[ CAS No. 81190-28-5 ] {[proInfo.proName]}

Name: 81190-28-5|3-Perfluorobutyl-1,2-epoxypropane|98%
Brand: Ambeed
SKU: A154803
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Quality Control of [ 81190-28-5 ]

COA NMR CNMR HPLC LC-MS

Related Doc. of [ 81190-28-5 ]

SDS Specification

Alternatived Products of [ 81190-28-5 ]

Product Details of [ 81190-28-5 ]

CAS No. :	81190-28-5	MDL No. :	MFCD00236085
Formula :	C₇H₅F₉O	Boiling Point :	-
Linear Structure Formula :	-	InChI Key :	WUKHWLIEBSRTRH-UHFFFAOYSA-N
M.W :	276.10	Pubchem ID :	2775819
Synonyms :

Calculated chemistry of [ 81190-28-5 ]

Physicochemical Properties

Num. heavy atoms :	17
Num. arom. heavy atoms :	0
Fraction Csp3 :	1.0
Num. rotatable bonds :	5
Num. H-bond acceptors :	10.0
Num. H-bond donors :	0.0
Molar Refractivity :	35.34
TPSA :	12.53 Å²

Pharmacokinetics

GI absorption :	Low
BBB permeant :	No
P-gp substrate :	No
CYP1A2 inhibitor :	No
CYP2C19 inhibitor :	Yes
CYP2C9 inhibitor :	No
CYP2D6 inhibitor :	No
CYP3A4 inhibitor :	No
Log Kp (skin permeation) :	-5.57 cm/s

Lipophilicity

Log Po/w (iLOGP) :	2.27
Log Po/w (XLOGP3) :	3.4
Log Po/w (WLOGP) :	7.03
Log Po/w (MLOGP) :	2.88
Log Po/w (SILICOS-IT) :	4.28
Consensus Log Po/w :	3.97

Druglikeness

Lipinski :	0.0
Ghose :	None
Veber :	0.0
Egan :	1.0
Muegge :	1.0
Bioavailability Score :	0.55

Water Solubility

Log S (ESOL) :	-3.36
Solubility :	0.119 mg/ml ; 0.000433 mol/l
Class :	Soluble
Log S (Ali) :	-3.34
Solubility :	0.125 mg/ml ; 0.000454 mol/l
Class :	Soluble
Log S (SILICOS-IT) :	-3.05
Solubility :	0.245 mg/ml ; 0.000887 mol/l
Class :	Soluble

Medicinal Chemistry

PAINS :	0.0 alert
Brenk :	2.0 alert
Leadlikeness :	0.0
Synthetic accessibility :	2.93

Safety of [ 81190-28-5 ]

Signal Word:	Danger	Class:	3
Precautionary Statements:	P210-P233-P240-P241+P242+P243-P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313-P403+P235-P501	UN#:	1993
Hazard Statements:	H225-H315-H319	Packing Group:	Ⅲ
GHS Pictogram:

Application In Synthesis of [ 81190-28-5 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Downstream synthetic route of [ 81190-28-5 ]

[ 81190-28-5 ] Synthesis Path-Downstream 1~66

1
[ 80233-96-1 ]
[ 81190-28-5 ]

