Home Cart 0 Sign in  

[ CAS No. 862081-38-7 ] {[proInfo.proName]}

,{[proInfo.pro_purity]}
Cat. No.: {[proInfo.prAm]}
Chemical Structure| 862081-38-7
Chemical Structure| 862081-38-7
Structure of 862081-38-7 * Storage: {[proInfo.prStorage]}
Cart0 Add to My Favorites Add to My Favorites Bulk Inquiry Inquiry Add To Cart

Quality Control of [ 862081-38-7 ]

Related Doc. of [ 862081-38-7 ]

Alternatived Products of [ 862081-38-7 ]

Product Details of [ 862081-38-7 ]

CAS No. :862081-38-7 MDL No. :MFCD18251724
Formula : C14H17BO4 Boiling Point : -
Linear Structure Formula :- InChI Key :-
M.W : 260.09 Pubchem ID :-
Synonyms :

Safety of [ 862081-38-7 ]

Signal Word: Class:
Precautionary Statements: UN#:
Hazard Statements: Packing Group:

Application In Synthesis of [ 862081-38-7 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 862081-38-7 ]

[ 862081-38-7 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 64169-34-2 ]
  • [ 19477-73-7 ]
  • [ 73183-34-3 ]
  • [ 862081-37-6 ]
  • [ 862081-38-7 ]
YieldReaction ConditionsOperation in experiment
To a stirring room temperature solution of 4-bromophthalic anhydride (3.00 g, 13.22 mmol) in ethanol (10 mL) and tetrahydrofuran (50 mL), under a blanket of nitrogen, add sodium borohydride (1.96 g, 52.86 mmol), in portions. Stir this mixture at ambient temperature for 8 hours and then quench with 2N HC1 (12 mL) and then excess water. Extract the resulting aqueous mixture with diethyl ether then ethyl acetate. Wash the combined extracts with water and brine; dry (sodium sulfate) and concentrate them in vacuo to give a mixture of 5-bromo-3H-isobenzofuran-l-one and 6-bromo-3H- isobenzofuran-1-one, 2.78 g (98%). Use as is without purification. Place the mixture of 5-bromo-3H-isobenzofuran-l-one and 6-bromo-3H- isobenzofuran-1-one (1.50 g, 7.04 mmol), bis (pinacolato) diboron (2.06 g, 8.10 mmol), PdCl2 (dppf) 2'CH2Cl2 (180 mg, 0.246 mmol), potassium acetate (2.07 g, 21.13 mmol) and anhydrous dimethyl sulfoxide (22 mL) in a round bottom flask. Put the reaction in an oil bath and stir it at 85C for 8 hours. Cool the dark brown colored reaction to ambient temperature, quench with ample water and extract the resulting aqueous mixture with dichloromethane. Wash the combined extracts with water and brine; then dry (sodium sulfate) and evaporate them in vacuo. Purify the resulting dark solid on a flash column (silica gel; 0%-20% gradient of THF in CH2C12 then 5% MeOH/20% THF/CH2C12) to provide the product as a mixture of the two title components, 785 mg (43%).
  • 2
  • [ 648904-51-2 ]
  • [ 862081-37-6 ]
  • [ 862081-38-7 ]
  • [ 862081-39-8 ]
  • [ 862081-40-1 ]
YieldReaction ConditionsOperation in experiment
With cesium fluoride; tricyclohexylphosphine In acetonitrile at 90℃; for 0.416667h; 15 In a round bottom flask add trifluoromethanesulfonic acid 6-benzyloxy-1- [4- (2- piperidin-l-yl-ethoxy)-phenoxy]-naphthalen-2-yl ester) (592 mg, 0.984 mmol), the mixture of 5- (4, 4,5, 5-tetramethyl- [1, 3,2] dioxaborolan-2-yl)-3H-isobenzofuran-1-one and 6- (4, 4,5, 5-tetramethyl- [1, 3,2] dioxaborolan-2-yl)-3H-isobenzofuran-l-one (0.640 g, 2. 46 mmol), a sonicated suspension of Palladium (II) Acetate (0.049 g, 0.220 mmol) and Tricyclohexylphosphine (0.091 g, 0.320 mmol) in acetonitrile (4 mL), and cesium fluoride (1.35 g, 8.86 mmol). Add acetonitrile (25 mL) and immediately place the reaction in a preheated oil bath at 90°C, and stir for 25 minutes. Then cool the reaction to ambient temperature and filter it through a pad of Celite (rinse with ample, hot ethyl acetate). Wash the filtrate with 50% aqueous sodium carbonate, saturated aqueous ammonium chloride, water and brine; then dry (sodium sulfate) and evaporate it in vacuo. Purify the resulting brown solid foam on a flash column (silica gel; 4%-10% MeOH gradient in CH2C12).
Same Skeleton Products
Historical Records