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Chemical Structure| 865886-84-6 Chemical Structure| 865886-84-6

Structure of 865886-84-6

Chemical Structure| 865886-84-6

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Product Details of [ 865886-84-6 ]

CAS No. :865886-84-6
Formula : C7H4BrF2NO3
M.W : 268.01
SMILES Code : FC(F)OC1=CC=C(Br)C([N+]([O-])=O)=C1
MDL No. :MFCD18390950
InChI Key :LSNTUFKHTNZVDL-UHFFFAOYSA-N
Pubchem ID :53414036

Safety of [ 865886-84-6 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P264-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P330-P332+P313-P337+P313-P362-P403+P233-P405-P501

Application In Synthesis of [ 865886-84-6 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 865886-84-6 ]

[ 865886-84-6 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 65094-22-6 ]
  • [ 78137-76-5 ]
  • [ 865886-84-6 ]
YieldReaction ConditionsOperation in experiment
With potassium hydroxide; In water; acetonitrile; at -30 - 20℃; for 0.5h; 3.62. Compound 63: (lR,2R)-N-(6-((5-(difluoromethoxy)-2-ethylphenyl)(methyl)amino)-l-methyl- lH-imidazo[4,5-c]pyridin-4-yl)-2-fluorocyclopropanecarboxamide 3.62.1. Step i): l-Bromo-4-difluoromethoxy-2-nitro-benzene Diethyl(bromodifluoromethyl)phosphonate (2 eq, 1.64mL) is added to a cooled (-30 °C) solution of 4-Bromo-3-nitro-phenol (1 eq, 1.0 g) and KOH (20 eq, 5.17 g) in MeCN/water (46 mL; 1 :1) and the reaction mixture is allowed to warm to room temperature. After 30 min, the mixture is diluted with Et20, the organic phase is separated and the water phase is washed with a further amount of Et20. The combined organics are dried and concentrated. The residue is purified by silica chromatography (5-50 percent EtOAc in petroleum ether) to give the desired product.
 

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