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Chemical Structure| 849217-50-1 Chemical Structure| 849217-50-1

Structure of 849217-50-1

Chemical Structure| 849217-50-1

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Product Details of [ 849217-50-1 ]

CAS No. :849217-50-1
Formula : C27H21F2N3O5
M.W : 505.47
SMILES Code : O=C(C1(C(NC2=CC=C(F)C=C2)=O)CC1)NC3=CC=C(OC4=CC=NC5=CC(O)=C(OC)C=C45)C(F)=C3
MDL No. :N/A

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Application In Synthesis of [ 849217-50-1 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 849217-50-1 ]

[ 849217-50-1 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 849217-50-1 ]
  • [ 57616-74-7 ]
  • [ 849217-64-7 ]
YieldReaction ConditionsOperation in experiment
72% With potassium carbonate; In N,N-dimethyl-formamide; at 90℃; for 5h; To a mechanically stirred slurry of cyclopropane-l, 1-dicarboxylic acid [3-FLUORO-4- (7-HYDROXY-6-METHOXY- quinolin-4-yloxy)-phenyl]-amide (4-fluoro-phenyl) -amide (16.6 g, 32. 8 mmol) and potassium carbonate (13.6 g, 98.6 mmol) in DMF (250 mL) was added 4- (3- chloropropyl) -morpholine hydrochloride (13,7. 92 g, 39.6 mmol). The resulting mixture was heated at 90C for 5 hours (until phenol completely consumed). The reaction mixture was allowed to cool to room temperature, then dumped into water (900 mL), followed by extraction with EtOAc (3X). The combined extracts were washed with 5% LiCl (aq. ) (3X) and brine (1X) followed by drying over MGS04 and concentration in vacuo. The crude (18.8g) obtained as brown solid was further purified by flash chromatography [silica gel, 4-stage gradient system: 1) EtOAc; 2) EtOAc: MeOH: 7N NH3/MEOH (95: 5: 0.5) ; 3) DCM: MeOH: 7N NH3/MeOH (95: 5: 0.5) ; 4) DCM: MeOH : 7N NH3/MeOH (93: 8 : 1)], affording N- [3-FLUORO-4- ( {6- (METHYLOXY)-7- [ (3-MORPHOLIN-4-YLPROPYL) OXY] QUINOLIN-4- YL} OXY) PHENYL]-N-(4-FLUOROPHENYL) CYCLOPROPANE-1, 1-DICARBOXAMIDE was obtained as an off white solid (15.0 g, 72% yield).
  • 2
  • [ 168268-00-6 ]
  • [ 849217-50-1 ]
 

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