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[ CAS No. 80351-58-2 ] {[proInfo.proName]}

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Chemical Structure| 80351-58-2
Chemical Structure| 80351-58-2
Structure of 80351-58-2 * Storage: {[proInfo.prStorage]}
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Product Details of [ 80351-58-2 ]

CAS No. :80351-58-2 MDL No. :MFCD22628354
Formula : C7H5BrF2O2S Boiling Point : -
Linear Structure Formula :- InChI Key :VYNTWHUALGNGNU-UHFFFAOYSA-N
M.W : 271.08 Pubchem ID :11119175
Synonyms :

Safety of [ 80351-58-2 ]

Signal Word:Warning Class:N/A
Precautionary Statements:P261-P305+P351+P338 UN#:N/A
Hazard Statements:H315-H319-H335 Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 80351-58-2 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Upstream synthesis route of [ 80351-58-2 ]
  • Downstream synthetic route of [ 80351-58-2 ]

[ 80351-58-2 ] Synthesis Path-Upstream   1~4

  • 1
  • [ 80351-58-2 ]
  • [ 108-95-2 ]
  • [ 458-92-4 ]
Reference: [1] Chemical Communications, 2007, # 48, p. 5149 - 5151
  • 2
  • [ 80351-58-2 ]
  • [ 1535-65-5 ]
YieldReaction ConditionsOperation in experiment
71% With n-butyllithium; chloro-trimethyl-silane In tetrahydrofuran at -78℃; for 6 h; To a solution of bromodifluoromethyl phenyl sulfone 9 (0.54 g, 2.00 mmol) and TMSCl (0.38 mL, 3.00 mmol) in dry THF cooled to -78 °C was added dropwise n-BuLi (1.6 M, 2.25 mL, 3.60 mmol). Reaction was stirred for 6 h at -78 °C. Saturated aqueous NH4Cl 15mL) was then added at -78 °C, the residue was brought to room temperature and extracted with Et2O (3 15 mL). The combined organic layers were washed with brine, water, then dried (Na2SO4) and concentrated under reduced pressure.The crude product was purified by silica gel column chromatography using CH2Cl2 and hexane as eluents (3:2). Rf = 0.38 (CH2Cl2/hexane,3:2).Yield: 0.27 g, 1.4 mmol, 71percent.
Reference: [1] European Journal of Organic Chemistry, 2012, # 30, p. 5943 - 5952,10
[2] European Journal of Organic Chemistry, 2012, # 30, p. 5943 - 5952
[3] Journal of Fluorine Chemistry, 2015, vol. 179, p. 175 - 178
[4] Tetrahedron Letters, 2005, vol. 46, # 48, p. 8273 - 8277
  • 3
  • [ 1073-67-2 ]
  • [ 80351-58-2 ]
  • [ 1535-65-5 ]
  • [ 1421521-00-7 ]
Reference: [1] European Journal of Organic Chemistry, 2012, # 30, p. 5943 - 5952,10
[2] European Journal of Organic Chemistry, 2012, # 30, p. 5943 - 5952
  • 4
  • [ 80351-58-2 ]
  • [ 802919-90-0 ]
Reference: [1] Synlett, 2011, # 7, p. 899 - 902
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