[ CAS No. 849138-20-1 ] {[proInfo.proName]}

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Quality Control of [ 849138-20-1 ]

COA NMR CNMR HPLC LC-MS

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Product Details of [ 849138-20-1 ]

CAS No. :	849138-20-1	MDL No. :	MFCD26392595
Formula :	C₂₆H₃₂B₂O₄	Boiling Point :	-
Linear Structure Formula :	-	InChI Key :	-
M.W :	430.15	Pubchem ID :	-
Synonyms :

Safety of [ 849138-20-1 ]

Signal Word:	Warning	Class:	N/A
Precautionary Statements:	P264-P280-P337+P313-P305+P351+P338-P302+P352-P332+P313-P362	UN#:	N/A
Hazard Statements:	H315-H319	Packing Group:	N/A
GHS Pictogram:

Application In Synthesis of [ 849138-20-1 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Downstream synthetic route of [ 849138-20-1 ]

[ 849138-20-1 ] Synthesis Path-Downstream 1~9

1
[ 186517-01-1 ]
[ 73183-34-3 ]
[ 849138-20-1 ]

Yield	Reaction Conditions	Operation in experiment
99%	With potassium phosphate; 2-dicyclohexylphosphino-2’,6’-dimethoxybiphenyl; palladium diacetate In 1,4-dioxane at 70℃; for 20h; Inert atmosphere; Sealed tube;
78%	With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; potassium phosphate; palladium diacetate In 1,4-dioxane at 85℃; for 22h; Inert atmosphere;	2,6-Dibromoanthracene and bis(pinacolato)diboron were reacted at 85 ° C for twenty-two hours using palladium acetate as a catalyst, 2-Dicyclohexylphosphino-2',6'-dimethoxybiphenyl as a ligand, potassium phosphate as a base, 1,4-Dioxane is used as a solvent . The crude product was filtered through a short silica gel column, and the system of ethyl acetate and methylene chloride was applied to a short column of silica gel. The obtained filtrate was spin dried, ultrasonicated with petroleum ether for fifteen minutes, the suspension was filtered, and the obtained solid was air-dried to obtain the compound of formula 2 with a yield of 78%.
76%	With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; potassium phosphate; palladium diacetate In 1,4-dioxane at 85℃; for 24h;	Using 2,6-dibromoanthracene with palladium acetate as a catalyst and 2-dicyclohexylphosphine-2 ', 6'-dimethoxybiphenyl as a ligand,Potassium phosphate as base, dioxane as solvent, and Maura Borylation Reaction at 85 ° C for one day.The crude product was washed with hot petroleum ether to obtain the compound of Formula 2, with a reaction yield of 76%.

