Home Cart 0 Sign in  
X

[ CAS No. 81748-72-3 ] {[proInfo.proName]}

,{[proInfo.pro_purity]}
Cat. No.: {[proInfo.prAm]}
3d Animation Molecule Structure of 81748-72-3
Chemical Structure| 81748-72-3
Chemical Structure| 81748-72-3
Structure of 81748-72-3 * Storage: {[proInfo.prStorage]}
Cart0 Add to My Favorites Add to My Favorites Bulk Inquiry Inquiry Add To Cart

Quality Control of [ 81748-72-3 ]

Related Doc. of [ 81748-72-3 ]

Alternatived Products of [ 81748-72-3 ]

Product Details of [ 81748-72-3 ]

CAS No. :81748-72-3 MDL No. :MFCD06740638
Formula : C10H10N2O Boiling Point : -
Linear Structure Formula :- InChI Key :KMNQWCOAYXOQKY-UHFFFAOYSA-N
M.W : 174.20 Pubchem ID :23008755
Synonyms :

Safety of [ 81748-72-3 ]

Signal Word:Warning Class:
Precautionary Statements:P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P330-P362-P403+P233-P501 UN#:
Hazard Statements:H302-H312-H332 Packing Group:
GHS Pictogram:

Application In Synthesis of [ 81748-72-3 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 81748-72-3 ]

