Home Cart Sign in  
Chemical Structure| 856408-80-5 Chemical Structure| 856408-80-5

Structure of 856408-80-5

Chemical Structure| 856408-80-5

*Storage: {[sel_prStorage]}

*Shipping: {[sel_prShipping]}

,{[proInfo.pro_purity]}

4.5 *For Research Use Only !

{[proInfo.pro_purity]}
Cat. No.: {[proInfo.prAm]} Purity: {[proInfo.pro_purity]}

Change View

Size Price VIP Price

US Stock

Global Stock

In Stock
{[ item.pr_size ]} Inquiry {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate,item.pr_is_large_size_no_price, item.vip_usd) ]}

US Stock: ship in 0-1 business day
Global Stock: ship in 5-7 days

  • {[ item.pr_size ]}

In Stock

- +

Please Login or Create an Account to: See VIP prices and availability

US Stock: ship in 0-1 business day
Global Stock: ship in 2 weeks

  • 1-2 Day Shipping
  • High Quality
  • Technical Support
Product Citations

Alternative Products

Product Details of [ 856408-80-5 ]

CAS No. :856408-80-5
Formula : C12H17NO3
M.W : 223.27
SMILES Code : O=C(OC1=CC=CC([C@H](O)C)=C1)N(CC)C
MDL No. :N/A

Safety of [ 856408-80-5 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Application In Synthesis of [ 856408-80-5 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 856408-80-5 ]

[ 856408-80-5 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 856408-80-5 ]
  • [ 124-40-3 ]
  • [ 123441-03-2 ]
YieldReaction ConditionsOperation in experiment
87% Stage 3; Materials :- Mw Mass, g mMole Mole Ratio s Alcohol substrate from Stage 2 223 3.40 15.25 1.0 Triethylamine 101. 1 4.60 45. 75 3.0 Methane sulphonic Anhydride 174. 2 3.45 19.8 1. 3 Dimethylamine 45. 05 91. 5 6 THF 70mL Method:- The alcohol obtained in stage 2, without further purification, (3.40g, 15. 25mmol) was dissolved in dry THF (40ml) and cooled in an ice-water bath. Then, triethylamine (4.60g, 45. 75mmol) was added and the solution kept cooled. Methanesulfonic anhydride (3.45g, 19. 8mmol) was dissolved in dry THF (30ml) and added to the cold reaction mixture dropwise over 30 minutes. The reaction mixture was stirred at 0C for 2 hours until conversion was 100% (GC) and then dimethylamine (46mol, 2M solution in THF) was added and the reaction mixture allowed to reach room temperature. After 48 h stirring conversion was 70% (GC), additional dimethylamine (46mmol) was then added and 24 hours later the conversion achieved was 99%. The reaction mixture was poured into 1M HCl (aq) (350ml) and extracted with dichloromethane (350ml), the organic layer was extracted again with 1M HC) (aq) (200m .) and both aqueous layers were combined and neutralized with 2M NaOH (aq) until the pH was above 10, then extracted with dichloromethane (3x350ml), the organic layers combined, dried and the solvent distilled to obtain 3.34g (87%) of the final product as a reddish oil. The specific optical rotation of the product was measured at-31 (3% solution in MeOH) (lit. Rivastigmine-32, Helv. Chim. Acta, 73 (3), 1990,739-753).
 

Historical Records