[ CAS No. 78863-99-7 ] {[proInfo.proName]}

Name: 78863-99-7|2-Bromo-6,7,8,9-tetrahydro-5H-carbazole|95%
Brand: Ambeed
SKU: A693918
Rating: 99 (28 reviews)

,{[proInfo.pro_purity]}

Cat. No.: {[proInfo.prAm]}

DV 2D 3D

3d Animation Molecule Structure of 78863-99-7

Structure of 78863-99-7 * Storage: {[proInfo.prStorage]}

Please Login or Create an Account to: See VIP prices and availability

Cart0 Add to My Favorites Add to My Favorites Bulk Inquiry Inquiry Add To Cart

Search after Editing

* Storage: {[proInfo.prStorage]}

* Shipping: {[proInfo.prShipping]}

For Research Only 120K+ Compounds Competitive Price 1-2 Day Shipping

Quality Control of [ 78863-99-7 ]

COA NMR CNMR HPLC LC-MS

Related Doc. of [ 78863-99-7 ]

SDS Specification

Alternatived Products of [ 78863-99-7 ]

Product Details of [ 78863-99-7 ]

CAS No. :	78863-99-7	MDL No. :	MFCD00473712
Formula :	C₁₂H₁₂BrN	Boiling Point :	-
Linear Structure Formula :	-	InChI Key :	ZNEUGUWVPAHTNJ-UHFFFAOYSA-N
M.W :	250.13	Pubchem ID :	4451313
Synonyms :

Safety of [ 78863-99-7 ]

Signal Word:	Warning	Class:	N/A
Precautionary Statements:	P264-P280-P302+P352-P305+P351+P338-P332+P313-P337+P313-P362	UN#:	N/A
Hazard Statements:	H315-H319	Packing Group:	N/A
GHS Pictogram:

Application In Synthesis of [ 78863-99-7 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Downstream synthetic route of [ 78863-99-7 ]

[ 78863-99-7 ] Synthesis Path-Downstream 1~50

1
[ 67-56-1 ]
[ 78863-99-7 ]
[ 41084-59-7 ]
[ 6933-49-9 ]
[ 3382-43-2 ]

Reference： [1]Chemical and pharmaceutical bulletin,1981,vol. 29,p. 1231 - 1236

2
[ 78863-99-7 ]
[ 41084-59-7 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1: sodium methoxide / cuprous iodide / dimethylformamide / 6 h / Heating 2: 50.8 percent / sodium methoxide / cuprous iodide / dimethylformamide / 7 h / Heating
	Multi-step reaction with 2 steps 1: sodium methoxide / cuprous iodide / dimethylformamide / 6 h / Heating 2: NaOMe / methanol / various catalysts, reaction time, various yields of products

3
[ 78863-99-7 ]
[ 6933-49-9 ]

Reference： [1]Chemical and pharmaceutical bulletin,1981,vol. 29,p. 1231 - 1236
[2]Chemical and pharmaceutical bulletin,1981,vol. 29,p. 1231 - 1236

4
[ 78863-99-7 ]
[ 79208-84-7 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 3 steps 1: tert-BuOCl 2: NaOH / methanol 3: ccHCl / methanol; H₂O
	Multi-step reaction with 4 steps 1: sulfuric acid 2: water; nitric acid; acetic acid / 80 °C 3: acetic acid anhydride 4: aq.-ethanolic KOH-solution

Reference： [1]Kirugawa, Yasuo; Miyake, Yuko; Kawase, Masami [Chemical and pharmaceutical bulletin, 1981, vol. 29, # 5, p. 1231 - 1236]
[2]Plant; Wilson [Journal of the Chemical Society, 1939, p. 237]