[ 81748-72-3 ] Synthesis Path-Downstream   1~41

  • 1
  • <i>N</i>-(8-hydroxy-[5]quinolylmethyl)-benzamide [ No CAS ]
  • [ 81748-72-3 ]
YieldReaction ConditionsOperation in experiment
With hydrogenchloride
YieldReaction ConditionsOperation in experiment
8-Hydroxy-5-acetaminomethyl-chinolin, HCl, Hydrolyse (als Dihydrochlorid);
  • 3
  • [ 148-24-3 ]
  • [ 81748-72-3 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 2 steps 1: H2SO4 2: concentrated aqueous HCl
Multi-step reaction with 3 steps 1: hydrogenchloride / water / 12 h / 20 °C 2: N,N-dimethyl-formamide / 5 h / 150 °C 3: hydrogenchloride / water / 20 °C / Reflux
  • 4
  • [ 81748-72-3 ]
  • [ 777085-55-9 ]
  • C20H24N4O3S [ No CAS ]
YieldReaction ConditionsOperation in experiment
66% With HBTU; N-ethyl-N,N-diisopropylamine In dimethyl sulfoxide; N,N-dimethyl-formamide at 20℃;
  • 5
  • [ 81748-72-3 ]
  • [ 1094606-91-3 ]
  • [ 1094606-82-2 ]
YieldReaction ConditionsOperation in experiment
49% With HBTU; N-ethyl-N,N-diisopropylamine In dimethyl sulfoxide; N,N-dimethyl-formamide
  • 6
  • [ 81748-72-3 ]
  • Fmoc-Glu(O-t-Bu)-NHS [ No CAS ]
  • C34H35N3O6 [ No CAS ]
YieldReaction ConditionsOperation in experiment
With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide
  • 7
  • C40H36BN8O4(1-)*Li(1+) [ No CAS ]
  • [ 81748-72-3 ]
YieldReaction ConditionsOperation in experiment
With water In methanol
  • 8
  • [ 10136-57-9 ]
  • [ 81748-72-3 ]
YieldReaction ConditionsOperation in experiment
70% Stage #1: 5-(chloromethyl)quinolin-8-ol With hexamethylenetetramine In dimethyl sulfoxide at 20℃; Stage #2: With hydrogenchloride In water at 20℃; for 48h;
Stage #1: 5-(chloromethyl)quinolin-8-ol With potassium phtalimide In N,N-dimethyl-formamide at 150℃; for 5h; Stage #2: With hydrogenchloride In water at 150℃; for 9h;
Multi-step reaction with 2 steps 1: N,N-dimethyl-formamide / 5 h / 150 °C 2: hydrogenchloride / water / 20 °C / Reflux
  • 9
  • [ 81748-72-3 ]
  • [ 1078-61-1 ]
  • [ 1094606-80-0 ]
YieldReaction ConditionsOperation in experiment
41% Stage #1: 5-(aminomethyl)-8-hydroxyquinoline; dihydrocaffeic acid With HBTU; N-ethyl-N,N-diisopropylamine In dimethyl sulfoxide; N,N-dimethyl-formamide Stage #2: With trifluoroacetic acid In dimethyl sulfoxide
  • 10
  • [ 81748-72-3 ]
  • [ 28920-43-6 ]
  • (9H-fluoren-9-yl)methyl (8-hydroxyquinolin-5-yl)methylcarbamate [ No CAS ]
YieldReaction ConditionsOperation in experiment
64% With sodium hydrogencarbonate In water; N,N-dimethyl-formamide
  • 11
  • [ 81748-72-3 ]
  • [ 59-30-3 ]
  • C29H27N9O6 [ No CAS ]
YieldReaction ConditionsOperation in experiment
59% With HBTU; N-ethyl-N,N-diisopropylamine In dimethyl sulfoxide; N,N-dimethyl-formamide
  • 12
  • [ 81748-72-3 ]
  • [ 84889-09-8 ]
  • C43H38N4O5 [ No CAS ]
  • 13
  • [ 81748-72-3 ]
  • [ 760190-09-8 ]
  • [ 1094606-83-3 ]
YieldReaction ConditionsOperation in experiment
98.6 mg With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide
  • 17
  • [ 81748-72-3 ]
  • [ 292638-85-8 ]
  • [ 1283093-93-5 ]
YieldReaction ConditionsOperation in experiment
In methanol at 20℃; for 24h;
  • 18
  • 2-((8-hydroxyquinolin-5-yl)methyl)isoindoline-1,3-dione [ No CAS ]
  • [ 81748-72-3 ]
YieldReaction ConditionsOperation in experiment
80% With hydrogenchloride In water at 20℃; Reflux;
75% With hydrogenchloride for 12h; Reflux; 5 Example 5 5-(Aminomethyl)quinoline-8-ol Add 2-(((8-hydroxyquinolin-5-yl)methyl)isoindolin-1,3-dione (780 mg, 2.56 mmol) to concentrated hydrochloric acid (50 mL). Heat to reflux After 12 hours, the solution changed from turbid to clear, and the reaction was completed.After cooling to room temperature, the solid obtained after vacuum drying was dissolved in water, sodium bicarbonate solution was added to adjust the pH to neutral, and then suction filtered to obtain 334.47 mg of brown solid with a yield of 75%.
  • 19
  • [ 81748-72-3 ]
  • [ 3140-75-8 ]
  • C54H39N9O6 [ No CAS ]
  • 20
  • [ 81748-72-3 ]
  • [ 951-82-6 ]
  • C21H22N2O5 [ No CAS ]
YieldReaction ConditionsOperation in experiment
