[ CAS No. 78364-55-3 ] {[proInfo.proName]}

Name: 78364-55-3|6-Fluoro-2-hydrazinylbenzo[d]thiazole|97%
Brand: Ambeed
SKU: A196956
Price: 55.0 USD
Availability: InStock
Rating: 95 (32 reviews)

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Quality Control of [ 78364-55-3 ]

COA NMR CNMR HPLC LC-MS

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SDS Specification

Alternatived Products of [ 78364-55-3 ]

Product Details of [ 78364-55-3 ]

CAS No. :	78364-55-3	MDL No. :	MFCD04448803
Formula :	C₇H₆FN₃S	Boiling Point :	-
Linear Structure Formula :	-	InChI Key :	QODXZESJVXQCSC-UHFFFAOYSA-N
M.W :	183.21	Pubchem ID :	2049844
Synonyms :

Calculated chemistry of [ 78364-55-3 ]

Physicochemical Properties

Num. heavy atoms :	12
Num. arom. heavy atoms :	9
Fraction Csp3 :	0.0
Num. rotatable bonds :	1
Num. H-bond acceptors :	3.0
Num. H-bond donors :	2.0
Molar Refractivity :	46.78
TPSA :	79.18 Å²

Pharmacokinetics

GI absorption :	High
BBB permeant :	No
P-gp substrate :	No
CYP1A2 inhibitor :	Yes
CYP2C19 inhibitor :	No
CYP2C9 inhibitor :	No
CYP2D6 inhibitor :	No
CYP3A4 inhibitor :	No
Log Kp (skin permeation) :	-5.96 cm/s

Lipophilicity

Log Po/w (iLOGP) :	1.21
Log Po/w (XLOGP3) :	2.05
Log Po/w (WLOGP) :	1.95
Log Po/w (MLOGP) :	1.62
Log Po/w (SILICOS-IT) :	2.04
Consensus Log Po/w :	1.77

Druglikeness

Lipinski :	0.0
Ghose :	None
Veber :	0.0
Egan :	0.0
Muegge :	1.0
Bioavailability Score :	0.55

Water Solubility

Log S (ESOL) :	-2.76
Solubility :	0.321 mg/ml ; 0.00175 mol/l
Class :	Soluble
Log S (Ali) :	-3.34
Solubility :	0.0835 mg/ml ; 0.000456 mol/l
Class :	Soluble
Log S (SILICOS-IT) :	-2.94
Solubility :	0.209 mg/ml ; 0.00114 mol/l
Class :	Soluble

Medicinal Chemistry

PAINS :	0.0 alert
Brenk :	1.0 alert
Leadlikeness :	1.0
Synthetic accessibility :	2.43

Safety of [ 78364-55-3 ]

Signal Word:	Warning	Class:	N/A
Precautionary Statements:	P280-P305+P351+P338-P310	UN#:	N/A
Hazard Statements:	H302-H315-H319-H332-H335	Packing Group:	N/A
GHS Pictogram:

Application In Synthesis of [ 78364-55-3 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Upstream synthesis route of [ 78364-55-3 ]
Downstream synthetic route of [ 78364-55-3 ]

[ 78364-55-3 ] Synthesis Path-Upstream 1~5

1
[ 78364-55-3 ]
[ 399-74-6 ]

Reference： [1] Bioorganic and Medicinal Chemistry Letters, 2007, vol. 17, # 14, p. 4022 - 4025
[2] Bioorganic and Medicinal Chemistry Letters, 2012, vol. 22, # 9, p. 3044 - 3049

2
[ 348-40-3 ]
[ 78364-55-3 ]

Yield	Reaction Conditions	Operation in experiment
89%	With hydrogenchloride; hydrazine hydrate In water at 5℃; for 5 h; Reflux	6-Fluoro-2-hydrazinobenzothiazole (2). Hydrochloric acid (10 mL) was added dropwise to hydrazine hydrate 99percent (10 g, 0.2 mol) at 5-10 °C, followed by addition of a solution of 2-amino-6-fluorobenzothiazole (1) (3.364 g, 0.02 mol) in ethylene glycol (40 mL). The mixture was heated at reflux temperature for 5 h. On cooling, the precipitated solid was collected by filtration, washed with water, dried and crystallized from ethanol. Yield 89percent, m.p. 194-196 °C [1].

Reference： [1] Journal of Heterocyclic Chemistry, 2014, vol. 51, # 2, p. 459 - 465
[2] Chinese Chemical Letters, 2015, vol. 26, # 12, p. 1522 - 1528
[3] Bioorganic and Medicinal Chemistry Letters, 2007, vol. 17, # 14, p. 4022 - 4025
[4] Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1981, vol. 20, # 4, p. 314 - 316
[5] European Journal of Medicinal Chemistry, 2010, vol. 45, # 9, p. 4293 - 4299
[6] Archiv der Pharmazie, 2010, vol. 343, # 11-12, p. 692 - 699
[7] Journal of Enzyme Inhibition and Medicinal Chemistry, 2011, vol. 26, # 4, p. 527 - 534
[8] Journal of the Indian Chemical Society, 2008, vol. 85, # 3, p. 333 - 335
[9] Chemistry and Biodiversity, 2011, vol. 8, # 2, p. 253 - 265
[10] Bioorganic and Medicinal Chemistry Letters, 2012, vol. 22, # 9, p. 3044 - 3049
[11] Journal of Medicinal Chemistry, 2013, vol. 56, # 13, p. 5514 - 5540
[12] Chinese Chemical Letters, 2016, vol. 27, # 3, p. 380 - 386
[13] Chemical Biology and Drug Design, 2016, p. 354 - 362
[14] Research on Chemical Intermediates, 2016, vol. 42, # 12, p. 8329 - 8344

3
[ 371-40-4 ]
[ 78364-55-3 ]

Reference： [1] Bioorganic and Medicinal Chemistry Letters, 2007, vol. 17, # 14, p. 4022 - 4025
[2] Archiv der Pharmazie, 2010, vol. 343, # 11-12, p. 692 - 699
[3] Journal of Enzyme Inhibition and Medicinal Chemistry, 2011, vol. 26, # 4, p. 527 - 534
[4] Bioorganic and Medicinal Chemistry Letters, 2012, vol. 22, # 9, p. 3044 - 3049
[5] Journal of Heterocyclic Chemistry, 2014, vol. 51, # 2, p. 459 - 465
[6] Chemical Biology and Drug Design, 2016, p. 354 - 362
[7] Research on Chemical Intermediates, 2016, vol. 42, # 12, p. 8329 - 8344

4
[ 399-74-6 ]
[ 78364-55-3 ]

Reference： [1] Chemistry and Biodiversity, 2011, vol. 8, # 2, p. 253 - 265

5
[ 459-05-2 ]
[ 78364-55-3 ]

Reference： [1] Chemical Biology and Drug Design, 2016, p. 354 - 362

[ 78364-55-3 ] Synthesis Path-Downstream 1~88

1
[ 609-14-3 ]
[ 78364-55-3 ]
[ 92537-78-5 ]

Reference： [1]Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry,1984,vol. 23,p. 125 - 128

2
[ 348-40-3 ]
[ 78364-55-3 ]

