Alternatived Products of [ 79757-31-6 ]
Product Details of [ 79757-31-6 ]
| CAS No. : | 79757-31-6 |
MDL No. : | MFCD07644551 |
| Formula : |
C9H10N2
|
Boiling Point : |
- |
| Linear Structure Formula : | - |
InChI Key : | - |
| M.W : |
146.19
|
Pubchem ID : | - |
| Synonyms : |
|
Safety of [ 79757-31-6 ]
| Signal Word: | |
Class: | |
| Precautionary Statements: | |
UN#: | |
| Hazard Statements: | |
Packing Group: | |
Application In Synthesis of [ 79757-31-6 ]
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
- Downstream synthetic route of [ 79757-31-6 ]
- 1
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[ 694-59-7 ]
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[ 78-67-1 ]
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[ 79757-31-6 ]
-
[ 81039-18-1 ]
| Yield | Reaction Conditions | Operation in experiment |
| 1: 1.5%
2: 3% |
In benzene for 5h; Heating; |
|
| 1: 3%
2: 1.5% |
In benzene for 5h; Heating; |
|
- 2
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[ 78-82-0 ]
-
[ 26156-84-3 ]
-
[ 79757-31-6 ]
| Yield | Reaction Conditions | Operation in experiment |
|
With benzyl peroxide; lithium diisopropyl amide 1.) THF, 25 deg C, 6 h, 2.) toluene, reflux, 16 h; Yield given. Multistep reaction; |
|
- 3
-
[ 13121-99-8 ]
-
[ 74-88-4 ]
-
[ 79757-31-6 ]
| Yield | Reaction Conditions | Operation in experiment |
| 90% |
With sodium tertiary butoxide In tetrahydrofuran at 20℃; |
19.1 first step:
2-(Pyridin-4-yl)acetonitrile (I-19-a) (0.9 g, 7.6 mmol) and iodomethane (3.5 g, 24.6 mmol) were added to 40 ml of tetrahydrofuran, followed by slow addition of tert. Sodium butoxide (2.7 g, 24.1 mmol) was stirred at room temperature overnight.The reaction solution was quenched by adding saturated brine, extracted once with ethyl acetate, the organic phase was washed twice with saturated brine, dried over anhydrous sodium sulfate, concentrated, and passed through a column (ethyl acetate: petroleum ether=0-70%) to obtain a brown color 1 g of oily 2-methyl-2-(pyridin-4-yl)propionitrile (I-19-b), yield 90%. |
- 4
-
[ 79757-31-6 ]
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2-methyl-2-(pyridin-4-yl)propanal
[ No CAS ]
| Yield | Reaction Conditions | Operation in experiment |
| 20% |
Stage #1: 2-methyl-2-(pyridin-4-yl)propionitrile With diisobutylaluminium hydride In tetrahydrofuran at -78 - 20℃;
Stage #2: With hydrogenchloride; lithium hydroxide monohydrate |
19.2 Step 2:
2-Methyl-2-(pyridin-4-yl)propionitrile (I-19-b) (1.2 g, 8.2 mmol) was added to 40 ml of tetrahydrofuran, followed by slow addition of diisobutyl hydrogenation at -78 °C Aluminum (20.5 ml, 20.5 mmol), stirred at this temperature for 2 h, then at room temperature overnight.The reaction solution was quenched by adding 2mol/L hydrochloric acid, extracted twice with ethyl acetate (3×30ml), dried over anhydrous sodium sulfate and concentrated, and separated by column chromatography (ethyl acetate:petroleum ether=0-60%) to obtain Brown oily substance 2-methyl-2-(pyridin-4-yl)propanal (I-19-c) 0.25 g, yield 20%. |
- 5
-
[ 79757-31-6 ]
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(6-(1-hydroxy-2-methyl-2-(pyridin-4-yl)propyl)pyridin-3-yl)carbamic acid tert-butyl ester
[ No CAS ]
| Yield | Reaction Conditions | Operation in experiment |
|
Multi-step reaction with 2 steps
1.1: diisobutylaluminium hydride / tetrahydrofuran / -78 - 20 °C
2.1: n-butyllithium / tetrahydrofuran / 1 h / -78 °C
2.2: -78 - 20 °C |
|
- 6
-
[ 79757-31-6 ]
-
tert-butyl (6-(2-methyl-2-(pyridin-4-yl)propionyl)pyridin-3-yl)carbamate
[ No CAS ]
| Yield | Reaction Conditions | Operation in experiment |
|
Multi-step reaction with 3 steps
1.1: diisobutylaluminium hydride / tetrahydrofuran / -78 - 20 °C
2.1: n-butyllithium / tetrahydrofuran / 1 h / -78 °C
2.2: -78 - 20 °C
3.1: 2-Iodobenzoic acid / ethyl acetate / Reflux |
|
- 7
-
[ 79757-31-6 ]
-
1-(5-aminopyridin-2-yl)-2-methyl-2-(pyridin-4-yl)propan-1-one
[ No CAS ]
| Yield | Reaction Conditions | Operation in experiment |
|
Multi-step reaction with 4 steps
1.1: diisobutylaluminium hydride / tetrahydrofuran / -78 - 20 °C
2.1: n-butyllithium / tetrahydrofuran / 1 h / -78 °C
2.2: -78 - 20 °C
3.1: 2-Iodobenzoic acid / ethyl acetate / Reflux
4.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C |
|
- 8
-
[ 79757-31-6 ]
-
C24H25N3O4S
[ No CAS ]
| Yield | Reaction Conditions | Operation in experiment |
|
Multi-step reaction with 5 steps
1.1: diisobutylaluminium hydride / tetrahydrofuran / -78 - 20 °C
2.1: n-butyllithium / tetrahydrofuran / 1 h / -78 °C
2.2: -78 - 20 °C
3.1: 2-Iodobenzoic acid / ethyl acetate / Reflux
4.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C
5.1: triethylamine; N-[(1H-1,2,3-benzotriazol-1-yloxy)(dimethylamino)methylene]-N-methylmethanaminium tetrafluoroborate / dichloromethane / 20 °C |
|
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