BINAP; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; sodium t-butanolate In tetrahydrofuran at 70℃;

Reference： [1]Palucki; Buchwald [Journal of the American Chemical Society, 1997, vol. 119, # 45, p. 11108 - 11109]

28
[ 781-35-1 ]
[ 5892-99-9 ]
N,N-Diethyl-4-(2-oxo-3,3-diphenyl-propyl)-benzamide [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
69%	With tol-BINAP; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; sodium t-butanolate In tetrahydrofuran at 70℃;

Reference： [1]Palucki; Buchwald [Journal of the American Chemical Society, 1997, vol. 119, # 45, p. 11108 - 11109]

29
[ 781-35-1 ]
[ 117-34-0 ]

Yield	Reaction Conditions	Operation in experiment
95%	With sodium hypochlorite; lithium hypochlorite In ethanol at 77℃; for 2h;

Reference： [1]Madler; Klucik; Soell; Brown; Liu; Berlin; Benbrook; Birckbichler; Nelson [Organic Preparations and Procedures International, 1998, vol. 30, # 2, p. 230 - 234]

30
[ 37595-74-7 ]
[ 781-35-1 ]
[ 29571-19-5 ]

Yield	Reaction Conditions	Operation in experiment
75%	Stage #1: 1,1-diphenylacetone With sodium hydride In tetrahydrofuran at 0℃; for 2h; Stage #2: N,N-phenylbistrifluoromethane-sulfonimide In tetrahydrofuran at 0 - 20℃;
	With sodium hydride 1.) DMF, mineral oil, 2 h, 2.) DMF, mineral oil, overnight; Yield given. Multistep reaction;

Reference： [1]Wallace, Debra J.; Klauber, David J.; Chen, Cheng-Yi; Volante, Ralph P. [Organic Letters, 2003, vol. 5, # 24, p. 4749 - 4752]
[2]Larock, Richard C.; Tian, Qingping [Journal of Organic Chemistry, 1998, vol. 63, # 6, p. 2002 - 2009]

31
[ 50-00-0 ]
[ 781-35-1 ]
[ 6091-44-7 ]
[ 5446-73-1 ]

Reference： [1]Bioorganic and Medicinal Chemistry,1999,vol. 7,p. 1837 - 1844

Yield	Reaction Conditions	Operation in experiment
	With lead acetate at 280℃;

33
[ 75-77-4 ]
[ 781-35-1 ]
[ 51425-63-9 ]

Yield	Reaction Conditions	Operation in experiment
88%	Stage #1: 1,1-diphenylacetone With potassium hydride In tetrahydrofuran at 20℃; for 2h; Stage #2: chloro-trimethyl-silane In tetrahydrofuran at 20℃; for 48h; Further stages.;

Reference： [1]Langer, Peter; Doering, Manfred; Seyferth, Dietmar; Goerls, Helmar [Chemistry - A European Journal, 2001, vol. 7, # 3, p. 573 - 584]

34
[ 13154-24-0 ]
[ 781-35-1 ]
triisopropyl-(1-methyl-2,2-diphenyl-vinyloxy)-silane [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
78%	Stage #1: 1,1-diphenylacetone With potassium hydride In tetrahydrofuran at 20℃; for 2h; Stage #2: triisopropylsilyl chloride In tetrahydrofuran at 20℃; for 48h; Further stages.;

Reference： [1]Langer, Peter; Doering, Manfred; Seyferth, Dietmar; Goerls, Helmar [Chemistry - A European Journal, 2001, vol. 7, # 3, p. 573 - 584]

35
[ 781-35-1 ]
[ 18162-48-6 ]
[ 169696-27-9 ]

Yield	Reaction Conditions	Operation in experiment
82%	Stage #1: 1,1-diphenylacetone With potassium hydride In tetrahydrofuran at 20℃; for 2h; Stage #2: tert-butyldimethylsilyl chloride In tetrahydrofuran at 20℃; for 48h; Further stages.;

Reference： [1]Langer, Peter; Doering, Manfred; Seyferth, Dietmar; Goerls, Helmar [Chemistry - A European Journal, 2001, vol. 7, # 3, p. 573 - 584]

36
[ 623-26-7 ]
[ 75-77-4 ]
[ 781-35-1 ]
(Z,Z)-α,α'-bis[3,3-diphenyl-2-(trimethylsilyloxy)-2-propenylidene]-N,N'-bis(trimethylsilyl)-1,4-benzenedimethanamine [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
80%	Stage #1: 1,1-diphenylacetone With potassium hydride In tetrahydrofuran at 20℃; for 1h; Stage #2: terephthalonitrile With n-butyllithium In tetrahydrofuran; hexane at 20℃; for 2h; Stage #3: chloro-trimethyl-silane In tetrahydrofuran; hexane at 20℃; for 12h;

Reference： [1]Langer, Peter; Anders, Joachim T. [European Journal of Organic Chemistry, 2002, # 4, p. 686 - 691]

37
[ 100-70-9 ]
[ 75-77-4 ]
[ 781-35-1 ]
(Z,Z)-[3,3-diphenyl-2-(trimethylsilyloxy)-2-propenylidene]-N-(trimethylsilyl)-[(2-pyridine)methanamine] [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
74%	Stage #1: 1,1-diphenylacetone With potassium hydride In tetrahydrofuran at 20℃; for 1h; Stage #2: 2-Cyanopyridine With n-butyllithium In tetrahydrofuran; hexane at 20℃; for 2h; Stage #3: chloro-trimethyl-silane In tetrahydrofuran; hexane at 20℃; for 12h;

Reference： [1]Langer, Peter; Anders, Joachim T. [European Journal of Organic Chemistry, 2002, # 4, p. 686 - 691]

38
[ 75-77-4 ]
[ 781-35-1 ]
[ 100-47-0 ]
(Z,Z)-[3,3-diphenyl-2-(trimethylsilyloxy)-2-propenylidene]-N-(trimethylsilyl)benzenemethanamine [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
85%	Stage #1: 1,1-diphenylacetone With potassium hydride In tetrahydrofuran at 20℃; for 1h; Stage #2: benzonitrile With n-butyllithium In tetrahydrofuran; hexane at 20℃; for 2h; Stage #3: chloro-trimethyl-silane In tetrahydrofuran; hexane at 20℃; for 12h;

Reference： [1]Langer, Peter; Anders, Joachim T. [European Journal of Organic Chemistry, 2002, # 4, p. 686 - 691]

39
3-methyl-2,2-diphenyl-1-(toluene-4-sulfonyl)-aziridine [ No CAS ]
[ 781-35-1 ]

Yield	Reaction Conditions	Operation in experiment
65%	With boron trifluoride diethyl etherate In chloroform at -40 - 20℃; for 168h;

Reference： [1]Sugihara, Yoshiaki; Iimura, Shinya; Nakayama, Juzo [Chemical Communications, 2002, # 2, p. 134 - 135]

40
[ 781-35-1 ]
[ 536-74-3 ]
[ 40650-77-9 ]

Yield	Reaction Conditions	Operation in experiment
10%	With gallium(III) trichloride In dichloromethane for 54h; Heating;

Reference： [1]Viswanathan, Ganapathy S.; Wang, Mingwen; Li, Chao-Jun [Angewandte Chemie - International Edition, 2002, vol. 41, # 12, p. 2138 - 2141]

