Alternatived Products of [ 83794-86-9 ]
Product Details of [ 83794-86-9 ]
CAS No. : | 83794-86-9 |
MDL No. : | MFCD08437610 |
Formula : |
C7H8OS
|
Boiling Point : |
- |
Linear Structure Formula : | - |
InChI Key : | - |
M.W : |
140.20
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Pubchem ID : | - |
Synonyms : |
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Safety of [ 83794-86-9 ]
Signal Word: | |
Class: | |
Precautionary Statements: | |
UN#: | |
Hazard Statements: | |
Packing Group: | |
Application In Synthesis of [ 83794-86-9 ]
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
- Downstream synthetic route of [ 83794-86-9 ]
- 1
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[ 4869-59-4 ]
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[ 83794-86-9 ]
Yield | Reaction Conditions | Operation in experiment |
22% |
With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 - 20℃;Inert atmosphere; |
To a stirred solution of <strong>[4869-59-4]3-mercaptobenzoic acid</strong> (1 g, 6.5 mmol) in THF (10 mL) was added LiAlH4 (246 mg, 13 mmol) at 0oC portion wise. After addition, the mixture was stirred at room temperature under N2 overnight. The reaction mixture was quenched by addition of NaSO4.10H2O at 0oC, filtered, the filtrate was concentrated to give crude product, which was purified by CC on silica gel eluting with PE : EA =4:1 to give (3-mercaptophenyl)methanol as a colorless oil (200 mg, yield 22.0 %).1H NMR (400 MHz, DMSO-d6) delta 7.25 (s, 1 H), 7.11 - 7.22 (m, 2 H), 7.02 - 7.08 (m, 1 H), 5.35 (s, 1 H), 5.19 (t, J = 5.69 Hz, 1 H), 4.43 (d, J = 5.63 Hz, 2 H). |
- 2
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[ 1227-49-2 ]
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[ 83794-86-9 ]
- 3
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[ 825-99-0 ]
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[ 83794-86-9 ]
- 4
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[ 2314-97-8 ]
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[ 83794-86-9 ]
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[ 82174-08-1 ]
Yield | Reaction Conditions | Operation in experiment |
73% |
With sodium dihydrosulfite; triethylamine In lithium hydroxide monohydrate; acetonitrile at -20 - 25℃; Inert atmosphere; |
4.2. General procedure
General procedure: Acetonitrile (150 mL), thiophenol (25 g, 227 mmol, 1 equiv.) andtriethylamine (25.3 g, 250 mmol, 1.1 equiv.) were placed in the flasksuccessively under stirring. The reaction mixture was cooled to -20 Cand the argon atmosphere was pumped out. A rubber balloon chargedwith CF3I (49 g, 250 mmol, 1.1 equiv.) was joined to the flask by a plug.After absorption of CF3I by the reaction solution, the flask was filled withan argon atmosphere. Sodium dithionite (39.5 g, 227 mmol, 1 equiv.)solution in H2O (100 mL) was added dropwise. Some self-heating forabout 1 to 30 C of the reaction mixture could be observed. Afterreaching ambient temperature (25 C) the reaction was judged completeand the mixture was ready for aqueous work up. |