Yield	Reaction Conditions	Operation in experiment
89%	With hydrogenchloride; hydrazine hydrate; In water; at 5℃; for 5h;Reflux;	6-Fluoro-2-hydrazinobenzothiazole (2). Hydrochloric acid (10 mL) was added dropwise to hydrazine hydrate 99% (10 g, 0.2 mol) at 5-10 C, followed by addition of a solution of 2-amino-6-fluorobenzothiazole (1) (3.364 g, 0.02 mol) in ethylene glycol (40 mL). The mixture was heated at reflux temperature for 5 h. On cooling, the precipitated solid was collected by filtration, washed with water, dried and crystallized from ethanol. Yield 89%, m.p. 194-196 C [1].
	With hydrazine hydrochloride; hydrazine hydrate; In ethylene glycol; at 140℃; for 2h;	General procedure: The substituted aniline (1eq.) and ammonium thiocyanate (2eq.) in 150mL glacial acetic acid were cooled in an ice bath and stirred mechanically. To the sulution, bromine (2eq.) in 25ml glacial acetic acid was added dropwise at such arate to keep the temperature below 10oC throughout the addition. Stirring was continued for additional 30 min after the bromine addition. The precipitate was collected and recrystallization from ethanol to give 2-aminobenzthiazoles. Then, the substituted 2-aminobenzthiazoles (1eq) in ethylene glycol were added hydrazine hydrate (2eq.) and hydrazine dihydrochloride (2eq). The mixture was heated at 140 oC for 2h. After cooling, the precipitate was filtered to give used directly for next step without further purification. Then, the hydrazino compound was added to thionyl chloride (1eq.) for 2h at 50 oC. After evaporated under reduced pressure, the residue was taken up in ethyl acetate and washed with 1 M NaHCO3 and brine each for twice. The organic layer was dried and evaporated to give the crude final product. The crude product was purified by silica gel column chromatography using PE-EA as an eluent.
	With hydrogenchloride; hydrazine hydrate; In water; ethylene glycol; at 5℃; for 5h;Reflux;	Hydrochloric acid (10 mL) was added dropwise to hydrazine hydrate 99% (10 g, 0.2 mol) at 5-10 C, followed by addition of a solution of 2-amino-6-fluorobenzothiazole (1) (3.364 g, 0.02 mol) in ethylene glycol (40 mL). The mixture was heated at reflux temperature for 5 h. On cooling, the precipitated solid was collected by filtration, washed with water, dried and crystallized from ethanol. Yield 89%, m.p. 194-196 C [1].

With hydrogenchloride; hydrazine hydrate; In water; ethylene glycol; at 5℃;Reflux;

Concentrated hydrochloric acid (0.067 mol) was added dropwise with stirring tohydrazine hydrate (0.12 mol) at 5-6 C followed by ethylene glycol (30 mL);thereafter, 6-uorobenzo[d]thiazol-2-amine (1) (20 mmol) was added in portionsand the resultant mixture was reuxed for 2-3 h and cooled at room temperature.The reaction progress was monitored by TLC using toluene:ethylacetate (75:25) asmobile phase. The reaction mixture was ltered and the resulting precipitates werewashed with distilled water. The resulting crude was recrystallized from ethanol. IR(KBr) mmax: 3010 (=C-H str), 1645 (C=C str), 1398 (C=N str). The 1HNMR(DMSO-d6) spectrum of this product showed signals: d 7.2-7.4 (3H, m, Ar C-H), at4.0 (1H, br, NH) and 4.75 (2H, br, NH2) ppm. The peaks in its 13CNMR (DMSO-d6)d: 106.1, 112.4, 115.5, 129.7, 145.5, 157.5, 171.2 ppm.

Reference： [1]Journal of Heterocyclic Chemistry,2014,vol. 51,p. 459 - 465
[2]Chinese Chemical Letters,2015,vol. 26,p. 1522 - 1528
[3]Bioorganic and Medicinal Chemistry Letters,2007,vol. 17,p. 4022 - 4025
[4]Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry,1981,vol. 20,p. 314 - 316
[5]European Journal of Medicinal Chemistry,2010,vol. 45,p. 4293 - 4299
[6]Archiv der Pharmazie,2010,vol. 343,p. 692 - 699
[7]Journal of Enzyme Inhibition and Medicinal Chemistry,2011,vol. 26,p. 527 - 534
[8]Journal of the Indian Chemical Society,2008,vol. 85,p. 333 - 335
[9]Chemistry and biodiversity,2011,vol. 8,p. 253 - 265
[10]Bioorganic and Medicinal Chemistry Letters,2012,vol. 22,p. 3044 - 3049
[11]Journal of Medicinal Chemistry,2013,vol. 56,p. 5514 - 5540
[12]Chinese Chemical Letters,2016,vol. 27,p. 380 - 386
[13]Chemical Biology and Drug Design,2016,p. 354 - 362
[14]Research on Chemical Intermediates,2016,vol. 42,p. 8329 - 8344
[15]Journal of Medicinal Chemistry,2019
[16]New Journal of Chemistry,2019,vol. 43,p. 7150 - 7161

3
[ 18835-02-4 ]
[ 78364-55-3 ]
[ 78364-46-2 ]

Reference： [1]Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry,1981,vol. 20,p. 314 - 316

4
[ 1115-30-6 ]
[ 78364-55-3 ]
[ 92537-76-3 ]

Reference： [1]Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry,1984,vol. 23,p. 125 - 128

5
[ 141-97-9 ]
[ 78364-55-3 ]
[ 92537-77-4 ]

Reference： [1]Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry,1984,vol. 23,p. 125 - 128

6
[ 141-97-9 ]
[ 78364-55-3 ]
[ 106515-45-1 ]

Reference： [1]Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry,1986,vol. 25,p. 569 - 570

7
[ 78364-55-3 ]
[ 1540-34-7 ]
[ 78364-36-0 ]

Reference： [1]Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry,1981,vol. 20,p. 314 - 316

8
[ 78364-55-3 ]
[ 1540-36-9 ]
[ 106690-12-4 ]

Reference： [1]Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry,1986,vol. 25,p. 288 - 291

9
[ 78364-55-3 ]
[ 815-57-6 ]
[ 78364-35-9 ]

Reference： [1]Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry,1981,vol. 20,p. 314 - 316

10
[ 78364-55-3 ]
[ 607-97-6 ]
[ 92537-79-6 ]

Reference： [1]Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry,1984,vol. 23,p. 125 - 128

11
[ 78364-55-3 ]
[ 607-97-6 ]
[ 106515-45-1 ]

Reference： [1]Organic Mass Spectrometry,1987,vol. 22,p. 36 - 38

12
[ 78364-55-3 ]
[ 1540-29-0 ]
[ 106690-17-9 ]

Reference： [1]Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry,1986,vol. 25,p. 288 - 291

13
[ 78364-55-3 ]
[ 123-54-6 ]
[ 75307-14-1 ]

Reference： [1]Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry,1981,vol. 20,p. 314 - 316
[2]Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry,1980,vol. 19,p. 395 - 396

14
[ 78364-55-3 ]
[ 609-15-4 ]
[ 92537-80-9 ]

Reference： [1]Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry,1984,vol. 23,p. 125 - 128

15
[ 78364-55-3 ]
[ 492-16-0 ]
2-(6-fluoro-benzothiazol-2-yl)-4-phenyl-5-trifluoromethyl-2H-pyrazol-3-ylamine [ No CAS ]

Reference： [1]European Journal of Medicinal Chemistry,2005,vol. 40,p. 922 - 927

16
[ 18931-61-8 ]
[ 78364-55-3 ]
1-(6'-fluorobenzothiazol-2'-yl)-5-(p-bromophenyl)-3-trifluoromethylpyrazole [ No CAS ]

Reference： [1]Journal of Heterocyclic Chemistry,2006,vol. 43,p. 1003 - 1014

17
[ 18931-61-8 ]
[ 78364-55-3 ]
1-(6'-fluorobenzothiazol-2'-yl)-3-(p-bromophenyl)-5-hydroxy-5-trifluoromethyl-Δ²-pyrazoline [ No CAS ]

Reference： [1]Journal of Heterocyclic Chemistry,2006,vol. 43,p. 1003 - 1014

18
[ 78364-55-3 ]
[ 18931-60-7 ]
1-(6'-fluorobenzothiazol-2'-yl)-5-(p-chlorophenyl)-3-trifluoromethylpyrazole [ No CAS ]

Reference： [1]Journal of Heterocyclic Chemistry,2006,vol. 43,p. 1003 - 1014

19
[ 78364-55-3 ]
[ 18931-60-7 ]
1-(6'-fluorobenzothiazol-2'-yl)-3-(p-chlorophenyl)-5-hydroxy-5-trifluoromethyl-Δ²-pyrazoline [ No CAS ]

Reference： [1]Journal of Heterocyclic Chemistry,2006,vol. 43,p. 1003 - 1014

20
[ 5841-70-3 ]
[ 78364-55-3 ]
2-(6-fluoro-benzothiazol-2-yl)-4-phenyl-2H-pyrazol-3-ylamine [ No CAS ]