With sodium hydrogencarbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; ethyl cyanoglyoxylate-2-oxime In water; N,N-dimethyl-formamide at 20℃; for 12h; Inert atmosphere; General procedure for synthesis of 5a-5f General procedure: To a stirred solution of compound 4 (1.0mmol, 140mg) or 5-amino-8-hydroxyquinoline dihydrochloride and carboxylic acid (1.2mmol) in DMF-H2O (1:5) were added oxyma (2.0mmol, 284mg), EDCI (2.0mmol, 310mg), and NaHCO3 (6.0mmol, 636mg). After stirring at room temperature for 12h, the solution was extracted with EtOAc. The combined organic layers were washed with brine (3mL), and then dried over Na2SO4. Concentration of organic phase gave crude product which was directly used for next step without purification.
  • 21
  • [ 81748-72-3 ]
  • [ 104-03-0 ]
  • C18H15N3O4 [ No CAS ]
YieldReaction ConditionsOperation in experiment
With sodium hydrogencarbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; ethyl cyanoglyoxylate-2-oxime In water; N,N-dimethyl-formamide Inert atmosphere; General procedure for synthesis of 5a-5f General procedure: To a stirred solution of compound 4 (1.0mmol, 140mg) or 5-amino-8-hydroxyquinoline dihydrochloride and carboxylic acid (1.2mmol) in DMF-H2O (1:5) were added oxyma (2.0mmol, 284mg), EDCI (2.0mmol, 310mg), and NaHCO3 (6.0mmol, 636mg). After stirring at room temperature for 12h, the solution was extracted with EtOAc. The combined organic layers were washed with brine (3mL), and then dried over Na2SO4. Concentration of organic phase gave crude product which was directly used for next step without purification.
  • 22
  • [ 81748-72-3 ]
  • [ 405-50-5 ]
  • C18H15FN2O2 [ No CAS ]
YieldReaction ConditionsOperation in experiment
With sodium hydrogencarbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; ethyl cyanoglyoxylate-2-oxime In water; N,N-dimethyl-formamide Inert atmosphere; General procedure for synthesis of 5a-5f General procedure: To a stirred solution of compound 4 (1.0mmol, 140mg) or 5-amino-8-hydroxyquinoline dihydrochloride and carboxylic acid (1.2mmol) in DMF-H2O (1:5) were added oxyma (2.0mmol, 284mg), EDCI (2.0mmol, 310mg), and NaHCO3 (6.0mmol, 636mg). After stirring at room temperature for 12h, the solution was extracted with EtOAc. The combined organic layers were washed with brine (3mL), and then dried over Na2SO4. Concentration of organic phase gave crude product which was directly used for next step without purification.
  • 23
  • [ 81748-72-3 ]
  • [ 32857-62-8 ]
  • C19H15F3N2O2 [ No CAS ]
YieldReaction ConditionsOperation in experiment
With sodium hydrogencarbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; ethyl cyanoglyoxylate-2-oxime In water; N,N-dimethyl-formamide Inert atmosphere; General procedure for synthesis of 5a-5f General procedure: To a stirred solution of compound 4 (1.0mmol, 140mg) or 5-amino-8-hydroxyquinoline dihydrochloride and carboxylic acid (1.2mmol) in DMF-H2O (1:5) were added oxyma (2.0mmol, 284mg), EDCI (2.0mmol, 310mg), and NaHCO3 (6.0mmol, 636mg). After stirring at room temperature for 12h, the solution was extracted with EtOAc. The combined organic layers were washed with brine (3mL), and then dried over Na2SO4. Concentration of organic phase gave crude product which was directly used for next step without purification.
  • 24
  • [ 4053-45-6 ]
  • [ 81748-72-3 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 2 steps 1: sodium azide / acetone / 20 h / Reflux; Inert atmosphere 2: palladium 10% on activated carbon; hydrogen / ethyl acetate / Reflux
  • 25
  • [ 1005143-73-6 ]
  • [ 81748-72-3 ]
YieldReaction ConditionsOperation in experiment
68% With palladium 10% on activated carbon; hydrogen In ethyl acetate Reflux; 38 Synthesis of 91 5-(aminomethyl)quinolin-8-ol (4) A suspension of azide 88 3 (2.00g, 10mol) and 10% 92 Pd/C (0.15g) in 93 ethylacetate (15mL) was hydrogenated overnight, the reaction mixture was filtered off and washed with dichloromethane-methanol (1:1). The combined filtration was evaporated under vacuum to give the oily crude which was purified with flash chromatography on silica. Compound 4 was eluted out with dichloromethane/94 methanol (15:0-10:1) (1.18g, 68%). 1H NMR (400MHz, DMSO-d6) δ 8.86 (dd, J=4.1, 1.6Hz, 1H), 8.57 (dd, J=8.6, 1.6Hz, 1H), 7.58 (dd, J=8.5, 4.1Hz, 1H), 7.44 (dd, J=7.8, 0.9Hz, 1H), 7.02 (d, J=7.8Hz, 1H), 4.10 (d, J=0.8Hz, 2H).