73%	With potassium acetate In 1,4-dioxane at 110℃; for 15h; Inert atmosphere;	13.A To a solution of 400 mg (1.49 mmol) of 2,6-Dibromo-anthracene (13a) in 1,4- dioxane (30 mL) was added bis-pinacol borate (3.28 mmol), Pd(dppf)Cl2 (0.075 mmol) and KOAc (8.94 mmol). The reaction mixture was put under N2 atmosphere,then heated to 110 0C and allowed to stir at this temperature for about 15 hours. The reaction mixture was then cooled to room temperature and concentrated in vacuo. The resulting residue was purified using column chromatography on silica gel (gradient elution using petroleum etheϖEtOAc from 50: 1 to 10: 1) to provide Compound 13b (467 mg, 73% yield).
73%	With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate In 1,4-dioxane at 110℃; for 15h;
71%	With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate In 1,4-dioxane at 20 - 80℃; for 20.5h; Inert atmosphere;
48%	With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate In dimethyl sulfoxide at 80℃; for 16h;
48%	With potassium acetate In dimethyl sulfoxide at 80℃; for 16h;	5 A nitrogen- flushed round bottom flask was charged with 2,6-dibromoanthracene (prepared as in Example 1 , 21.73 g, 64.67 mmol), bis(pinacolato)diboron (41.06 g, 161.67 mmol), potassium acetate (25.90 g, 263.85 mmol) and [1 ,1'-bis(diphenylphosphino)ferrocene]-dichloropalladium complex with dichloromethane (1 :1 ) (1.64 g, 2.0 mmol). Dimethyl sulfoxide (DMSO, 300 ml) was then added and the mixture was bubbled with nitrogen for 15 min. After heating at 80 0C for 16 h, the reaction mixture was cooled to room temperature and poured into ice-water (600 ml). It was then extracted with methylene chloride (2x) and the combined organic layer was dried over anhydrous magnesium sulfate. The solvent was removed by rotary evaporation and the residue was purified several times by flash silica gel column with chloroform/hexane (1 :2 to 1 :1 to 2:1 to chloroform) as eluent to give 13.4698 g of (48%) bright yellow fine crystals, mp: >260 0C. 1H NMR (CDCI3, 500 MHz): δ 8.56 ppm (s, 2 H), 8.44 ppm (s, 2 H), 7.99-7.97 ppm (d, 2 H, J = 8.5 Hz), 7.79-7.77 ppm (d, 2 H1 J = 8.5 Hz ), δ 1.41 ppm (s, 24 H); 13C-NMR (CDCI3, 500 MHz): δ 137.7, 133.1 , 132.2, 129.5, 127.8, 127.5, 84.37, 25.33 ppm. El, MS m/z (%): 430 (100, M+). Anal. Found: C, 71.76; H, 7.32; B, 4.89
38%	With potassium acetate In dimethyl sulfoxide at 80℃; Inert atmosphere;	AA1 A mixture of 2,6- dibromoanthracene (500 mg, 1.49 mmol), bis(pinacolato)diboron (756 mg, 2.98 mmol)and KOAc (585 mg, 5.96 mmol) in DMSO (10 mL) was degassed with N2 gas for 20 minutes. To the degassed solution was added PdCl2(dppf) (55 mg, 0.075 mmol) then the reaction was heated to 8O°C overnight. After cooling to room temperature, the reaction was poured into H2O and extracted with CH2Cl2. The organic phase was collected then washed with H2O and brine. After drying over Na2Sθ4, the organic phase was concentrated then purified by silica gel chromatography (30-100% CH2Cl2-hexanes gradient) to afford 2,6-anthracene-bis-4,4,5,5- tetramethyl-1,3,2-dioxaborolane (241 mg, 0.56 mmol, 38% yield). 1H-NMR: 400 MHz, (DMSO-d6) δ: 8.57 (s, 2H), 8.46 (s, 2H), 8.00 (d, 2H), 7.79 (d, 2H).
	With potassium acetate
	With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; potassium phosphate; palladium diacetate In 1,4-dioxane at 80℃; for 20h; Inert atmosphere;
	With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate at 80℃;	1.1 Step 1 : A Miyaura borylation reaction can be used to form (a). 2,6- dibromoanthracene can be reacted with bis(pinacolato)diboron in the presence of KOAc and PdCl2(dppf) catalyst in a solvent such as dioxane or DMSO at a temperature of 80°C. The product (a) can be isolated by conventional techniques.

