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Chemical Structure| 835595-19-2 Chemical Structure| 835595-19-2

Structure of 835595-19-2

Chemical Structure| 835595-19-2

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Product Details of [ 835595-19-2 ]

CAS No. :835595-19-2
Formula : C11H12Cl2INO2
M.W : 388.03
SMILES Code : O=C(OC(C)(C)C)NC1=CC(Cl)=C(Cl)C=C1I

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Application In Synthesis of [ 835595-19-2 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 835595-19-2 ]

[ 835595-19-2 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 24424-99-5 ]
  • [ 220185-63-7 ]
  • [ 835595-19-2 ]
YieldReaction ConditionsOperation in experiment
Example 14 Preparation of 5 « 6-DICHLORO-2-R4-(1 H-TETRAZOL-5-VL)-PHENYL1-1 H-INDOLE a) [4, 5-DICHLORO-2- (4-CYANO-PHENYLETHYNYL)-PHENYL]-CARBAMIC acid t-butyl ester To a stirring solution of (4, 5-dichloro-2-iodo-phenyl)-carbamic acid t-butyl ester (1.2 g, 0.48 MMOL) (prepared by reacting 2-iodo-3, 4-dichloro-aniline and BOC20) was added 4-ethynyl-benzonitrile (0.16 g, 1.24 MMOL) in triethylamine (0.8 mL) and DMF (16 mL). To this solution was added copper iodide (47 mg, 0.25 MMOL) and palladium bis (triphenylphosphine) dichloride (88 mg, 0.12 MMOL). The mixture was stirred for 3.5 h at rt. The reaction mixture was concentrated and the crude product was dissolved in EtOAc. The EtOAc solution was washed with saturated, aqueous bicarbonate, H2O, and brine. The EtOAc layer was dried over NA2SO4 and filtered. The EtOAc extracts were triturated with CH3CN to afford afford a precipitate. The off-white solids were washed with EtOAc and dried under vacuum to provide the title compound, 0.32 g (67%). LCMS 387.0 (M+H).
 

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