41
1,1-diphenyl-2-propanol [ No CAS ]
[ 781-35-1 ]
(S)-(-)-1,1-diphenylpropan-2-ol [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
1: 38% 2: 57%	With 3 A molecular sieve; oxygen; (-)-sparteine In <i>tert</i>-butyl alcohol at 65℃; for 24h;

Reference： [1]Mandal, Sunil K.; Jensen, David R.; Pugsley, Jacob S.; Sigman, Matthew S. [Journal of Organic Chemistry, 2003, vol. 68, # 11, p. 4600 - 4603]

42
1,1-diphenyl-2-propanol [ No CAS ]
[ 781-35-1 ]
(S)-(-)-1,1-diphenylpropan-2-ol [ No CAS ]
(R)-(+)-1,1-diphenylpropan-2-ol [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	With 3 A molecular sieve; oxygen; sodium carbonate In <i>tert</i>-butyl alcohol at 65℃; for 24h; Title compound not separated from byproducts;
	With bis(1,5-cyclooctadiene)diiridium(I) dichloride; bis(triphenylphosphine)iminium chloride; acetone; potassium hydroxide; N,N'-bis[o-(diphenylphosphino)benzylidene]-(1S,2S)-diaiminocyclohexane In dichloromethane; water; isopropyl alcohol at 45℃; for 32h; Resolution of racemate; Inert atmosphere; enantioselective reaction;

Reference： [1]Mandal, Sunil K.; Sigman, Matthew S. [Journal of Organic Chemistry, 2003, vol. 68, # 19, p. 7535 - 7537]
[2]Zhang, Juanni; Yang, Xiangren; Zhou, Han; Li, Yanyun; Dong, Zhenrong; Gao, Jingxing [Green Chemistry, 2012, vol. 14, # 5, p. 1289 - 1292]

43
[ 781-35-1 ]
[ 95-92-1 ]
2,4-dioxo-5,5-diphenyl-pentanoic acid ethyl ester [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	With sodium ethanolate In tetrahydrofuran at 20℃;

Reference： [1]Summa, Vincenzo; Petrocchi, Alessia; Pace, Paola; Matassa, Victor G.; De Francesco, Raffaele; Altamura, Sergio; Tomei, Licia; Koch, Uwe; Neuner, Philippe [Journal of Medicinal Chemistry, 2004, vol. 47, # 1, p. 14 - 17]

44
[ 781-35-1 ]
[ 109-94-4 ]
[ 143547-74-4 ]

Yield	Reaction Conditions	Operation in experiment
40%	With sodium methylate; hydrazine In isopropyl alcohol; toluene

Reference： [1]Rheingold, Arnold L.; Liable-Sands, Louise M.; Golen, James A.; Yap, Glenn P.A.; Trofimenko, Swiatoslaw [Dalton Transactions, 2004, # 4, p. 598 - 604]

45
[ 4741-91-7 ]
[ 781-35-1 ]

Yield	Reaction Conditions	Operation in experiment
99%	With rhenium(I) pentacarbonyl bromide In monoethylene glycol diethyl ether at 80℃; for 1h; Inert atmosphere; chemoselective reaction;	2. General Procedure General procedure: A 1,2-dichloroethane (2 mL) solution of oxirane (0.3 mmol) and ReBr(CO)5 (5 mol %) was stirred under an atmosphere of nitrogen at 80 °C for 1-5 h. After the reaction was complete, H2O was added to the reaction mixture and extracted with ethyl acetate. The organic layer was dried with MgSO4. The resulting mixture was filtered, and the filtrate was concentrated. Purification of the residue by silica gel column chromatography afforded carbonyl compounds. Further purification was carried out by recyclable preparative HPLC, if necessary. The structures of the products were assigned by their 1H and 13C-NMR, and mass spectra. The products were characterized by comparing their 1H and 13C-NMR spectra data with those of authentic sample or previous reports. Yields were determined by 1H-NMR using internal standard.
	With zeolite at 20℃; for 24h;

Reference： [1]Umeda, Rui; Muraki, Masahito; Nakamura, Yuudai; Tanaka, Tomoyuki; Kamiguchi, Kyohei; Nishiyama, Yutaka [Tetrahedron Letters, 2017, vol. 58, # 24, p. 2393 - 2395]
[2]Clennan, Edward L.; Pan, Gui-Ian [Organic Letters, 2003, vol. 5, # 26, p. 4979 - 4982]

46
[ 5162-44-7 ]
[ 781-35-1 ]
[ 752207-03-7 ]

Yield	Reaction Conditions	Operation in experiment
59%	Stage #1: 1,1-diphenylacetone With lithium diisopropyl amide In tetrahydrofuran Stage #2: 1-bromo-4-butene In tetrahydrofuran at 20℃;

Reference： [1]Qian, Hua; Han, Xiaoqing; Widenhoefer, Ross A. [Journal of the American Chemical Society, 2004, vol. 126, # 31, p. 9536 - 9537]

47
[ 4894-61-5 ]
[ 781-35-1 ]
[ 119296-87-6 ]
[ 107556-98-9 ]

Yield	Reaction Conditions	Operation in experiment
85%	Stage #1: 1,1-diphenylacetone With lithium diisopropyl amide In tetrahydrofuran Stage #2: trans-but-2-enyl chloride In tetrahydrofuran at 20℃; Title compound not separated from byproducts;

Reference： [1]Qian, Hua; Han, Xiaoqing; Widenhoefer, Ross A. [Journal of the American Chemical Society, 2004, vol. 126, # 31, p. 9536 - 9537]

48
[ 111-26-2 ]
[ 781-35-1 ]
[ 7501-79-3 ]
[ 101-81-5 ]

Yield	Reaction Conditions	Operation in experiment
1: 74% 2: 65%	With n-butyllithium; diisopropylamine In tetrahydrofuran; hexane at 0 - 20℃; for 5.5h;

Reference： [1]Ishihara, Kazuaki; Yano, Takayuki [Organic Letters, 2004, vol. 6, # 12, p. 1983 - 1986]

49
[ 7348-78-9 ]
[ 781-35-1 ]
[ 752207-00-4 ]

Yield	Reaction Conditions	Operation in experiment
23%	Stage #1: 1,1-diphenylacetone With lithium diisopropyl amide In tetrahydrofuran Stage #2: (Z)-1-bromo-2-pentene In tetrahydrofuran

Reference： [1]Qian, Hua; Han, Xiaoqing; Widenhoefer, Ross A. [Journal of the American Chemical Society, 2004, vol. 126, # 31, p. 9536 - 9537]

50
[ 2441-97-6 ]
[ 781-35-1 ]
[ 752207-01-5 ]

Yield	Reaction Conditions	Operation in experiment
96%	Stage #1: 1,1-diphenylacetone With lithium diisopropyl amide In tetrahydrofuran Stage #2: 3-chloro-cyclohexene In tetrahydrofuran at 20℃;

Reference： [1]Qian, Hua; Han, Xiaoqing; Widenhoefer, Ross A. [Journal of the American Chemical Society, 2004, vol. 126, # 31, p. 9536 - 9537]

51
[ 781-35-1 ]
[ 37677-17-1 ]
[ 752207-02-6 ]