Reference： [1]Huang, Ze-Ao; Chen, Chen; Yang, Xiao-Di; Fan, Xiang-Bing; Zhou, Wen; Tung, Chen-Ho; Wu, Li-Zhu; Cong, Huan [Journal of the American Chemical Society, 2016, vol. 138, # 35, p. 11144 - 11147]
[2]Current Patent Assignee: CHINESE ACADEMY OF SCIENCES; Technical Institute of Physics & Chemistry(in: CAS) - CN108586187, 2018, A Location in patent: Paragraph 0032; 0033
[3]Current Patent Assignee: CHINESE ACADEMY OF SCIENCES; Technical Institute of Physics & Chemistry(in: CAS) - CN110272332, 2019, A Location in patent: Paragraph 0036-0037; 0052
[4]Current Patent Assignee: MERCK & CO INC - WO2010/132538, 2010, A1 Location in patent: Page/Page column 110
[5]Yu, Wensheng; Coburn, Craig A.; Yang, De-Yi; Meinke, Peter T.; Wong, Michael; Rosenblum, Stuart B.; Chen, Kevin X.; Njoroge, George F.; Chen, Lei; Dwyer, Michael P.; Jiang, Yueheng; Nair, Anilkumar G.; Selyutin, Oleg; Tong, Ling; Zeng, Qingbei; Zhong, Bin; Ji, Tao; Hu, Bin; Agrawal, Sony; Xia, Ellen; Zhai, Ying; Liu, Rong; Kong, Rong; Ingravallo, Paul; Asante-Appiah, Ernest; Nomeir, Amin; Fells, James; Kozlowski, Joseph A. [Bioorganic and Medicinal Chemistry Letters, 2016, vol. 26, # 13, p. 3158 - 3162]
[6]Sonar, Prashant; Singh, Samarendra P.; Williams, Evan L.; Li, Yuning; Soh, Mui Siang; Dodabalapur, Ananth [Journal of Materials Chemistry, 2012, vol. 22, # 10, p. 4425 - 4435]
[7]Meng, Hong; Sun, Fangping; Goldfinger, Marc B.; Jaycox, Gary D.; Li, Zhigang; Marshall, Will J.; Blackman, Gregory S. [Journal of the American Chemical Society, 2005, vol. 127, # 8, p. 2406 - 2407]
[8]Current Patent Assignee: DUPONT DE NEMOURS INC - WO2006/50496, 2006, A1 Location in patent: Page/Page column 40
[9]Current Patent Assignee: GILEAD SCIENCES INC - WO2010/132601, 2010, A1 Location in patent: Page/Page column 458
[10]Zhao, Yang; Yan, Lijia; Murtaza, Imran; Liang, Xiao; Meng, Hong; Huang, Wei [Organic electronics, 2017, vol. 43, p. 105 - 111]
[11]Xu, Wei; Yang, Xiao-Di; Fan, Xiang-Bing; Wang, Xin; Tung, Chen-Ho; Wu, Li-Zhu; Cong, Huan [Angewandte Chemie - International Edition, 2019, vol. 58, # 12, p. 3943 - 3947][Angew. Chem., 2019, vol. 131, # 12, p. 3983 - 3987,5]
[12]Current Patent Assignee: DUPONT DE NEMOURS INC - WO2020/33480, 2020, A1 Location in patent: Page/Page column 77

2
[ 211737-28-9 ]
[ 849138-20-1 ]
2-[6-(5-hexyl-thiophen-2-yl)-anthracen-2-yl]-4,4,5,5-tetramethyl-[1,3,2]dioxaborolane [ No CAS ]
bis-(5'-hexylthiophen-2'-yl)-2,6-anthracene [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
53%	With tetrakis(triphenylphosphine) palladium⁽⁰⁾; Aliquat 336; sodium carbonate In toluene at 90℃; for 72h;

Reference： [1]Meng, Hong; Sun, Fangping; Goldfinger, Marc B.; Jaycox, Gary D.; Li, Zhigang; Marshall, Will J.; Blackman, Gregory S. [Journal of the American Chemical Society, 2005, vol. 127, # 8, p. 2406 - 2407]

3
[ 211737-28-9 ]
[ 849138-20-1 ]
bis-(5'-hexylthiophen-2'-yl)-2,6-anthracene [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
53%	With sodium carbonate In water; toluene at 90℃; for 72h;	6 To a solution of 2,6- anthracene-bis-4',4',5',5'-tetramethyl-1 ',3',2'-dioxaborolane (prepared as in Example 5, 6.8220 g, 15.86 mmol) and 2-bromo-5-hexylthophene (8.6251 g, 34.89 mmol) dissolved in toluene (240 ml) was added sodium carbonate (8.48 g, 80 mmol) dissolved in water (40 ml) followed by th e addition of phase-transfer agent Aliquat 336 (3.2 g, 8.0 mmol). The mixture was bubbled with nitrogen for 15 min. Then, tetrakis(triphenylphosphine)palladium(0) (368 mg, 2 % mol) was added. The mixture was heated to 90 0C for three days under a nitrogen atmosphere. The reaction mixture was cooled to room temperature and poured into methanol (600 ml). The yellow precipitate was filtered off, washed with water, dilute acid (5 % HCI), water, methanol, then with acetone (3x) to remove the starting material and mono-substituted by¬ product. The crude product was purified by sublimation (2Z0 °C/60 mmTorr) in a 3-zone furnace, followed by recrystallization from xylenes to give 4.2802 g (53%) of bright yellow product. 1H NMR (p-d ichlorobenzene- d4, 500 MHz): δ 8.15 ppm (s, 2 H), 8.01 ppm (s, 2 H), 7.82-7.80 ppm (d, 2 H, J = 8.5 Hz), 7.61-7.59 ppm (d, 2 H, J = 8.5 Hz ), 7.19 ppm (d, 2 H, J = 3.45 Hz), 7.02 ppm (d, 2 H, J = 3.45 Hz), 6.71 ppm (s, 2 H ), 2.80-2.77 ppm (t, 2 H, J = 8.6 Hz), 1.70 ppm (m, 2 H), 1.32 ppm (m, 6 H), 0.89 ppm (t, 3 H, J = 7.5 Hz);; 13C-NMR (CDCI3, 500 MHz): δ 146.6, 142.7, 132.8, 132.4, 132.2, 130.2, 129.3, 126.8, 125.9, 125.1 , 124.0, 32.36, 32.28, 31.11 , 29.64, 23.33, 14.63 ppm. El, MS m/z (%): 510 (100, M+); HRMS found: 510.241463. Compounds 9 - 15 were synthesized in a similar manner as that described for the synthesis of DHTAnt.