Reference： [1]Bioorganic and Medicinal Chemistry,2006,vol. 14,p. 1785 - 1791

21
[ 5515-14-0 ]
[ 78364-55-3 ]
5-amino-3-(4-chloro-phenyl)-1-(6-fluoro-benzothiazol-2-yl)-1H-pyrazole-4-carbonitrile [ No CAS ]

Reference： [1]Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry,2006,vol. 45,p. 1426 - 1430

22
[ 78364-55-3 ]
[ 4468-48-8 ]
2-(6-fluoro-benzothiazol-2-yl)-5-methyl-4-phenyl-2H-pyrazol-3-ylamine [ No CAS ]

Reference： [1]Bioorganic and Medicinal Chemistry,2006,vol. 14,p. 1785 - 1791

23
[ 78364-55-3 ]
[ 5417-82-3 ]
5-amino-1-(6-fluoro-benzothiazol-2-yl)-3-methyl-1H-pyrazole-4-carbonitrile [ No CAS ]

Reference： [1]Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry,2006,vol. 45,p. 1426 - 1430

24
[ 78364-55-3 ]
C₁₆H₁₂F₂N₄S₂ [ No CAS ]

Reference： [1]Bioorganic and Medicinal Chemistry Letters,2007,vol. 17,p. 4022 - 4025

25
[ 78364-55-3 ]
C₁₈H₁₆F₂N₄S₂ [ No CAS ]

Reference： [1]Bioorganic and Medicinal Chemistry Letters,2007,vol. 17,p. 4022 - 4025

26
[ 371-40-4 ]
[ 78364-55-3 ]

Reference： [1]Bioorganic and Medicinal Chemistry Letters,2007,vol. 17,p. 4022 - 4025
[2]Archiv der Pharmazie,2010,vol. 343,p. 692 - 699
[3]Journal of Enzyme Inhibition and Medicinal Chemistry,2011,vol. 26,p. 527 - 534
[4]Bioorganic and Medicinal Chemistry Letters,2012,vol. 22,p. 3044 - 3049
[5]Journal of Heterocyclic Chemistry,2014,vol. 51,p. 459 - 465
[6]Chemical Biology and Drug Design,2016,p. 354 - 362
[7]Research on Chemical Intermediates,2016,vol. 42,p. 8329 - 8344
[8]Journal of Medicinal Chemistry,2019

27
[ 78364-55-3 ]
1-(6'-fluorobenzothiazol-2'-yl)-3-(p-chlorophenyl)-5-trifluoromethylpyrazole [ No CAS ]

Reference： [1]Journal of Heterocyclic Chemistry,2006,vol. 43,p. 1003 - 1014

28
[ 78364-55-3 ]
1-(6'-fluorobenzothiazol-2'-yl)-3-(p-bromophenyl)-5-trifluoromethylpyrazole [ No CAS ]

Reference： [1]Journal of Heterocyclic Chemistry,2006,vol. 43,p. 1003 - 1014

29
[ 78364-55-3 ]
[ 78364-53-1 ]

Reference： [1]Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry,1981,vol. 20,p. 314 - 316

30
[ 78364-55-3 ]
[ 92537-81-0 ]

Reference： [1]Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry,1984,vol. 23,p. 125 - 128

31
[ 22966-25-2 ]
[ 78364-55-3 ]
[ 1033804-50-0 ]

Reference： [1]Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry,2007,vol. 46,p. 1332 - 1336

32
[ 22966-32-1 ]
[ 78364-55-3 ]
[ 1033804-52-2 ]

Reference： [1]Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry,2007,vol. 46,p. 1332 - 1336

33
[ 2805-56-3 ]
[ 78364-55-3 ]
[ 1033804-51-1 ]

Reference： [1]Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry,2007,vol. 46,p. 1332 - 1336

34
[ 126443-11-6 ]
[ 78364-55-3 ]
[ 1033804-54-4 ]

Reference： [1]Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry,2007,vol. 46,p. 1332 - 1336

35
[ 102692-41-1 ]
[ 78364-55-3 ]
[ 1033804-55-5 ]

Reference： [1]Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry,2007,vol. 46,p. 1332 - 1336

36
[ 78364-55-3 ]
[ 313236-80-5 ]
[ 1033804-53-3 ]

Reference： [1]Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry,2007,vol. 46,p. 1332 - 1336

38
[ 78364-55-3 ]
[ 2131-55-7 ]
[ 1111097-33-6 ]

Reference： [1]Journal of the Indian Chemical Society,2008,vol. 85,p. 333 - 335

39
[ 78364-55-3 ]
[ 1544-68-9 ]
[ 1111097-27-8 ]

Reference： [1]Journal of the Indian Chemical Society,2008,vol. 85,p. 333 - 335

40
[ 78364-55-3 ]
[ 1985-12-2 ]
[ 1111097-30-3 ]

Reference： [1]Journal of the Indian Chemical Society,2008,vol. 85,p. 333 - 335

41
[ 78364-55-3 ]
[ 56352-92-2 ]
[ 1246493-39-9 ]

Reference： [1]European Journal of Medicinal Chemistry,2010,vol. 45,p. 4293 - 4299

42
[ 78364-55-3 ]
[ 56352-93-3 ]
[ 1268376-06-2 ]

Reference： [1]Archiv der Pharmazie,2010,vol. 343,p. 692 - 699

43
[ 5413-05-8 ]
[ 78364-55-3 ]
[ 1068515-57-0 ]

Reference： [1]Bioorganic and Medicinal Chemistry Letters,2012,vol. 22,p. 90 - 95

44
[ 78364-55-3 ]
ethyl 3,4-dihydro-2-hydroxy-naphthalene-1-carboxylate [ No CAS ]
[ 1062648-94-5 ]

Reference： [1]Bioorganic and Medicinal Chemistry Letters,2012,vol. 22,p. 90 - 95

45
[ 78364-55-3 ]
[ 56352-95-5 ]
[ 1316270-34-4 ]

Reference： [1]Journal of Enzyme Inhibition and Medicinal Chemistry,2011,vol. 26,p. 527 - 534
[2]Medicinal Chemistry Research,2013,vol. 22,p. 1320 - 1329

46
[ 78364-55-3 ]
[ 1374820-47-9 ]

Reference： [1]Bioorganic and Medicinal Chemistry Letters,2012,vol. 22,p. 3044 - 3049

47
[ 78364-55-3 ]
[ 1329987-41-8 ]

Reference： [1]Bioorganic and Medicinal Chemistry Letters,2012,vol. 22,p. 3044 - 3049

48
[ 78364-55-3 ]
C₁₇H₁₄Cl₂FN₃S [ No CAS ]

Reference： [1]Bioorganic and Medicinal Chemistry Letters,2012,vol. 22,p. 3044 - 3049

49
[ 78364-55-3 ]
[ 1374820-29-7 ]

Reference： [1]Bioorganic and Medicinal Chemistry Letters,2012,vol. 22,p. 3044 - 3049

50
[ 367-57-7 ]
[ 78364-55-3 ]
[ 7391-28-8 ]
[ 1384952-46-8 ]

Yield	Reaction Conditions	Operation in experiment
88%		General procedure: Equimolar amounts of appropriate 2-hydrazinobenzothiazole1a-b, alpha-cyanoacetophenone 2a-c, and PTSA were mixed thoroughly in pestle mortar and heated on water bath for 4-5 min and then equimolar amount of appropriate trifluoromethyl beta-diketones 3a-d was added to it and mixed thoroughly. The reaction mixture was again heated 80-90 ° C for 15 min on water bath. The solid was obtained by addition of aq. ethanol, filtered and crystallized from the mixture of ethanol and chloroform to give pure 4.