Yield	Reaction Conditions	Operation in experiment
76%	Stage #1: 1,1-diphenylacetone With lithium diisopropyl amide In tetrahydrofuran Stage #2: 1-bromomethylcyclohexene In tetrahydrofuran at 20℃;

Reference： [1]Qian, Hua; Han, Xiaoqing; Widenhoefer, Ross A. [Journal of the American Chemical Society, 2004, vol. 126, # 31, p. 9536 - 9537]

52
[ 781-35-1 ]
[ 781-03-3 ]
[ 752207-04-8 ]

Yield	Reaction Conditions	Operation in experiment
17%	Stage #1: 1,1-diphenylacetone With lithium diisopropyl amide In tetrahydrofuran Stage #2: isopentenyl tosylate In tetrahydrofuran at 20℃;

Reference： [1]Qian, Hua; Han, Xiaoqing; Widenhoefer, Ross A. [Journal of the American Chemical Society, 2004, vol. 126, # 31, p. 9536 - 9537]

53
[ 781-35-1 ]
[ 106-95-6 ]
[ 107556-96-7 ]

Yield	Reaction Conditions	Operation in experiment
81%	Stage #1: 1,1-diphenylacetone With lithium diisopropyl amide In tetrahydrofuran; hexane at -78℃; for 0.75h; Stage #2: allyl bromide In tetrahydrofuran at 20℃;

Reference： [1]Qian, Hua; Han, Xiaoqing; Widenhoefer, Ross A. [Journal of the American Chemical Society, 2004, vol. 126, # 31, p. 9536 - 9537]

54
[ 781-35-1 ]
[ 870-63-3 ]
[ 107557-03-9 ]

Yield	Reaction Conditions	Operation in experiment
92%	Stage #1: 1,1-diphenylacetone With lithium diisopropyl amide In tetrahydrofuran Stage #2: prenyl bromide In tetrahydrofuran at 20℃;

Reference： [1]Qian, Hua; Han, Xiaoqing; Widenhoefer, Ross A. [Journal of the American Chemical Society, 2004, vol. 126, # 31, p. 9536 - 9537]

55
[ 781-35-1 ]
(S)-(-)-1,1-diphenylpropan-2-ol [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
90%	In isopropyl alcohol at 20℃; for 17h;
	Multi-step reaction with 3 steps 1: LiAlH₄ / diethyl ether 2: Py / Heating 3: aq. KOH / methanol / Heating

Reference： [1]Chen, Jian-Shan; Li, Yan-Yun; Dong, Zhen-Rong; Li, Bao-Zhu; Gao, Jing-Xing [Tetrahedron Letters, 2004, vol. 45, # 45, p. 8415 - 8418]
[2]Haller; Schneider [Archiv der Pharmazie, 1973, vol. 306, # 11, p. 846 - 856]

56
[ 781-35-1 ]
(R)-(+)-1,1-diphenylpropan-2-ol [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
99%	With carbonylhydridotris(triphenylphosphine)iridium(I); N,N'-bis[o-(diphenylphosphino)benzylidene]-(1S,2S)-diaiminocyclohexane In isopropyl alcohol at 75℃; for 8.5h;
93%	With C₃₈H₃₈IrN₄S₂⁽¹⁺⁾*F₆P^(1-); ammonium formate; 3-methyl-5-p-methoxyphenyl-1-hydropyrazole In tetrahydrofuran; water at 40℃; for 15h; enantioselective reaction;
68%	With triiron dodecarbonyl; C₅₂H₅₈N₄P₂; hydrogen; potassium hydroxide In methanol at 45℃; for 10h; enantioselective reaction;

	In isopropyl alcohol at 20℃; for 4h;
	Multi-step reaction with 3 steps 1: LiAlH₄ / diethyl ether 2: Py / Heating 3: aq. KOH / methanol / Heating
91 %Spectr.	With bromopentacarbonylmanganese(I); C₅₂H₅₀N₄P₂; isopropyl alcohol; potassium hydroxide at 65℃; for 3h; Inert atmosphere; Schlenk technique; enantioselective reaction;	2. Typical procedure for ATH of ketones General procedure: Chiral ligands were synthesized using the procedure we previously reported.1-3 Under a nitrogen atmosphere, the complex [MnBr(CO)5] (2.7 mg, 0.01 mmol), (R,R,R',R')-CyP2N4 (L5) (8.0 mg, 0.01 mmol) were placed in a schlenk tube equipped with a Teflon-coated magnetic stirring bar. Then, iPrOH was added and the mixture was stirred at 55 oC for 30 min. Next, an appropriate amount of KOH/iPrOH solution was added, and the mixture was continually stirred for another 15 min. Later, ketone (0.5 mmol) was introduced, and the mixture was stirred at the desired temperature for the required reaction time. At the end of experiment, 1,3,5-trimethoxybenzene (28.0 mg,0.1667 mmol) as an internal standard was added, the reaction products were determined by GC using a chiralCP-Chiralsil-Dex CB column. Yields were determined by 1H NMR analysis of the crude reaction mixture.

Reference： [1]Dong, Zhen-Rong; Li, Yan-Yun; Chen, Jian-Shan; Li, Bao-Zhu; Xing, Yan; Gao, Jing-Xing [Organic Letters, 2005, vol. 7, # 6, p. 1043 - 1045]
[2]Tian, Cheng; Gong, Lei; Meggers, Eric [Chemical Communications, 2016, vol. 52, # 22, p. 4207 - 4210]
[3]Li, Yanyun; Yu, Shenluan; Wu, Xiaofeng; Xiao, Jianliang; Shen, Weiyi; Dong, Zhenrong; Gao, Jingxing [Journal of the American Chemical Society, 2014, vol. 136, # 10, p. 4031 - 4039]
[4]Chen, Jian-Shan; Li, Yan-Yun; Dong, Zhen-Rong; Li, Bao-Zhu; Gao, Jing-Xing [Tetrahedron Letters, 2004, vol. 45, # 45, p. 8415 - 8418]
[5]Haller; Schneider [Archiv der Pharmazie, 1973, vol. 306, # 11, p. 846 - 856]
[6]Zhang, Guang-Ya; Ruan, Sun-Hong; Li, Yan-Yun; Gao, Jing-Xing [Chinese Chemical Letters, 2021, vol. 32, # 4, p. 1415 - 1418]

57
[ 22875-82-7 ]
[ 781-35-1 ]
[ 2042-85-5 ]

Yield	Reaction Conditions	Operation in experiment
1: 9% 2: 87%	With gallium(III) trichloride; methyl cyclohexane In 1,2-dichloro-ethane at 80℃; for 1h;

Reference： [1]Oshita, Masayuki; Okazaki, Takao; Ohe, Kouichi; Chatani, Naoto [Organic Letters, 2005, vol. 7, # 2, p. 331 - 334]

58
[ 781-35-1 ]
[ 4124-41-8 ]
[ 849943-94-8 ]

