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Chemical Structure| 86927-03-9 Chemical Structure| 86927-03-9

Structure of 86927-03-9

Chemical Structure| 86927-03-9

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Product Details of [ 86927-03-9 ]

CAS No. :86927-03-9
Formula : C12H12BrNO3
M.W : 298.13
SMILES Code : O=C1N(CCOCCBr)C(C2=C1C=CC=C2)=O
MDL No. :MFCD20484990

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Application In Synthesis of [ 86927-03-9 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 86927-03-9 ]

[ 86927-03-9 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 52022-77-2 ]
  • [ 86927-03-9 ]
  • 2-(2-(2-(3-nitrophenethoxy)ethoxy)ethyl)isoindoline-1,3-dione [ No CAS ]
YieldReaction ConditionsOperation in experiment
1.2 g A solution of <strong>[52022-77-2]2-(3-nitrophenyl)ethanol</strong> (3.2 g, 19.14 mmol) in DMF (5 mL) was cooled in an ice-water bath then treated portionwise with sodium hydride (1 .531 g, 38.3 mmol). The solution was (1787) stirred for 50 min. then treated portionwise with 2-(2-(2-bromoethoxy)ethyl)isoindoline-1 ,3- dione (5.71 g, 19.14 mmol) over 20 min. The mixture was stirred at room temperature overnight. The mixture was treated with water (50 mL) then extracted with EtOAc (3 x 50 mL) then the organic layers dried and evaporated and the residue purified by chromatography (silica gel, 0-5% MeOH in DCM) to afford the desired product (1 .2 g) as a colorless solid. LCMS m/z 406.9 (M+Na)+, 385.0 (M+H)+.
 

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