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Chemical Structure| 825643-73-0 Chemical Structure| 825643-73-0

Structure of 825643-73-0

Chemical Structure| 825643-73-0

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Product Details of [ 825643-73-0 ]

CAS No. :825643-73-0
Formula : C25H20ClF7N2O
M.W : 532.88
SMILES Code : CC(C)(C1=CC(C(F)(F)F)=CC(C(F)(F)F)=C1)C(N(C2=C(C3=CC=C(F)C=C3C)C=C(Cl)N=C2)C)=O

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Application In Synthesis of [ 825643-73-0 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 825643-73-0 ]

[ 825643-73-0 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 825643-73-0 ]
  • [ 117810-52-3 ]
  • 2-[3,5-bis(trifluoromethyl)phenyl]-N-{4-(4-fluoro-2-methylphenyl)-6-[6-oxohexahydropyrrolo[1,2-a]pyrazin-2(1H)-yl]-3-pyridinyl}-N,2-dimethylpropanamide [ No CAS ]
YieldReaction ConditionsOperation in experiment
A 8 ml sealed vial was charged with 100 mg (0.187 mmoles) of 2-[3,5- bis(trifluoromethyl)phenyl]-Λ/-[6-chloro-4-(4-fluoro-2-methylphenyl)-3-pyridinyl]-Λ/,2- dimethylpropanamide (WO 2005/002577), 78.6 mg (0.561 mmol) of hexahydropyrrolo[1 ,2- a]pyrazin-6(2H)-one (WO 2003/066635), 52 mg (0.374 mmol) of potassium carbonate; the reagents were dissolved in 0.8ml of DMSO. The reaction mixture was heated at 1800C for 36-48hrs and then added to a saturated NH4CI solution and back extracted with dichloromethane; the crude material was purified on SPE cartridge (Silica) eluting with a gradient from cyclohexane/ethyl acetate 9:1 , to ethyl acetate 100% and affording 71 mg of the title compound as pale yellow solid.MS (ES/+): 637 [M+H]+ EPO <DP n="118"/>NMR (DMSO-Cl6): δ (ppm) 8.01 (s, 1 H); 7.78 (s, 1 H); 7.65 (s, 2H); 7.05-6.87 (m, 3H); 6.52 (S, 1 H); 4.67-4.52 (m, 1 H); 4.32-4.19 (m, 1 H); 4.14-4.10 (d, 1 H); 3.77-3.64 (m, 1 H); 3.02- 2.84 (m, 2H); 2.61 (t, 1 H); 2.48-2.44 (dd, 2H); 2.41-2.33 (s, 3H); 2.30-2.22 (m, 1 H); 2.13 (s, 3H); 1.79-1.65 (m, 1 H); 1.53 (s, 3H); 1.38 (s, 3H)
  • 2
  • [ 400777-00-6 ]
  • [ 825643-73-0 ]
 

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