Yield	Reaction Conditions	Operation in experiment
83%	Stage #1: 1,1-diphenylacetone With potassium <i>tert</i>-butylate In tetrahydrofuran at -20 - 0℃; for 1.66667h; Inert atmosphere; Stage #2: p-toluenesulfonylanhydride In tetrahydrofuran at -20 - 0℃; for 6h; Inert atmosphere;	3.1 General procedure for the synthesis of alkenyl tosylate 1a-1i, 1k-1l General procedure: The solution of ketone or aldehyde (ca. 3 mmol) in THF (10 mL) was cooled to -20 °C. 1.0 M t-BuOK in THF (1.1-1.5 equiv) was added dropwise to the solution over 10 min. The mixture was warmed to 0 °C, stirred for 1.5 h, and then cooled to -20 °C. p-Toluenesulfonic anhydride (1.1-1.5 equiv) was added to the solution and the mixture was stirred for 1 h, then warmed to 0 °C, and stirred for 5 h. The mixture was diluted with EtOAc, washed with H2O and brine, dried over MgSO4, filtered, and concentrated. The obtained residue was purified by silica gel column chromatography (SiO2, hexane/EtOAc 30/1-10/1) to afford the desired alkenyl tosylate.
75%	Stage #1: 1,1-diphenylacetone With sodium t-butanolate In tetrahydrofuran at -20 - 20℃; for 1.5h; Inert atmosphere; Stage #2: p-toluenesulfonylanhydride In tetrahydrofuran at -15 - -5℃; for 1.5h; Inert atmosphere;
75%	Stage #1: 1,1-diphenylacetone With sodium t-butanolate In tetrahydrofuran at -20 - 20℃; Inert atmosphere; Stage #2: p-toluenesulfonylanhydride In tetrahydrofuran at -15 - -5℃; for 1.5h; Inert atmosphere;

73%

Stage #1: 1,1-diphenylacetone With sodium t-butanolate In 1-methyl-pyrrolidin-2-one at -5 - 20℃; for 1.25h; Stage #2: p-toluenesulfonylanhydride In 1-methyl-pyrrolidin-2-one at -15 - -5℃; for 1h;

Reference： [1]Ueda, Tsuyoshi; Konishi, Hideyuki; Manabe, Kei [Tetrahedron Letters, 2012, vol. 53, # 38, p. 5171 - 5175]
[2]Reeves, Diana C.; Rodriguez, Sonia; Lee, Heewon; Haddad, Nizar; Krishnamurthy, Dhileep; Senanayake, Chris H. [Tetrahedron Letters, 2009, vol. 50, # 24, p. 2870 - 2873]
[3]Reeves, Diana C.; Rodriguez, Sonia; Lee, Heewon; Haddad, Nizar; Krishnamurthy, Dhileepkumar; Senanayake, Chris H. [Organic Letters, 2011, vol. 13, # 9, p. 2495 - 2497]
[4]Klapars, Artis; Campos, Kevin R.; Chen, Cheng-Yi; Volante, Ralph P. [Organic Letters, 2005, vol. 7, # 6, p. 1185 - 1188]

59
[ 781-35-1 ]
[ 71713-10-5 ]
6,6'-bis(2-(diphenylmethylene)-4-phenylquinoline) [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
81%	With diphenyl hydrogen phosphate In toluene at 120℃; for 24h;

Reference： [1]Tonzola, Christopher J.; Hancock, Jessica M.; Babel, Amit; Jenekhe, Samson A. [Chemical Communications, 2005, # 41, p. 5214 - 5216]

60
[ 781-35-1 ]
[ 109-77-3 ]
2-methyl-3,3-diphenylprop-1-ene-1,1-dicarbonitrile [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
41%	With aluminum oxide at 60℃; for 1h;	3.2. Preparation of 1a A mixture of 1,1-diphenylacetone (1.051 g, 5.0 mmol), malononitrile (0.330 g, 5.0 mmol) and activated alumina (1.5 g) was stirred at 60 C for 1 h [34]. The solids were removed by filtration. Concentration of the filtrate gave a residue that was subjected to silica gel column chromatography followed by recrystallization from hexane to give 2-(1,1-diphenylpropan-2-ylidene)malononitrile (1a, white solid, 0.531 g, 2.06 mmol, 41% yield). Lit [35].
32.3%	With piperidine; ammonium acetate; acetic acid In benzene for 15h; Heating;
27%	With acetic acid In benzene Heating;

Reference： [1]Maeda, Hajime; Iida, Masayuki; Ogawa, Daisuke; Mizuno, Kazuhiko [Molecules, 2019, vol. 24, # 14]
[2]Kozik, Bartłomiej; Wilamowski, Jarosław; Góra, Maciej; Sepioł, Janusz J. [Tetrahedron, 2008, vol. 64, # 27, p. 6452 - 6460]
[3]Kozik, Bartłomiej; Wilamowski, Jarosław; Góra, Maciej; Sepioł, Janusz J. [Tetrahedron Letters, 2006, vol. 47, # 20, p. 3435 - 3438]

61
[ 108-86-1 ]
[ 1833-53-0 ]
[ 781-35-1 ]
[ 103-79-7 ]

Yield	Reaction Conditions	Operation in experiment
	With manganese(II) fluoride; zinc(II) fluoride; tri-tert-butyl phosphine In N,N-dimethyl-formamide at 70℃;

Reference： [1]Su, Weiping; Raders, Steven; Verkade, John G.; Liao, Xuebin; Hartwig, John F. [Angewandte Chemie - International Edition, 2006, vol. 45, # 35, p. 5852 - 5855]

62
[ 781-35-1 ]
[ 4757-69-1 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 3 steps 1: NaOAc; NH₂OH*HCl / methanol; H₂O / 4 h / 20 °C 2: 75 mg / DIAD; tri-n-butylphosphine / acetonitrile / 2 h / 20 °C 3: 89 percent / o-xylene / 16 h / 150 °C
	Multi-step reaction with 4 steps 1: trifluoroacetic acid / benzene / 4 h / Reflux 2: 13 h / 40 °C 3: sodium hydride / N,N-dimethyl-formamide / 1 h / 0 °C 4: Ni(1,5-cyclooctadiene)2; tricyclopentylphosphine / toluene / 12 h / 80 °C

Reference： [1]Taber, Douglass F.; Tian, Weiwei [Journal of the American Chemical Society, 2006, vol. 128, # 4, p. 1058 - 1059]
[2]Okamoto, Kazuhiro; Mashida, Ayano; Watanabe, Masahito; Ohe, Kouichi [Chemical Communications, 2012, vol. 48, # 29, p. 3554 - 3556]

63
[ 781-35-1 ]
[ 65817-54-1 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1: NaOAc; NH₂OH*HCl / methanol; H₂O / 4 h / 20 °C 2: 75 mg / DIAD; tri-n-butylphosphine / acetonitrile / 2 h / 20 °C
	Multi-step reaction with 3 steps 1: 86 percent / AcOH, NaOAc / ethanol / 24 h / Heating 2: 16 h / Ambient temperature 3: 55 percent / NaH / dimethylsulfoxide / 4 h / Ambient temperature
	Multi-step reaction with 3 steps 1: trifluoroacetic acid / benzene / 4 h / Reflux 2: 13 h / 40 °C 3: sodium hydride / N,N-dimethyl-formamide / 1 h / 0 °C

	Multi-step reaction with 3 steps 1: hydroxylamine hydrochloride; sodium acetate / methanol / 120 °C 2: dichloromethane / 60 °C 3: caesium carbonate / N,N-dimethyl-formamide / 60 °C / Inert atmosphere
	Multi-step reaction with 3 steps 1: sodium acetate; acetic acid / ethanol / 36 h / Reflux 2: 4 h / 40 °C 3: sodium hydride / dimethyl sulfoxide / 2 h / 20 °C

