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Chemical Structure| 848498-05-5 Chemical Structure| 848498-05-5

Structure of 848498-05-5

Chemical Structure| 848498-05-5

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Product Details of [ 848498-05-5 ]

CAS No. :848498-05-5
Formula : C13H21NO5
M.W : 271.31
SMILES Code : O=C(O)[C@@H](NC(OC(C)(C)C)=O)C1CCC(CC1)=O

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Application In Synthesis of [ 848498-05-5 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 848498-05-5 ]

[ 848498-05-5 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 848498-05-5 ]
  • [ 848497-98-3 ]
  • [ 848498-06-6 ]
YieldReaction ConditionsOperation in experiment
With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 0 - 20℃; Step 3 (S)- [ (N-CYCLOBUTYL-N-METHYLCARBAMOYL)- (4- oxocyclohexyl) methyl] carbamic acid tert-butyl ester A solution of (S)-2- (TERT-BUTOXYCARBONYLAMINO)-2- (4- oxocyclohexyl) acetic acid (29.47 g) obtained in Step 2 in N, N- DIMETHYLFORMAMIDE (150 ml) was COOLEDTO 0OC. N- hydrochloride (19. 1 G) SYNTHESIZED in accordance with the method described in Journal of Medicinal Chemistry, 1994,37, 3482, and diisopropylethylamine (35.07 ml) were added, (benzotriazol-1-yloxy) tripyrrolidinophosphonium hexafluorophosphate (59.84 g) was gradually added. After the completion of the addition, the mixture was allowed to warm to room temperature. Water (150 ml) was added and the mixture was extracted with a mixture of ethyl acetate-hexane. The organic layer was washed successively with 5% aqueous potassium hydrogen sulfate solution, saturated aqueous sodium hydrogen carbonate solution, and saturated brine, and dried over sodium sulfate. The drying agent was filtered off, and the filtrate was concentrated under reduced pressure. The residue was purified by silica gel chromatography (hexane: ethyl acetate=2: 3) to give the title compound (23.5 g). H-NMR (8PPM, CDCL3) 1.23-2. 49 (24H, m), 2.88-3. 09 (3H, s), 4.30- 4.58 (lH, m), 4.58-4. 75 (0.6H, m), 4.76-4. 93 (0.4H, m), 5.26-5. 49 (lH, m).
 

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