With water; triphenylphosphine In tetrahydrofuran at 20℃; for 24h;
  • 26
  • [ 81748-72-3 ]
  • N-((8-hydroxy-7-(pyrrolidin-1-ylmethyl)quinolin-5-yl)methyl)-2-(3,4,5-trimethoxyphenyl)acetamide [ No CAS ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 2 steps 1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium hydrogencarbonate; ethyl cyanoglyoxylate-2-oxime / N,N-dimethyl-formamide; water / 12 h / 20 °C / Inert atmosphere 2: ethanol / Reflux; Inert atmosphere
  • 27
  • [ 81748-72-3 ]
  • N-((8-hydroxy-7-(pyrrolidin-1-ylmethyl)quinolin-5-yl)methyl)-2-(4-nitrophenyl)acetamide [ No CAS ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 2 steps 1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium hydrogencarbonate; ethyl cyanoglyoxylate-2-oxime / N,N-dimethyl-formamide; water / Inert atmosphere 2: ethanol / Reflux; Inert atmosphere
  • 28
  • [ 81748-72-3 ]
  • 2-(4-fluorophenyl)-N-((8-hydroxy-7-(pyrrolidin-1-ylmethyl)quinolin-5-yl)methyl)acetamide [ No CAS ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 2 steps 1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium hydrogencarbonate; ethyl cyanoglyoxylate-2-oxime / N,N-dimethyl-formamide; water / Inert atmosphere 2: ethanol / Reflux; Inert atmosphere
  • 29
  • [ 81748-72-3 ]
  • 1-(4-bromobenzyl)-3-((8-hydroxy-7-(pyrrolidin-1-ylmethyl)quinolin-5-yl)methyl)urea [ No CAS ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 2 steps 1: trimethylamine / dichloromethane / 5 h / 20 °C / Inert atmosphere 2: ethanol / Reflux; Inert atmosphere
  • 30
  • [ 81748-72-3 ]
  • 1-bromo-4-(isocyanatomethyl)benzene [ No CAS ]
  • 1-(4-bromobenzyl)-3-((8-hydroxyquinolin-5-yl)methyl)urea [ No CAS ]
YieldReaction ConditionsOperation in experiment
With trimethylamine In dichloromethane at 20℃; for 5h; Inert atmosphere; 39 Synthesis of 1-(4-bromobenzyl)-3-((8-hydroxyquinolin-5-yl)methyl)urea (7) To a stirred solution of compound 91 4 (1.0mmol, 140mg) and 96 4-bromobenzyl isocyanate (1.0mmol, 212mg) in anhydrous 97 dichloromethane (5mL) were added catalytic amount of 98 trimethylamine (0.1mmol, 10.1mg). After stirring at room temperature for 5h, solvent was removed under reduced pressure to give crude 99 product which was directly used for next step without purification.
  • 31
  • [ 81748-72-3 ]
  • [ 100-52-7 ]
  • C17H14N2O [ No CAS ]
YieldReaction ConditionsOperation in experiment
56% With triethylamine In ethyl acetate for 20h; Heating; General procedure: Azomethine derivative were prepared in moderate yield (56% for BDHQ and 60% for MDHQ) by the condensation of 5-aminomethyl-8-hydroxyquinoline (1eq), aldehydes (1eq) and of triethylamine (1eq) in 20 mL of dried ethyl acetate was heated under stirring for 20 hours. After completion and cooling to room temperature, water (50 mL+10 ml of sodium bisulfite) was subsequently added and the product extracted. The combined organic phases were combined, dried over anhydrous sodium sulfate, filtered and evaporated. The obtained residue was purified by column chromatography with hexane/acetone (8:3 to 1:9 v/v). Identification of the structure of the synthesized Schiff base was performed by, 1H NMR, 13C NMR spectroscopy and elemental analysis. Analysis calculated for C17H14N2O: Calcd. C, 77.84; H, 5.38; N, 10.68%; Found: C, 77.76; H, 5.29; N, 10.75%. The 1H NMR spectrum show signals of the aromatic protons in the range 6.9-8.94 ppm, the signals of the methylene protons appear at 4.83 ppm, and those of the imine protons appear at 8.4 ppm and the 13C NMR for the BDHQ exhibited the aromatic carbons in the range 111.32-152.74 ppm, while that of imine at 168.92 ppm and those of methylene appear at 60.84 ppm.
  • 32
  • [ 81748-72-3 ]
  • [ 123-11-5 ]
  • C18H16N2O2 [ No CAS ]
YieldReaction ConditionsOperation in experiment