5
[ 78863-99-7 ]
[ 79208-89-2 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1: 53.7 percent / sodium methoxide / cuprous iodide / dimethylformamide / 6 h / Heating 2: 51.5 percent / LiAlH₄ / diethyl ether / reflux, 5 min, RT, 3 h
	Multi-step reaction with 3 steps 1: sodium methoxide / cuprous iodide / dimethylformamide / 6 h / Heating 2: 50.8 percent / sodium methoxide / cuprous iodide / dimethylformamide / 7 h / Heating 3: 51.5 percent / LiAlH₄ / diethyl ether / reflux, 5 min, RT, 3 h
	Multi-step reaction with 3 steps 1: sodium methoxide / cuprous iodide / dimethylformamide / 6 h / Heating 2: NaOMe / methanol / various catalysts, reaction time, various yields of products 3: 51.5 percent / LiAlH₄ / diethyl ether / reflux, 5 min, RT, 3 h

Reference： [1]Kirugawa, Yasuo; Miyake, Yuko; Kawase, Masami [Chemical and pharmaceutical bulletin, 1981, vol. 29, # 5, p. 1231 - 1236]
[2]Kirugawa, Yasuo; Miyake, Yuko; Kawase, Masami [Chemical and pharmaceutical bulletin, 1981, vol. 29, # 5, p. 1231 - 1236]
[3]Kirugawa, Yasuo; Miyake, Yuko; Kawase, Masami [Chemical and pharmaceutical bulletin, 1981, vol. 29, # 5, p. 1231 - 1236]

6
[ 78863-99-7 ]
[ 79208-88-1 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 4 steps 1: tert-BuOCl 2: NaOH / methanol 3: ccHCl / methanol; H₂O 4: 64.9 percent / sodium methoxide / cuprous iodide / dimethylformamide / 4 h / Heating

Reference： [1]Kirugawa, Yasuo; Miyake, Yuko; Kawase, Masami [Chemical and pharmaceutical bulletin, 1981, vol. 29, # 5, p. 1231 - 1236]

7
[ 78863-99-7 ]
C₁₃H₁₄BrNO [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1: tert-BuOCl 2: NaOH / methanol

Reference： [1]Kirugawa, Yasuo; Miyake, Yuko; Kawase, Masami [Chemical and pharmaceutical bulletin, 1981, vol. 29, # 5, p. 1231 - 1236]

8
[ 27246-81-7 ]
[ 108-94-1 ]
[ 78863-99-7 ]

Yield	Reaction Conditions	Operation in experiment
33%	With hydrogenchloride In ethanol; water for 1h; Reflux;	21.a Cyclohexanone (7.7 mL, 73 mmol) was added to a suspension of 3-bromophenyl hydrazine hydrochloride (15 g, 67 mmol) in EtOH (150 mL) and 12 N HCl (30 mL), and the resulting suspension was heated at reflux for 1 h. The suspension was cooled and diluted with H2O (200 mL). The resulting solids were collected by filtration. The solids were dissolved in EtOAc, and the solution was made basic with saturated NaHCO3 solution. The resulting solution was extracted with EtOAc (2×100 mL). The combined organic extracts were dried over Na2SO4, filtered and concentrated to dryness. The solids were suspended in CH2Cl2 (100 mL) and collected by filtration. The solids were washed with MeOH (50 mL) and dried under reduced pressure to provide the title compound (5.74 g, 33%) as a white solid: 1H NMR (500 MHz, CD3OD) δ 7.35 (d, J=1.5 Hz, 1H), 7.22 (d, J=8.0 Hz, 1H), 7.02 (dd, J=8.0, 1.5 Hz, 1H), 2.70 (t, J=6.0 Hz, 2H), 2.64 (t, J=5.5 Hz, 2H), 1.91-1.84 (m, 4H).
30%	In ethanol at 65℃; for 1h;	5.2 (2) Synthesis of Compound Represented by Formula 5-b 48.7 g (218.0 mmol) of the compound represented by the formula 5-a and 21.4 g (218.0 mmol) of the cyclohexanone obtained from the above-mentioned scheme 25 are added to 500 ml of ethyl alcohol and stirred at 65 ° C for 1 hour. When the reaction is completed, the reaction mixture is cooled to room temperature, filtered and washed with ethyl alcohol. And dried under reduced pressure at room temperature to obtain 16.4 g of a compound represented by the formula (5-b). (Yield: 30%)