Reference： [1]Current Patent Assignee: DUPONT DE NEMOURS INC - WO2006/50496, 2006, A1 Location in patent: Page/Page column 42

4
[ 1007882-59-8 ]
[ 849138-20-1 ]
[ 1240886-16-1 ]

Yield	Reaction Conditions	Operation in experiment
61%	With sodium carbonate In tetrahydrofuran; water for 15h; Inert atmosphere; Reflux;	13.B A suspension of Compound 13b (467 mg, 1.09 mmol, prepared as described in theJournal of the American Chemical Society, 127: 8; 2005; 2406 - 2407), (S)-tert-butyl 2-(5-bromo-lH-imidazol-2-yl)pyrrolidine-l-carboxylate (2.18 mmol), Pd(dppf)2Cl2 (0.109 mol), Na2CO3 (6.52 mmol) in THF/H2O (10:1, 20 mL) was put under N2 atmosphere, then heated to reflux and allowed to stir at this temperature for about 15 hours. The reaction mixture was cooled to room temperature and filtered and the filtrate was washed with water (20 mL) and extracted with EtOAc (50 mL). The combined organic extracts were washed with brine, dried over anhydrous sodium sulfate, filtered and concentrated in vacuo. The residue obtained was purified using column chromatography (Gradient Pet ether: Ethyl Acetate from 10: 1 to 1:9) to provide Compound 13c (706 mg, 61% yield). MS (ESI) m/e (M+H)+: 649
61%	With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium carbonate In tetrahydrofuran; water for 15h; Reflux;

Reference： [1]Current Patent Assignee: MERCK & CO INC - WO2010/132538, 2010, A1 Location in patent: Page/Page column 111
[2]Yu, Wensheng; Coburn, Craig A.; Yang, De-Yi; Meinke, Peter T.; Wong, Michael; Rosenblum, Stuart B.; Chen, Kevin X.; Njoroge, George F.; Chen, Lei; Dwyer, Michael P.; Jiang, Yueheng; Nair, Anilkumar G.; Selyutin, Oleg; Tong, Ling; Zeng, Qingbei; Zhong, Bin; Ji, Tao; Hu, Bin; Agrawal, Sony; Xia, Ellen; Zhai, Ying; Liu, Rong; Kong, Rong; Ingravallo, Paul; Asante-Appiah, Ernest; Nomeir, Amin; Fells, James; Kozlowski, Joseph A. [Bioorganic and Medicinal Chemistry Letters, 2016, vol. 26, # 13, p. 3158 - 3162]