60% With triethylamine In ethyl acetate for 20h; Heating; General procedure: Azomethine derivative were prepared in moderate yield (56% for BDHQ and 60% for MDHQ) by the condensation of 5-aminomethyl-8-hydroxyquinoline (1eq), aldehydes (1eq) and of triethylamine (1eq) in 20 mL of dried ethyl acetate was heated under stirring for 20 hours. After completion and cooling to room temperature, water (50 mL+10 ml of sodium bisulfite) was subsequently added and the product extracted. The combined organic phases were combined, dried over anhydrous sodium sulfate, filtered and evaporated. The obtained residue was purified by column chromatography with hexane/acetone (8:3 to 1:9 v/v).
  • 33
  • [ 81748-72-3 ]
  • [ 105-53-3 ]
  • Ethyl 3-(((8-hydroxyquinolin-5-yl)-methyl)-amino)-3-oxopropanoate [ No CAS ]
YieldReaction ConditionsOperation in experiment
74% With triethylamine In acetonitrile at 90℃; for 10h; 2.2.2. Synthesis of ethyl-3-(((8-hydroxyquinolin-5-yl)-methyl)-amino)-3-oxopropanoate (3) To a solution of 5-aminomethyl-8-hydroxyquinoline (0.80 g,4.7 mmol) in 20 mL of acetonitrile, were added diethyl malonate(0.75 g, 4.7mmol) and a catalytic amount of triethylamine. The reactionmixture was stirred at 90 °C for 10 h. The excess of acetonitrile was distilledunder reduced pressure. The reaction mixture was hydrolyzedwith saturated ammonium chloride solution and extracted withCHC13 (3 × 25 mL). The combined organic layers was dried over anhydrousMgSO4 and filtered. After removal of the solvent, the residue obtainedwas recrystallized from ethanol to afford ethyl-3-(((8-hydroxyquinolin-5-yl)-methyl)-amino)-3-oxopropanoate (EHQP) (3)(1.00 g, 74%) as a white solid.
  • 34
  • [ 81748-72-3 ]
  • [ 24424-99-5 ]
  • tert-butyl ((8-hydroxyquinolin-5-yl)-methyl)-carbamate [ No CAS ]
YieldReaction ConditionsOperation in experiment
87% With triethylamine In acetonitrile at 90℃; for 6h; 2.2.3. Synthesis of tert-butyl ((8-hydroxyquinolin-5-yl)-methyl)-carbamate (4) To a suspension of 5-aminomethyl-8-hydroxyquinoline (0.17 g,1 mmol) in dry Acetonitrile, were added boc-anhydride (0.217 g,1 mmol) and a catalytic amount of triethylamine. The reaction mixturewas heated at 90 °C for 6 h. Reaction completionwas monitored by TLC.The excess of acetonitrile was distilled under reduced pressure and thereaction mixture was hydrolyzed with saturated ammonium chloridesolution and extracted with CHC13 (3 × 25 mL). The combined organicphases were washed thrice with 20 mL of saturated aqueous chloridesodium, dried over anhydrous MgSO4, and evaporated under vacuum.The crude product was recrystallized from ethanol to give tert-butyl((8-hydroxyquinolin-5-yl)-methyl)-carbamate (BHQC) (4) (0.24 g,87%) as a white solid. The two synthesized molecules show excellentsolubility in polar solvents such as DMSO and ethanol. The toxicity ofthe two compounds was determined theoretically using appropriatesoftware, we found that the compound BHQC is slightly toxic whilethe compound EHQP is non-toxic.
  • 35
  • [ 81748-72-3 ]
  • [ 87-51-4 ]
  • N-((8-hydroxyquinolin-5-yl)methyl)-2-(1H-indol-3-yl)acetamide [ No CAS ]
YieldReaction ConditionsOperation in experiment
58% Stage #1: indole-3-acetic acid With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In dichloromethane at 20℃; for 3h; Stage #2: 5-(aminomethyl)-8-hydroxyquinoline In dichloromethane at 20℃; 15 Example 15 N-(((8-Hydroxyquinolin-5-yl)methyl)-2-(1H-indol-3-yl)acetamide (Compound 11a) Add 2-(1H-indol-3-yl)acetic acid (227.734mg, 1.3mmol) to anhydrous dichloromethane (3mL) at room temperature, continue to add HATU (380.23mg, 1mmol) and DIPEA (258.5mg, 2mmol).After stirring the reaction for 3 hours, 5-(aminomethyl)quinolin-8-ol (174.1 mg, 1 mmol) was added. After continuing to stir at room temperature overnight, the mixture was extracted with CH2Cl2.The combined organic phases were dried (Na2SO4) and the solvent was evaporated to give a crude product, which was purified by column chromatography using a mixture of silica gel and CH2Cl2/MeOH. Yield: 58%.
  • 36
  • [ 81748-72-3 ]
  • [ 100-09-4 ]
  • N-((8-hydroxyquinolin-5-yl)methyl)-4-methoxybenzamide [ No CAS ]
YieldReaction ConditionsOperation in experiment