Reference： [1]Taber, Douglass F.; Tian, Weiwei [Journal of the American Chemical Society, 2006, vol. 128, # 4, p. 1058 - 1059]
[2]Padwa, Albert; Rosenthal, Robert J.; Dent, William; Filho, Pedro; Turro, Nicholas J.; et al. [Journal of Organic Chemistry, 1984, vol. 49, # 17, p. 3174 - 3180]
[3]Okamoto, Kazuhiro; Mashida, Ayano; Watanabe, Masahito; Ohe, Kouichi [Chemical Communications, 2012, vol. 48, # 29, p. 3554 - 3556]
[4]Zhao, Mi-Na; Zhang, Wei; Wang, Xu-Cai; Zhang, Ying; Yang, De-Suo; Guan, Zheng-Hui [Organic and Biomolecular Chemistry, 2018, vol. 16, # 23, p. 4333 - 4337]
[5]Khaidarov, Adel R.; Rostovskii, Nikolai V.; Zolotarev, Andrey A.; Khlebnikov, Alexander F.; Novikov, Mikhail S. [Journal of Organic Chemistry, 2019, vol. 84, # 7, p. 3743 - 3753]

64
[ 781-35-1 ]
N-(2,2-diphenyl-1-methylethenyl)formamide [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1.1: t-BuONa / 1-methyl-pyrrolidin-2-one / 1.25 h / -5 - 20 °C 1.2: 73 percent / 1-methyl-pyrrolidin-2-one / 1 h / -15 - -5 °C 2.1: 91 percent / K₃PO₄; dipf / Pd₂dba3 / 2-methyl-butan-2-ol / 20 h / 100 °C

Reference： [1]Klapars, Artis; Campos, Kevin R.; Chen, Cheng-Yi; Volante, Ralph P. [Organic Letters, 2005, vol. 7, # 6, p. 1185 - 1188]

65
[ 781-35-1 ]
N-(2,2-diphenyl-1-methylethenyl)acetamide [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1.1: t-BuONa / 1-methyl-pyrrolidin-2-one / 1.25 h / -5 - 20 °C 1.2: 73 percent / 1-methyl-pyrrolidin-2-one / 1 h / -15 - -5 °C 2.1: 96 percent / K₃PO₄; dipf / Pd₂dba3 / 2-methyl-butan-2-ol / 20 h / 100 °C
	Multi-step reaction with 2 steps 1.1: sodium hydride / tetrahydrofuran / 2 h / 0 °C 1.2: 75 percent / tetrahydrofuran / 0 - 20 °C 2.1: 76 percent / Cs₂CO₃; Xantphos / Pd₂(dba)3 / dioxane / 20 h / 80 °C

Reference： [1]Klapars, Artis; Campos, Kevin R.; Chen, Cheng-Yi; Volante, Ralph P. [Organic Letters, 2005, vol. 7, # 6, p. 1185 - 1188]
[2]Wallace, Debra J.; Klauber, David J.; Chen, Cheng-Yi; Volante, Ralph P. [Organic Letters, 2003, vol. 5, # 24, p. 4749 - 4752]

66
[ 781-35-1 ]
[ 412335-94-5 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1.1: LDA / tetrahydrofuran; hexane / 0.75 h / -78 °C 1.2: 81 percent / tetrahydrofuran / 20 °C 2.1: 86 percent / LiAlH₄ / tetrahydrofuran / 20 °C

Reference： [1]Qian, Hua; Han, Xiaoqing; Widenhoefer, Ross A. [Journal of the American Chemical Society, 2004, vol. 126, # 31, p. 9536 - 9537]

67
[ 781-35-1 ]
[ 167300-48-3 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1.1: LDA / tetrahydrofuran 1.2: 59 percent / tetrahydrofuran / 20 °C 2.1: 84 percent / LiAlH₄ / tetrahydrofuran / 20 °C

Reference： [1]Qian, Hua; Han, Xiaoqing; Widenhoefer, Ross A. [Journal of the American Chemical Society, 2004, vol. 126, # 31, p. 9536 - 9537]

68
[ 781-35-1 ]
2-methyl-5,5-diphenyltetrahydro-2H-pyran [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 3 steps 1.1: LDA / tetrahydrofuran 1.2: 59 percent / tetrahydrofuran / 20 °C 2.1: 84 percent / LiAlH₄ / tetrahydrofuran / 20 °C 3.1: 90 percent / P(4-C₆H₄CF₃)3 / [PtCl₂(CH₂=CH₂)]2 / 1,1,2,2-tetrachloro-ethane / 70 °C

Reference： [1]Qian, Hua; Han, Xiaoqing; Widenhoefer, Ross A. [Journal of the American Chemical Society, 2004, vol. 126, # 31, p. 9536 - 9537]

69
[ 781-35-1 ]
4,4-diphenyl-2-propyltetrahydrofuran [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 3 steps 1.1: LDA / tetrahydrofuran 1.2: 23 percent / tetrahydrofuran 2.1: 79 percent / LiAlH₄ / tetrahydrofuran / 20 °C 3.1: 47 percent / P(4-C₆H₄CF₃)3 / [PtCl₂(CH₂=CH₂)]2 / 1,1,2,2-tetrachloro-ethane / 64 h / 70 °C

Reference： [1]Qian, Hua; Han, Xiaoqing; Widenhoefer, Ross A. [Journal of the American Chemical Society, 2004, vol. 126, # 31, p. 9536 - 9537]

70
[ 781-35-1 ]
[ 752206-82-9 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1.1: LDA / tetrahydrofuran 1.2: 92 percent / tetrahydrofuran / 20 °C 2.1: 62 percent / LiAlH₄ / tetrahydrofuran / 20 °C

Reference： [1]Qian, Hua; Han, Xiaoqing; Widenhoefer, Ross A. [Journal of the American Chemical Society, 2004, vol. 126, # 31, p. 9536 - 9537]

71
[ 781-35-1 ]
2,2-dimethyl-5,5-diphenyltetrahydro-2H-pyran [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 3 steps 1.1: LDA / tetrahydrofuran 1.2: 17 percent / tetrahydrofuran / 20 °C 2.1: 87 percent / LiAlH₄ / tetrahydrofuran / 20 °C 3.1: 50 percent / P(4-C₆H₄CF₃)3 / [PtCl₂(CH₂=CH₂)]2 / 1,1,2,2-tetrachloro-ethane / 70 °C
	Multi-step reaction with 3 steps 1.1: LDA / tetrahydrofuran 1.2: 92 percent / tetrahydrofuran / 20 °C 2.1: 62 percent / LiAlH₄ / tetrahydrofuran / 20 °C 3.1: 98 percent / P(4-C₆H₄CF₃)3 / [PtCl₂(CH₂=CH₂)]2 / 1,1,2,2-tetrachloro-ethane / 80 °C

Reference： [1]Qian, Hua; Han, Xiaoqing; Widenhoefer, Ross A. [Journal of the American Chemical Society, 2004, vol. 126, # 31, p. 9536 - 9537]
[2]Qian, Hua; Han, Xiaoqing; Widenhoefer, Ross A. [Journal of the American Chemical Society, 2004, vol. 126, # 31, p. 9536 - 9537]

