Home Cart Sign in  
HazMat Fee +

There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.

Type HazMat fee for 500 gram (Estimated)
Excepted Quantity USD 0.00
Limited Quantity USD 15-60
Inaccessible (Haz class 6.1), Domestic USD 80+
Inaccessible (Haz class 6.1), International USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic USD 100+
Accessible (Haz class 3, 4, 5 or 8), International USD 200+
Chemical Structure| 856834-95-2 Chemical Structure| 856834-95-2

Structure of 856834-95-2

Chemical Structure| 856834-95-2

*Storage: {[sel_prStorage]}

*Shipping: {[sel_prShipping]}

,{[proInfo.pro_purity]}

4.5 *For Research Use Only !

{[proInfo.pro_purity]}
Cat. No.: {[proInfo.prAm]} Purity: {[proInfo.pro_purity]}

Change View

Size Price VIP Price

US Stock

Global Stock

In Stock
{[ item.pr_size ]} Inquiry {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate,item.pr_is_large_size_no_price, item.vip_usd) ]}

US Stock: ship in 0-1 business day
Global Stock: ship in 5-7 days

  • {[ item.pr_size ]}

In Stock

- +

Please Login or Create an Account to: See VIP prices and availability

US Stock: ship in 0-1 business day
Global Stock: ship in 2 weeks

  • 1-2 Day Shipping
  • High Quality
  • Technical Support
Product Citations

Alternative Products

Product Details of [ 856834-95-2 ]

CAS No. :856834-95-2
Formula : C6H4BrClN2O2
M.W : 251.47
SMILES Code : O=[N+](C1=C(C)N=C(Cl)C(Br)=C1)[O-]
MDL No. :MFCD09839270
InChI Key :WKGHUAZJNBXABN-UHFFFAOYSA-N
Pubchem ID :29919369

Safety of [ 856834-95-2 ]

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H301-H318
Precautionary Statements:P280-P301+P310-P305+P351+P338
Class:8(6.1)
UN#:2923
Packing Group:

Application In Synthesis of [ 856834-95-2 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Upstream synthesis route of [ 856834-95-2 ]

[ 856834-95-2 ] Synthesis Path-Upstream   1~9

  • 1
  • [ 874493-25-1 ]
  • [ 856834-95-2 ]
YieldReaction ConditionsOperation in experiment
81.4% at 80℃; 3-Bromo-6-methyl-5-nitropyridin-2-ol (9.2 g, 36.7 mmol) in POCl3 (56.2 g, 366.7 mmol) was stirred at 80° C. overnight.
The mixture was slowly poured into water (800 mL) and a solid was formed.
The solid was collected and dried to afford the desired product (7.5 g, 81.4percent yield).
65% for 7 h; Reflux Preparation 13D: 3 -bromo-2-chloro-6-methyl-5 -nitropyridine [00276j In a 500-mL single round-bottomed flask, POC13 (12 g, 78.1 mmol) was added dropwise to 3-bromo-6-methyl-5-nitropyridin-2-ol (4 g, 15.87 mmol). This mixture was then stirred at reflux for 7 h. The reaction mixture was cooled to 30 °C, poured into ice water and stirred for 10 mm. Saturated NaHCO3 solution (30 mL) was then added. The aqueous layer was extracted with EtOAc (200 mL x 3). The combined organic layers were washed with water, brine (200 mL x 2), dried over Na2504, filtered and concentrated to give 2.8 g (65 percent) of the title compound as a yellow solid. ‘H NMR (400 MHz, CDC13) ö 8.55 (s, 1 H), 2.83 (s, 3 H).
65% for 7 h; Reflux In a 500-mL single round-bottomed flask, POCI3 (12 g, 78.1 mmol) was added dropwise to 3-bromo-6-methyl-5-nitropyridin-2-ol (4 g, 15.87 mmol). This mixture was then stirred at reflux for 7 h. The reaction mixture was cooled to 30 °C, poured into ice water and stirred for 10 min. Saturated NaHC03 solution (30 mL) was then added. The aqueous layer was extracted with EtOAc (200 mL x 3). The combined organic layers were washed with water, brine (200 mL x 2), dried over Na2S04, filtered and concentrated to give 2.8 g (65 percent) of the title compound as a yellow solid. 1H NMR (400 MHz, CDC13) δ 8.55 (s, 1 H), 2.83 (s, 3 H).
References: [1] Patent: US2018/170909, 2018, A1, . Location in patent: Paragraph 1925; 1926.
[2] Patent: WO2015/89192, 2015, A1, . Location in patent: Paragraph 00275; 00276.
[3] Patent: WO2016/37005, 2016, A1, . Location in patent: Paragraph 00259-00260.
[4] Patent: WO2008/101682, 2008, A2, . Location in patent: Page/Page column 42-43.
  • 2
  • [ 109-06-8 ]
  • [ 856834-95-2 ]
References: [1] Journal of the American Chemical Society, 1947, vol. 69, p. 63,66.
  • 3
  • [ 1824-81-3 ]
  • [ 856834-95-2 ]
References: [1] Journal of the American Chemical Society, 1947, vol. 69, p. 63,66.
  • 4
  • [ 22280-62-2 ]
  • [ 856834-95-2 ]
References: [1] Journal of the American Chemical Society, 1947, vol. 69, p. 63,66.
  • 5
  • [ 150935-62-9 ]
  • [ 874493-25-1 ]
  • [ 856834-95-2 ]
References: [1] Journal of the American Chemical Society, 1947, vol. 69, p. 63,66.
  • 6
  • [ 500587-45-1 ]
  • [ 856834-95-2 ]
References: [1] Patent: WO2015/89192, 2015, A1, .
[2] Patent: WO2016/37005, 2016, A1, .
[3] Patent: WO2008/101682, 2008, A2, .
  • 7
  • [ 374633-33-7 ]
  • [ 856834-95-2 ]
References: [1] Patent: WO2015/89192, 2015, A1, .
[2] Patent: WO2016/37005, 2016, A1, .
[3] Patent: WO2008/101682, 2008, A2, .
  • 8
  • [ 3279-76-3 ]
  • [ 856834-95-2 ]
References: [1] Patent: WO2015/89192, 2015, A1, .
[2] Patent: WO2016/37005, 2016, A1, .
[3] Patent: WO2008/101682, 2008, A2, .
  • 9
  • [ 28489-45-4 ]
  • [ 856834-95-2 ]
References: [1] Patent: US2018/170909, 2018, A1, .
 

