[ CAS No. 78507-19-4 ] {[proInfo.proName]}

Name: 78507-19-4|4-((Methylamino)methyl)phenol|98%
Brand: Ambeed
SKU: A159579
Rating: 99 (22 reviews)

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Cat. No.: {[proInfo.prAm]}

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Quality Control of [ 78507-19-4 ]

COA NMR CNMR HPLC LC-MS

Related Doc. of [ 78507-19-4 ]

SDS Specification

Alternatived Products of [ 78507-19-4 ]

Product Details of [ 78507-19-4 ]

CAS No. :	78507-19-4	MDL No. :	MFCD09046544
Formula :	C₈H₁₁NO	Boiling Point :	-
Linear Structure Formula :	-	InChI Key :	AMKMYXVFAOJGGQ-UHFFFAOYSA-N
M.W :	137.18	Pubchem ID :	13104924
Synonyms :

Safety of [ 78507-19-4 ]

Signal Word:	Danger	Class:	8
Precautionary Statements:	P280-P305+P351+P338-P310	UN#:	3259
Hazard Statements:	H314	Packing Group:	Ⅲ
GHS Pictogram:

Application In Synthesis of [ 78507-19-4 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Upstream synthesis route of [ 78507-19-4 ]
Downstream synthetic route of [ 78507-19-4 ]

[ 78507-19-4 ] Synthesis Path-Upstream 1~8

1
[ 5766-74-5 ]
[ 78507-19-4 ]

Reference： [1] Chemical Research in Toxicology, 1999, vol. 12, # 12, p. 1254 - 1261
[2] Journal of Medicinal Chemistry, 2015, vol. 58, # 21, p. 8694 - 8712

2
[ 5129-87-3 ]
[ 78507-19-4 ]

Reference： [1] Journal of Organic Chemistry, 1966, vol. 31, p. 133 - 137

3
[ 123-08-0 ]
[ 78507-19-4 ]

Reference： [1] Journal of Medicinal Chemistry, 2015, vol. 58, # 21, p. 8694 - 8712

4
[ 2746-25-0 ]
[ 78507-19-4 ]

Reference： [1] Bulletin de la Societe Chimique de France, 1911, vol. <4> 9, p. 824
[2] Bulletin de la Societe Chimique de France, 1911, vol. <4> 9, p. 824

5
[ 824-94-2 ]
[ 78507-19-4 ]

Reference： [1] Bulletin de la Societe Chimique de France, 1911, vol. <4> 9, p. 824
[2] Bulletin de la Societe Chimique de France, 1911, vol. <4> 9, p. 824

6
[ 105-13-5 ]
[ 78507-19-4 ]

Reference： [1] Bulletin de la Societe Chimique de France, 1911, vol. <4> 9, p. 824
[2] Bulletin de la Societe Chimique de France, 1911, vol. <4> 9, p. 824

7
[ 702-24-9 ]
[ 78507-19-4 ]

Reference： [1] Bulletin de la Societe Chimique de France, 1911, vol. <4> 9, p. 824

8
[ 78507-15-0 ]
[ 74-89-5 ]
[ 78507-19-4 ]

Reference： [1] Tetrahedron, 1981, vol. 37, p. 503 - 508

[ 78507-19-4 ] Synthesis Path-Downstream 1~31

1
[ 702-24-9 ]
[ 78507-19-4 ]

Reference： [1]Bulletin de la Societe Chimique de France,1911,vol. <4> 9,p. 824

2
[ 5129-87-3 ]
[ 78507-19-4 ]

Reference： [1]Journal of Organic Chemistry,1966,vol. 31,p. 133 - 137

3
[ 78507-15-0 ]
[ 74-89-5 ]
[ 78507-19-4 ]

Reference： [1]Tetrahedron,1981,vol. 37,p. 503 - 508

5
4-hydroxy-benzaldehyde methylimine [ No CAS ]
[ 78507-19-4 ]

Reference： [1]Journal of the American Chemical Society,1945,vol. 67,p. 1658

6
[ 5766-74-5 ]
[ 78507-19-4 ]

Reference： [1]Chemical Research in Toxicology,1999,vol. 12,p. 1254 - 1261
[2]Journal of Medicinal Chemistry,2015,vol. 58,p. 8694 - 8712

