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Chemical Structure| 862081-47-8 Chemical Structure| 862081-47-8

Structure of 862081-47-8

Chemical Structure| 862081-47-8

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Product Details of [ 862081-47-8 ]

CAS No. :862081-47-8
Formula : C15H18BNO4
M.W : 287.12
SMILES Code : O=C1N(C)C(C2=C1C=CC(B3OC(C)(C)C(C)(C)O3)=C2)=O

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Application In Synthesis of [ 862081-47-8 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 862081-47-8 ]

[ 862081-47-8 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 862081-47-8 ]
  • [ 7089-68-1 ]
  • [ 1357008-80-0 ]
YieldReaction ConditionsOperation in experiment
60% With tetrakis(triphenylphosphine) palladium(0); caesium carbonate; In 1,2-dimethoxyethane; at 80℃; for 6h;Inert atmosphere; In the atmosphere of nitrogen, intermediate A2 (1.6g, 5.6 mmol), <strong>[7089-68-1]2-chlorophenanthroline</strong> (0.8g, 3.7 mmol), tetrakis(triphenylphosphine)palladium (0) (0.1g, 0.11 mmol), cesium carbonate (3.0g, 9.3 mmol) and 1,2-dimethoxyethane (37 mL) were mixed, followed by stirring at 80°C for 6 hours. Water (50 mL) was added to the reaction mixture, and the precipitates were filtered out to obtain a yellow solid (compound (2-A); 0.76g, 60percent).1H-NMR (400MHz, CDCl3, TMS)delta: 3.25 (s,3H), 7.70 (d,J8.0,1H), 8.03 (d,J8.0,1H), 8.18 (d,J8.0,1H), 8.30 (d,J8.0,1 H), 8.41 (d,J8.0,1H), 8.69 (s,1H), 8.83 (d,J8.0,1 H), 9.26 (d,J8.0,1H).
  • 2
  • [ 862081-47-8 ]
  • [ 66127-01-3 ]
  • [ 1357008-81-1 ]
YieldReaction ConditionsOperation in experiment
90% With tetrakis(triphenylphosphine) palladium(0); caesium carbonate; In 1,2-dimethoxyethane; at 80℃; for 6h;Inert atmosphere; In the atmosphere of nitrogen, intermediate A2 (0.33g, 1.15 mmol) synthesized in Example 1 (2), <strong>[66127-01-3]3-bromophenanthroline</strong> (0.2g, 0.77 mmol), cesium carbonate (0.63g, 2.0 mmol), tetrakis(triphenylphosphine)palladium (0) (0.027g, 0.023 mmol) and 1,2-dimethoxyethane (10 mL) were mixed, followed by stirring at 80C for 6 hours. Water (50 mL) was added to the reaction mixture, and the precipitates were filtered out to obtain a yellow solid (compound (2-B); 0.23g, 90%). 1H-NMR (400MHz, CDCl3,TMS)delta: 3.24 (s,3H), 7.69 (d,J8.0,1H), 7.90 (s,1H), 8.03 (d,J8.0,1H), 8.13 (d,J8.0,1H), 8.26-8.31 (m,2H), 8.50 (d,J8.0,1 H), 9.24 (d,J8.0,1 H), 9.46 (d,J8.0,1 H).
 

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