Yield	Reaction Conditions	Operation in experiment
71%	With sodium hydroxide In water at 85℃; for 5h; Inert atmosphere;	2,2,3,3,4,4,5,5,5-Nonafluoropentyloxirane (2) Compound 1 (41.00 g, 0.10 mol) was placed in a 250 mL three-necked glass round-bottomed flask fitted with a thermometer jacket, dropping funnel, and a condenser and heated with stirring to 85°C. Aqueous NaOH (20 %, 30.00 g) was introduced using the dropping funnel. The reaction mixture was stirred for 5 h at 85°C. After cooling, the mixture was filtered and the organic phase was extracted with Et2O (3 x 50 mL) and the extracts were merged and washed with H2O (3 x 50 mL) and then dried by MgSO4. The epoxide was obtained after evaporating under reduced pressure (yields: 19.6 g, 71 %). νmax (KBr)/ cm-1 νCH 2938.6-3066.5, νC-F 1422.5, νC-O-C 1023.7-1134.7. δH (400 MHz, CDCl3) 2.24, 2.39 (2 x dm, 2H, CH2CF2), 2.60 (dd, 1H (a), CH2), 2.90 (t, 1H (b), CH2), 3.23 (dq, 1H, CH). δF (376 MHz, CDCl3) -81.7 (m, 3F, CF3), -114.3 (q, 2F, CF2), -125.1 (m, 2F, CF2), -126.6 (m, 2F, CF2).
71%	With sodium hydroxide In water at 85℃; for 5h; Inert atmosphere;	Synthesis of 3-perfluoro-n-butyl-1,2-epoxypropane (FBE) 41.00 g (0.10 mol) of compound FBIP was taken in a glassware and heated, while stirring, to 85 °C. Afterward, aqueous NaOH (20%, 30.00 g) was introduced into the dropping funnel. The reaction mixture was stirred for 5 h at 85 °C. After cooling, the mixture was filtered and the organic phase was extracted with Et2O and washed with H2O several times. After drying with MgSO4, the epoxide (a colorless oily liquid) was obtained after evaporating under reduce pressure with a yield of 71%. FT-IR (KBr): νCH 2938.6-3066.5 cm-1,νC-F 1422.5 cm-1, νC-O-C 1023.7-1134.7 cm-1. 1H NMR(400 MHz, CDCl3):δ 2.24, 2.39 (2 × dm, 2H, CH2CF2);2.60(dd, lH (a), CH2);2.90 (t, 1H (b), CH2);3.23 (dq, lH, CH).19F NMR (376 MHz, CDCl3):δ - 81.7 (m, 3F, CF3);- 114.3(q, 2F, CF2),- 125.1 (m, 2F, CF2),- 126.6 (m, 2F, CF2).
	With potassium hydroxide In dichloromethane for 1h; Yield given;

Reference： [1]Wang, Lei; Chen, Lei; Li, Zhanxiong [Australian Journal of Chemistry, 2018, vol. 71, # 11, p. 855 - 862]
[2]Zong, Yakun; Wang, Lei; Sun, Yi; Li, Zhanxiong [Chemical Papers, 2019, vol. 73, # 10, p. 2563 - 2574]
[3]Laurent, Philippe; Blancou, Hubert; Commeyras, Auguste [Journal of Fluorine Chemistry, 1993, vol. 64, # 1-2, p. 125 - 128]

2
[ 81190-28-5 ]
[ 125672-24-4 ]

Yield	Reaction Conditions	Operation in experiment
70%	With fluorhydrate de diisopropylamine at 110℃; for 3h;

Reference： [1]Chaabouni, Mohamed Moncef; Baklouti, Ahmed [Bulletin de la Societe Chimique de France, 1989, # 4, p. 549 - 553]

3
[ 110-91-8 ]
[ 81190-28-5 ]
1-Morpholino-4,4,5,5,6,6,7,7,7-nonafluoro-2-heptanol [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
97%	for 2h; Heating;

Reference： [1]Guyot, Bernard; Ameduri, Bruno; Boutevin, Bernard [Journal of Fluorine Chemistry, 1995, vol. 74, # 2, p. 233 - 240]

4
[ 83310-91-2 ]
[ 81190-28-5 ]

Yield	Reaction Conditions	Operation in experiment
55%	With potassium hydroxide In hexane for 16h; Heating;

Reference： [1]Guyot, Bernard; Ameduri, Bruno; Boutevin, Bernard [Journal of Fluorine Chemistry, 1995, vol. 74, # 2, p. 233 - 240]

5
[ 868-77-9 ]
[ 81190-28-5 ]
7,7,8,8,9,9,10,10,10-nonafluoro-5-hydroxy-3-oxadecyl methacrylate [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
92%	With di-tert-octylpyrocatechol; boron trifluoride diethyl etherate at 80℃; for 2h;

Reference： [1]Cirkva, Vladimir; Ameduri, Bruno; Boutevin, Bernard; Paleta, Oldrich [Journal of Fluorine Chemistry, 1997, vol. 84, # 1, p. 53 - 61]

