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Chemical Structure| 857439-68-0 Chemical Structure| 857439-68-0

Structure of 857439-68-0

Chemical Structure| 857439-68-0

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Product Details of [ 857439-68-0 ]

CAS No. :857439-68-0
Formula : C12H11ClN2
M.W : 218.68
SMILES Code : NC1=CC=CC=C1NC2=CC=CC(Cl)=C2

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Application In Synthesis of [ 857439-68-0 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 857439-68-0 ]

[ 857439-68-0 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 5555-00-0 ]
  • [ 857439-68-0 ]
  • N-(2-((3-chlorophenyl)amino)phenyl)-2-methylfuran-3-carboxamide [ No CAS ]
YieldReaction ConditionsOperation in experiment
With triethylamine; In dichloromethane; at 20℃; for 2h; General procedure: To a solution of compounds 4a-j (0.02 mol) in triethylamine (5 mL) and dichloromethane (15 mL)in an ice bath, freshly prepared 3-furoyl chloride was added dropwise and theresulting mixture was stirred at room temperature for 2 hours. The mixture wasthen filtered, successively washed with aqueous sodium hydroxide (5%, 3 x 15mL) and water (2 x 15 mL). The organic phase wasthen dried over anhydrous sodium sulfate, filtered and evaporated in vacuo to remove dichloromethane.Finally, the residue was purified by column chromatography to yield the finaltarget compounds 5a-j.4 2-methyl-N-(2-(phenylamino)phenyl)furan-3-carboxamide(5a).Yield, 62.8 %; white solid; mp, 133.8-134.6 ; 1HNMR (400 MHz, DMSO) delta 9.25 (s, 1H), 7.60 - 7.52 (m, 2H), 7.44 (s, 1H), 7.30 (dd, J =8.1, 1.1 Hz, 1H), 7.20 (d, J = 7.5 Hz, 1H), 7.19 - 7.12 (m, 2H), 7.04 -6.97 (m, 1H), 6.91 (s, 1H), 6.89 (s, 1H), 6.87 (d, J = 1.7 Hz, 1H), 6.79(t, J = 7.3 Hz, 1H), 2.53 (d, J = 3.3 Hz, 3H). 13C NMR(400 MHz, DMSO): delta 161.70, 156.40, 143.87, 140.53, 136.28, 128.89, 125.75, 125.54, 121.53,120.01, 119.19, 116.05, 109.23, 13.05. ESI MS: m / z 314.98 [M + Na]+.
 

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