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Structure of 813433-76-0

Chemical Structure| 813433-76-0

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Product Details of [ 813433-76-0 ]

CAS No. :813433-76-0
Formula : C11H21NO4
M.W : 231.29
SMILES Code : OCC[C@@H]1N(C(OC(C)(C)C)=O)CCOC1
MDL No. :MFCD12406993
InChI Key :ISQYKHGGGYDEKA-VIFPVBQESA-N
Pubchem ID :44182330

Safety of [ 813433-76-0 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P264-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P330-P332+P313-P337+P313-P362-P403+P233-P405-P501

Application In Synthesis of [ 813433-76-0 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 813433-76-0 ]

[ 813433-76-0 ] Synthesis Path-Downstream   1~9

  • 1
  • [ 108-95-2 ]
  • [ 813433-76-0 ]
  • 3-(2-phenoxy-ethyl)-morpholine-4-carboxylic acid <i>tert</i>-butyl ester [ No CAS ]
  • 3
  • [ 761460-04-2 ]
  • [ 813433-76-0 ]
  • 4
  • [ 24424-99-5 ]
  • 1.) NaH; 2.) SOCl2 [ No CAS ]
  • [ 813433-76-0 ]
  • 5
  • [ 81684-84-6 ]
  • [ 813433-76-0 ]
  • 6
  • [ 86236-84-2 ]
  • [ 813433-76-0 ]
  • 7
  • [ 813433-72-6 ]
  • [ 813433-76-0 ]
  • 8
  • [ 1000806-54-1 ]
  • (5R)-N-tert-butoxycarbonyl-5-(2-hydroxyethyl)morpholine [ No CAS ]
  • [ 813433-76-0 ]
YieldReaction ConditionsOperation in experiment
1.04 g General procedure: To a solution of the Compound 1 (1.46 g) in1 ,2-dimethoxyethane (10 mE) were added N-methylmorpholine (604 tE) and isobutyl chloroformate (714 tE) under ice-cooling, and the resulting mixture was stirred at the same temperature for 40 minutes. The precipitated insoluble matters were removed by filtration, and to the resulting filtrate was added a solution of sodium borohydride (284 mg) in water (5 mE) under ice-cooling, and the resulting mixture was stirred at the same temperature for 2 hours. To the reaction mixture were added water and ethyl acetate, and the resulting mixture was stirred, and then the resulting organic layers were separated, dried, and then concentrated under reduced pressure. The resulting residues were purified by NH silica gel colunm chromatography (hexane:ethyl acetate=90: 10 to 60:40) and silica gel colunm chromatography (hexane:ethyl acetate=85: 15 to 60:40) to give the Compound 2 (1.15 g) as a colorless solid. MS (APCI): mlz 278 [M+H]
1.04 g General procedure: Compound 1 (1.46 g) in 1,2-dimethoxyethane (10 mL)N-methylmorpholine (604 μL) and isobutyl chloroformate (714 μL) were added to the solution under ice cooling,And the mixture was stirred at the same temperature for 40 minutes.The precipitated unnecessary substances were filtered off,Sodium borohydride (284 mg) was added to the filtrate under ice cooling,(5 mL), and the mixture was stirred at the same temperature for 2 hours.Water and ethyl acetate were added to the reaction mixture, and after stirring,The organic layer was separated,After drying,And concentrated under reduced pressure.The residue was purified by NH silica gel column chromatography (hexane: ethyl acetate = 90: 10 to 60:40) and silica gel column chromatography (hexane: ethyl acetate = 85: 15 to 60: 40)To obtain Compound 2 (1.15 g)As a colorless solid
 

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Technical Information

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Related Parent Nucleus of
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Morpholines

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