6
[ 79-41-4 ]
[ 81190-28-5 ]
4,4,5,5,6,6,7,7,7-nonafluoro-2-hydroxyheptan-1-yl methacrylate [ No CAS ]
4,4,5,5,6,6,7,7,7-nonafluoro-1-hydroxyheptan-2-yl methacrylate [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	With di-tert-octylpyrocatechol; triethylamine at 100℃; for 2h; Yield given. Yields of byproduct given. Title compound not separated from byproducts;

Reference： [1]Cirkva, Vladimir; Ameduri, Bruno; Boutevin, Bernard; Paleta, Oldrich [Journal of Fluorine Chemistry, 1997, vol. 84, # 1, p. 53 - 61]

7
[ 591-87-7 ]
[ 423-39-2 ]
[ 81190-28-5 ]

Yield	Reaction Conditions	Operation in experiment
	With potassium hydroxide; Phthalic acid dibutyl ester 2.) hexane, reflux, 3 h; Yield given. Multistep reaction;

Reference： [1]Cirkva, Vladimir; Ameduri, Bruno; Boutevin, Bernard; Paleta, Oldrich [Journal of Fluorine Chemistry, 1997, vol. 83, # 2, p. 151 - 158]

8
[ 591-87-7 ]
[ 423-39-2 ]
[ 81190-28-5 ]
3-(Nonafluoro-n-butyl)prop-2-enol [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	With potassium hydroxide; Phthalic acid dibutyl ester 2.) Et₂O, reflux, 5 h; Yield given. Multistep reaction. Yields of byproduct given;

Reference： [1]Cirkva, Vladimir; Ameduri, Bruno; Boutevin, Bernard; Paleta, Oldrich [Journal of Fluorine Chemistry, 1997, vol. 83, # 2, p. 151 - 158]

9
[ 81190-28-5 ]
2-(2,2,3,3,4,4,5,5,5-nonafluoropentyl)thiirane [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
86%	With thiourea In methanol for 4h; Heating;

Reference： [1]Cirkva, Vladimir; Ameduri, Bruno; Boutevin, Bernard; Paleta, Oldrich [Journal of Fluorine Chemistry, 1997, vol. 84, # 1, p. 53 - 61]

10
[ 81190-28-5 ]
3-(Nonafluoro-n-butyl)prop-2-enol [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
9%	With potassium hydroxide In diethyl ether for 5h; Heating;

Reference： [1]Cirkva, Vladimir; Ameduri, Bruno; Boutevin, Bernard; Paleta, Oldrich [Journal of Fluorine Chemistry, 1997, vol. 83, # 2, p. 151 - 158]

11
[ 81190-28-5 ]
[ 67-64-1 ]
[ 196513-80-1 ]

Yield	Reaction Conditions	Operation in experiment
95%	With boron trifluoride diethyl etherate for 0.5h; Heating;

Reference： [1]Cirkva, Vladimir; Ameduri, Bruno; Boutevin, Bernard; Paleta, Oldrich [Journal of Fluorine Chemistry, 1997, vol. 84, # 1, p. 53 - 61]

12
[ 83310-91-2 ]
[ 81190-28-5 ]
3-(Nonafluoro-n-butyl)prop-2-enol [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
94%	With potassium hydroxide In hexane for 2.5h; Heating; Yields of byproduct given;

Reference： [1]Cirkva, Vladimir; Ameduri, Bruno; Boutevin, Bernard; Paleta, Oldrich [Journal of Fluorine Chemistry, 1997, vol. 83, # 2, p. 151 - 158]

13
[ 83310-91-2 ]
[ 81190-28-5 ]
3-(Nonafluoro-n-butyl)prop-2-enol [ No CAS ]
Acetic acid (E)-4,4,5,5,6,6,7,7,7-nonafluoro-hept-2-enyl ester [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
50%	With potassium hydroxide In diethyl ether for 5h; Heating; Yields of byproduct given;
	With potassium hydroxide In diethyl ether for 5h; Heating; various solvents and time;
	With potassium hydroxide In diethyl ether for 5h; Heating; Yield given. Title compound not separated from byproducts;

Reference： [1]Cirkva, Vladimir; Ameduri, Bruno; Boutevin, Bernard; Paleta, Oldrich [Journal of Fluorine Chemistry, 1997, vol. 83, # 2, p. 151 - 158]
[2]Cirkva, Vladimir; Ameduri, Bruno; Boutevin, Bernard; Paleta, Oldrich [Journal of Fluorine Chemistry, 1997, vol. 83, # 2, p. 151 - 158]
[3]Cirkva, Vladimir; Ameduri, Bruno; Boutevin, Bernard; Paleta, Oldrich [Journal of Fluorine Chemistry, 1997, vol. 83, # 2, p. 151 - 158]

