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Chemical Structure| 837392-67-3 Chemical Structure| 837392-67-3

Structure of 837392-67-3

Chemical Structure| 837392-67-3

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Product Details of [ 837392-67-3 ]

CAS No. :837392-67-3
Formula : C19H28BNO4
M.W : 345.24
SMILES Code : O=C(N1CCC2=C1C=CC(B3OC(C)(C)C(C)(C)O3)=C2)OC(C)(C)C
MDL No. :MFCD12408237

Safety of [ 837392-67-3 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H315-H319-H335
Precautionary Statements:P261-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P332+P313-P337+P313-P362-P403+P233-P405-P501

Application In Synthesis of [ 837392-67-3 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Upstream synthesis route of [ 837392-67-3 ]
  • Downstream synthetic route of [ 837392-67-3 ]

[ 837392-67-3 ] Synthesis Path-Upstream   1~1

  • 1
  • [ 837392-67-3 ]
  • [ 1062174-44-0 ]
YieldReaction ConditionsOperation in experiment
87%
Stage #1: With trifluoroacetic acid In dichloromethane at 20℃; for 2 h;
Ste 3: 5-(4,4,5,5-tetramethyl-l,3,2-dioxaborolan-2-yl)indolineTo the solution of tert-butyl 5-(4,4,5,5-tetramethyl-l,3,2- dioxaborolan-2-yl)indoline-l-carboxylate (120 mg, 0.35 mmol) in CH2CI2 (5 mL) was added 2,2,2-trifluoroacetic acid (1 mL) and the resulting mixture was stirred at room temperature for 2 hours. The mixture was neutralized to pH = 8 with saturated aqueous NaHC03 and extracted with CH2CI2. The combined extracts were washed with brine, dried and concentrated in vacuo to afford the desired product (74 mg, 87percent).1H NMR (CDC13): δ 7.56 (1H, s), 7.50 (1H, d, / = 8.0 Hz), 6.60 (1H, d, / = 8.0 Hz), 3.57 (2H, t, / = 8.8 Hz), 3.02 (2H, t, / = 8.8 Hz), 1.32 (12H, s).
References: [1] Patent: WO2012/103806, 2012, A1, . Location in patent: Page/Page column 48.
 

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[ 837392-67-3 ]

Indolines

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A200000 [1235451-62-3]

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