Reference： [1]Journal of Fluorine Chemistry,2012,vol. 140,p. 31 - 37

51
[ 326-06-7 ]
[ 78364-55-3 ]
[ 7391-28-8 ]
[ 1384952-47-9 ]

Yield	Reaction Conditions	Operation in experiment
84%		General procedure: Equimolar amounts of appropriate 2-hydrazinobenzothiazole1a-b, alpha-cyanoacetophenone 2a-c, and PTSA were mixed thoroughly in pestle mortar and heated on water bath for 4-5 min and then equimolar amount of appropriate trifluoromethyl beta-diketones 3a-d was added to it and mixed thoroughly. The reaction mixture was again heated 80-90 ° C for 15 min on water bath. The solid was obtained by addition of aq. ethanol, filtered and crystallized from the mixture of ethanol and chloroform to give pure 4.

Reference： [1]Journal of Fluorine Chemistry,2012,vol. 140,p. 31 - 37

52
[ 78364-55-3 ]
[ 7391-28-8 ]
[ 1384952-55-9 ]

Yield	Reaction Conditions	Operation in experiment
	With acetic acid; In ethanol; for 5h;Reflux;	General procedure: A mixture of 2-hydrazinobenzothiazole 1a (0.825 g, 5 mmol)and alpha-cyanoacetophenone 2a (0.73 g, 5 mmol) was refluxed in ethanol containing acetic acid (3ml) for 5-6 h. Excess solvent was removed by distillation. The crude product so obtained was recrystallized from ethanol to give 5a (1.09 g, 75percent), Mp 201 ° C (lit.[20], 202 ° C). Other compounds (5b-d) of this type were prepared similarly.

Reference： [1]Journal of Fluorine Chemistry,2012,vol. 140,p. 31 - 37

53
[ 78364-55-3 ]
[ 1384952-53-7 ]

Reference： [1]Journal of Fluorine Chemistry,2012,vol. 140,p. 31 - 37

54
[ 78364-55-3 ]
[ 1384952-54-8 ]

Reference： [1]Journal of Fluorine Chemistry,2012,vol. 140,p. 31 - 37

55
[ 957511-10-3 ]
[ 78364-55-3 ]
[ 1389337-62-5 ]

Reference： [1]Asian Journal of Chemistry,2012,vol. 24,p. 2789 - 2792

56
[ 78364-55-3 ]
[ 56352-94-4 ]
[ 1384203-27-3 ]

Reference： [1]Medicinal Chemistry Research,2013,vol. 22,p. 1320 - 1329

57
[ 1135871-42-9 ]
[ 78364-55-3 ]
[ 1445800-03-2 ]

Reference： [1]Journal of Medicinal Chemistry,2013,vol. 56,p. 5514 - 5540

58
[ 94853-74-4 ]
[ 78364-55-3 ]
[ 1415668-21-1 ]

Reference： [1]Medicinal Chemistry Research,2013,vol. 22,p. 3566 - 3573

59
[ 78364-55-3 ]
[ 94-41-7 ]
6-fluoro-2-(4,5-dihydro-3,5-diphenylpyrazol-1-yl)benzo[d]thiazole [ No CAS ]

Reference： [1]Journal of Heterocyclic Chemistry,2014,vol. 51,p. 459 - 465

60
[ 4224-87-7 ]
[ 78364-55-3 ]
6-fluoro-2-(4,5-dihydro-3-phenyl-5-p-tolylpyrazol-1-yl)benzo[d]thiazole [ No CAS ]

Reference： [1]Journal of Heterocyclic Chemistry,2014,vol. 51,p. 459 - 465

61
[ 78364-55-3 ]
[ 959-33-1 ]
6-fluoro-2-(4,5-dihydro-5-(4-methoxyphenyl)-3-phenylpyrazol-1-yl)benzo[d]thiazole [ No CAS ]

Reference： [1]Journal of Heterocyclic Chemistry,2014,vol. 51,p. 459 - 465

62
[ 956-04-7 ]
[ 78364-55-3 ]
2-(5-(4-chlorophenyl)-4,5-dihydro-3-phenylpyrazol-1-yl)-6-fluorobenzo[d]thiazole [ No CAS ]

Reference： [1]Journal of Heterocyclic Chemistry,2014,vol. 51,p. 459 - 465

63
ethyl 2-(2-(2-methyl-5-nitrophenyl)hydrazono)-3-oxobutanoate [ No CAS ]
[ 78364-55-3 ]
1-(6-fluorobenzothiazol-2-yl)-3-methyl-4-(2-(2-methyl-5-nitrophenyl)hydrazono)pyrazol-5(4H)-one [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
82%	With acetic acid;Reflux;	General procedure: 1-(6-Fluorobenzothiazol-2-yl)-3-methyl-4-(2-(substituted phenyl)hydrazono)pyrazol-5(4H)-ones 4a-e. General Procedure B. A solution of 6-fluoro-2-hydrazinobenzothiazole (2) (0.549 g, 0.003 mol) in glacial acetic acid (10 mL) was added to a solution of the appropriate ethyl 3-oxo-2-(2-(substituted phenyl)hydrazono)butanoate 3a-e (0.003 mol) in glacial acetic acid (10 mL). The mixture was heated at reflux temperature for 10-16 h, then cooled and allowed to stand overnight. The precipitated solid was collected by filtration, washed with water, dried and crystallized from ethanol to give compounds 4a-e.

Reference： [1]Chinese Chemical Letters,2015,vol. 26,p. 1522 - 1528

64
[ 91-56-5 ]
[ 78364-55-3 ]
6-fluoro-2-(2-(2-oxoindolin-3-ylidene)hydrazino)benzothiazole [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
62%	With acetic acid; In ethanol;Reflux;	General procedure: 6-Fluoro-2-(2-(5-(un)substituted-2-oxoindolin-3-ylidene)hydrazino)benzothiazoles 5a-c. General Procedure C. A mixture of compound 2 (0.183 g, 0.001 mol), the appropriate isatin (0.001 mol) and glacial acetic acid (0.1 mL) in ethanol (20 mL) was heated at reflux temperature for 4-6 h. The precipitated yellow to orange solid was collected by filtration, washed with ethanol, dried and crystallized from methanol to yield compounds 5a-c.

Reference： [1]Chinese Chemical Letters,2015,vol. 26,p. 1522 - 1528

65
[ 87-48-9 ]
[ 78364-55-3 ]
2-(2-(5-bromo-2-oxoindolin-3-ylidene)hydrazino)-6-fluorobenzothiazole [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
66%	With acetic acid; In ethanol;Reflux;	General procedure: 6-Fluoro-2-(2-(5-(un)substituted-2-oxoindolin-3-ylidene)hydrazino)benzothiazoles 5a-c. General Procedure C. A mixture of compound 2 (0.183 g, 0.001 mol), the appropriate isatin (0.001 mol) and glacial acetic acid (0.1 mL) in ethanol (20 mL) was heated at reflux temperature for 4-6 h. The precipitated yellow to orange solid was collected by filtration, washed with ethanol, dried and crystallized from methanol to yield compounds 5a-c.

Reference： [1]Chinese Chemical Letters,2015,vol. 26,p. 1522 - 1528

66
[ 608-05-9 ]
[ 78364-55-3 ]
6-fluoro-2-(2-(5-methyl-2-oxoindolin-3-ylidene)hydrazino)benzothiazole [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
63%	With acetic acid; In ethanol;Reflux;	General procedure: 6-Fluoro-2-(2-(5-(un)substituted-2-oxoindolin-3-ylidene)hydrazino)benzothiazoles 5a-c. General Procedure C. A mixture of compound 2 (0.183 g, 0.001 mol), the appropriate isatin (0.001 mol) and glacial acetic acid (0.1 mL) in ethanol (20 mL) was heated at reflux temperature for 4-6 h. The precipitated yellow to orange solid was collected by filtration, washed with ethanol, dried and crystallized from methanol to yield compounds 5a-c.