14
[ 81190-28-5 ]
4,4,5,5,6,6,7,7,7-Nonafluoro-2-hydroxy-heptanoic acid [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
75%	With nitric acid; copper 1.) r.t., 12 h, 2.) 60-80 deg C, 48 h;

Reference： [1]Ould Amanetoullah; Chaabouni; Baklouti [Journal of Fluorine Chemistry, 1997, vol. 84, # 2, p. 149 - 153]

15
[ 423-39-2 ]
[ 107-18-6 ]
[ 375-17-7 ]
[ 307-34-6 ]
[ 72016-05-8 ]
[ 81190-28-5 ]

Yield	Reaction Conditions	Operation in experiment
1: 60% 2: 25% 3: 8% 4: 7%	With potassium hydroxide; 2,2'-azobis(isobutyronitrile) In 1,2-dichloro-ethane at 70℃; for 2h;

Reference： [1]Rubio; Blancou; Commeyras [Journal of Fluorine Chemistry, 2000, vol. 106, # 1, p. 1 - 5]

16
[ 3663-46-5 ]
[ 81190-28-5 ]
2,2,5-trimethyl-5-(6,6,7,7,8,8,9,9,9-nonafluoro-4-hydroxy-2-oxanonyl)-1,3-dioxane [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
82%	With boron trifluoride diethyl etherate at 90℃; for 2h;

Reference： [1]Cirkva, Vladimir; Kaplanek, Robert; Paleta, Oldrich; Kodicek, Milan [Collection of Czechoslovak Chemical Communications, 2002, vol. 67, # 10, p. 1436 - 1448]

17
[ 81190-28-5 ]
[ 100-79-8 ]
2,2-dimethyl-4-(6,6,7,7,8,8,9,9,9-nonafluoro-4-hydroxy-2-oxanonyl)-1,3-dioxolane [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
83%	With boron trifluoride diethyl etherate at 90℃; for 2h;

Reference： [1]Cirkva, Vladimir; Kaplanek, Robert; Paleta, Oldrich; Kodicek, Milan [Collection of Czechoslovak Chemical Communications, 2002, vol. 67, # 10, p. 1436 - 1448]

18
[ 87-99-0 ]
[ 81190-28-5 ]
[ 67-64-1 ]
2,3:4,5-di-O-isopropylidene-1-O-(4,4,5,5,6,6,7,7,7-nonafluoro-2-hydroxyheptyl)-DL-xylitol [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Stage #1: XYLITOL; acetone With hydrogen cation Stage #2: 3‑(perfluoro‑n‑butyl)‑1,2‑epoxypropane With boron trifluoride diethyl etherate In di-isopropyl ether for 10h; Heating;

Reference： [1]Církva, Vladimír; Polák, Radek; Paleta, Oldřich; Kefurt, Karel; Moravcová, Jitka; Kodíček, Milan; Forman, Stanislav [Carbohydrate Research, 2004, vol. 339, # 13, p. 2177 - 2185]

19
[ 81190-28-5 ]
[ 4064-06-6 ]
1,2:3,4-di-O-isopropylidene-6-O-(4,4,5,5,6,6,7,7,7-nonafluoro-2-hydroxyheptyl)-α-D-galactopyranose [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
73%	With boron trifluoride diethyl etherate In di-isopropyl ether for 5h; Heating;

20
[ 81190-28-5 ]
[ 60-24-2 ]
2-(2-hydroxy-4,4,5,5,6,6,7,7,7-nonafluoroheptylsulfanyl)ethanol [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
94%	In methanol for 24h; Heating;

Reference： [1]Kaplánek, Robert; Paleta, Oldřich [Journal of Fluorine Chemistry, 2007, vol. 128, # 7, p. 789 - 796]

21
[ 123-90-0 ]
[ 81190-28-5 ]
N-(2-hydroxy-4,4,5,5,6,6,7,7,7-nonafluoroheptyl)thiomorpholine [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
96%	In isopropyl alcohol for 24h; Heating;