72
[ 781-35-1 ]
[ 752206-85-2 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1.1: LDA / tetrahydrofuran 1.2: 96 percent / tetrahydrofuran / 20 °C 2.1: 57 percent / LiAlH₄ / tetrahydrofuran / 20 °C

Reference： [1]Qian, Hua; Han, Xiaoqing; Widenhoefer, Ross A. [Journal of the American Chemical Society, 2004, vol. 126, # 31, p. 9536 - 9537]

73
[ 781-35-1 ]
(Z)-2,2-diphenyl-4-hepten-1-ol [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1.1: LDA / tetrahydrofuran 1.2: 23 percent / tetrahydrofuran 2.1: 79 percent / LiAlH₄ / tetrahydrofuran / 20 °C

Reference： [1]Qian, Hua; Han, Xiaoqing; Widenhoefer, Ross A. [Journal of the American Chemical Society, 2004, vol. 126, # 31, p. 9536 - 9537]

74
[ 781-35-1 ]
2,2-diphenyl-5-methyl-5-hexen-1-ol [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1.1: LDA / tetrahydrofuran 1.2: 17 percent / tetrahydrofuran / 20 °C 2.1: 87 percent / LiAlH₄ / tetrahydrofuran / 20 °C

Reference： [1]Qian, Hua; Han, Xiaoqing; Widenhoefer, Ross A. [Journal of the American Chemical Society, 2004, vol. 126, # 31, p. 9536 - 9537]

75
[ 781-35-1 ]
rac-(3aR,7aR)-3,3-Diphenyloctahydrobenzofuran [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 3 steps 1.1: LDA / tetrahydrofuran 1.2: 96 percent / tetrahydrofuran / 20 °C 2.1: 57 percent / LiAlH₄ / tetrahydrofuran / 20 °C 3.1: 87 percent / P(4-C₆H₄CF₃)3 / [PtCl₂(CH₂=CH₂)]2 / 1,1,2,2-tetrachloro-ethane / 70 °C

Reference： [1]Qian, Hua; Han, Xiaoqing; Widenhoefer, Ross A. [Journal of the American Chemical Society, 2004, vol. 126, # 31, p. 9536 - 9537]

76
[ 781-35-1 ]
3,3-diphenyl-1-oxa-spiro[4.5]decane [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 3 steps 1.1: LDA / tetrahydrofuran 1.2: 76 percent / tetrahydrofuran / 20 °C 2.1: 87 percent / LiAlH₄ / tetrahydrofuran / 20 °C 3.1: 98 percent / P(4-C₆H₄CF₃)3 / [PtCl₂(CH₂=CH₂)]2 / 1,1,2,2-tetrachloro-ethane / 70 °C

Reference： [1]Qian, Hua; Han, Xiaoqing; Widenhoefer, Ross A. [Journal of the American Chemical Society, 2004, vol. 126, # 31, p. 9536 - 9537]

77
[ 781-35-1 ]
[ 752206-86-3 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1.1: LDA / tetrahydrofuran 1.2: 76 percent / tetrahydrofuran / 20 °C 2.1: 87 percent / LiAlH₄ / tetrahydrofuran / 20 °C

Reference： [1]Qian, Hua; Han, Xiaoqing; Widenhoefer, Ross A. [Journal of the American Chemical Society, 2004, vol. 126, # 31, p. 9536 - 9537]

78
[ 781-35-1 ]
[ 4528-64-7 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 3 steps 1: 98 percent / t-BuOK / various solvent(s) / 20 °C 2: PTSA / toluene 3: Red-Al / toluene / 0 - 20 °C
	Multi-step reaction with 3 steps 1: 92 percent / potassium tert-butoxide / diethyl ether / 18 h / Ambient temperature 2: 32 percent / KOH-H₂O / tetrahydrofuran; diethyl ether; various solvent(s) / 18 h / Ambient temperature 3: 61 percent / LiAlH₄ / tetrahydrofuran; diethyl ether / 0.5 h / Heating
	Multi-step reaction with 3 steps 1: 92 percent / potassium tert-butoxide / diethyl ether / 18 h / Ambient temperature 2: 80 percent / p-TsOH / benzene / 0.5 h / Heating 3: 61 percent / LiAlH₄ / tetrahydrofuran; diethyl ether / 0.5 h / Heating

Reference： [1]Daubie, Christophe; Mutti, Stephane [Tetrahedron Letters, 1996, vol. 37, # 43, p. 7743 - 7744]
[2]Zimmerman, Howard E.; Pasteris, Robert J. [Journal of Organic Chemistry, 1980, vol. 45, # 24, p. 4876 - 4891]
[3]Zimmerman, Howard E.; Pasteris, Robert J. [Journal of Organic Chemistry, 1980, vol. 45, # 24, p. 4876 - 4891]

79
[ 781-35-1 ]
2-methoxy-2,5-dimethyl-5-(1,1-diphenylmethyl)-Δ³-1,3,4-oxadiazoline [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1: 73 percent / acetic acid / ethanol / 24 h / Heating 2: 63 percent / lead tetraacetate

Reference： [1]Jefferson, Elizabeth A.; Warkentin, John [Journal of the American Chemical Society, 1992, vol. 114, # 16, p. 6318 - 6325]

80
[ 781-35-1 ]
[ 143300-70-3 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 3 steps 1: 73 percent / acetic acid / ethanol / 24 h / Heating 2: 63 percent / lead tetraacetate 3: 50 percent / CHCl₃ / 6 h / Ambient temperature; Irradiation

Reference： [1]Jefferson, Elizabeth A.; Warkentin, John [Journal of the American Chemical Society, 1992, vol. 114, # 16, p. 6318 - 6325]

81
[ 781-35-1 ]
[ 118318-10-8 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 3 steps 1: t-BuOK / 1.) tert-butyl alcohol, reflux, 30 min; 2.) 60 deg C, 1 h 2: 40 percent / diethyl ether; benzene / 1 h / Ambient temperature 3: 62.5 percent / POCl₃, pyridine / 3.5 h / 80 °C

Reference： [1]Zimmerman, Howard E.; Oaks, Frank L.; Campos, Pedro [Journal of the American Chemical Society, 1989, vol. 111, # 3, p. 1007 - 1018]

82
[ 781-35-1 ]
[ 118318-13-1 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 4 steps 1: t-BuOK / 1.) tert-butyl alcohol, reflux, 30 min; 2.) 60 deg C, 1 h 2: 40 percent / diethyl ether; benzene / 1 h / Ambient temperature 3: 62.5 percent / POCl₃, pyridine / 3.5 h / 80 °C 4: 84.4 percent / Li, NH₃(liquid) / tetrahydrofuran / 0.08 h / -78 °C

Reference： [1]Zimmerman, Howard E.; Oaks, Frank L.; Campos, Pedro [Journal of the American Chemical Society, 1989, vol. 111, # 3, p. 1007 - 1018]

83
[ 781-35-1 ]
[ 118318-19-7 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1: t-BuOK / 1.) tert-butyl alcohol, reflux, 30 min; 2.) 60 deg C, 1 h 2: 40 percent / diethyl ether; benzene / 1 h / Ambient temperature

Reference： [1]Zimmerman, Howard E.; Oaks, Frank L.; Campos, Pedro [Journal of the American Chemical Society, 1989, vol. 111, # 3, p. 1007 - 1018]

