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Chemical Structure| 842974-69-0 Chemical Structure| 842974-69-0

Structure of 842974-69-0

Chemical Structure| 842974-69-0

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Product Details of [ 842974-69-0 ]

CAS No. :842974-69-0
Formula : C9H11N3O2
M.W : 193.20
SMILES Code : O=CC1=CN=C(N2CCOCC2)N=C1
MDL No. :MFCD06589848

Safety of [ 842974-69-0 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H315-H319-H335
Precautionary Statements:P264-P302+P352-P304+P340-P305+P351+P338-P332+P313-P337+P313

Application In Synthesis of [ 842974-69-0 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 842974-69-0 ]

[ 842974-69-0 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 84539-22-0 ]
  • [ 33513-42-7 ]
  • [ 842974-69-0 ]
YieldReaction ConditionsOperation in experiment
60% To a solution of <strong>[84539-22-0]4-(5-bromopyrimidin-2-yl)morpholine</strong> (3;6.00 g, 24.6 mmol) in THF (100 mL) was added n-BuLi (1.59 M,19.0 mL, 30.2 mmol) at 78 C under an argon atmosphere. Afterbeing stirred at 78 C for 10 min, DMF (2.85 mL, 36.9 mmol)was added, and the mixture was warm to 0 C over 1 h. After beingstirred at 0 C for 1 h, the mixture was diluted with H2O, andextracted with EtOAc. The organic layer was dried over Na2SO4,and concentrated in vacuo. The residue was purified by columnchromatography on silica gel (hexane/EtOAc) to give the product(2.86 g, 60%). 1H NMR (CDCl3): d 3.75-3.82 (4H, m), 3.95-4.02(4H, m), 8.73 (2H, s), 9.79 (1H, s); MS (ESI) m/z [M+H]+ 194.
 

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