5
[ 1352718-88-7 ]
[ 849138-20-1 ]
C₃₈H₄₄N₆O₄ [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
32%	With potassium carbonate;(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tetrakis(triphenylphosphine) palladium(0); In water; N,N-dimethyl-formamide; toluene; at 80.0℃;Inert atmosphere;	A solution of 2,6-anthracene-bis-4,4,5,5- tetramethyl-l ,3,2-dioxaborolane (241 mg, 0.56 mmol), 2-(5-bromo-1H-imidazol-2-yl)- pyrrolidine-1-carboxylic acid tert-butyl ester (531 mg, 1.68 mmol) and aq K2Ctheta3 (1.12 mL of a 2M solution, 2.24 mmol) in toluene (6 mL) and DMF (1 mL) was degassed with N2 gas for 20 minutes. To the degassed solution was added Pd(PPh3)4 (32 mg, 0.028 mmol) and PdCl2(dppf) (21 mg, 0.028 mmol) then the reaction was heated to 80C overnight. After cooling to room temperature, the reaction was concentrated. The crude material was diluted with EtOAc then washed with saturated NaHCO3. The aqueous phase was back-extracted two times then the organic layers were combined, dried over Na2SO4, and concentrated. The crude product was purified by reverse phase preparative HPLC (20-80% MeCN-H2O; 0.1% formic acid modifier) to afford l-[2-(5-{6-[2-(l-1-/err-butoxycarbonyl-py?-olidin-2-yl)-3H-imidazol-4-yl]-anthracen- 2-yl}-1H-imidazol-2-yl)-pyrrolidin-1-yl]-ethanone (117 mg, 0.18 mmol, 32% yield). LCMS- ESI+: CaIcd. for C38H45N6O4: 649.4 (M+H+); Found: 648.9 (M+H+).

Reference： [1]Patent: WO2010/132601,2010,A1 .Location in patent: Page/Page column 458-459

6
CH₂Cl₂-hexanes [ No CAS ]
bis(pinacolato)diboron [ No CAS ]
PdCl₂dppf2 [ No CAS ]
[ 186517-01-1 ]
[ 849138-20-1 ]

Yield	Reaction Conditions	Operation in experiment
	With potassium acetate In dimethyl sulfoxide	13 Preparation of Compound 13 Example 13 Preparation of Compound 13 2,6-Anthracene-bis-4,4,5,5-tetramethyl-1,3,2-dioxaborolane: A mixture of 2,6-dibromoanthracene (500 mg, 1.49 mmol), bis(pinacolato)diboron (756 mg, 2.98 mmol) and KOAc (585 mg, 5.96 mmol) in DMSO (10 mL) was degassed with N2 gas for 20 minutes. To the degassed solution was added PdCl2dppf2 (55 mg, 0.075 mmol) then the reaction was heated to 80° C. overnight. After cooling to room temperature, the reaction was poured into H2O and extracted with CH2Cl2. The organic phase was collected then washed with H2O and brine. After drying over Na2SO4, the organic phase was concentrated then purified by silica gel chromatography (30-100% CH2Cl2-hexanes gradient) to afford 2,6-anthracene-bis-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (241 mg, 0.56 mmol, 38% yield). 1H-NMR: 400 MHz, (DMSO-d6) δ: 8.57 (s, 2H), 8.46 (s, 2H), 8.00 (d, 2H), 7.79 (d, 2H).

Reference： [1]Current Patent Assignee: GILEAD SCIENCES INC - US2011/306541, 2011, A1

7
[ 186517-01-1 ]
[ 25015-63-8 ]
[ 849138-20-1 ]

Yield	Reaction Conditions	Operation in experiment
	With triethylamine In toluene

Reference： [1]Current Patent Assignee: CANON INC. - US8148543, 2012, B2 Location in patent: Page/Page column 7

8
[ 26608-06-0 ]
[ 849138-20-1 ]
2,6-bis(dibenzo[b,d]furan-3-yl)anthracene [ No CAS ]

Reference： [1]Organic electronics,2017,vol. 43,p. 105 - 111

9
[ 393-36-2 ]
[ 849138-20-1 ]
2,6-bis(4-amino-2-trifluoromethylphenyl)anthracene [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	With tetrakis(triphenylphosphine) palladium(0); potassium carbonate; In ethanol; water; toluene; at 85℃; for 72h;Inert atmosphere;	A mixture of 2,6-bis-Bpin anthracene 1 (14.5 g, 33.71 mmole), 4- bromo-3-(trifluoromethyl)aniline 2 (24.27 g, 101 .13 mmole), Pd(PPh3)4 (3.9 g, 3.37 mmole) and potassium carbonate (23.29 g, 169 mmole) in toluene (400 ml), ethanol (200 ml) and water (80 ml) was degassed and stirred with heating at 85C under nitrogen atmosphere for 3 days. Precipitated from reaction mixture product 3 (9.7 g) was collected by hot filtration. Filtrate cooled down, precipitate collected by filtration to give 3.2 g of the product with lower purity. 1H-NMR (DMSO-d6, 500 MHz): 5.69 (s, 4H), (0641) 6.88 (dd, 2H, J1 = 2 Hz, J2 = 8 Hz), 7.03 (d, 2H, J = 2 Hz), 7.18 (d, 2H, J = 8 Hz), 7.40 (d, 2H, J = 9 Hz), 7.92 (s, 2H), 8.05 (d, 2H, J = 9 Hz), 8.58 (s, 2H).

