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Chemical Structure| 86996-25-0 Chemical Structure| 86996-25-0

Structure of 86996-25-0

Chemical Structure| 86996-25-0

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Product Details of [ 86996-25-0 ]

CAS No. :86996-25-0
Formula : C10H17NO2
M.W : 183.25
SMILES Code : CC(C)C(NC1CCC(CC1)=O)=O
MDL No. :MFCD12106624

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Application In Synthesis of [ 86996-25-0 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 86996-25-0 ]

[ 86996-25-0 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 86996-25-0 ]
  • [ 6971-45-5 ]
  • [ 918792-66-2 ]
YieldReaction ConditionsOperation in experiment
4% With acetyl chloride; In ethanol; for 57h;Heating / reflux; Preparation 7N-(8-methoxy-2,3,4,9-tetrahydro-lH-carbazol-3-yl)-isobutyramideAdd acetyl chloride (34.1 mL, 480 mmol) portionwise to absolute ethanol (120 mL) cooled in an ice bath and stir for 2 h. Add 4-methoxyphenylhydrazine hydrochloride (1.74 g, 10 mmol) and N-(4-oxo-cyclohexyl)-isobutyramide (Preparation 2) (1.83 g, 120 mmol) and reflux with stirring for 18 h. Follow the procedures essentially as described in Preparation 6, above, to give 6.0 g green gum after workup. Pass over a silica pad eluting with dichloromethane/25% ethyl acetate to provide 1.29 g of a brown foam. Further purify the residue by flash EPO <DP n="90"/>chromatography, eluting with dichloromethane, dichloromethane/25% ethyl acetate and then a gradient up to dichloromethane/40% ethyl acetate to obtain a pale tan solid. Triturate in diethyl ether with a bit of hexane to give 421 mg (4%) of an off- white solid. MS (ES): m/z 287 (M+l), 285 (M-I); 1H NMR(DMS0-d6): delta 10.77 (s, IH), 7.83 (d, IH, J = 7.5 Hz), 6.95 (d, IH, J = 7.9 Hz), 6.86 (t, IH, J = 7.7 Hz), 6.61 (d, IH, J = 7.5 Hz), 4.02 (m, IH), 3.90 (s, 3H), 2.89 (dd, IH, J = 15.0, 5.3 Hz), 2.76 (m, 2H), 2.50-2.34 (m, 3H), 1.95 (m, IH), 1.76 (m, IH), 1.03 (d, 6H, / = 7.0 Hz).
 

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