Reference： [1]Kaplánek, Robert; Paleta, Oldřich [Journal of Fluorine Chemistry, 2007, vol. 128, # 7, p. 789 - 796]

22
[ 81190-28-5 ]
[ 124-40-3 ]
[ 1023972-12-4 ]

Yield	Reaction Conditions	Operation in experiment
98%	In ethanol at 60℃; for 2h;
	In methanol at 60℃;
	In methanol at 60℃;

Reference： [1]Kaplánek, Robert; Paleta, Oldřich [Journal of Fluorine Chemistry, 2007, vol. 128, # 7, p. 789 - 796]
[2]Padoan, Gennifer; De Givenchy, Elisabeth Taffin; Zaggia, Alessandro; Amigoni, Sonia; Darmanin, Thierry; Conte, Lino; Guittard, Frederic [Soft Matter, 2013, vol. 9, # 37, p. 8992 - 8999]
[3]Padoan, Gennifer; Darmanin, Thierry; Zaggia, Alessandro; Amigoni, Sonia; Conte, Lino; Guittard, Frédéric [Journal of Fluorine Chemistry, 2015, vol. 178, p. 241 - 248]

23
[ 81190-28-5 ]
1-O-(4,4,5,5,6,6,7,7,7-nonafluoro-2-hydroxyheptyl)-DL-xylitol [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1.1: H⁺ 1.2: BF₃*Et₂O / diisopropyl ether / 10 h / Heating 2.1: 75 percent / CF₃COOH / H₂O / 0.5 h / 20 °C

24
[ 81190-28-5 ]
6-O-(4,4,5,5,6,6,7,7,7-nonafluoro-2-hydroxyheptyl)-D-galactopyranose [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1: 73 percent / BF₃*Et₂O / diisopropyl ether / 5 h / Heating 2: 85 percent / CF₃COOH / H₂O / 0.5 h / 20 °C

25
[ 81190-28-5 ]
8,8,9,9,10,10,11,11,11-nonafluoro-4-oxaundecane-1,2,6-triol [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1: 83 percent / BF₃*Et₂O / 2 h / 90 °C 2: 89 percent / aq. HCl / methanol / 2 h / Heating

Reference： [1]Cirkva, Vladimir; Kaplanek, Robert; Paleta, Oldrich; Kodicek, Milan [Collection of Czechoslovak Chemical Communications, 2002, vol. 67, # 10, p. 1436 - 1448]

26
[ 81190-28-5 ]
8,8,9,9,10,10,11,11,11-nonafluoro-2-hydroxymethyl-2-methyl-4-oxaundecane-1,6-diol [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1: 82 percent / BF₃*Et₂O / 2 h / 90 °C 2: 88 percent / aq. HCl / methanol / 2 h / Heating

Reference： [1]Cirkva, Vladimir; Kaplanek, Robert; Paleta, Oldrich; Kodicek, Milan [Collection of Czechoslovak Chemical Communications, 2002, vol. 67, # 10, p. 1436 - 1448]

27
[ 81190-28-5 ]
4,4,5,5,6,6,7,7,7-Nonafluoro-2-hydroxy-heptanoic acid methyl ester [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1: 75 percent / Cu, 60percent aq. HNO₃ / 1.) r.t., 12 h, 2.) 60-80 deg C, 48 h 2: 91 percent / conc. H₂SO₄ / 5 h / Heating

Reference： [1]Ould Amanetoullah; Chaabouni; Baklouti [Journal of Fluorine Chemistry, 1997, vol. 84, # 2, p. 149 - 153]

28
[ 81190-28-5 ]
[ 125070-38-4 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1: 95 percent / BF₃*Et₂O / 0.5 h / Heating 2: 96 percent / aq. HCl, MeOH / 2 h / Heating

Reference： [1]Cirkva, Vladimir; Ameduri, Bruno; Boutevin, Bernard; Paleta, Oldrich [Journal of Fluorine Chemistry, 1997, vol. 84, # 1, p. 53 - 61]

29
[ 81190-28-5 ]
4,4,5,5,6,6,7,7,7-nonafluoroheptane-1,2-diyl bis-methacrylate [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 3 steps 1: 95 percent / BF₃*Et₂O / 0.5 h / Heating 2: 96 percent / aq. HCl, MeOH / 2 h / Heating 3: 81 percent / Et₃N, di-tert-octylpyrocatechol / diethyl ether / 2 h / Ambient temperature

