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Chemical Structure| 877160-63-9 Chemical Structure| 877160-63-9

Structure of 877160-63-9

Chemical Structure| 877160-63-9

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Product Details of [ 877160-63-9 ]

CAS No. :877160-63-9
Formula : C12H17BClNO2
M.W : 253.53
SMILES Code : NC1=CC=C(B2OC(C)(C)C(C)(C)O2)C(Cl)=C1
MDL No. :MFCD09864184
InChI Key :YKQXROMICPMQBZ-UHFFFAOYSA-N
Pubchem ID :44755206

Safety of [ 877160-63-9 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Application In Synthesis of [ 877160-63-9 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 877160-63-9 ]

[ 877160-63-9 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 1120-95-2 ]
  • [ 877160-63-9 ]
  • 3-chloro-4-pyridazin-3-ylphenylamine [ No CAS ]
YieldReaction ConditionsOperation in experiment
With tetrakis(triphenylphosphine) palladium(0); sodium carbonate; In ethanol; water; toluene; at 115℃; for 5h;Inert atmosphere; In a 250 mL round-bottomed flask, 3-chloro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2- yl)aniline (950 mg, 3.75 mmol, Eq: 1.00), <strong>[1120-95-2]3-<strong>[1120-95-2]chloropyridazine</strong></strong> (437 mg, 3.82 mmol, Eq: 1.02) and tetrakis(triphenylphosphine)palladium(O) (437 mg, 378 flmol, Eq: 0.101) were combined with toluene (38.0 mL) to give a brown solution. A 2.0 M aqueous solution of sodium carbonate (7.6 ml, 15.2 mmol, Eq: 4.06) and ethanol (7.6 mL) were added. The reaction mixture was stirred at115 oc for 5 hours.The reaction mixture was cooled to room temperature, and it was stirred at room temperature overnight. The reaction mixture was partitioned between ethyl acetate (10 mL) and water (10 mL). The organic phase was dried (Na2S04), filtered, then concentrated over silica gel. The silica-supported crude product was loaded onto a 115 gram silica gel column (Analogix). Flash chromatography (70percent ethyl acetate in hexanes) gave 3-chloro-4-pyridazin-3-yl-phenylamine (700 mg, 90percent) containing triphenylphosphine oxide as a minor impurity.
 

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