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Quality Control of [ 848092-84-2 ]

COA NMR CNMR HPLC LC-MS

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SDS Specification

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Product Details of [ 848092-84-2 ]

CAS No. :	848092-84-2	MDL No. :	MFCD20690673
Formula :	C₉H₁₁NO₄	Boiling Point :	-
Linear Structure Formula :	-	InChI Key :	KVKBPICSIFDGGR-UHFFFAOYSA-N
M.W :	197.19	Pubchem ID :	23132473
Synonyms :

Safety of [ 848092-84-2 ]

Signal Word:	Warning	Class:	N/A
Precautionary Statements:	P280-P305+P351+P338	UN#:	N/A
Hazard Statements:	H302	Packing Group:	N/A
GHS Pictogram:

Application In Synthesis of [ 848092-84-2 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Upstream synthesis route of [ 848092-84-2 ]
Downstream synthetic route of [ 848092-84-2 ]

[ 848092-84-2 ] Synthesis Path-Upstream 1~3

1
[ 848092-84-2 ]
[ 77287-34-4 ]
[ 162012-72-8 ]

Yield	Reaction Conditions	Operation in experiment
85%	at 140℃; for 4 h;	A mixture of formamide (29 mL), ammonium formate (3.41 g, 54 mmol) and methyl 2-amino-4-hydroxy-5-methoxybenzoate (6.56 g, 36.0 mmol) was heated to 140C for 4 h. After cooling to r.t., water (75 mL) was added. Afterstirring for 1 h, the precipitated 7-hydroxy-6-methoxy-3,4-dihydroquinazolin-4-one was filtered off, washed with waterand dried (grey solid, 5.86 g, 30.5 mmol, 85 percent). LC/ESI-MS: m/ z = 193 [M +H]+; m/ z = 191 [M-H]-; Rt = 1.53 min.
85%	at 140℃; for 4 h;	A mixture of formamide (29 mL), ammonium formate (3.41 g, 54 mmol) and methyl 2-amino-4-hydroxy-5-methoxybenzoate (6.56 g, 36.0 mmol) was heated to 140°C for 4 h. After cooling to r.t., water (75 mL) was added. After stirring for 1 h, the precipitated 7-hydroxy-6-methoxy-3,4-dihydroquinazolin-4-one was filtered off, washed with water and dried (grey solid, 5.86 g, 30.5 mmol, 85 percent). LC/ESI-MS: m/z = 193 [M +H]⁺; m/z = 191 [M-H]^-; R_t = 1.53 min.
85%	at 140℃; for 4 h;	Step 4. A mixture of formamide (29 mL), ammonium formate (3.41 g, 54 mmol) and methyl 2-amino-4-hydroxy-5-methoxybenzoate (6.56 g, 36.0 mmol) was heated to 140° C. for 4 h. After cooling to r.t., water (75 mL) was added. After stirring for 1 h, the precipitated 7-hydroxy-6-methoxy-3,4-dihydroquinazolin-4-one was filtered off, washed with water and dried (grey solid, 5.86 g, 30.5 mmol, 85percent). LC/ESI-MS: m/z=193 [M+H]⁺; m/z=191 [M-H]^-; R_t=1.53 min.

76%

at 140℃; for 4 h;

Step 4.
A mixture of formamide (29 mL), ammonium formate (3.41 g, 54 mmol) and crude material of step 3 (36.0 mmol) was heated to 140° C. for 4 h.
After cooling to r.t., water (75 mL) was added.
After stirring for 1 h, the precipitated 7-hydroxy-6-methoxy-3,4-dihydroquinazolin-4-one or 6-hydroxy-7-methoxy-3,4-dihydroquinazolin-4-one, respectively, was filtered off, washed with water and dried (76-85percent).

