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[ CAS No. 80051-07-6 ]

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Chemical Structure| 80051-07-6
Chemical Structure| 80051-07-6
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CAS No. :80051-07-6 MDL No. :MFCD11505984
Formula : C10H13NO2 Boiling Point : -
Linear Structure Formula :- InChI Key :N/A
M.W :179.22 g/mol Pubchem ID :20134240
Synonyms :

Safety of [ 80051-07-6 ]

Signal Word:Warning Class:N/A
Precautionary Statements:P261-P305+P351+P338 UN#:N/A
Hazard Statements:H302-H315-H319-H335 Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 80051-07-6 ]

  • Upstream synthesis route of [ 80051-07-6 ]
  • Downstream synthetic route of [ 80051-07-6 ]

[ 80051-07-6 ] Synthesis Path-Upstream   1~5

  • 1
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YieldReaction ConditionsOperation in experiment
75% With methanol; sodium cyanoborohydride In tetrahydrofuran at 65℃; for 16 h; Methyl 4-acetylbenzoate (1.07 g, 6 mmol), methylamine (33 percent in EtOH, 4.5 mL), methylamine hydrochloride (1.62 g, 24.0 mmol) and sodium cyanoborohydride (0.56 g, 9.0 mmol) were dissolved in a mixture of THF (12 mL) and Methanol (7 mL) and the reaction stirred at 65 0C for 16 h. The reaction was concentrated in vacuo and the residue redissolved in DCM (20 mL) and washed with water (20 mL). The organic phase was dried over Na2SO4 and concentrated in vacuo to afford the title compound, which was used without further purification. Yield: 0.86 g, 75 percent LCMS method B: rt 0.98 min, 89 percent; m/z 194.05 (MH+, 100 percent).
Reference: [1] Patent: WO2010/20556, 2010, A1, . Location in patent: Page/Page column 169-170
  • 2
  • [ 74733-31-6 ]
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Reference: [1] Patent: WO2017/156179, 2017, A1, . Location in patent: Paragraph 00399; 00402; 00403
  • 3
  • [ 113023-73-7 ]
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Reference: [1] Journal of Medicinal Chemistry, 2017, vol. 60, # 18, p. 7703 - 7724
  • 4
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  • [ 80051-07-6 ]
Reference: [1] Journal of Medicinal Chemistry, 2017, vol. 60, # 18, p. 7703 - 7724
  • 5
  • [ 3609-53-8 ]
  • [ 80051-07-6 ]
Reference: [1] Patent: WO2017/156179, 2017, A1,
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