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[ CAS No. 78364-55-3 ]

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2D
Chemical Structure| 78364-55-3
Chemical Structure| 78364-55-3
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Product Details of [ 78364-55-3 ]

CAS No. :78364-55-3MDL No. :MFCD04448803
Formula : C7H6FN3S Boiling Point : 351.1±44.0°C at 760 mmHg
Linear Structure Formula :-InChI Key :-
M.W :183.21Pubchem ID :2049844
Synonyms :

Computed Properties of [ 78364-55-3 ]

TPSA : 79.2 H-Bond Acceptor Count : 5
XLogP3 : 2.1 H-Bond Donor Count : 2
SP3 : 0.00 Rotatable Bond Count : 1

Safety of [ 78364-55-3 ]

Signal Word:WarningClass:N/A
Precautionary Statements:P280-P305+P351+P338-P310UN#:N/A
Hazard Statements:H302-H315-H319-H332-H335Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 78364-55-3 ]

  • Upstream synthesis route of [ 78364-55-3 ]
  • Downstream synthetic route of [ 78364-55-3 ]

[ 78364-55-3 ] Synthesis Path-Upstream   1~5

  • 1
  • [ 78364-55-3 ]
  • [ 399-74-6 ]
Reference: [1] Bioorganic and Medicinal Chemistry Letters, 2007, vol. 17, # 14, p. 4022 - 4025
[2] Bioorganic and Medicinal Chemistry Letters, 2012, vol. 22, # 9, p. 3044 - 3049
  • 2
  • [ 348-40-3 ]
  • [ 78364-55-3 ]
YieldReaction ConditionsOperation in experiment
89% With hydrogenchloride; hydrazine hydrate In water at 5℃; for 5 h; Reflux 6-Fluoro-2-hydrazinobenzothiazole (2). Hydrochloric acid (10 mL) was added dropwise to hydrazine hydrate 99percent (10 g, 0.2 mol) at 5-10 °C, followed by addition of a solution of 2-amino-6-fluorobenzothiazole (1) (3.364 g, 0.02 mol) in ethylene glycol (40 mL). The mixture was heated at reflux temperature for 5 h. On cooling, the precipitated solid was collected by filtration, washed with water, dried and crystallized from ethanol. Yield 89percent, m.p. 194-196 °C [1].
Reference: [1] Journal of Heterocyclic Chemistry, 2014, vol. 51, # 2, p. 459 - 465
[2] Chinese Chemical Letters, 2015, vol. 26, # 12, p. 1522 - 1528
[3] Bioorganic and Medicinal Chemistry Letters, 2007, vol. 17, # 14, p. 4022 - 4025
[4] Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1981, vol. <B> 20, # 4, p. 314 - 316
[5] European Journal of Medicinal Chemistry, 2010, vol. 45, # 9, p. 4293 - 4299
[6] Archiv der Pharmazie, 2010, vol. 343, # 11-12, p. 692 - 699
[7] Journal of Enzyme Inhibition and Medicinal Chemistry, 2011, vol. 26, # 4, p. 527 - 534
[8] Journal of the Indian Chemical Society, 2008, vol. 85, # 3, p. 333 - 335
[9] Chemistry and Biodiversity, 2011, vol. 8, # 2, p. 253 - 265
[10] Bioorganic and Medicinal Chemistry Letters, 2012, vol. 22, # 9, p. 3044 - 3049
[11] Journal of Medicinal Chemistry, 2013, vol. 56, # 13, p. 5514 - 5540
[12] Chinese Chemical Letters, 2016, vol. 27, # 3, p. 380 - 386
[13] Chemical Biology and Drug Design, 2016, p. 354 - 362
[14] Research on Chemical Intermediates, 2016, vol. 42, # 12, p. 8329 - 8344
  • 3
  • [ 371-40-4 ]
  • [ 78364-55-3 ]
Reference: [1] Bioorganic and Medicinal Chemistry Letters, 2007, vol. 17, # 14, p. 4022 - 4025
[2] Archiv der Pharmazie, 2010, vol. 343, # 11-12, p. 692 - 699
[3] Journal of Enzyme Inhibition and Medicinal Chemistry, 2011, vol. 26, # 4, p. 527 - 534
[4] Bioorganic and Medicinal Chemistry Letters, 2012, vol. 22, # 9, p. 3044 - 3049
[5] Journal of Heterocyclic Chemistry, 2014, vol. 51, # 2, p. 459 - 465
[6] Chemical Biology and Drug Design, 2016, p. 354 - 362
[7] Research on Chemical Intermediates, 2016, vol. 42, # 12, p. 8329 - 8344
  • 4
  • [ 399-74-6 ]
  • [ 78364-55-3 ]
Reference: [1] Chemistry and Biodiversity, 2011, vol. 8, # 2, p. 253 - 265
  • 5
  • [ 459-05-2 ]
  • [ 78364-55-3 ]
Reference: [1] Chemical Biology and Drug Design, 2016, p. 354 - 362
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