Reference： [1]Current Patent Assignee: HARMONY BIOSCIENCES - US2011/3793, 2011, A1 Location in patent: Page/Page column 48
[2]Current Patent Assignee: HODOGAYA CHEMICAL CO LTD - KR101970987, 2019, B1 Location in patent: Paragraph 0415; 0422-0427

9
[ 78863-99-7 ]
[ 847987-95-5 ]

Yield	Reaction Conditions	Operation in experiment
68%	With periodic acid In methanol; water at 0 - 20℃;	18.a MeOH (60 mL) and 7-bromo-2,3,4,9-tetrahydro-1H-carbazole (2.60 g, 10.4 mmol) were added to a solution of periodic acid (4.76 g, 20.8 mmol) in 1:1 MeOH/H2O (50 mL), cooled to 0° C., and the resulting slurry was warmed to ambient temperature with stirring for 18 h. The mixture was concentrated to dryness. The resulting solids were dissolved in CHCl3 (100 mL), and the resulting solution was washed with 10% Na2CO3 (2×100 mL) and 10% Na2SO3 (2×50 mL). The organic solution was dried over Na2SO4, filtered and concentrated to dryness under reduced pressure. The solids were washed with MeOH (75 mL) and dried to yield the title compound (1.86 g, 68%) as a yellow solid: 1H NMR (500 MHz, DMSO-d6) δ 11.73 (s, 1H), 7.64 (d, J=8.5 Hz, 1H), 7.55 (d, J=1.5 Hz, 1H), 7.21 (d, J=8.5, 2.0 Hz, 1H), 2.94 (t, J=6.0 Hz, 2H), 2.56 (t, J=6.0 Hz, 2H), 2.17-2.12 (m, 2H).

Reference： [1]Current Patent Assignee: HARMONY BIOSCIENCES - US2011/3793, 2011, A1 Location in patent: Page/Page column 44

10
[ 78863-99-7 ]
[ 1260493-98-8 ]

Yield	Reaction Conditions	Operation in experiment
81%	With 2,3-dicyano-5,6-dichloro-p-benzoquinone In tetrahydrofuran; water at 0℃; for 0.75h;	21.b b) 7-Bromo-2,3-dihydro-1H-carbazol-4(9H)-one A solution 7-bromo-2,3,4,9-tetrahydro-1H-carbazole (2.87 g, 11.5 mmol) in THF (103 mL) and H2O (11.5 mL) was cooled to 0° C. and treated with a solution of 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (5.23 g, 23.1 mmol) in THF (46 mL) at such a rate that the reaction mixture did not exceed 4° C. The resulting solution was allowed to stir for an additional 45 min at 0° C. The solution was concentrated to dryness under reduced pressure. The resulting solids were suspended in EtOAc (100 mL) and saturated NaHCO3 solution (300 mL). The solids were collected by filtration and washed with additional saturated NaHCO3 solution (400 mL) followed by H2O (150 mL). The solid was dried to provide the title compound (2.46 g, 81%) as a light pink solid: 1H NMR (500 MHz, DMSO-d6) δ 11.97 (s, 1H), 7.86 (d, J=8.5 Hz, 1H), 7.58 (d, J=1.5 Hz, 1H), 7.27 (dd, J=8.5, 2.0 Hz, 1H), 2.95 (t, J=6.0 Hz, 2H), 2.42 (t, J=6.0 Hz, 2H), 2.14-2.09 (m, 2H); ESI MS m/z 263 [M+H]+.

Reference： [1]Current Patent Assignee: HARMONY BIOSCIENCES - US2011/3793, 2011, A1 Location in patent: Page/Page column 48-49

11
[ 78863-99-7 ]
[ 1260493-91-1 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1: periodic acid / water; methanol / 0 - 20 °C 2: caesium carbonate / N,N-dimethyl-formamide / 4 h / 20 °C