Home Cart 0 Sign in  

[ CAS No. 843673-58-5 ] {[proInfo.proName]}

,{[proInfo.pro_purity]}
Cat. No.: {[proInfo.prAm]}
Chemical Structure| 843673-58-5
Chemical Structure| 843673-58-5
Structure of 843673-58-5 * Storage: {[proInfo.prStorage]}
Cart0 Add to My Favorites Add to My Favorites Bulk Inquiry Inquiry Add To Cart

Quality Control of [ 843673-58-5 ]

Related Doc. of [ 843673-58-5 ]

Alternatived Products of [ 843673-58-5 ]

Product Details of [ 843673-58-5 ]

CAS No. :843673-58-5 MDL No. :MFCD19689889
Formula : C6H7BrClN Boiling Point : -
Linear Structure Formula :- InChI Key :-
M.W : 208.48 Pubchem ID :-
Synonyms :

Safety of [ 843673-58-5 ]

Signal Word: Class:
Precautionary Statements: UN#:
Hazard Statements: Packing Group:

Application In Synthesis of [ 843673-58-5 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 843673-58-5 ]

[ 843673-58-5 ] Synthesis Path-Downstream   1~3

  • 1
  • [ 843673-58-5 ]
  • [ 173405-78-2 ]
  • [ 1246508-52-0 ]
YieldReaction ConditionsOperation in experiment
35% Stage #1: tert-butyl 3,9-diazaspiro[5.5]undecane-3-carboxylate With sodium hydride In N,N-dimethyl-formamide; mineral oil at 0 - 20℃; for 2h; Stage #2: 4-(bromomethyl)-pyridine hydrochloride In N,N-dimethyl-formamide; mineral oil at 20℃; for 16h; Synthesis of amine (AMN CC-23): 9-(Pyridin-4-yl-methyl)-3,9-diazaspiro[5.5]undecane-3-carboxylic acid tert-butyl ester (AMN_CC-23) NaH (60% strength in mineral oil, 709 mg, 29.52 mmol) was added to a mixture of 3,9-diazaspiro[5.5]undecane-3-carboxylic acid tert-butyl ester (2.5 g, 9.84 mmol) in DMF (50 ml) at 0° C., the mixture was stirred at room temperature for 2 h, 4-(bromomethyl)-pyridine HCl (2.42 mg, 14.76 mmol) was then added and the mixture was stirred at room temperature for 16 h. Finally, ice was added and the reaction mixture was extracted with ethyl acetate. The combined organic phases were washed with water and sat. NaCl solution, dried over sodium sulfate and concentrated under reduced pressure. The crude product was purified by column chromatography (mobile phase methanol/methylene chloride). Yield: 35%
  • 2
  • [ 843673-58-5 ]
  • [ 15297-33-3 ]
  • (R)-N-methyl-1-(naphthalen-1-yl)-N-(pyridin-4-ylmethyl)ethanamine [ No CAS ]
YieldReaction ConditionsOperation in experiment
With N-ethyl-N,N-diisopropylamine; In acetonitrile; for 2h;Reflux; Inert atmosphere; General procedure: N-Methyl-1-(naphthalen-1-yl)ethanamine (8) (0.37g, 2.00mmol), N,N-diisopropylethylamine (0.39g, 3.02mmol), 1-(bromomethyl)-4-tert-butylbenzene (0.50g, 2.20mmol) and acetonitrile (5mL) were mixed and stirred at reflux under an N2-atmosphere for 2h. The solvent was then removed at reduced pressure and CH2Cl2 (5mL) was added. The dichloromethane phase was washed with water (5mL) and the water phase was back extracted with CH2Cl2 (3×5mL). The combined organic fractions were dried over Na2SO4, and concentrated in vacuum. The crude product was purified by silica-gel column chromatography. Alternatively, the purification was done by filtration through a short silica-gel column (pentane:EtOAc, 9:1), followed by precipitation as it hydrochloride salt by addition of HCl saturated ether. The solid material was washed with cold pentane. Alternatively, using 8·HCl the reaction was run similarly, but employing a 3-fold excess of N,N-diisopropylethylamine.
  • 3
  • [ 269410-08-4 ]
  • [ 843673-58-5 ]
  • [ 864754-20-1 ]
YieldReaction ConditionsOperation in experiment
6% With potassium carbonate In N,N-dimethyl-formamide at 80℃; for 8h; 6.1 step 1:Compound 4 - ((4- (4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)1H-pyrazol-1-yl) methyl) pyridine 4- (Bromomethyl) pyridine hydrochloride(3.3 g, 16 mmol) and 4-pyrazole boronic acid pinacol ester (3.01 g,15.6 mmol) was dissolved in DMF (20 mL). Potassium carbonate (2.25 g, 16.3 mmol) was added to the system, and the mixture was heated to 80 ° C. for 8 h.The reaction mixture was poured into water (50 mL), extracted with ethyl acetate (50 mL × 3), washed with saturated brine (20 mL) and dried over anhydrous sodium sulfateThe solvent was removed by drying and the residue was subjected to column chromatography (eluent: PE / EtOAc (v / v) = 1/1) to give 267 mg of a pale yellow oil. Yield: 6%.
Same Skeleton Products
Historical Records