Reference： [1] Patent: EP1674467, 2006, A1, . Location in patent: Page/Page column 26
[2] Patent: EP1674466, 2006, A1, . Location in patent: Page/Page column 26
[3] Patent: US2006/142570, 2006, A1, . Location in patent: Page/Page column 17
[4] Patent: US2007/149523, 2007, A1, . Location in patent: Page/Page column 13
[5] Patent: US2006/135782, 2006, A1, . Location in patent: Page/Page column 23
[6] Bioorganic and Medicinal Chemistry, 2009, vol. 17, # 18, p. 6728 - 6737

2
[ 848092-84-2 ]
[ 16712-16-6 ]
[ 162012-72-8 ]

Yield	Reaction Conditions	Operation in experiment
86%	at 150℃; for 5 h;	4.1.6 7-Hydroxy-6-methoxyquinazolin-4(3H)-one (14) A mixture of formamide (25 mL), ammonium formate (3.59 g, 57 mmol) and 13 (6.5 g, 33 mmol) was heated at 150 °C for 5 h. The mixture was cooled to room temperature, and water (100 mL) was added in order to precipitate the quinazolinone 14. After stirring for 1 h, the resulting precipitate was filtered off, washed with water and dried to obtain intermediate 14 as a white solid. Yield: 86percent, mp: >250 °C.

Reference： [1] Bioorganic and Medicinal Chemistry, 2014, vol. 22, # 24, p. 6796 - 6805

3
[ 848092-84-2 ]
[ 16712-16-6 ]
[ 77287-34-4 ]
[ 162012-72-8 ]

Yield	Reaction Conditions	Operation in experiment
76%	at 140℃; for 4 h;	Step 4. A mixture of formamide (29 mL), ammonium formate (3.41 g, 54 mmol) and crude material of step 3 (36.0 mmol) was heated to 140° C. for 4 h. After cooling to r.t., water (75 mL) was added. After stirring for 1 h, the precipitated 7-hydroxy-6-methoxy-3,4-dihydroquinazolin-4-one or 6-hydroxy-7-methoxy-3,4-dihydroquinazolin-4-one, respectively, was filtered off, washed with water and dried (76-85percent).
76%	at 140℃; for 4 h;	Step 4. A mixture of formamide (29 mL), ammonium formate (3.41 g, 54 mmol) and crude material of step 3 (36.0 mmol) was heated to 140°C for 4 h. After cooling to r.t., water (75 mL) was added. After stirring for 1 h, the precipitated 7-hydroxy-6-methoxy-3,4-dihydroquinazolin-4-one or 6-hydroxy-7-methoxy-3,4-dihydroquinazolin-4-one, respectively, was filtered off, washed with water and dried (76-85percent).

Reference： [1] Patent: US2007/21446, 2007, A1, . Location in patent: Page/Page column 14
[2] Patent: EP1785420, 2007, A1, . Location in patent: Page/Page column 18
[3] Patent: EP1746096, 2007, A1, . Location in patent: Page/Page column 24

[ 848092-84-2 ] Synthesis Path-Downstream 1~6

1
[ 61032-41-5 ]
[ 848092-84-2 ]

Yield	Reaction Conditions	Operation in experiment
100%	With hydrogen;palladium 10% on activated carbon; In tetrahydrofuran; at 20℃; under 750.075 Torr;	Step 3. In a 1l Schlenk flask filled with argon, product of step 2 (36.6 mmol) and palladium on charcoal (1.17 g, 10% Pd, 1.1 mmol Pd) were combined and tetrahydrofuran (250 mL) was added. The argon was replaced with hydrogen (1 bar), and the mixture was vigorously stirred at r.t. until completion of the reaction. The palladium was separated by filtration through a pad of celite and the solvent was removed to obtain methyl 2-amino-4-hydroxy-5-methoxybenzoate or methyl 2-amino-5-hydroxy-4-methoxybenzoate, respectively, quantitatively, which, again, was used without further purification.
100%	With hydrogen;palladium 10% on activated carbon; In tetrahydrofuran; at 20℃; under 750.075 Torr;	Step 3. In a 1 L Schlenk flask filled with argon, product of step 2 (36.6 mmol) and palladium on charcoal (1.17 g, 10% Pd, 1.1 mmol Pd) were combined and tetrahydrofuran (250 mL) was added. The argon was replaced with hydrogen (1 bar), and the mixture was vigorously stirred at r.t. until completion of the reaction. The palladium was separated by filtration through a pad of celite and the solvent was removed to obtain methyl 2-amino-4-hydroxy-5-methoxybenzoate or methyl 2-amino-5-hydroxy-4-methoxybenzoate, respectively, quantitatively, which, again, was used without further purification.
100%	With hydrogen;palladium 10% on activated carbon; In tetrahydrofuran; at 20℃; under 750.075 Torr;	Step 3. In a 1 1 Schlenk flask filled with argon, product of step 2 (36.6 mmol) and palladium on charcoal (1.17 g, 10% Pd, 1.1 mmol Pd) were combined and tetrahydrofuran (250 mL) was added. The argon was replaced with hydrogen (1 bar), and the mixture was vigorously stirred at r.t. until completion of the reaction. The palladium was separated by filtration through a pad of celite and the solvent was removed to obtain methyl 2-amino-4-hydroxy-5-methoxybenzoate or methyl 2-amino-5-hydroxy-4-methoxybenzoate, respectively, quantitatively, which, again, was used without further purification.