Historical Records

Technical Information

Categories

Related Functional Groups of
[ 856834-95-2 ]

Bromides

Chemical Structure| 5470-17-7

A242324 [5470-17-7]

3-Bromo-2-chloro-5-nitropyridine

Similarity: 0.93

Chemical Structure| 1268521-33-0

A207058 [1268521-33-0]

3-Bromo-2-chloro-5-nitropyridin-4-amine

Similarity: 0.83

Chemical Structure| 15862-30-3

A360004 [15862-30-3]

3-Bromo-5-nitropyridine

Similarity: 0.75

Chemical Structure| 15862-31-4

A102267 [15862-31-4]

3-Bromo-5-nitropyridin-2-amine

Similarity: 0.71

Chemical Structure| 1352886-90-8

A774237 [1352886-90-8]

3-Bromo-2-chloro-6-ethylpyridine

Similarity: 0.71

Chlorides

Chemical Structure| 5470-17-7

A242324 [5470-17-7]

3-Bromo-2-chloro-5-nitropyridine

Similarity: 0.93

Chemical Structure| 1268521-33-0

A207058 [1268521-33-0]

3-Bromo-2-chloro-5-nitropyridin-4-amine

Similarity: 0.83

Chemical Structure| 22280-60-0

A161894 [22280-60-0]

6-Chloro-2-methyl-3-nitropyridine

Similarity: 0.82

Chemical Structure| 4548-45-2

A176909 [4548-45-2]

2-Chloro-5-nitropyridine

Similarity: 0.75

Chemical Structure| 1352886-90-8

A774237 [1352886-90-8]

3-Bromo-2-chloro-6-ethylpyridine

Similarity: 0.71

Nitroes

Chemical Structure| 5470-17-7

A242324 [5470-17-7]

3-Bromo-2-chloro-5-nitropyridine

Similarity: 0.93

Chemical Structure| 1268521-33-0

A207058 [1268521-33-0]

3-Bromo-2-chloro-5-nitropyridin-4-amine

Similarity: 0.83

Chemical Structure| 22280-60-0

A161894 [22280-60-0]

6-Chloro-2-methyl-3-nitropyridine

Similarity: 0.82

Chemical Structure| 4548-45-2

A176909 [4548-45-2]

2-Chloro-5-nitropyridine

Similarity: 0.75

Chemical Structure| 15862-30-3

A360004 [15862-30-3]

3-Bromo-5-nitropyridine

Similarity: 0.75

Related Parent Nucleus of
[ 856834-95-2 ]

Pyridines

Chemical Structure| 5470-17-7

A242324 [5470-17-7]

3-Bromo-2-chloro-5-nitropyridine

Similarity: 0.93

Chemical Structure| 1268521-33-0

A207058 [1268521-33-0]

3-Bromo-2-chloro-5-nitropyridin-4-amine

Similarity: 0.83

Chemical Structure| 22280-60-0

A161894 [22280-60-0]

6-Chloro-2-methyl-3-nitropyridine

Similarity: 0.82

Chemical Structure| 4548-45-2

A176909 [4548-45-2]

2-Chloro-5-nitropyridine

Similarity: 0.75

Chemical Structure| 15862-30-3

A360004 [15862-30-3]

3-Bromo-5-nitropyridine

Similarity: 0.75