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Chemical Structure| 85951-09-3 Chemical Structure| 85951-09-3

Structure of 85951-09-3

Chemical Structure| 85951-09-3

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Product Details of [ 85951-09-3 ]

CAS No. :85951-09-3
Formula : C15H36O3Si2
M.W : 320.62
SMILES Code : OC(CO[Si](C)(C(C)(C)C)C)CO[Si](C)(C(C)(C)C)C
MDL No. :MFCD30471985
Boiling Point : No data available
InChI Key :BICVCKKJDDTEIV-UHFFFAOYSA-N
Pubchem ID :10758091

Safety of [ 85951-09-3 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P264-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P330-P332+P313-P337+P313-P362-P403+P233-P405-P501

Application In Synthesis of [ 85951-09-3 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 85951-09-3 ]

[ 85951-09-3 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 380380-60-9 ]
  • [ 85951-09-3 ]
  • [ 700370-50-9 ]
  • C21H38BrN5O2Si2 [ No CAS ]
YieldReaction ConditionsOperation in experiment
With di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; at 0 - 20℃; 2-[5-(5-bromopyridin-2-yl)-1H-tetrazol-1-ylpropane-1,3-diol. 5-Bromo-2-(2H-tetrazol-5-yl)pyridiue 0.56 g (2.5 mmol) (WO 0194342 Al, the free acid was generated by dissolving the material obtained following the procedure in WO 0194342 Al (1 g) in hot water (70 mL, 90 C) ; upon addition OF HCl (aqueous, 1M, 4 mL) and cooling to room temperature the free acid precipitated, was collected by filtration, washed with water and dried under high vacuum to give 0.56 g free acid), triphenylphosphine (0.65 g, 2.5 mmol) and 1,3-bis-(tert-butyl-dimethyl-silanyloxy)-propan-2-ol (0.79 g, 2.5 mmol) (D. P. Curran and J.-C. Chao, Synth. Commun. 20, No 22, 1990, 3575-3584) were dissolved/suspended in dry THF (25 mL). It was cooled to 0C and diisopropylazodicarboxylate (0.49 mL, 2.5 mmol) was added and the reaction was allowed to warm to room temp. over night. The solvent was evaporated under reduced pressure and the residue subjected to chromatography on silica gel with hexanes/ethyl acetate (30: 1) to give the bis-silyl ether of the title compound as a mixture together with the corresponding 2H-tetrazole regioisomer (809 mg). This mixture was dissolved in dry THF (10 mL), cooled to 0C and tetrabutylammonium fluoride (1M in THF, 5 mL, 5 mmol) was added drop wise. After one hour solvent was evaporated and the residue subjected to chromatography on silica gel with dichloromethane/acetone (3:1 to 2:1) to give 318 mg of the title compound and 69 mg of the corresponding regioisomeric 2H-substituted tetrazole. The assignment of structure was based on NOE-NMR experiments with the title compound. 1H-NMR (DMSO-d6) delta: 3.80-3.95 (m, 4H); 5.01 (t, 2H); 5.69 (m, 1H) ; 8.14 (m, 1H); 8.35 (m, 1H) ; 8.94 (m, 1H).
 

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