Reference： [1]Chinese Chemical Letters,2015,vol. 26,p. 1522 - 1528

67
[ 98-01-1 ]
[ 78364-55-3 ]
6-fluoro-2-[2-((furan-2-yl)methylene)hydrazino]benzothiazole [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
72%	With acetic acid; In ethanol; at 80℃; for 0.166667h;Microwave irradiation;	General procedure: 2-(2-Arylidenehydrazino)-6-fluorobenzothiazoles 6a-r. General Procedure D. A mixture of compound 2 (0.0549 g, 0.0003 mol), the appropriate aromatic aldehyde (0.00033 mol) and glacial acetic acid (0.1 mL) in ethanol (5 mL) was heated under microwave (20 W) at 80 °C for 10 min. On cooling, the precipitated solid was collected by filtration, washed with water, dried and crystallized from the appropriate solvent to give the desired compounds 6a-r.

Reference： [1]Chinese Chemical Letters,2015,vol. 26,p. 1522 - 1528

68
[ 698-63-5 ]
[ 78364-55-3 ]
[ 1374874-17-5 ]

Yield	Reaction Conditions	Operation in experiment
68%	With acetic acid; In ethanol; at 80℃; for 0.166667h;Microwave irradiation;	General procedure: 2-(2-Arylidenehydrazino)-6-fluorobenzothiazoles 6a-r. General Procedure D. A mixture of compound 2 (0.0549 g, 0.0003 mol), the appropriate aromatic aldehyde (0.00033 mol) and glacial acetic acid (0.1 mL) in ethanol (5 mL) was heated under microwave (20 W) at 80 °C for 10 min. On cooling, the precipitated solid was collected by filtration, washed with water, dried and crystallized from the appropriate solvent to give the desired compounds 6a-r.

Reference： [1]Chinese Chemical Letters,2015,vol. 26,p. 1522 - 1528

69
[ 1003-29-8 ]
[ 78364-55-3 ]
6-fluoro-2-[2-((1H-pyrrol-2-yl)methylene)hydrazino]benzothiazole [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
79%	With acetic acid; In ethanol; at 80℃; for 0.166667h;Microwave irradiation;	General procedure: 2-(2-Arylidenehydrazino)-6-fluorobenzothiazoles 6a-r. General Procedure D. A mixture of compound 2 (0.0549 g, 0.0003 mol), the appropriate aromatic aldehyde (0.00033 mol) and glacial acetic acid (0.1 mL) in ethanol (5 mL) was heated under microwave (20 W) at 80 °C for 10 min. On cooling, the precipitated solid was collected by filtration, washed with water, dried and crystallized from the appropriate solvent to give the desired compounds 6a-r.

Reference： [1]Chinese Chemical Letters,2015,vol. 26,p. 1522 - 1528

70
[ 78364-55-3 ]
[ 6361-21-3 ]
2-(2-(2-chloro-5-nitrobenzylidene)hydrazino)-6-fluorobenzothiazole [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
68%	With acetic acid; In ethanol; at 80℃; for 0.166667h;Microwave irradiation;	General procedure: 2-(2-Arylidenehydrazino)-6-fluorobenzothiazoles 6a-r. General Procedure D. A mixture of compound 2 (0.0549 g, 0.0003 mol), the appropriate aromatic aldehyde (0.00033 mol) and glacial acetic acid (0.1 mL) in ethanol (5 mL) was heated under microwave (20 W) at 80 °C for 10 min. On cooling, the precipitated solid was collected by filtration, washed with water, dried and crystallized from the appropriate solvent to give the desired compounds 6a-r.

Reference： [1]Chinese Chemical Letters,2015,vol. 26,p. 1522 - 1528

71
[ 78364-55-3 ]
[ 591-31-1 ]
6-fluoro-2-(2-(3-methoxybenzylidene)hydrazino)benzothiazole [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
75%	With acetic acid; In ethanol; at 80℃; for 0.166667h;Microwave irradiation;	General procedure: 2-(2-Arylidenehydrazino)-6-fluorobenzothiazoles 6a-r. General Procedure D. A mixture of compound 2 (0.0549 g, 0.0003 mol), the appropriate aromatic aldehyde (0.00033 mol) and glacial acetic acid (0.1 mL) in ethanol (5 mL) was heated under microwave (20 W) at 80 °C for 10 min. On cooling, the precipitated solid was collected by filtration, washed with water, dried and crystallized from the appropriate solvent to give the desired compounds 6a-r.

Reference： [1]Chinese Chemical Letters,2015,vol. 26,p. 1522 - 1528

72
[ 78364-55-3 ]
[ 123-11-5 ]
6-fluoro-2-(2-(4-methoxybenzylidene)hydrazino)benzothiazole [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
72%	With acetic acid; In ethanol; at 80℃; for 0.166667h;Microwave irradiation;	General procedure: 2-(2-Arylidenehydrazino)-6-fluorobenzothiazoles 6a-r. General Procedure D. A mixture of compound 2 (0.0549 g, 0.0003 mol), the appropriate aromatic aldehyde (0.00033 mol) and glacial acetic acid (0.1 mL) in ethanol (5 mL) was heated under microwave (20 W) at 80 °C for 10 min. On cooling, the precipitated solid was collected by filtration, washed with water, dried and crystallized from the appropriate solvent to give the desired compounds 6a-r.
	In ethanol; at 70 - 80℃; for 3h;	General procedure: The mixture of <strong>[78364-55-3]6-fluoro-2-hydrazinylbenzo[d]thiazole</strong> (2) (0.01 mol) and benzalde-hyde/substituted benzaldehyde (0.01 mol) was reuxed in ethanol (15 ml) at 70?80 °C for 3 h. The separated product obtained was ltered off, washed withdistilled water and recrystallized from methanol to give the correspondinghydrazone. The product obtained was further dissolved in acetic acid (20 ml) atroom temperature followed by the addition of sodium acetate (0.5 g). Bromine(2 mmol) in acetic acid (10 ml) was added dropwise to the reuxing reactionmixture. After 1 h, the mixture was poured onto crushed ice (100 g). The precipitateobtained was ltered off and crystallized from ethanol-dimethylformamide (1:1) togive crystals of (3a?3t).

Reference： [1]Chinese Chemical Letters,2015,vol. 26,p. 1522 - 1528
[2]Research on Chemical Intermediates,2016,vol. 42,p. 8329 - 8344

73
[ 78364-55-3 ]
[ 552-89-6 ]
6-fluoro-2-(2-(2-nitrobenzylidene)hydrazino)benzothiazole [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
82%	With acetic acid; In ethanol; at 80℃; for 0.166667h;Microwave irradiation;	General procedure: 2-(2-Arylidenehydrazino)-6-fluorobenzothiazoles 6a-r. General Procedure D. A mixture of compound 2 (0.0549 g, 0.0003 mol), the appropriate aromatic aldehyde (0.00033 mol) and glacial acetic acid (0.1 mL) in ethanol (5 mL) was heated under microwave (20 W) at 80 °C for 10 min. On cooling, the precipitated solid was collected by filtration, washed with water, dried and crystallized from the appropriate solvent to give the desired compounds 6a-r.
	In ethanol; at 70 - 80℃; for 3h;	General procedure: The mixture of <strong>[78364-55-3]6-fluoro-2-hydrazinylbenzo[d]thiazole</strong> (2) (0.01 mol) and benzalde-hyde/substituted benzaldehyde (0.01 mol) was reuxed in ethanol (15 ml) at 70?80 °C for 3 h. The separated product obtained was ltered off, washed withdistilled water and recrystallized from methanol to give the correspondinghydrazone. The product obtained was further dissolved in acetic acid (20 ml) atroom temperature followed by the addition of sodium acetate (0.5 g). Bromine(2 mmol) in acetic acid (10 ml) was added dropwise to the reuxing reactionmixture. After 1 h, the mixture was poured onto crushed ice (100 g). The precipitateobtained was ltered off and crystallized from ethanol-dimethylformamide (1:1) togive crystals of (3a?3t).

