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Chemical Structure| 80548-40-9 Chemical Structure| 80548-40-9

Structure of 80548-40-9

Chemical Structure| 80548-40-9

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Product Details of [ 80548-40-9 ]

CAS No. :80548-40-9
Formula : C5H8O4S
M.W : 164.18
SMILES Code : O=C(C1CCCS1(=O)=O)O
MDL No. :MFCD20621123

Safety of [ 80548-40-9 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H315-H319-H335
Precautionary Statements:P261-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P362-P403+P233-P501

Application In Synthesis of [ 80548-40-9 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 80548-40-9 ]

[ 80548-40-9 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 126-33-0 ]
  • [ 124-38-9 ]
  • [ 80548-40-9 ]
YieldReaction ConditionsOperation in experiment
A solution of LDA, 2 M in THF (66.6 mL, 133 mmol) was added dropwise to a stirred solution of tetrahydrothiophene 1,1-dioxide (6.30 mL, 66.6 mmol) in THF (333 mL) at -78 C. and under N2. After 30 min, the yellow suspension was brought to RT for 10 min, and then cooled to -50 C. The nitrogen inlet was removed, and CO2 was bubbled through the suspension for 1 h. The reaction mixture became a white suspension, and this was allowed to warm gradually to RT and stir 3 d. The reaction was quenched with DI water, and the mixture was partitioned between water and EtOAc. The aqueous layer was washed with EtOAc (2×). The aqueous layer was acidified with 1 N and 6 N HCl and then extracted with chloroform (3×). NaCl (s) was added to the aqueous phase and it was again extracted with chloroform. The combined organic phase was dried over Na2SO4, filtered, and concentrated in vacuo to afford I-29A as a yellow oil. The crude product also contained unreacted starting material and residual solvent and was used without further purification. MS m/z 165.0 (M+1).
 

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