100%	With palladium 10% on activated carbon; hydrogen; In methanol; at 20℃; under 750.075 Torr; for 5h;	4.1.5 Methyl 2-amino-4-hydroxy-5-methoxybenzoate (13) A solution of intermediate 12 (11.7 g, 37 mmol) in MeOH (250 mL) was treated with H2 (1.0 bar, room temperature) in the presence of 10% palladium on charcoal (1.17 g, 1.1 mmol Pd). After completion (5 h), the catalyst was removed by filtration, and the solvent was evaporated to obtain the aniline 13 as a white solid quantitatively. Mp: 122-124 C.
100%	With hydrogen;palladium 10% on activated carbon; In tetrahydrofuran; at 20℃; under 750.075 Torr;	Step 3. In a 1L Schlenk flask filled with argon, product of step 2 (36.6 mmol) and palladium on charcoal (1.17 g, 10% Pd, 1.1 mmol Pd) were combined and tetrahydrofuran (250 mL) was added. The argon was replaced with hydrogen (1 bar), and the mixture was vigorously stirred at r.t. until completion of the reaction. The palladium was separated by filtration through a pad of celite and the solvent was removed to obtain methyl 2-amino-4-hydroxy-5-methoxybenzoate or methyl 2-amino-5-hydroxy-4-methoxybenzoate, respectively, quantitatively, which, again, was used without further purification.
98%	With hydrogen;palladium 10% on activated carbon; In tetrahydrofuran; at 20℃; under 750.075 Torr;	In a 11 Schlenk flask filled with argon, <strong>[61032-41-5]methyl 4-benzyloxy-5-methoxy-2-nitrobenzoate</strong> (11.60 g, 36.6 mmol) andpalladium on charcoal (1.17 g, 10 % Pd, 1.1 mmol Pd) were combined and tetrahydrofuran (250 mL) was added. Theargon was replaced with hydrogen (1 bar), and the mixture was vigorously stirred at r.t. until completion of the reaction.The palladium was separated by filtration through a pad of celite and the solvent was removed to obtain methyl 2-amino-4-hydroxy-5-methoxybenzoate (6.56 g, 36.0 mmol, 98 %) which was used without further purification. LC/ESI-MS: m/ z= 166 [M-CH4O+H]+; Rt = 2.17 min
98%	With hydrogen;palladium 10% on activated carbon; In tetrahydrofuran;	Step 3. In a 1 l Schlenk flask filled with argon, methyl 4benzyloxy-5-methoxy-2-nitrobenzoate (11.60 g, 36.6 mmol) and palladium on charcoal (1.17 g, 10% Pd, 1.1 mmol Pd) were combined and tetrahydrofuran (250 mL) was added. The argon was replaced with hydrogen (1 bar), and the mixture was vigorously stirred at r.t. until completion of the reaction. The palladium was separated by filtration through a pad of celite and the solvent was removed to obtain methyl 2-amino-4-hydroxy-5-methoxybenzoate (6.56 g, 36.0 mmol, 98%) which was used without further purification LC/ESI-MS: m/z=166 [M-CH4O+H]+; Rt=2.17 min.