Reference： [1]Chinese Chemical Letters,2015,vol. 26,p. 1522 - 1528
[2]Research on Chemical Intermediates,2016,vol. 42,p. 8329 - 8344

74
[ 78364-55-3 ]
[ 100-83-4 ]
6-fluoro-2-(2-(3-hydroxybenzylidene)hydrazino)benzothiazole [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
69%	With acetic acid; In ethanol; at 80℃; for 0.166667h;Microwave irradiation;	General procedure: 2-(2-Arylidenehydrazino)-6-fluorobenzothiazoles 6a-r. General Procedure D. A mixture of compound 2 (0.0549 g, 0.0003 mol), the appropriate aromatic aldehyde (0.00033 mol) and glacial acetic acid (0.1 mL) in ethanol (5 mL) was heated under microwave (20 W) at 80 °C for 10 min. On cooling, the precipitated solid was collected by filtration, washed with water, dried and crystallized from the appropriate solvent to give the desired compounds 6a-r.
	In ethanol; at 70 - 80℃; for 3h;	General procedure: The mixture of <strong>[78364-55-3]6-fluoro-2-hydrazinylbenzo[d]thiazole</strong> (2) (0.01 mol) and benzalde-hyde/substituted benzaldehyde (0.01 mol) was reuxed in ethanol (15 ml) at 70?80 °C for 3 h. The separated product obtained was ltered off, washed withdistilled water and recrystallized from methanol to give the correspondinghydrazone. The product obtained was further dissolved in acetic acid (20 ml) atroom temperature followed by the addition of sodium acetate (0.5 g). Bromine(2 mmol) in acetic acid (10 ml) was added dropwise to the reuxing reactionmixture. After 1 h, the mixture was poured onto crushed ice (100 g). The precipitateobtained was ltered off and crystallized from ethanol-dimethylformamide (1:1) togive crystals of (3a?3t).

Reference： [1]Chinese Chemical Letters,2015,vol. 26,p. 1522 - 1528
[2]Research on Chemical Intermediates,2016,vol. 42,p. 8329 - 8344

75
[ 78364-55-3 ]
[ 6630-33-7 ]
2-(2-(2-bromobenzylidene)hydrazino)-6-fluorobenzothiazole [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
76%	With acetic acid; In ethanol; at 80℃; for 0.166667h;Microwave irradiation;	General procedure: 2-(2-Arylidenehydrazino)-6-fluorobenzothiazoles 6a-r. General Procedure D. A mixture of compound 2 (0.0549 g, 0.0003 mol), the appropriate aromatic aldehyde (0.00033 mol) and glacial acetic acid (0.1 mL) in ethanol (5 mL) was heated under microwave (20 W) at 80 °C for 10 min. On cooling, the precipitated solid was collected by filtration, washed with water, dried and crystallized from the appropriate solvent to give the desired compounds 6a-r.

Reference： [1]Chinese Chemical Letters,2015,vol. 26,p. 1522 - 1528

76
[ 78364-55-3 ]
[ 139-85-5 ]
6-fluoro-2-(2-(3,4-dihydroxybenzylidene)hydrazino)benzothiazole [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
81%	With acetic acid; In ethanol; at 80℃; for 0.166667h;Microwave irradiation;	General procedure: 2-(2-Arylidenehydrazino)-6-fluorobenzothiazoles 6a-r. General Procedure D. A mixture of compound 2 (0.0549 g, 0.0003 mol), the appropriate aromatic aldehyde (0.00033 mol) and glacial acetic acid (0.1 mL) in ethanol (5 mL) was heated under microwave (20 W) at 80 °C for 10 min. On cooling, the precipitated solid was collected by filtration, washed with water, dried and crystallized from the appropriate solvent to give the desired compounds 6a-r.

Reference： [1]Chinese Chemical Letters,2015,vol. 26,p. 1522 - 1528

77
[ 7468-67-9 ]
[ 78364-55-3 ]
2-(2-(2-cyanobenzylidene)hydrazino)-6-fluorobenzothiazole [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
79%	With acetic acid; In ethanol; at 80℃; for 0.166667h;Microwave irradiation;	General procedure: 2-(2-Arylidenehydrazino)-6-fluorobenzothiazoles 6a-r. General Procedure D. A mixture of compound 2 (0.0549 g, 0.0003 mol), the appropriate aromatic aldehyde (0.00033 mol) and glacial acetic acid (0.1 mL) in ethanol (5 mL) was heated under microwave (20 W) at 80 °C for 10 min. On cooling, the precipitated solid was collected by filtration, washed with water, dried and crystallized from the appropriate solvent to give the desired compounds 6a-r.

Reference： [1]Chinese Chemical Letters,2015,vol. 26,p. 1522 - 1528

78
[ 78364-55-3 ]
[ 100-10-7 ]
2-[2-(4-(N,N-dimethylamino)benzylidene)hydrazino]-6-fluorobenzothiazole [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
68%	With acetic acid; In ethanol; at 80℃; for 0.166667h;Microwave irradiation;	General procedure: 2-(2-Arylidenehydrazino)-6-fluorobenzothiazoles 6a-r. General Procedure D. A mixture of compound 2 (0.0549 g, 0.0003 mol), the appropriate aromatic aldehyde (0.00033 mol) and glacial acetic acid (0.1 mL) in ethanol (5 mL) was heated under microwave (20 W) at 80 °C for 10 min. On cooling, the precipitated solid was collected by filtration, washed with water, dried and crystallized from the appropriate solvent to give the desired compounds 6a-r.
	In ethanol; at 70 - 80℃; for 3h;	General procedure: The mixture of <strong>[78364-55-3]6-fluoro-2-hydrazinylbenzo[d]thiazole</strong> (2) (0.01 mol) and benzalde-hyde/substituted benzaldehyde (0.01 mol) was reuxed in ethanol (15 ml) at 70?80 °C for 3 h. The separated product obtained was ltered off, washed withdistilled water and recrystallized from methanol to give the correspondinghydrazone. The product obtained was further dissolved in acetic acid (20 ml) atroom temperature followed by the addition of sodium acetate (0.5 g). Bromine(2 mmol) in acetic acid (10 ml) was added dropwise to the reuxing reactionmixture. After 1 h, the mixture was poured onto crushed ice (100 g). The precipitateobtained was ltered off and crystallized from ethanol-dimethylformamide (1:1) togive crystals of (3a?3t).

Reference： [1]Chinese Chemical Letters,2015,vol. 26,p. 1522 - 1528
[2]Research on Chemical Intermediates,2016,vol. 42,p. 8329 - 8344

79
[ 17754-90-4 ]
[ 78364-55-3 ]
2-[2-(4-(N,N-diethylamino)-2-hydroxybenzylidene)hydrazino]-6-fluorobenzothiazole [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
64%	With acetic acid; In ethanol; at 80℃; for 0.166667h;Microwave irradiation;	General procedure: 2-(2-Arylidenehydrazino)-6-fluorobenzothiazoles 6a-r. General Procedure D. A mixture of compound 2 (0.0549 g, 0.0003 mol), the appropriate aromatic aldehyde (0.00033 mol) and glacial acetic acid (0.1 mL) in ethanol (5 mL) was heated under microwave (20 W) at 80 °C for 10 min. On cooling, the precipitated solid was collected by filtration, washed with water, dried and crystallized from the appropriate solvent to give the desired compounds 6a-r.

Reference： [1]Chinese Chemical Letters,2015,vol. 26,p. 1522 - 1528

80
[ 1121-60-4 ]
[ 78364-55-3 ]
6-fluoro-2-[2-((pyridin-2-yl)methylene)hydrazino]benzothiazole [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
69%	With acetic acid; In ethanol; at 80℃; for 0.166667h;Microwave irradiation;	General procedure: 2-(2-Arylidenehydrazino)-6-fluorobenzothiazoles 6a-r. General Procedure D. A mixture of compound 2 (0.0549 g, 0.0003 mol), the appropriate aromatic aldehyde (0.00033 mol) and glacial acetic acid (0.1 mL) in ethanol (5 mL) was heated under microwave (20 W) at 80 °C for 10 min. On cooling, the precipitated solid was collected by filtration, washed with water, dried and crystallized from the appropriate solvent to give the desired compounds 6a-r.