90% With thionyl chloride; triethylamine In dichloromethane at 20℃; for 9h; 2.5. Inhibitors General procedure: 8-quinolinol analogs with amide-substituted have been synthesized pursuant to the procedures reported earlier [43]. So, 2 mmol of thionyl chloride were added to the mixture of a solution of carboxylic acid (2 mmol), 5-Aminomethyl-8-quinolinol (synthesized pursuant to the procedures established in [22]) (2 mmol), and triethylamine (5 mmol) in CH2Cl2 (30 mL) at room temperature. After 9 h stirring at room temperature, the solvent was distilled off. The obtained residue was dissolved again in CH2Cl2 and washed first with 0.5 N HCl, and then with saturated NaHCO3. The organic phase was dried (MgSO4), concentrated in vacuo to afford the crude product, which was then recrystallized from ethanol to yield the corresponding amide as a brown powder (Scheme 1). The analytical findings of 8-quinolinol analogs with amide substituted are collected in Table 1, the spectra of 1H, 13C NMR are joined to the supplementary file.
  • 37
  • [ 81748-72-3 ]
  • [ 802294-64-0 ]
  • N-((8-hydroxyquinolin-5-yl)methyl)propionamide [ No CAS ]
YieldReaction ConditionsOperation in experiment
95% With thionyl chloride; triethylamine In dichloromethane at 20℃; for 9h; 2.5. Inhibitors General procedure: 8-quinolinol analogs with amide-substituted have been synthesized pursuant to the procedures reported earlier [43]. So, 2 mmol of thionyl chloride were added to the mixture of a solution of carboxylic acid (2 mmol), 5-Aminomethyl-8-quinolinol (synthesized pursuant to the procedures established in [22]) (2 mmol), and triethylamine (5 mmol) in CH2Cl2 (30 mL) at room temperature. After 9 h stirring at room temperature, the solvent was distilled off. The obtained residue was dissolved again in CH2Cl2 and washed first with 0.5 N HCl, and then with saturated NaHCO3. The organic phase was dried (MgSO4), concentrated in vacuo to afford the crude product, which was then recrystallized from ethanol to yield the corresponding amide as a brown powder (Scheme 1). The analytical findings of 8-quinolinol analogs with amide substituted are collected in Table 1, the spectra of 1H, 13C NMR are joined to the supplementary file.
  • 38
  • aluminum(III) sulfate [ No CAS ]
  • [ 81748-72-3 ]
  • C30H27AlN6O3 [ No CAS ]
YieldReaction ConditionsOperation in experiment
In methanol; water at 70℃; for 20h; General procedure for the preparation of the aluminum complexes General procedure: The 8-hydroxyquinoline ligand (1.0 mmol) was added to anhydrous methanol at room temperature, and then the temperature was raised to 70 °C. An aqueous solution of aluminum sulfate (1.0 mmol) was slowly added dropwise, and the mixture was maintained at 70 °C for 20 h. The pH of the mixture was adjusted with ammonia solution to about 7-8. After stirring for 4 h, the obtained precipitate was filtered and recrystallized from anhydrous methanol to give the pure product.
  • 39
  • [ 81748-72-3 ]
  • cadmium(II) nitrate [ No CAS ]
  • C20H18CdN4O2 [ No CAS ]
YieldReaction ConditionsOperation in experiment
In methanol; water at 80℃; for 24h; General procedure for the preparation of the cadmium complexes General procedure: A mixture of CdNO3 (0.5 mol), 8-hydroxyquinoline ligand (1.0 mmol), water, and MeOH in a capped vial was heated at 80 °C for 1 day. Colored block-like crystals were collected by filtration, washed with ether, and dried to give the desired product.
  • 40
  • [ 81748-72-3 ]
  • [ 7646-85-7 ]
  • C20H18N4O2Zn [ No CAS ]
YieldReaction ConditionsOperation in experiment
In methanol
  • 41
  • [ 81748-72-3 ]
  • copper(II) choride dihydrate [ No CAS ]
  • C20H18CuN4O2 [ No CAS ]
YieldReaction ConditionsOperation in experiment
In methanol for 0.5h; General procedure for the preparation of the copper complexes General procedure: A pale green solution of CuCl2·2H2O (0.5 mmol) dissolved in methanol was added slowly to a solution of the 8-hydroxyquinoline ligand (1.0 mmol) in methanol. After stirring for 30 min, the solid was filtered, washed with ether, and dried to give the desired product.
Same Skeleton Products
Historical Records