Reference： [1]Patent: WO2020/33475,2020,A1 .Location in patent: Page/Page column 69-70

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P304 + P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P304 + P341	IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P306 + P360	IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes.
P307 + P311	IF exposed: call a POISON CENTER or doctor/physician.
P308 + P313	IF exposed or concerned: Get medical advice/attention.
P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P370 + P376	In case of fire: Stop leak if safe to Do so.
P370 + P378	In case of fire:
P370 + P380	In case of fire: Evacuate area.
P370 + P380 + P375	In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion.
P371 + P380 + P375	In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
Storage
Code	Phrase
P401
P402	Store in a dry place.
P403	Store in a well-ventilated place.
P404	Store in a closed container.
P405	Store locked up.
P406	Store in corrosive resistant/ container with a resistant inner liner.
P407	Maintain air gap between stacks/pallets.
P410	Protect from sunlight.
P411
P412	Do not expose to temperatures exceeding 50 oC/ 122 oF.
P413
P420	Store away from other materials.
P422
P402 + P404	Store in a dry place. Store in a closed container.
P403 + P233	Store in a well-ventilated place. Keep container tightly closed.
P403 + P235	Store in a well-ventilated place. Keep cool.
P410 + P403	Protect from sunlight. Store in a well-ventilated place.
P410 + P412	Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
P411 + P235	Keep cool.
Disposal
Code	Phrase
P501	Dispose of contents/container to ...
P502	Refer to manufacturer/supplier for information on recovery/recycling

Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed
H304	May be fatal if swallowed and enters airways
H305	May be harmful if swallowed and enters airways
H310	Fatal in contact with skin
H311	Toxic in contact with skin
H312	Harmful in contact with skin
H313	May be harmful in contact with skin
H314	Causes severe skin burns and eye damage
H315	Causes skin irritation
H316	Causes mild skin irritation
H317	May cause an allergic skin reaction
H318	Causes serious eye damage
H319	Causes serious eye irritation
H320	Causes eye irritation
H330	Fatal if inhaled
H331	Toxic if inhaled
H332	Harmful if inhaled
H333	May be harmful if inhaled
H334	May cause allergy or asthma symptoms or breathing difficulties if inhaled
H335	May cause respiratory irritation
H336	May cause drowsiness or dizziness
H340	May cause genetic defects
H341	Suspected of causing genetic defects
H350	May cause cancer
H351	Suspected of causing cancer
H360	May damage fertility or the unborn child
H361	Suspected of damaging fertility or the unborn child
H361d	Suspected of damaging the unborn child
H362	May cause harm to breast-fed children
H370	Causes damage to organs
H371	May cause damage to organs
H372	Causes damage to organs through prolonged or repeated exposure
H373	May cause damage to organs through prolonged or repeated exposure
Environmental hazards
Code	Phrase
H400	Very toxic to aquatic life
H401	Toxic to aquatic life
H402	Harmful to aquatic life
H410	Very toxic to aquatic life with long-lasting effects
H411	Toxic to aquatic life with long-lasting effects
H412	Harmful to aquatic life with long-lasting effects
H413	May cause long-lasting harmful effects to aquatic life
H420	Harms public health and the environment by destroying ozone in the upper atmosphere

[ CAS No. 849138-20-1 ] {[proInfo.proName]}

Quality Control of [ 849138-20-1 ]

Related Doc. of [ 849138-20-1 ]

Product Details of [ 849138-20-1 ]

Safety of [ 849138-20-1 ]

Application In Synthesis of [ 849138-20-1 ]

[ 849138-20-1 ] Synthesis Path-Downstream 1~9

Precautionary Statements-General

Prevention

Response

Storage

Disposal

Physical hazards

Health hazards

Environmental hazards

Inquiry