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Chemical Structure| 82401-08-9 Chemical Structure| 82401-08-9

Structure of 82401-08-9

Chemical Structure| 82401-08-9

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Product Details of [ 82401-08-9 ]

CAS No. :82401-08-9
Formula : C6H6ClNO
M.W : 143.57
SMILES Code : [O-][N+]1=CC=CC(CCl)=C1
MDL No. :MFCD10697573

Safety of [ 82401-08-9 ]

Application In Synthesis of [ 82401-08-9 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 82401-08-9 ]

[ 82401-08-9 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 82401-08-9 ]
  • [ 33100-27-5 ]
  • [ 120068-37-3 ]
  • 1-(2,6-dichloro-4-trifluoromethylphenyl)-4-methylsulfenyl-5-(1-oxy-pyridin-3-ylmethylamino)pyrazole-3-carbonitrile [ No CAS ]
YieldReaction ConditionsOperation in experiment
With hydrogenchloride; In water; ethyl acetate; N,N-dimethyl-formamide; EXAMPLE 3 Production of 1-(2,6-dichloro-4-trifluoromethylphenyl)-4-methylsulfenyl-5-(1-oxy-pyridin-3-ylmethylamino)pyrazole-3-carbonitrile (Compound No. 14) In 10 ml of N,N-dimethylformamide was suspended 0.1 g of 60% sodium hydride, and 1 g of 5-amino-1-(2,6-dichloro-4-trifluoromethylphenyl)-4-trifluoromethylsulfinylpyrazole-3-carbonitrile was gradually added thereto. After 20 minutes of stirring at room temperature, 3 drops of 15-crown-5-ether and then 0.3 g of 3-chloromethylpyridine-1-oxide were added thereto, followed by stirring at room temperature. After standing over one night, water and ethyl acetate were added thereto and the mixture was neutralized by 1N hydrochloric acid. After liquid separation, the organic layer was washed with saturated saline and then dried over anhydrous sodium sulfate. The residue was purified by a silica gel column chromatography to obtain 0.9 g of the compound (No. 14) described in the following Table 1.
 

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