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Chemical Structure| 870062-30-9 Chemical Structure| 870062-30-9

Structure of 870062-30-9

Chemical Structure| 870062-30-9

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Product Details of [ 870062-30-9 ]

CAS No. :870062-30-9
Formula : C13H20N2O
M.W : 220.31
SMILES Code : NCC1=CC=CC(OC2CCN(C)CC2)=C1

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Application In Synthesis of [ 870062-30-9 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 870062-30-9 ]

[ 870062-30-9 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 870062-30-9 ]
  • [ 173282-69-4 ]
  • C25H27N3O2 [ No CAS ]
YieldReaction ConditionsOperation in experiment
With acetic acid; In methanol; at 50℃; for 0.333333h;pH 4.5 - 5; 6-Phenoxynicotinaldehyde (0.054 g, 0.272 mmol) and Intermediate D (0.100 g, 0.406 mmol) were allowed to stir in 15 mL of MeOH. Glacial acetic acid was added via pipet until a pH of ~ 4.5-5.0 was reached. The reaction was allowed to stir and heat at 50 0C for twenty min. Sodium cyanoborohydride (0.014 g, 0.2 mmol) was added and the reaction was allowed to continue stirring and heating for 16 h. LC/MS monitoring of reaction indicated reaction completion. The reaction was quenched with 1 mL H2O and concentrated to dryness. The residue re-dissolved in methylene chloride and washed with Brine (3x15mL). The organic layer was dried over MgSO4 concentrated to dryness. Purification via SiO2 chromatography using a (9/0.9/0.1) mixture of (CH2CI2ZCH3OHZNH3OH) afforded 42 mgs (23%) of the desired target compound. 1H NMR (300 MHz, CDCl3) δ 8.13 (d, IH), 7.70 (m, IH), 7.39 (m, 2H), 7.18 (m, 4H), 6.87 (m, 4H), 4.32 (m, IH), 3.75 (d, 4H), 2.69 (m, 2H), 2.30 (m, 5H), 19.7 (m, 2H), 1.85 (m, 2H), 1.70 (bs, 2H).
 

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