Reference： [1]Cirkva, Vladimir; Ameduri, Bruno; Boutevin, Bernard; Paleta, Oldrich [Journal of Fluorine Chemistry, 1997, vol. 84, # 1, p. 53 - 61]

30
[ 81190-28-5 ]
1-Morpholinomethyl-3,3,4,4,5,5,6,6,6-nonafluorohexyl methacrylate [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1: 97 percent / 2 h / Heating 2: 90 percent / CH₂Cl₂ / 5 h / Heating

Reference： [1]Guyot, Bernard; Ameduri, Bruno; Boutevin, Bernard [Journal of Fluorine Chemistry, 1995, vol. 74, # 2, p. 233 - 240]

Yield	Reaction Conditions	Operation in experiment
		Preferable examples of epoxide D may include 3-trifluoromethyl-1,2-epoxypropane, 3-perfluoroethyl-1,2-epoxypropane, 3-perfluoropropyl-1,2-epoxypropane, 3-perfluorobutyl-1,2-epoxypropane, 3-perfluoropentyl-1,2-epoxypropane, 3-perfluorohexyl-1,2-epoxypropane, 3-perfluoroheptyl-1,2-epoxypropane, 3-perfluorooctyl-1,2-epoxypropane, 3-perfluorononyl-1,2-epoxypropane, ...

32
[ 81190-28-5 ]
(+)-3-(nonafluorobutyl)-1,2-epoxypropane [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
4.9%	With water In acetic acid; toluene at 0℃; for 7h;

Reference： [1]Sakakibara, Ken; Nakano, Koji; Nozaki, Kyoko [Chemical Communications, 2006, # 31, p. 3334 - 3336]

33
[ 81190-28-5 ]
poly[3-(nonafluorobutyl)-1,2-epoxypropane], atactic, M_n = 11000 g/mol, M_w/M_n = 1.9; monomer(s): (+)-3-(nonafluorobutyl)-1,2-epoxypropane [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
33%	With triisobutylaluminum In Hexafluorobenzene; toluene at 0℃; for 2h;

Reference： [1]Sakakibara, Ken; Nakano, Koji; Nozaki, Kyoko [Chemical Communications, 2006, # 31, p. 3334 - 3336]

34
[ 81190-28-5 ]
poly[3-(nonafluorobutyl)-1,2-epoxypropane], atactic, M_n = 14000 g/mol, M_w/M_n = 2.1; monomer(s): (+)-3-(nonafluorobutyl)-1,2-epoxypropane [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
95%	With triisobutylaluminum In Hexafluorobenzene; toluene at 0℃; for 1h;

Reference： [1]Sakakibara, Ken; Nakano, Koji; Nozaki, Kyoko [Chemical Communications, 2006, # 31, p. 3334 - 3336]

35
[ 81190-28-5 ]
poly[3-(nonafluorobutyl)-1,2-epoxypropane], atactic, M_n = 17000 g/mol, M_w/M_n = 1.8; monomer(s): (+)-3-(nonafluorobutyl)-1,2-epoxypropane [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
29%	With triisobutylaluminum In Hexafluorobenzene; toluene at 0℃; for 2h;

Reference： [1]Sakakibara, Ken; Nakano, Koji; Nozaki, Kyoko [Chemical Communications, 2006, # 31, p. 3334 - 3336]

36
[ 201230-82-2 ]
[ 81190-28-5 ]
4-(2,2,3,3,4,4,5,5,5-nonafluoropentyl)-2-propiolactone [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
85%	In 1,2-dimethoxyethane at 25℃; for 6h;
84%	With [N,N'-bis(3,5-di-tert-butylsalicylidene)-1,2-phenylenediaminochromium-di-tetrahydrofuran]tetracarbonylcobaltate In 1,2-dimethoxyethane at 20 - 26℃; for 6h; Autoclave;

Reference： [1]Kramer, John W.; Coates, Geoffrey W. [Tetrahedron, 2008, vol. 64, # 29, p. 6973 - 6978]
[2]Location in patent: experimental part Kramer, John W.; Treitler, Daniel S.; Coates, Geoffrey W.; Denmark, Scott E.; Hoover, Andrew J. [Organic Syntheses, 2009, vol. 86, p. 287 - 297]

