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CAS No. : | 849062-30-2 | MDL No. : | MFCD06411349 |
Formula : | C9H12BFO3 | Boiling Point : | - |
Linear Structure Formula : | - | InChI Key : | IEBGLDYEUYTUMZ-UHFFFAOYSA-N |
M.W : | 198.00 | Pubchem ID : | 16217681 |
Synonyms : |
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Signal Word: | Warning | Class: | N/A |
Precautionary Statements: | P233-P260-P261-P264-P271-P280-P302+P352-P304-P304+P340-P305+P351+P338-P312-P321-P332+P313-P337+P313-P340-P362-P403-P403+P233-P405-P501 | UN#: | N/A |
Hazard Statements: | H315-H319-H335 | Packing Group: | N/A |
GHS Pictogram: |
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
77% | With tetrakis(triphenylphosphine) palladium(0); caesium carbonate In 1,4-dioxane at 20 - 100℃; for 18h; Inert atmosphere; | 41A 41A. 3-(2'-Fluoro-5'-isopropoxy-[1 ,1 '-biphenyl]-4-yl)propan-1-ol To a solution of 3-(4-bromophenyl)propan-1-ol(1.5 g, 6.97 mmol) in dioxane (20 mL) was added (2-fluoro-5-isopropoxyphenyl)boronic acid (1.381 g, 6.97 mmol),Pd(Ph3P)4 (0.806 g, 0.697 mmol), and Cs2C03 (2.95 g, 9.07mmol). The mixture was degassed and charged with Ar. Themixture was stirred under Ar for 10 hat 100° C., then cooledtort and stirred for 8 hat rt, after which sat'd aq. NaHC03was added. The aqueous layer was extracted with EtOAc(2x). The combined organic extracts were dried over MgS04and concentrated in vacuo. The residue was chromatographed(Si02 ; 40 g; Et0Ac/Hexane=1/4) and then purifiedby preparative HPLC (PHENOMENEX 30x100 mmAxiaLuna column with 65-100% B over 10 min, A=90:10:0.1H20:MeOH:TFA and 8=90:10:0.1 MeOH:H20:TFA) togive the title compound (1.62 g, 5.34 mmol, 77% yield). 1HNMR (400 MHz, CDC13 ) ll7.54-7.45 (m, lH), 7.36-7.29 (m,lH), 7.08 (dd, 1=10.1, 9.0 Hz, lH), 6.98 (dd, 1=6.4, 3.1 Hz,lH), 6.85 (dt, 1=9.0, 3.5 Hz, lH), 4.55 (dt, 1=12.1, 6.1 Hz,lH), 3.77 (t, 1=6.5 Hz, 2H), 2.85-2.71 (m, 2H), 1.97 (dd,1=7.8, 6.7 Hz, 2H), 1.36 (d, 1=5.9 Hz, 6H). |