7
[ 78507-19-4 ]
[ 90465-99-9 ]

Reference： [1]Chemical Research in Toxicology,1999,vol. 12,p. 1254 - 1261

8
[ 123-08-0 ]
/PXGAB₁₁₄--212/ [ No CAS ]
[ 78507-19-4 ]

Reference： [1]Chemical Research in Toxicology,1999,vol. 12,p. 1254 - 1261

9
[ 2746-25-0 ]
[ 78507-19-4 ]

Reference： [1]Bulletin de la Societe Chimique de France,1911,vol. <4> 9,p. 824
[2]Bulletin de la Societe Chimique de France,1911,vol. <4> 9,p. 824

10
[ 824-94-2 ]
[ 78507-19-4 ]

Reference： [1]Bulletin de la Societe Chimique de France,1911,vol. <4> 9,p. 824
[2]Bulletin de la Societe Chimique de France,1911,vol. <4> 9,p. 824

11
[ 105-13-5 ]
[ 78507-19-4 ]

Reference： [1]Bulletin de la Societe Chimique de France,1911,vol. <4> 9,p. 824
[2]Bulletin de la Societe Chimique de France,1911,vol. <4> 9,p. 824

12
[ 108-95-2 ]
1-halo-dodecane [ No CAS ]
[ 78507-19-4 ]

Reference： [1]Journal of Organic Chemistry,1966,vol. 31,p. 133 - 137

13
[ 877264-49-8 ]
[ 78507-19-4 ]
[ 877264-50-1 ]

Yield	Reaction Conditions	Operation in experiment
65%	With N-ethyl-N,N-diisopropylamine; In dichloromethane; for 24.0h;	Step G: The product from Step F (3.70 g, 14.5 mmol), <strong>[78507-19-4]4-hydroxy-N-methyl benzylamine</strong> (2.37 g, 17.5 mmol) and N,N-diisopropylethylamine (2.8 mL, 16.0 mmol) were suspended in methylene chloride and stirred for over 24 hours. Water was added to the reaction mixture and was extracted with methylene chloride. The organic layer was then washed with 1N HCl, then with saturated sodium chloride solution. The solution was dried over sodium sulfate, filtered, concentrated in vacuo and purified by column chromatography (2-10% methanol/methylene chloride as the eluent) to give the desired product (2.94 g, 65%): 1H NMR (500 MHz, CDCl3) delta 8.52 (d, J=0.5 Hz, 1H), 7.95 (dd, J=8.4, 1.5 Hz, 1H), 7.84 (d, J=8.4 Hz, 1H), 7.66 (d, J=5.4 Hz, 1H), 7.38 (d, J=5.4 Hz, 1H), 7.20 (d, J=7.8 Hz, 1H), 6.92-6.90 (m, 2H), 6.77-6.75 (m, 1H), 3.86 (s, 2H), 3.65 (s, 2H), 2.40 (s, 3H).

Reference： [1]Patent: US2006/52378,2006,A1 .Location in patent: Page/Page column 150

14
Boc-D-Arg(NO₂)-OH [ No CAS ]
[ 64-17-5 ]
[ 78507-19-4 ]
[ 164647-46-5 ]

Yield	Reaction Conditions	Operation in experiment
80%	With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate;	a (R)-N5 -[Amino(nitroimino)methyl]-N2 -[(tert.-butyloxy)carbonyl]-N-[(4-hydroxyphenyl)methyl]-N-methyl-ornithinamide Prepared analogously to Example 8a) from Boc-D-Arg(NO2)-OH, N-methyl-4-hydroxybenzenemethylamine (the hydrochloride melts at 190-192 C. [ethanol]) and TBTU in a yield of 80% of theory. Colourless crystals, mp. 78-81 C. IR (KBr): 1705 cm-1 (ester-C=O) 1635 cm-1 (C=O, C=N) 1520 cm-1 (amide-II) ESI-MS: (M+Na)+ =461 (M+K)+ =477 (2M+Na)+ =899

Reference： [1]Patent: US5616620,1997,A

15
[ 862780-35-6 ]
[ 78507-19-4 ]
2-bromo-2,2-difluoro-N-(4-hydroxybenzyl)-N-methyl-N'-phenylacetimidamide [ No CAS ]