84
2,2-diphenyl-1,1a,2,2a-tetrahydro-7H-cyclobut<a>inden-1-one [ No CAS ]
[ 781-35-1 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1: 92 percent / diethyl ether / 3 h 2: DCNB / Irradiation

Reference： [1]Majima, Tetsuro; Pac, Chyongjin; Sakurai, Hiroshi [Journal of the American Chemical Society, 1980, vol. 102, # 16, p. 5265 - 5273]

85
[ 781-35-1 ]
[ 4571-02-2 ]

Yield	Reaction Conditions	Operation in experiment
98.54%	With oxygen; sodium hydroxide; sodium sulfite In ethanol at 15℃; for 6h;	18 Example 18 Synthesis of 1-hydroxy-1,1-diphenylacetone To a 250 ml three-necked flask was added sodium hydroxide (8 g, 0.2 mol) and ethanol (150 ml) at 15 ° C,0.5h. Followed by the addition of sodium sulfite (25.21 g, 0.2 mol), 1,1-diphenylacetone (42.05 g, 0.2 mol)1000ml size of the oxygen balloon, stirring reaction 6h.After completion of the reaction, the pH of the reaction solution was adjusted to 7 with 2M hydrochloric acid, and ethanol was distilled off under reduced pressure. Add 50 ml of water to(30 ml x 3), the combined organic phase was dried over anhydrous Na2SO4, and the mixture was partitioned with toluene. The solvent was evaporated to dryness to give 45.50 g of a pale yellow solid, 98% purity and 98.54% yield.
82%	Stage #1: 1,1-diphenylacetone With sulfuric acid; sodium dodecyl-sulfate In water at 60℃; Stage #2: With iodine In water at 60℃; Stage #3: With sodium nitrite In water at 60℃; regioselective reaction;
53%	With oxygen; caesium carbonate; triethyl phosphite In dimethyl sulfoxide at 25℃; for 24h; Schlenk technique; regioselective reaction;

53%	With 1,3,4,6,7,8-hexahydro-2H-pyrimido[1,2-a]pyrimidine; oxygen; dimethyl sulfoxide at 25℃; for 24h; Schlenk technique;
	Multi-step reaction with 2 steps 1: acetic acid; bromine 2: aqueous dioxane
	Multi-step reaction with 2 steps 1: tetrachloromethane; carbon dioxide; bromine 2: BaCO₃; water

Reference： [1]Current Patent Assignee: ZHEJIANG UNIVERSITY; ZHEJIANG NHU CO., LTD. - CN106748693, 2017, A Location in patent: Paragraph 0049; 0050; 0051; 0052; 0053
[2]Location in patent: experimental part Stavber, Gaj; Iskra, Jernej; Zupan, Marko; Stavber, Stojan [Green Chemistry, 2009, vol. 11, # 8, p. 1262 - 1267]
[3]Liang, Yu-Feng; Jiao, Ning [Angewandte Chemie - International Edition, 2014, vol. 53, # 2, p. 548 - 552][Angew. Chem., 2014, vol. 53, # 2, p. 558 - 562,5]
[4]Wang, Yongtao; Lu, Rui; Yao, Jia; Li, Haoran [Angewandte Chemie - International Edition, 2021, vol. 60, # 12, p. 6631 - 6638][Angew. Chem., 2021, vol. 133, # 12, p. 6705 - 6712,8]
[5]Stevens; Lenk [Journal of Organic Chemistry, 1954, vol. 19, p. 538,541]
[6]Temnikowa [Zhurnal Obshchei Khimii, 1945, vol. 15, p. 514,521][Chem.Abstr., 1946, p. 4695]

86
[ 781-35-1 ]
[ 6000-59-5 ]
C₁₇ H₁₄ N₂ O C [ No CAS ]
[ 172937-96-1 ]

Yield	Reaction Conditions	Operation in experiment
	With hydrazine hydrate In 1,2-dimethoxyethane	7 Preparation 7 Preparation 7 A solution of 1,1-diphenylacetone (25 g) and glyoxylic acid monohydrate (41.6 g) in 1,2-dimethoxyethane (75 ml) was refluxed for 3 days. The solution was partitioned between ethyl acetate and water. The organic layer was washed with water (twice) and evaporated in vacuo. The residue was partitioned between ethyl acetate and ammonia solution (200 ml) and the aqueous layer was separated. To the aqueous layer was added hydrazine hydrate (22.6 g) and the mixture was stirred for 2 hours at 100° C. After being cooled, the reaction mixture was extracted with ethyl acetate. The extract was dried over magnesium sulfate and evaporated in vacuo. The residue was recrystallized from ethyl acetate to give 6-diphenylmethyl-3(2H)-pyridazinone (6.26 g) as a white powder. mp: 161°-162° C. IR (Nujol) 3300-2800, 1660, 1600, 760, 740, 700 cm-1 NMR (CDCl3, δ): 5.44 (1H, s), 6.88 (1H, d, J=9.8 Hz), 7.10-7.40 (11H, m), 11.29 (1H, br s) MASS (+APCI): 263 (M+ +1) Elemental Analysis Calcd. for C17 H14 N2 O C 77.84, H 5.38, N 10.68 Found C 77.76, H 5.39, N 10.66

Reference： [1]Current Patent Assignee: ASTELLAS PHARMA INC. - US5763489, 1998, A

87
[ 505-18-0 ]
[ 781-35-1 ]
[ 14171-36-9 ]
1,1-diphenyl-3-piperidin-2-yl-propan-2-one [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
37%	With hydrogenchloride In <i>N</i>-methyl-acetamide	IX 1,1-Diphenyl-3-(2-piperidyl)propan-2-one EXAMPLE IX 1,1-Diphenyl-3-(2-piperidyl)propan-2-one Magnesium methyl carbonate (1.2 moles, 2 N in dimethylformamide) is heated to 120°C. under an atmosphere of carbon dioxide. The compound 1,1-diphenylacetone, 63.0 g (0.3 moles), is added and the mixture is stirred at 120°C. for a period of 4 hours under a stream of nitrogen to form the chelate, allowing the methyl alcohol that forms to escape. The mixture is cooled to room temperature under an atmosphere of carbon dioxide and 30.0 g (0.36 moles) of 2,3,4,5-tetrahydropyridine (as α-tripiperidein) is added and stirring continued at room temperature for a period of 6 days under an atmosphere of carbon dioxide. The reaction mixture is poured into 375 ml of concentrated HCl on 400 g of ice and the resulting mixture is extracted with methylene dichloride. The extracts are combined, dried over anhydrous sodium sulfate and the solvent is removed. The crude oil is recrystallized twice from an aqueous isopropyl alcohol solution to yield 37.9 g (37% yield) of 1,1-diphenyl-3-(2-piperidyl)propan- 2-one as the hydrochloride salt having a M.P. of 197-9°C. (dec.)