37
[ 141-97-9 ]
[ 81190-28-5 ]
cis-3-acetyl-5-(2,2,3,3,4,4,5,5,5-nonafluoropentyl)tetrahydrofuran-2-one [ No CAS ]
trans-3-acetyl-5-(2,2,3,3,4,4,5,5,5-nonafluoropentyl)tetrahydrofuran-2-one [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Stage #1: ethyl acetoacetate; 3‑(perfluoro‑n‑butyl)‑1,2‑epoxypropane With sodium ethanolate In ethanol Stage #2: With acetic acid In ethanol

Reference： [1]Location in patent: experimental part Kodess; Matochkina; Bazhin; Gorbunova; Zapevalov [Russian Journal of General Chemistry, 2009, vol. 79, # 4, p. 800 - 807]

38
[ 111-77-3 ]
[ 81190-28-5 ]
[ 1185746-40-0 ]

Yield	Reaction Conditions	Operation in experiment
93%	With boron trifluoride diethyl etherate at 100℃; for 10h; Inert atmosphere; regioselective reaction;

Reference： [1]Location in patent: experimental part Kaplánek, Robert; Paleta, Oldřich; Ferjentsiková, Ivana; Kodíček, Milan [Journal of Fluorine Chemistry, 2009, vol. 130, # 3, p. 308 - 316]

39
[ 1232237-15-8 ]
[ 81190-28-5 ]
[ 1232237-16-9 ]

Yield	Reaction Conditions	Operation in experiment
86%	In ethanol for 8h; Reflux;

Reference： [1]Location in patent: experimental part Kaplánek, Robert; Polák, Radek; Paleta, Oldřich; Kefurt, Karel; Moravcová, Jitka; Křenová, Iva; Kodíček, Milan [Carbohydrate Research, 2010, vol. 345, # 8, p. 1008 - 1014]

40
[ 488-43-7 ]
[ 81190-28-5 ]
[ 1232237-25-0 ]

Yield	Reaction Conditions	Operation in experiment
98%	In 2,2,2-trifluoroethanol for 6h; Reflux;

41
[ 6284-40-8 ]
[ 81190-28-5 ]
[ 1232237-23-8 ]

Yield	Reaction Conditions	Operation in experiment
91%	In ethanol for 6h; Reflux;

Yield	Reaction Conditions	Operation in experiment
	With 1-vinylimidazole at 20 - 250℃;

43
[ 81190-28-5 ]
1-trimethylammonium-4,4,5,5,6,6,7,7,7-nonafluoroheptan-2-ol, iodide [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1: methanol / 60 °C 2: acetonitrile / 24 h / 60 °C
	Multi-step reaction with 2 steps 1: methanol / 60 °C 2: 60 °C

Reference： [1]Padoan, Gennifer; De Givenchy, Elisabeth Taffin; Zaggia, Alessandro; Amigoni, Sonia; Darmanin, Thierry; Conte, Lino; Guittard, Frederic [Soft Matter, 2013, vol. 9, # 37, p. 8992 - 8999]
[2]Padoan, Gennifer; Darmanin, Thierry; Zaggia, Alessandro; Amigoni, Sonia; Conte, Lino; Guittard, Frédéric [Journal of Fluorine Chemistry, 2015, vol. 178, p. 241 - 248]

44
[ 81190-28-5 ]
1-diethylmethylammonium-4,4,5,5,6,6,7,7,7-nonafluoroheptan-2-ol, iodide [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1: methanol / 60 °C 2: acetonitrile / 24 h / 60 °C
	Multi-step reaction with 2 steps 1: methanol / 60 °C 2: 60 °C

45
[ 81190-28-5 ]
[ 109-89-7 ]
1-diethylamino-4,4,5,5,6,6,7,7,7-nonafluoroheptan-2-ol [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	In methanol at 60℃;
	In methanol at 60℃;

46
[ 142-84-7 ]
[ 81190-28-5 ]
1-dipropylamino-4,4,5,5,6,6,7,7,7-nonafluoroheptan-2-ol [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	In methanol at 60℃;