98%	With hydrogen;palladium 10% on activated carbon; In tetrahydrofuran; at 20℃; under 750.075 Torr;	In a 1 1 Schlenk flask filled with argon, <strong>[61032-41-5]methyl 4-benzyloxy-5-methoxy-2-nitrobenzoate</strong> (11.60 g, 36.6 mmol) and palladium on charcoal (1.17 g, 10 % Pd, 1.1 mmol Pd) were combined and tetrahydrofuran (250 mL) was added. The argon was replaced with hydrogen (1 bar), and the mixture was vigorously stirred at r.t. until completion of the reaction. The palladium was separated by filtration through a pad of celite and the solvent was removed to obtain methyl 2-amino-4-hydroxy-5-methoxybenzoate (6.56 g, 36.0 mmol, 98 %) which was used without further purification. LC/ESI-MS: m/z = 166 [M-CH4O+H]+; Rt = 2.17 min.
	With hydrogen;palladium 10% on activated carbon; In tetrahydrofuran; at 20℃; under 750.075 Torr;	In a 1 l Schlenk flask filled with argon, product of step 2 (36.6 mmol) and palladium on charcoal (1.17 g, 10% Pd, 1.1 mmol Pd) were combined and tetrahydrofuran (250 mL) was added. The argon was replaced with hydrogen (1 bar), and the mixture was vigorously stirred at r.t. until completion of the reaction. The palladium was separated by filtration through a pad of celite and the solvent was removed to obtain methyl 2-amino-4-hydroxy-5-methoxybenzoate or methyl 2-amino-5-hydroxy-4-methoxybenzoate, respectively, quantitatively, which, again, was used without further purification.
	With palladium 10% on activated carbon; hydrogen; In methanol; at 25℃; for 16h;	into a 500-mL round-bottom flask, was placed a mixture of methyl 4-(henzvloxv)-5-methoxy- 2-nitrobenzoate (15.00 g, 47.2.7 mmol, 1.00 eq.), MeOH (150 mL) and 10% Pd/C (3.00 g). The mixture was degassed and purged with hydrogen for 3 times. The resulting mixture was allowed to stir at 25 C for 16 h. The solids were filtered out. The filtrate was concentrated under reduced pressure to provide crude product of methyl 2-an:iino-4-hy droxy-5-methoxybenzoate as a gray solid(8.5 g, 91%). LCMS (ES) [M*ij m/z 198.1.

