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[ CAS No. 81569-41-7 ] {[proInfo.proName]}

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Chemical Structure| 81569-41-7
Chemical Structure| 81569-41-7
Structure of 81569-41-7 * Storage: {[proInfo.prStorage]}
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Product Details of [ 81569-41-7 ]

CAS No. :81569-41-7 MDL No. :MFCD27958715
Formula : C9H12BrNO2S Boiling Point : -
Linear Structure Formula :- InChI Key :-
M.W : 278.17 Pubchem ID :-
Synonyms :

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Application In Synthesis of [ 81569-41-7 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 81569-41-7 ]

[ 81569-41-7 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 40003-41-6 ]
  • [ 75-65-0 ]
  • [ 81569-41-7 ]
YieldReaction ConditionsOperation in experiment
53% With sulfuric acid; magnesium sulfate In dichloromethane at 20℃; for 12h; Inert atmosphere;
  • 2
  • [ 40003-41-6 ]
  • [ 24424-99-5 ]
  • [ 81569-41-7 ]
YieldReaction ConditionsOperation in experiment
39.7% With dmap In <i>tert</i>-butyl alcohol at 30℃; for 3h; 24.B Step B. Synthesis of tert-butyl 2-bromo-4-methylthiazole-5-carboxylate. To a solution of 2-bromo-4-methylthiazole-5-carboxylic acid (80 mg 0.36 mmol) in t-BuOH (10 mL) was added (Boc)2O (157 mg 0.72 mmol) and DMAP(13 mg, 0.108 mmol). The reaction mixture was stirred at 30°C for 3 hrs. The reaction mixture was partitioned between EtOAc (50 mL) and water (15 mL). The organic layer was washed with brine (20 mL), dried over Na2SO4, filtered, concentrated to dryness and the residue was purified by by flash column chromatography on silica gel (PE/EA=12:1) to afford tert-butyl 2-bromo-4-methylthiazole-5-carboxylate (40mg, 39.7% yield) as a white solid. LCMS (M+1): 279.
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