Related Functional Groups of
[ 81748-72-3 ]

Alcohols

Chemical Structure| 1285210-52-7

[ 1285210-52-7 ]

5-(Aminomethyl)quinolin-8-ol hydrochloride

Similarity: 0.98

Chemical Structure| 103040-80-8

[ 103040-80-8 ]

5-Aminomethylquinolin-8-ol dihydrochloride

Similarity: 0.98

Chemical Structure| 7545-62-2

[ 7545-62-2 ]

5-((Dimethylamino)methyl)quinolin-8-ol

Similarity: 0.91

Chemical Structure| 918907-58-1

[ 918907-58-1 ]

5,5'-(((1,4-Phenylenebis(methylene))bis(azanediyl))bis(methylene))bis(quinolin-8-ol)

Similarity: 0.91

Chemical Structure| 5541-67-3

[ 5541-67-3 ]

5-Methylquinolin-8-ol

Similarity: 0.90

Amines

Chemical Structure| 1285210-52-7

[ 1285210-52-7 ]

5-(Aminomethyl)quinolin-8-ol hydrochloride

Similarity: 0.98

Chemical Structure| 103040-80-8

[ 103040-80-8 ]

5-Aminomethylquinolin-8-ol dihydrochloride

Similarity: 0.98

Chemical Structure| 7545-62-2

[ 7545-62-2 ]

5-((Dimethylamino)methyl)quinolin-8-ol

Similarity: 0.91

Chemical Structure| 886496-57-7

[ 886496-57-7 ]

(8-Methoxyquinolin-5-yl)methanamine

Similarity: 0.91

Chemical Structure| 918907-58-1

[ 918907-58-1 ]

5,5'-(((1,4-Phenylenebis(methylene))bis(azanediyl))bis(methylene))bis(quinolin-8-ol)

Similarity: 0.91

Related Parent Nucleus of
[ 81748-72-3 ]

Quinolines

Chemical Structure| 1285210-52-7

[ 1285210-52-7 ]

5-(Aminomethyl)quinolin-8-ol hydrochloride

Similarity: 0.98

Chemical Structure| 103040-80-8

[ 103040-80-8 ]

5-Aminomethylquinolin-8-ol dihydrochloride

Similarity: 0.98

Chemical Structure| 7545-62-2

[ 7545-62-2 ]

5-((Dimethylamino)methyl)quinolin-8-ol

Similarity: 0.91

Chemical Structure| 886496-57-7

[ 886496-57-7 ]

(8-Methoxyquinolin-5-yl)methanamine

Similarity: 0.91

Chemical Structure| 918907-58-1

[ 918907-58-1 ]

5,5'-(((1,4-Phenylenebis(methylene))bis(azanediyl))bis(methylene))bis(quinolin-8-ol)

Similarity: 0.91