Reference： [1]Patent: US2007/21446,2007,A1 .Location in patent: Page/Page column 14
[2]Patent: EP1785420,2007,A1 .Location in patent: Page/Page column 18
[3]Bioorganic and Medicinal Chemistry,2009,vol. 17,p. 6728 - 6737
[4]Patent: EP1746096,2007,A1 .Location in patent: Page/Page column 23
[5]Bioorganic and Medicinal Chemistry,2014,vol. 22,p. 6796 - 6805
[6]Patent: US2007/149523,2007,A1 .Location in patent: Page/Page column 13
[7]Patent: EP1674467,2006,A1 .Location in patent: Page/Page column 26
[8]Patent: US2006/142570,2006,A1 .Location in patent: Page/Page column 17
[9]Patent: EP1674466,2006,A1 .Location in patent: Page/Page column 26
[10]Patent: US2006/135782,2006,A1 .Location in patent: Page/Page column 23
[11]Patent: WO2016/148674,2016,A1
[12]Patent: WO2017/142947,2017,A1 .Location in patent: Page/Page column 56

2
[ 848092-84-2 ]
[ 77287-34-4 ]
[ 162012-72-8 ]

Yield	Reaction Conditions	Operation in experiment
85%	With ammonium formate; at 140℃; for 4h;	A mixture of formamide (29 mL), ammonium formate (3.41 g, 54 mmol) and methyl 2-amino-4-hydroxy-5-methoxybenzoate (6.56 g, 36.0 mmol) was heated to 140C for 4 h. After cooling to r.t., water (75 mL) was added. Afterstirring for 1 h, the precipitated 7-hydroxy-6-methoxy-3,4-dihydroquinazolin-4-one was filtered off, washed with waterand dried (grey solid, 5.86 g, 30.5 mmol, 85 %). LC/ESI-MS: m/ z = 193 [M +H]+; m/ z = 191 [M-H]-; Rt = 1.53 min.
85%	With ammonium formate; at 140℃; for 4h;	A mixture of formamide (29 mL), ammonium formate (3.41 g, 54 mmol) and methyl 2-amino-4-hydroxy-5-methoxybenzoate (6.56 g, 36.0 mmol) was heated to 140C for 4 h. After cooling to r.t., water (75 mL) was added. After stirring for 1 h, the precipitated 7-hydroxy-6-methoxy-3,4-dihydroquinazolin-4-one was filtered off, washed with water and dried (grey solid, 5.86 g, 30.5 mmol, 85 %). LC/ESI-MS: m/z = 193 [M +H]+; m/z = 191 [M-H]-; Rt = 1.53 min.
85%	With ammonium formate; at 140℃; for 4h;	Step 4. A mixture of formamide (29 mL), ammonium formate (3.41 g, 54 mmol) and methyl 2-amino-4-hydroxy-5-methoxybenzoate (6.56 g, 36.0 mmol) was heated to 140 C. for 4 h. After cooling to r.t., water (75 mL) was added. After stirring for 1 h, the precipitated 7-hydroxy-6-methoxy-3,4-dihydroquinazolin-4-one was filtered off, washed with water and dried (grey solid, 5.86 g, 30.5 mmol, 85%). LC/ESI-MS: m/z=193 [M+H]+; m/z=191 [M-H]-; Rt=1.53 min.

76 - 85%	With ammonium formate; at 140℃; for 4h;	Step 4. A mixture of formamide (29 mL), ammonium formate (3.41 g, 54 mmol) and crude material of step 3 (36.0 mmol) was heated to 140 C. for 4 h. After cooling to r.t., water (75 mL) was added. After stirring for 1 h, the precipitated 7-hydroxy-6-methoxy-3,4-dihydroquinazolin-4-one or 6-hydroxy-7-methoxy-3,4-dihydroquinazolin-4-one, respectively, was filtered off, washed with water and dried (76-85%).
	With ammonium formate; at 140℃; for 4h;	A mixture of formamide (29 mL), ammonium formate (3.41 g, 54 mmol) and crude material of step 3 (36.0 mmol) was heated to 140 C. for 4 h. After cooling to r.t., water (75 mL) was added. After stirring for 1 h, the precipitated 7-hydroxy-6-methoxy-3,4-dihydroquinazolin-4-one or 6-hydroxy-7-methoxy-3,4-dihydroquinazolin-4-one, respectively, was filtered off, washed with water and dried (76-85%).

Reference： [1]Patent: EP1674467,2006,A1 .Location in patent: Page/Page column 26
[2]Patent: EP1674466,2006,A1 .Location in patent: Page/Page column 26
[3]Patent: US2006/142570,2006,A1 .Location in patent: Page/Page column 17
[4]Patent: US2007/149523,2007,A1 .Location in patent: Page/Page column 13
[5]Patent: US2006/135782,2006,A1 .Location in patent: Page/Page column 23
[6]Bioorganic and Medicinal Chemistry,2009,vol. 17,p. 6728 - 6737

3
[ 848092-84-2 ]
[ 16712-16-6 ]
[ 77287-34-4 ]
[ 162012-72-8 ]

