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Chemical Structure| 859537-27-2 Chemical Structure| 859537-27-2

Structure of 859537-27-2

Chemical Structure| 859537-27-2

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Product Details of [ 859537-27-2 ]

CAS No. :859537-27-2
Formula : C11H14FNO3
M.W : 227.24
SMILES Code : O=C(OC(C)(C)C)NC1=CC=C(O)C(F)=C1
MDL No. :MFCD12913382

Safety of [ 859537-27-2 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H315-H319
Precautionary Statements:P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313

Application In Synthesis of [ 859537-27-2 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 859537-27-2 ]

[ 859537-27-2 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 859537-27-2 ]
  • [ 68500-37-8 ]
  • [ 1437323-96-0 ]
YieldReaction ConditionsOperation in experiment
With dmap; In N,N-dimethyl-formamide; at 145℃; for 5h; A mixture of <strong>[68500-37-8]4-chloro-7-methoxyquinoline</strong> (1.0 g mg, 5 mmol), (3-fluoro-4- hydroxyphenyl)-carbamic acid t-butyl ester (1.88 mg, 8.26 mmol) and 4- dimethylaminopyridine (1010 mg, 8.26 mmol) in N,N-dimethylformamide (25 mL) was stirred at 145 °C for 5h. The mixture was cooled to rt, the solvent was removed and the residue was taken in DCM and washed with water and brine. After drying, the solvent was evaporated. The crude product was purified by flash chromatography (hexanes:EtOAc 1 : 1) to give a white solid; LCMS = 385 (M + 1).
  • 2
  • [ 859537-27-2 ]
  • [ 68500-37-8 ]
  • 3-fluoro-4-(7-methoxyquinolin-4-yloxy)-benzenamine hydrochloride [ No CAS ]
 

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