Reference： [1]Chinese Chemical Letters,2015,vol. 26,p. 1522 - 1528

81
[ 78364-55-3 ]
[ 136590-83-5 ]
2-(2-[((3,5-dichloropyridin-4-yl)methylene)hydrazino])-6-fluorobenzothiazole [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
74%	With acetic acid; In ethanol; at 80℃; for 0.166667h;Microwave irradiation;	General procedure: 2-(2-Arylidenehydrazino)-6-fluorobenzothiazoles 6a-r. General Procedure D. A mixture of compound 2 (0.0549 g, 0.0003 mol), the appropriate aromatic aldehyde (0.00033 mol) and glacial acetic acid (0.1 mL) in ethanol (5 mL) was heated under microwave (20 W) at 80 °C for 10 min. On cooling, the precipitated solid was collected by filtration, washed with water, dried and crystallized from the appropriate solvent to give the desired compounds 6a-r.

Reference： [1]Chinese Chemical Letters,2015,vol. 26,p. 1522 - 1528

82
[ 173089-81-1 ]
[ 78364-55-3 ]
6-fluoro-2-[2-((isoquinolin-5-yl)methylene)hydrazino]benzothiazole [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
72%	With acetic acid; In ethanol; at 80℃; for 0.166667h;Microwave irradiation;	General procedure: 2-(2-Arylidenehydrazino)-6-fluorobenzothiazoles 6a-r. General Procedure D. A mixture of compound 2 (0.0549 g, 0.0003 mol), the appropriate aromatic aldehyde (0.00033 mol) and glacial acetic acid (0.1 mL) in ethanol (5 mL) was heated under microwave (20 W) at 80 °C for 10 min. On cooling, the precipitated solid was collected by filtration, washed with water, dried and crystallized from the appropriate solvent to give the desired compounds 6a-r.

Reference： [1]Chinese Chemical Letters,2015,vol. 26,p. 1522 - 1528

83
[ 29668-44-8 ]
[ 78364-55-3 ]
2-[2-((2,3-dihydrobenzo[b][1,4]dioxin-6-yl)methylene)hydrazino]-6-fluorobenzothiazole [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
81%	With acetic acid; In ethanol; at 80℃; for 0.166667h;Microwave irradiation;	General procedure: 2-(2-Arylidenehydrazino)-6-fluorobenzothiazoles 6a-r. General Procedure D. A mixture of compound 2 (0.0549 g, 0.0003 mol), the appropriate aromatic aldehyde (0.00033 mol) and glacial acetic acid (0.1 mL) in ethanol (5 mL) was heated under microwave (20 W) at 80 °C for 10 min. On cooling, the precipitated solid was collected by filtration, washed with water, dried and crystallized from the appropriate solvent to give the desired compounds 6a-r.

Reference： [1]Chinese Chemical Letters,2015,vol. 26,p. 1522 - 1528

84
[ 26933-87-9 ]
[ 78364-55-3 ]
6-fluoro-2-[2-((pyren-2-yl)methylene)hydrazino]benzothiazole [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
72%	With acetic acid; In ethanol; at 80℃; for 0.166667h;Microwave irradiation;	General procedure: 2-(2-Arylidenehydrazino)-6-fluorobenzothiazoles 6a-r. General Procedure D. A mixture of compound 2 (0.0549 g, 0.0003 mol), the appropriate aromatic aldehyde (0.00033 mol) and glacial acetic acid (0.1 mL) in ethanol (5 mL) was heated under microwave (20 W) at 80 °C for 10 min. On cooling, the precipitated solid was collected by filtration, washed with water, dried and crystallized from the appropriate solvent to give the desired compounds 6a-r.

Reference： [1]Chinese Chemical Letters,2015,vol. 26,p. 1522 - 1528

85
[ 13329-40-3 ]
[ 78364-55-3 ]
6-fluoro-2-[2-(1-(4-iodophenyl)ethylidene)hydrazino]benzothiazole [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
65%	With acetic acid; In ethanol;Reflux;	General procedure: 6-Fluoro-2-[2-(1-(substituted phenyl)ethylidene)hydraizno]benzothiazoles 7a-d. General Procedure E. A mixture of compound 2 (0.183 g, 0.001 mol), the appropriate acetophenone (0.001 mol) and glacial acetic acid (0.1 mL) in ethanol (20 mL) was heated at reflux temperature for 6-8 h. On cooling, the precipitated solid was collected by filtration, washed with ethanol, dried and crystallized from ethyl acetate : ethanol (3:1) to furnish compounds 7a-d.

Reference： [1]Chinese Chemical Letters,2015,vol. 26,p. 1522 - 1528

86
[ 20954-35-2 ]
[ 78364-55-3 ]
4-(2-(2-chloro-4-nitrophenyl)hydrazono)-1-(6-fluorobenzothiazol-2-yl)-3-methylpyrazol-5(4H)-one [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
81%	With acetic acid;Reflux;	General procedure: 1-(6-Fluorobenzothiazol-2-yl)-3-methyl-4-(2-(substituted phenyl)hydrazono)pyrazol-5(4H)-ones 4a-e. General Procedure B. A solution of 6-fluoro-2-hydrazinobenzothiazole (2) (0.549 g, 0.003 mol) in glacial acetic acid (10 mL) was added to a solution of the appropriate ethyl 3-oxo-2-(2-(substituted phenyl)hydrazono)butanoate 3a-e (0.003 mol) in glacial acetic acid (10 mL). The mixture was heated at reflux temperature for 10-16 h, then cooled and allowed to stand overnight. The precipitated solid was collected by filtration, washed with water, dried and crystallized from ethanol to give compounds 4a-e.

Reference： [1]Chinese Chemical Letters,2015,vol. 26,p. 1522 - 1528

87
[ 78364-55-3 ]
[ 18795-00-1 ]
1-(6-fluorobenzothiazol-2-yl)-3-methyl-4-(2-(4-nitrophenyl)hydrazono)pyrazol-5(4H)-one [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
82%	With acetic acid;Reflux;	General procedure: 1-(6-Fluorobenzothiazol-2-yl)-3-methyl-4-(2-(substituted phenyl)hydrazono)pyrazol-5(4H)-ones 4a-e. General Procedure B. A solution of 6-fluoro-2-hydrazinobenzothiazole (2) (0.549 g, 0.003 mol) in glacial acetic acid (10 mL) was added to a solution of the appropriate ethyl 3-oxo-2-(2-(substituted phenyl)hydrazono)butanoate 3a-e (0.003 mol) in glacial acetic acid (10 mL). The mixture was heated at reflux temperature for 10-16 h, then cooled and allowed to stand overnight. The precipitated solid was collected by filtration, washed with water, dried and crystallized from ethanol to give compounds 4a-e.

Reference： [1]Chinese Chemical Letters,2015,vol. 26,p. 1522 - 1528

88
[ 78364-55-3 ]
[ 129493-70-5 ]
4-(2-(2,4-dichlorophenyl)hydrazono)-1-(6-fluorobenzothiazol-2-yl)-3-methylpyrazol-5(4H)-one [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
72%	With acetic acid;Reflux;	General procedure: 1-(6-Fluorobenzothiazol-2-yl)-3-methyl-4-(2-(substituted phenyl)hydrazono)pyrazol-5(4H)-ones 4a-e. General Procedure B. A solution of 6-fluoro-2-hydrazinobenzothiazole (2) (0.549 g, 0.003 mol) in glacial acetic acid (10 mL) was added to a solution of the appropriate ethyl 3-oxo-2-(2-(substituted phenyl)hydrazono)butanoate 3a-e (0.003 mol) in glacial acetic acid (10 mL). The mixture was heated at reflux temperature for 10-16 h, then cooled and allowed to stand overnight. The precipitated solid was collected by filtration, washed with water, dried and crystallized from ethanol to give compounds 4a-e.

