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Chemical Structure| 834884-74-1 Chemical Structure| 834884-74-1

Structure of 834884-74-1

Chemical Structure| 834884-74-1

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Product Details of [ 834884-74-1 ]

CAS No. :834884-74-1
Formula : C10H9NS
M.W : 175.25
SMILES Code : NC1=CC=C(C2=CSC=C2)C=C1
MDL No. :MFCD06740168

Safety of [ 834884-74-1 ]

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H301-H315-H319-H335
Precautionary Statements:P261-P301+P310-P305+P351+P338
Class:6.1
UN#:2811
Packing Group:

Application In Synthesis of [ 834884-74-1 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 834884-74-1 ]

[ 834884-74-1 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 834884-74-1 ]
  • [ 40359-34-0 ]
  • [ 13395-36-3 ]
  • [ 1219485-52-5 ]
YieldReaction ConditionsOperation in experiment
41% With acetic acid; In 1,4-dioxane;Reflux; Example 1 Preparation of 4-(2,2-dimethylpropionyl)-3-hydroxy-5-(2-methoxycarbonylmethyloxyphenyl)-1-(4-thiophene-3-ylphenyl)-1,5-dihydropyrrole-2-one [Show Image] A mixture of <strong>[13395-36-3]ethyl trimethylacetopyruvate</strong> (0.40g, 2 mmol), 4-thiophene-3-ylaniline (0.35g, 2 mmol), 2-(methoxycarbonylmethyloxy)benzaldehyde (0.39, 2 mmol), acetic acid (0.057 mL, 1 mmol) and dioxane (4 mL) was heated at reflux overnight. After the reacton was completed, saturated sodium bicarbonate solution and brine were poured into the reaction mixture, and the resulting mixture was extracted with ethyl acetate. The extract was dried over anhydrous sodium sulphate, and then concentrated in vacuo. The resulting residue was purified on a silica gel column chromatography (methanol/chloroform), and the aimed compound was triturated with ethyl acetate and diisopropyl ether to give 4-(2,2-dimethylpropionyl)-3-hydroxy-5-(2-methoxycarbonylmethyloxyphenyl)-1-(4-thiophene-3-ylphenyl)-1,5-dihydropyrrole-2-one (0.42g, yield: 41%) as pale brown solid. 1H-NMR (delta ppm TMS / DMSO-d6): 1.10 (9H, s), 3.78 (3H, s), 4.50-4.90 (2H, m), 6.00-6.45 (1H, m), 6.60-7.11 (11H, m).
 

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