Yield	Reaction Conditions	Operation in experiment
76 - 85%	at 140℃; for 4h;	Step 4. A mixture of formamide (29 mL), ammonium formate (3.41 g, 54 mmol) and crude material of step 3 (36.0 mmol) was heated to 140 C. for 4 h. After cooling to r.t., water (75 mL) was added. After stirring for 1 h, the precipitated 7-hydroxy-6-methoxy-3,4-dihydroquinazolin-4-one or 6-hydroxy-7-methoxy-3,4-dihydroquinazolin-4-one, respectively, was filtered off, washed with water and dried (76-85%).
76 - 85%	at 140℃; for 4h;	Step 4. A mixture of formamide (29 mL), ammonium formate (3.41 g, 54 mmol) and crude material of step 3 (36.0 mmol) was heated to 140C for 4 h. After cooling to r.t., water (75 mL) was added. After stirring for 1 h, the precipitated 7-hydroxy-6-methoxy-3,4-dihydroquinazolin-4-one or 6-hydroxy-7-methoxy-3,4-dihydroquinazolin-4-one, respectively, was filtered off, washed with water and dried (76-85%).
	at 140℃; for 4h;	Step 4. A mixture of formamide (29 mL), ammonium formate (3.41 g, 54 mmol) and crude material of step 3 (36.0 mmol) was heated to 140C for 4 h. After cooling to r.t., water (75 mL) was added. After stirring for 1 h, the precipitated 7-hydroxy-6-methoxy-3,4-dihydroquinazolin-4-one or 6-hydroxy-7-methoxy-3,4-dihydroquinazolin-4-one, respectively, was filtered off, washed with water and dried (76-85%).

Reference： [1]Patent: US2007/21446,2007,A1 .Location in patent: Page/Page column 14
[2]Patent: EP1785420,2007,A1 .Location in patent: Page/Page column 18
[3]Patent: EP1746096,2007,A1 .Location in patent: Page/Page column 24

4
[ 56441-97-5 ]
[ 848092-84-2 ]

Reference： [1]Bioorganic and Medicinal Chemistry,2014,vol. 22,p. 6796 - 6805
[2]Patent: WO2016/148674,2016,A1
[3]Patent: US2007/149523,2007,A1

5
[ 848092-84-2 ]
[ 16712-16-6 ]
[ 162012-72-8 ]

Yield	Reaction Conditions	Operation in experiment
86%	In formamide; at 150℃; for 5h;	4.1.6 7-Hydroxy-6-methoxyquinazolin-4(3H)-one (14) A mixture of formamide (25 mL), ammonium formate (3.59 g, 57 mmol) and 13 (6.5 g, 33 mmol) was heated at 150 C for 5 h. The mixture was cooled to room temperature, and water (100 mL) was added in order to precipitate the quinazolinone 14. After stirring for 1 h, the resulting precipitate was filtered off, washed with water and dried to obtain intermediate 14 as a white solid. Yield: 86%, mp: >250 C.

Reference： [1]Bioorganic and Medicinal Chemistry,2014,vol. 22,p. 6796 - 6805

6
[ 27883-60-9 ]
[ 848092-84-2 ]

Yield	Reaction Conditions	Operation in experiment
781.0 mg	With palladium 10% on activated carbon; hydrogen; In ethanol; for 3h;	EC1882 (1.0331 g, 4.55 mmol) was dissolved in ethanol (200 proof, 70 mL). Pd/C (10%, 200mg) was added. The reaction flask was evacuated and backfilled with H2 three times. H2 wasapplied by balloon for 3 hours, at which point the flask was evacuated and backfilled with air three times. Celite was added and the product filtered through with ethanol and concentrated. Typical yield 781.0 mg, 90% recovery, brown solid. ?H NMR (CD3OD, oe in ppm): 7.25 (s, 1H), 6.20 (s, 1H), 3.85 (s, 3H), 3.80 (s, 3H). MS (ESI): mlz = 196.23 (M-H).

