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Chemical Structure| 80322-74-3 Chemical Structure| 80322-74-3

Structure of 80322-74-3

Chemical Structure| 80322-74-3

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Product Details of [ 80322-74-3 ]

CAS No. :80322-74-3
Formula : C6H7Cl2NO
M.W : 180.03
SMILES Code : OC1=CC=CN=C1CCl.[H]Cl
MDL No. :MFCD18384628

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Application In Synthesis of [ 80322-74-3 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 80322-74-3 ]

[ 80322-74-3 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 14173-30-9 ]
  • [ 80322-74-3 ]
YieldReaction ConditionsOperation in experiment
83% With thionyl chloride; for 12h;Reflux; A suspension of 3-hydroxy-2-(hydroxymethyl)pyridine hydrochloride (2) (5.0 g, 31.0 mmol) in thionyl chloride (30 mL, 646.0 mmol) was refluxed for 12 h. Then, the reaction mixture was cooled to ~20 C. A precipitate was filtered off and washed with light petroleum ether. The yield was 4.60 g (83%), a white crystalline compound, m.p. 220 C (decomp.) (cf. Ref. 35: m.p. 160 C). 1H NMR (DMSO-d6), d: 4.92 (s, 2 H, CH2Cl); 7.74 (ABX-system, 1 H, 5-PyH, J1 = 8.4 Hz, J2 = 5.2 Hz); 7.97 (ABX-system, 1 H, 4-PyH, J = 8.4 Hz); 8.30 (ABX-system, 1 H, 6-PyH, J = = 5.2 Hz); 12.16 (br.s, 1 H, OH). 13C NMR (DMSO-d6), d: 37.67 (s, CH2Cl); 127.53 (s, CPyr); 130.09 (s, CPyr); 134.12 (s, CPyr); 139.18 (s, CPyr); 154.32 (s, CPyr).
 

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