Reference： [1]Current Patent Assignee: SANOFI - US3931155, 1976, A

Purity	Size	Price	VIP Price	USA Stock *0-1 Day	Global Stock *5-7 Days	Quantity
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CAS No. :	781-35-1	MDL No. :	MFCD00008759
Formula :	C₁₅H₁₄O	Boiling Point :	-
Linear Structure Formula :	-	InChI Key :	DBNWBEGCONIRGQ-UHFFFAOYSA-N
M.W :	210.27	Pubchem ID :	69907
Synonyms :

Signal Word:	Warning	Class:	N/A
Precautionary Statements:	P261-P305+P351+P338	UN#:	N/A
Hazard Statements:	H302-H315-H319-H335	Packing Group:	N/A
GHS Pictogram:

Precautionary Statements-General
Code	Phrase
P101	If medical advice is needed,have product container or label at hand.
P102	Keep out of reach of children.
P103	Read label before use
Prevention
Code	Phrase
P201	Obtain special instructions before use.
P202	Do not handle until all safety precautions have been read and understood.
P210	Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P211	Do not spray on an open flame or other ignition source.
P220	Keep/Store away from clothing/combustible materials.
P221	Take any precaution to avoid mixing with combustibles
P222	Do not allow contact with air.
P223	Keep away from any possible contact with water, because of violent reaction and possible flash fire.
P230	Keep wetted
P231	Handle under inert gas.
P232	Protect from moisture.
P233	Keep container tightly closed.
P234	Keep only in original container.
P235	Keep cool
P240	Ground/bond container and receiving equipment.
P241	Use explosion-proof electrical/ventilating/lighting/equipment.
P242	Use only non-sparking tools.
P243	Take precautionary measures against static discharge.
P244	Keep reduction valves free from grease and oil.
P250	Do not subject to grinding/shock/friction.
P251	Pressurized container: Do not pierce or burn, even after use.
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P261	Avoid breathing dust/fume/gas/mist/vapours/spray.
P262	Do not get in eyes, on skin, or on clothing.
P263	Avoid contact during pregnancy/while nursing.
P264	Wash hands thoroughly after handling.
P265	Wash skin thouroughly after handling.
P270	Do not eat, drink or smoke when using this product.
P271	Use only outdoors or in a well-ventilated area.
P272	Contaminated work clothing should not be allowed out of the workplace.
P273	Avoid release to the environment.
P280	Wear protective gloves/protective clothing/eye protection/face protection.
P281	Use personal protective equipment as required.
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P285	In case of inadequate ventilation wear respiratory protection.
P231 + P232	Handle under inert gas. Protect from moisture.
P235 + P410	Keep cool. Protect from sunlight.
Response
Code	Phrase
P301	IF SWALLOWED:
P304	IF INHALED:
P305	IF IN EYES:
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P311	Call a POISON CENTER or doctor/physician.
P312	Call a POISON CENTER or doctor/physician if you feel unwell.
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P320
P302 + P352	IF ON SKIN: wash with plenty of soap and water.
P321
P322
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P378
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P390	Absorb spillage to prevent material damage.
P391	Collect spillage. Hazardous to the aquatic environment
P301 + P310	IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P301 + P312	IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P301 + P330 + P331	IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P302 + P334	IF ON SKIN: Immerse in cool water/wrap in wet bandages.
P302 + P350	IF ON SKIN: Gently wash with plenty of soap and water.
P303 + P361 + P353	IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304 + P312	IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell.
P304 + P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P304 + P341	IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P306 + P360	IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes.
P307 + P311	IF exposed: call a POISON CENTER or doctor/physician.
P308 + P313	IF exposed or concerned: Get medical advice/attention.
P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P370 + P376	In case of fire: Stop leak if safe to Do so.
P370 + P378	In case of fire:
P370 + P380	In case of fire: Evacuate area.
P370 + P380 + P375	In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion.
P371 + P380 + P375	In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
Storage
Code	Phrase
P401
P402	Store in a dry place.
P403	Store in a well-ventilated place.
P404	Store in a closed container.
P405	Store locked up.
P406	Store in corrosive resistant/ container with a resistant inner liner.
P407	Maintain air gap between stacks/pallets.
P410	Protect from sunlight.
P411
P412	Do not expose to temperatures exceeding 50 oC/ 122 oF.
P413
P420	Store away from other materials.
P422
P402 + P404	Store in a dry place. Store in a closed container.
P403 + P233	Store in a well-ventilated place. Keep container tightly closed.
P403 + P235	Store in a well-ventilated place. Keep cool.
P410 + P403	Protect from sunlight. Store in a well-ventilated place.
P410 + P412	Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
P411 + P235	Keep cool.
Disposal
Code	Phrase
P501	Dispose of contents/container to ...
P502	Refer to manufacturer/supplier for information on recovery/recycling

Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed
H304	May be fatal if swallowed and enters airways
H305	May be harmful if swallowed and enters airways
H310	Fatal in contact with skin
H311	Toxic in contact with skin
H312	Harmful in contact with skin
H313	May be harmful in contact with skin
H314	Causes severe skin burns and eye damage
H315	Causes skin irritation
H316	Causes mild skin irritation
H317	May cause an allergic skin reaction
H318	Causes serious eye damage
H319	Causes serious eye irritation
H320	Causes eye irritation
H330	Fatal if inhaled
H331	Toxic if inhaled
H332	Harmful if inhaled
H333	May be harmful if inhaled
H334	May cause allergy or asthma symptoms or breathing difficulties if inhaled
H335	May cause respiratory irritation
H336	May cause drowsiness or dizziness
H340	May cause genetic defects
H341	Suspected of causing genetic defects
H350	May cause cancer
H351	Suspected of causing cancer
H360	May damage fertility or the unborn child
H361	Suspected of damaging fertility or the unborn child
H361d	Suspected of damaging the unborn child
H362	May cause harm to breast-fed children
H370	Causes damage to organs
H371	May cause damage to organs
H372	Causes damage to organs through prolonged or repeated exposure
H373	May cause damage to organs through prolonged or repeated exposure
Environmental hazards
Code	Phrase
H400	Very toxic to aquatic life
H401	Toxic to aquatic life
H402	Harmful to aquatic life
H410	Very toxic to aquatic life with long-lasting effects
H411	Toxic to aquatic life with long-lasting effects
H412	Harmful to aquatic life with long-lasting effects
H413	May cause long-lasting harmful effects to aquatic life
H420	Harms public health and the environment by destroying ozone in the upper atmosphere

[ CAS No. 781-35-1 ] {[proInfo.proName]}

Quality Control of [ 781-35-1 ]

Related Doc. of [ 781-35-1 ]

Product Details of [ 781-35-1 ]

Safety of [ 781-35-1 ]

Application In Synthesis of [ 781-35-1 ]

[ 781-35-1 ] Synthesis Path-Downstream 1~87

Related Functional Groups of
[ 781-35-1 ]

Aryls

Ketones

Precautionary Statements-General

Prevention

Response

Storage

Disposal

Physical hazards

Health hazards

Environmental hazards

Inquiry

[ CAS No. 781-35-1 ] {[proInfo.proName]}

Quality Control of [ 781-35-1 ]

Related Doc. of [ 781-35-1 ]

Product Details of [ 781-35-1 ]

Safety of [ 781-35-1 ]

Application In Synthesis of [ 781-35-1 ]

[ 781-35-1 ] Synthesis Path-Downstream 1~87

Related Functional Groups of [ 781-35-1 ]

Aryls

Ketones

Precautionary Statements-General

Prevention

Response

Storage

Disposal

Physical hazards

Health hazards

Environmental hazards

Inquiry

Related Functional Groups of
[ 781-35-1 ]