Reference： [1]Patent: WO2016/148674,2016,A1 .Location in patent: Page/Page column 114

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P374	Fight fire with normal precautions from a reasonable distance.
P376	Stop leak if safe to do so. Oxidising gases (section 2.4) 1
P377	Leaking gas fire: Do not extinguish, unless leak can be stopped safely.
P378
P380	Evacuate area.
P381	Eliminate all ignition sources if safe to do so.
P390	Absorb spillage to prevent material damage.
P391	Collect spillage. Hazardous to the aquatic environment
P301 + P310	IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P301 + P312	IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P301 + P330 + P331	IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P302 + P334	IF ON SKIN: Immerse in cool water/wrap in wet bandages.
P302 + P350	IF ON SKIN: Gently wash with plenty of soap and water.
P303 + P361 + P353	IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304 + P312	IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell.
P304 + P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P304 + P341	IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P306 + P360	IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes.
P307 + P311	IF exposed: call a POISON CENTER or doctor/physician.
P308 + P313	IF exposed or concerned: Get medical advice/attention.
P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P370 + P376	In case of fire: Stop leak if safe to Do so.
P370 + P378	In case of fire:
P370 + P380	In case of fire: Evacuate area.
P370 + P380 + P375	In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion.
P371 + P380 + P375	In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
Storage
Code	Phrase
P401
P402	Store in a dry place.
P403	Store in a well-ventilated place.
P404	Store in a closed container.
P405	Store locked up.
P406	Store in corrosive resistant/ container with a resistant inner liner.
P407	Maintain air gap between stacks/pallets.
P410	Protect from sunlight.
P411
P412	Do not expose to temperatures exceeding 50 oC/ 122 oF.
P413
P420	Store away from other materials.
P422
P402 + P404	Store in a dry place. Store in a closed container.
P403 + P233	Store in a well-ventilated place. Keep container tightly closed.
P403 + P235	Store in a well-ventilated place. Keep cool.
P410 + P403	Protect from sunlight. Store in a well-ventilated place.
P410 + P412	Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
P411 + P235	Keep cool.
Disposal
Code	Phrase
P501	Dispose of contents/container to ...
P502	Refer to manufacturer/supplier for information on recovery/recycling

Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed
H304	May be fatal if swallowed and enters airways
H305	May be harmful if swallowed and enters airways
H310	Fatal in contact with skin
H311	Toxic in contact with skin
H312	Harmful in contact with skin
H313	May be harmful in contact with skin
H314	Causes severe skin burns and eye damage
H315	Causes skin irritation
H316	Causes mild skin irritation
H317	May cause an allergic skin reaction
H318	Causes serious eye damage
H319	Causes serious eye irritation
H320	Causes eye irritation
H330	Fatal if inhaled
H331	Toxic if inhaled
H332	Harmful if inhaled
H333	May be harmful if inhaled
H334	May cause allergy or asthma symptoms or breathing difficulties if inhaled
H335	May cause respiratory irritation
H336	May cause drowsiness or dizziness
H340	May cause genetic defects
H341	Suspected of causing genetic defects
H350	May cause cancer
H351	Suspected of causing cancer
H360	May damage fertility or the unborn child
H361	Suspected of damaging fertility or the unborn child
H361d	Suspected of damaging the unborn child
H362	May cause harm to breast-fed children
H370	Causes damage to organs
H371	May cause damage to organs
H372	Causes damage to organs through prolonged or repeated exposure
H373	May cause damage to organs through prolonged or repeated exposure
Environmental hazards
Code	Phrase
H400	Very toxic to aquatic life
H401	Toxic to aquatic life
H402	Harmful to aquatic life
H410	Very toxic to aquatic life with long-lasting effects
H411	Toxic to aquatic life with long-lasting effects
H412	Harmful to aquatic life with long-lasting effects
H413	May cause long-lasting harmful effects to aquatic life
H420	Harms public health and the environment by destroying ozone in the upper atmosphere

[ CAS No. 848092-84-2 ] {[proInfo.proName]}

Quality Control of [ 848092-84-2 ]

Related Doc. of [ 848092-84-2 ]

Product Details of [ 848092-84-2 ]

Safety of [ 848092-84-2 ]

Application In Synthesis of [ 848092-84-2 ]

[ 848092-84-2 ] Synthesis Path-Upstream 1~3

[ 848092-84-2 ] Synthesis Path-Downstream 1~6

Precautionary Statements-General

Prevention

Response

Storage

Disposal

Physical hazards

Health hazards

Environmental hazards

Inquiry