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Chemical Structure| 83060-43-9 Chemical Structure| 83060-43-9

Structure of 83060-43-9

Chemical Structure| 83060-43-9

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Product Details of [ 83060-43-9 ]

CAS No. :83060-43-9
Formula : C8H11N3O3
M.W : 197.19
SMILES Code : O=C(OC)NC1=NC(C)=CC(OC)=N1

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Application In Synthesis of [ 83060-43-9 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 83060-43-9 ]

[ 83060-43-9 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 7749-47-5 ]
  • aqueous NaCl [ No CAS ]
  • [ 616-38-6 ]
  • [ 83060-43-9 ]
YieldReaction ConditionsOperation in experiment
With hydrogenchloride; In tetrahydrofuran; EXAMPLE 6 Methyl (4-methoxy-6-methylpyrimidin-2-yl)carbamate 2-Amino-4-methoxy-6-methylpyrimidine (50 g) was added portion wise to 50% sodium hydride (42.8 g) in 1 L dry THF. After stirring for 1/2 hour, dimethyl carbonate (58.5 g) was added dropwise with cooling. The mixture was stirred under nitrogen for ~16 hours at ambient temperature. Concentrated HCl (80 ml) was added slowly and using external cooling a pot temperature of ~25 C. was maintained. Saturated aqueous NaCl (80 ml) was then added. The solvents were decanted from the precipitated solids and dried over Na2 SO4. Filtering and evaporating the solvents afforded the crude material which was recrystallized from hexane. 54 g m.p. 89-92.5 C. The infrared spectrum showed characteristic absorption bonds at 3400 and 1760 cm-1.
  • 2
  • [ 7749-47-5 ]
  • [ 616-38-6 ]
  • [ 83060-43-9 ]
YieldReaction ConditionsOperation in experiment
With hydrogenchloride; In tetrahydrofuran; EXAMPLE 6 Methyl (4-methoxy-6-methylpyrimidin-2-yl)carbamate To a suspension of 50 g of 2-amino-4-methoxy-6-methylpyrimidine in 1000 ml of tetrahydrofuran was added portionwise, under a nitrogen atmosphere, 42.8 g of 50% sodium hydride while cooling the reaction flask in an ice-water bath. After stirring one hour at 25 C., 58.5 g of dimethylcarbonate was added dropwise at 5 to 25 C. The suspension was stirred about 16 hours at ambient temperature, then 80 ml of concentrated hydrochloric acid was added dropwise while maintaining a reaction temperature of 20 to 25 C. with external ice-bath cooling. The suspension was stirred 0.5 hour, filtered, and the filtrate was dried over sodium sulfate and then concentrated in vacuo. The residue was recrystallized from hexane to yield 54 g of the title compound, m.p. 89-92.5 C.
 

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