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Chemical Structure| 807382-47-4 Chemical Structure| 807382-47-4

Structure of 807382-47-4

Chemical Structure| 807382-47-4

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Product Details of [ 807382-47-4 ]

CAS No. :807382-47-4
Formula : C12H12O4
M.W : 220.22
SMILES Code : O=C(O)C1=CC=C(C2(C(OC)=O)CC2)C=C1

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Application In Synthesis of [ 807382-47-4 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 807382-47-4 ]

[ 807382-47-4 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 630384-36-0 ]
  • [ 201230-82-2 ]
  • [ 807382-47-4 ]
YieldReaction ConditionsOperation in experiment
97% With water; potassium carbonate;palladium diacetate; In DMF (N,N-dimethyl-formamide); at 20℃; under 760.051 Torr; Part A. 4-Iodophenylcyclopropyl acid, methyl ester (1.40 g, 4.63 mmol) was dissolved in DMF/H2O (1:2, v/v, 5 mL total) and K2CO3 (1.28 g, 9.26 mmol, 2 eq) and was added to a slurry of Pd(OAc)2 (2.08 g, 9.26 mmol, 2 eq) under CO atmosphere (1 atm). After overnight at rt, the mixture was quenched by diluting with EtOAc and H2O. The organic layer was washed with H2O (2*). The combined aqueous layers were acidified with conc. HCl, extracted with CH2Cl2 (3*), dried over MgSO4, filtered, and concentrated under vacuum overnight to give 4-(1-methoxycarbonyl-cyclopropyl)-benzoic acid (0.987 g, yield: 97%). 1H NMR (acetone-d6) delta 7.95 (d, J=8.1 Hz, 2H), 7.46 (d, J=8.1 Hz, 2H), 3.55 (s, 3H), 1.55 (m, 2H), 1.22 (m, 2H) ppm.
 

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