Reference： [1]Chinese Chemical Letters,2015,vol. 26,p. 1522 - 1528

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Precautionary Statements-General
Code	Phrase
P101	If medical advice is needed,have product container or label at hand.
P102	Keep out of reach of children.
P103	Read label before use
Prevention
Code	Phrase
P201	Obtain special instructions before use.
P202	Do not handle until all safety precautions have been read and understood.
P210	Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P211	Do not spray on an open flame or other ignition source.
P220	Keep/Store away from clothing/combustible materials.
P221	Take any precaution to avoid mixing with combustibles
P222	Do not allow contact with air.
P223	Keep away from any possible contact with water, because of violent reaction and possible flash fire.
P230	Keep wetted
P231	Handle under inert gas.
P232	Protect from moisture.
P233	Keep container tightly closed.
P234	Keep only in original container.
P235	Keep cool
P240	Ground/bond container and receiving equipment.
P241	Use explosion-proof electrical/ventilating/lighting/equipment.
P242	Use only non-sparking tools.
P243	Take precautionary measures against static discharge.
P244	Keep reduction valves free from grease and oil.
P250	Do not subject to grinding/shock/friction.
P251	Pressurized container: Do not pierce or burn, even after use.
P260	Do not breathe dust/fume/gas/mist/vapours/spray.
P261	Avoid breathing dust/fume/gas/mist/vapours/spray.
P262	Do not get in eyes, on skin, or on clothing.
P263	Avoid contact during pregnancy/while nursing.
P264	Wash hands thoroughly after handling.
P265	Wash skin thouroughly after handling.
P270	Do not eat, drink or smoke when using this product.
P271	Use only outdoors or in a well-ventilated area.
P272	Contaminated work clothing should not be allowed out of the workplace.
P273	Avoid release to the environment.
P280	Wear protective gloves/protective clothing/eye protection/face protection.
P281	Use personal protective equipment as required.
P282	Wear cold insulating gloves/face shield/eye protection.
P283	Wear fire/flame resistant/retardant clothing.
P284	Wear respiratory protection.
P285	In case of inadequate ventilation wear respiratory protection.
P231 + P232	Handle under inert gas. Protect from moisture.
P235 + P410	Keep cool. Protect from sunlight.
Response
Code	Phrase
P301	IF SWALLOWED:
P304	IF INHALED:
P305	IF IN EYES:
P306	IF ON CLOTHING:
P307	IF exposed:
P308	IF exposed or concerned:
P309	IF exposed or if you feel unwell:
P310	Immediately call a POISON CENTER or doctor/physician.
P311	Call a POISON CENTER or doctor/physician.
P312	Call a POISON CENTER or doctor/physician if you feel unwell.
P313	Get medical advice/attention.
P314	Get medical advice/attention if you feel unwell.
P315	Get immediate medical advice/attention.
P320
P302 + P352	IF ON SKIN: wash with plenty of soap and water.
P321
P322
P330	Rinse mouth.
P331	Do NOT induce vomiting.
P332	IF SKIN irritation occurs:
P333	If skin irritation or rash occurs:
P334	Immerse in cool water/wrap n wet bandages.
P335	Brush off loose particles from skin.
P336	Thaw frosted parts with lukewarm water. Do not rub affected area.
P337	If eye irritation persists:
P338	Remove contact lenses, if present and easy to do. Continue rinsing.
P340	Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P341	If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P342	If experiencing respiratory symptoms:
P350	Gently wash with plenty of soap and water.
P351	Rinse cautiously with water for several minutes.
P352	Wash with plenty of soap and water.
P353	Rinse skin with water/shower.
P360	Rinse immediately contaminated clothing and skin with plenty of water before removing clothes.
P361	Remove/Take off immediately all contaminated clothing.
P362	Take off contaminated clothing and wash before reuse.
P363	Wash contaminated clothing before reuse.
P370	In case of fire:
P371	In case of major fire and large quantities:
P372	Explosion risk in case of fire.
P373	DO NOT fight fire when fire reaches explosives.
P374	Fight fire with normal precautions from a reasonable distance.
P376	Stop leak if safe to do so. Oxidising gases (section 2.4) 1
P377	Leaking gas fire: Do not extinguish, unless leak can be stopped safely.
P378
P380	Evacuate area.
P381	Eliminate all ignition sources if safe to do so.
P390	Absorb spillage to prevent material damage.
P391	Collect spillage. Hazardous to the aquatic environment
P301 + P310	IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P301 + P312	IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P301 + P330 + P331	IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P302 + P334	IF ON SKIN: Immerse in cool water/wrap in wet bandages.
P302 + P350	IF ON SKIN: Gently wash with plenty of soap and water.
P303 + P361 + P353	IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304 + P312	IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell.
P304 + P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P304 + P341	IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P306 + P360	IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes.
P307 + P311	IF exposed: call a POISON CENTER or doctor/physician.
P308 + P313	IF exposed or concerned: Get medical advice/attention.
P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P370 + P376	In case of fire: Stop leak if safe to Do so.
P370 + P378	In case of fire:
P370 + P380	In case of fire: Evacuate area.
P370 + P380 + P375	In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion.
P371 + P380 + P375	In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
Storage
Code	Phrase
P401
P402	Store in a dry place.
P403	Store in a well-ventilated place.
P404	Store in a closed container.
P405	Store locked up.
P406	Store in corrosive resistant/ container with a resistant inner liner.
P407	Maintain air gap between stacks/pallets.
P410	Protect from sunlight.
P411
P412	Do not expose to temperatures exceeding 50 oC/ 122 oF.
P413
P420	Store away from other materials.
P422
P402 + P404	Store in a dry place. Store in a closed container.
P403 + P233	Store in a well-ventilated place. Keep container tightly closed.
P403 + P235	Store in a well-ventilated place. Keep cool.
P410 + P403	Protect from sunlight. Store in a well-ventilated place.
P410 + P412	Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
P411 + P235	Keep cool.
Disposal
Code	Phrase
P501	Dispose of contents/container to ...
P502	Refer to manufacturer/supplier for information on recovery/recycling

Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed
H304	May be fatal if swallowed and enters airways
H305	May be harmful if swallowed and enters airways
H310	Fatal in contact with skin
H311	Toxic in contact with skin
H312	Harmful in contact with skin
H313	May be harmful in contact with skin
H314	Causes severe skin burns and eye damage
H315	Causes skin irritation
H316	Causes mild skin irritation
H317	May cause an allergic skin reaction
H318	Causes serious eye damage
H319	Causes serious eye irritation
H320	Causes eye irritation
H330	Fatal if inhaled
H331	Toxic if inhaled
H332	Harmful if inhaled
H333	May be harmful if inhaled
H334	May cause allergy or asthma symptoms or breathing difficulties if inhaled
H335	May cause respiratory irritation
H336	May cause drowsiness or dizziness
H340	May cause genetic defects
H341	Suspected of causing genetic defects
H350	May cause cancer
H351	Suspected of causing cancer
H360	May damage fertility or the unborn child
H361	Suspected of damaging fertility or the unborn child
H361d	Suspected of damaging the unborn child
H362	May cause harm to breast-fed children
H370	Causes damage to organs
H371	May cause damage to organs
H372	Causes damage to organs through prolonged or repeated exposure
H373	May cause damage to organs through prolonged or repeated exposure
Environmental hazards
Code	Phrase
H400	Very toxic to aquatic life
H401	Toxic to aquatic life
H402	Harmful to aquatic life
H410	Very toxic to aquatic life with long-lasting effects
H411	Toxic to aquatic life with long-lasting effects
H412	Harmful to aquatic life with long-lasting effects
H413	May cause long-lasting harmful effects to aquatic life
H420	Harms public health and the environment by destroying ozone in the upper atmosphere

[ CAS No. 78364-55-3 ] {[proInfo.proName]}

Quality Control of [ 78364-55-3 ]

Related Doc. of [ 78364-55-3 ]

Product Details of [ 78364-55-3 ]

Calculated chemistry of [ 78364-55-3 ]

Physicochemical Properties

Pharmacokinetics

Lipophilicity

Druglikeness

Water Solubility

Medicinal Chemistry

Safety of [ 78364-55-3 ]

Application In Synthesis of [ 78364-55-3 ]

[ 78364-55-3 ] Synthesis Path-Upstream 1~5

[ 78364-55-3 ] Synthesis Path-Downstream 1~88

Related Functional Groups of [ 78364-55-3 ]

Fluorinated Building Blocks

Amines

Hydrazines

Precautionary Statements-General

Prevention

Response

Storage

Disposal

Physical hazards

Health hazards

Environmental hazards

Inquiry

Related Functional Groups of
[ 78364-55-3 ]