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CAS No. : | 81569-41-7 | MDL No. : | MFCD27958715 |
Formula : | C9H12BrNO2S | Boiling Point : | - |
Linear Structure Formula : | - | InChI Key : | - |
M.W : | 278.17 | Pubchem ID : | - |
Synonyms : |
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Signal Word: | Class: | ||
Precautionary Statements: | UN#: | ||
Hazard Statements: | Packing Group: |
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
53% | With sulfuric acid; magnesium sulfate In dichloromethane at 20℃; for 12h; Inert atmosphere; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
39.7% | With dmap In <i>tert</i>-butyl alcohol at 30℃; for 3h; | 24.B Step B. Synthesis of tert-butyl 2-bromo-4-methylthiazole-5-carboxylate. To a solution of 2-bromo-4-methylthiazole-5-carboxylic acid (80 mg 0.36 mmol) in t-BuOH (10 mL) was added (Boc)2O (157 mg 0.72 mmol) and DMAP(13 mg, 0.108 mmol). The reaction mixture was stirred at 30°C for 3 hrs. The reaction mixture was partitioned between EtOAc (50 mL) and water (15 mL). The organic layer was washed with brine (20 mL), dried over Na2SO4, filtered, concentrated to dryness and the residue was purified by by flash column chromatography on silica gel (PE/EA=12:1) to afford tert-butyl 2-bromo-4-methylthiazole-5-carboxylate (40mg, 39.7% yield) as a white solid. LCMS (M+1): 279. |