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CAS No. : | 858516-70-8 | MDL No. : | MFCD00444782 |
Formula : | C14H11BrN2 | Boiling Point : | - |
Linear Structure Formula : | - | InChI Key : | - |
M.W : | 287.15 | Pubchem ID : | - |
Synonyms : |
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Signal Word: | Warning | Class: | N/A |
Precautionary Statements: | P261-P305+P351+P338 | UN#: | N/A |
Hazard Statements: | H302-H315-H319-H335 | Packing Group: | N/A |
GHS Pictogram: |
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Stage #1: N,N-dimethyl-formamide With trichlorophosphate at 0 - 5℃; Stage #2: 6-bromo-2-(4-methylphenyl)imidazo[1,2-a]pyridine at 80℃; for 6h; | Procedure for the synthesis of 8-methyl-2-phenylimidazo[1,2-a]pyridine-3-carbaldehyde (2a): General procedure: Vilsmeier-Haack complex was prepared by adding POCl3 (2.3 mL, 25.4 mmol) drop-wisely to a dry RB containing DMF (1.85 mL, 25.4 mmol) maintaining temperature at 0-5 oC. Later, a solution of 1a (1.5 g, 6.35 mmol) in 10 mL of DMF was added to the resulting complex at a stretch. The resulting solution was stirred at 80 oC for about 6 hrs. The container was cooled to room temperature and quenched to ice cold water while stirring. The solid obtained was filtered, washed with excess of water and then purified by column chromatographic technique using ethyl acetate and hexane (1:9) system. |