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Chemical Structure| 81102-83-2 Chemical Structure| 81102-83-2

Structure of 81102-83-2

Chemical Structure| 81102-83-2

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Product Details of [ 81102-83-2 ]

CAS No. :81102-83-2
Formula : C16H20N2
M.W : 240.34
SMILES Code : CC1=CC(NC2CCCCC2)=NC3=CC=CC=C13

Safety of [ 81102-83-2 ]

Application In Synthesis of [ 81102-83-2 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 81102-83-2 ]

[ 81102-83-2 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 931-53-3 ]
  • [ 52562-19-3 ]
  • [ 81102-83-2 ]
YieldReaction ConditionsOperation in experiment
61% With copper diacetate; palladium diacetate; 1,8-diazabicyclo[5.4.0]undec-7-ene; 1,2-bis-(diphenylphosphino)ethane; In acetonitrile; at 100℃; for 0.24h;Sealed tube; General procedure: General procedure for the palladium-catalyzed intermolecularoxidative cyclization of 2-vinylanilines with isocyanides to thesynthesis of 2-aminoquinolines: A mixture of 2-vinylaniline 1(0.2 mmol) and isocyanide 2 (0.4 mmol, 2.0 equiv), Pd(OAc)2(10 mol %), dppe (20 mol %), Cu(OAc)2 (0.4 mmol, 2.0 equiv), DBU(0.4 mmol, 2.0 equiv), and CH3CN (2 mL) were added into a sealedtube. The mixture was stirred at 100 C or about 24 h (monitored byTLC). After being cooling to room temperature, evaporation of thesolvent under reduced pressure followed purication by silica gel chromatography using petroleum ether/ethyl acetate (20:1 to 10:1)as eluent to provide the desired products 3.
 

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