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Chemical Structure| 860029-79-4 Chemical Structure| 860029-79-4

Structure of 860029-79-4

Chemical Structure| 860029-79-4

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Product Details of [ 860029-79-4 ]

CAS No. :860029-79-4
Formula : C8H5Cl2FO
M.W : 207.03
SMILES Code : O=C(C1=CC=C(Cl)C(F)=C1)CCl

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Application In Synthesis of [ 860029-79-4 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 860029-79-4 ]

[ 860029-79-4 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 67442-07-3 ]
  • [ 60811-18-9 ]
  • [ 860029-79-4 ]
YieldReaction ConditionsOperation in experiment
Step 1: 4-bromo-1-chloro-2-fluorobenzene (64 kg) and dry toluene (170 kg) were charged to the 2000 L steel reaction vessel under nitrogen. The reactor was evacuated and backfilled with N2 for three times, and cooled to between -10 and 5° C. under nitrogen atmosphere. To the solution was added dropwise i-PrMgCl.LiCl (280 kg, 1.3M in THF) at between -10 and 10° C. The reaction was stirred for a further 15 to 30 min at between -10 and 10° C. and then warmed to about 20 to 25° C. over 1 h. The reaction mixture was stirred for another 6 h stir to complete the exchange. The resulting solution was cooled to between -50 and -40° C. A solution of <strong>[67442-07-3]2-chloro-N-methoxy-N-methylacetamide</strong> (44.5 kg) in dry toluene (289 kg) was added dropwise to the above solution at while maintaining the temperature between -50 and -30° C. The reaction mixture was warmed to between 20 and 25° C. over 1 h and then stirred for 3 h to complete the reaction. The reaction was quenched by addition of 1N aq. HCl (8081 g) at a temperature between -5 and 15° C. The aqueous layer was separated and organic layer was filtered through a pad of diatomaceous earth. The organic layer was washed with 10percent aq. NaCl solution (320 kg) twice, then concentrated to about 300 L to obtain 1-(4-chloro-3-fluorophenyl)-2-chloroethanone (51.8 kg, 81.9percent yield) as product in toluene.
 

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